Abstracts tagged "ANCA"

Abstract Number: 738 • 2013 ACR/ARHP Annual Meeting
Pulmonary Fibrosis In ANCA-Associated Vasculitis
Cloé Comarmond¹, Bruno Crestani², Abdellatif Tazi³, Baptiste Hervier⁴, Sylvain Adam-Marchand⁵, Hilario Nunes⁶, Fleur Cohen-Aubart⁷, Marie Wislez⁸, Jacques Cadranel⁸, Bruno Housset⁹, Célia Lloret-Linares¹⁰, Pascal Sève¹¹, Christian Pagnoux¹², Sébastien Abad¹³, Juliette Camuset¹⁴, Boris Bienvenu¹⁵, Michael Duruisseaux¹⁶, Eric Hachulla¹⁷, Jean-Benoît Arlet¹⁸, Mohamed Hamidou¹⁹, Alfred Mahr²⁰, Anne-Laure Brun²¹, Philippe Grenier²¹, Patrice Cacoub²² and David Saadoun²³, ¹Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, ²Pneumology A, Hôpital Bichat, Paris, France, ³Hôpital Saint-Louis, Paris, France, ⁴Internal Medicine & Clinical Immunology Dpt, Pitié-Salpêtrière Hospital, APHP, Paris, France, ⁵Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, ⁶Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France, ⁷Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, ⁸Pneumology, Hôpital Tenon, Paris, France, ⁹Pneumology, Centre Hospitalier Intercommunal de Créteil, Créteil, France, ¹⁰Médecine Interne A, Hôpital Lariboisière, Paris, France, ¹¹Internal medicine, CHU Lyon, Lyon, France, ¹²Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, ¹³Internal Medicine, Avicenne Hospital, Bobigny, France, ¹⁴Pneumology, Centre Hospitalier Victor Dupouy, Argenteuil, France, ¹⁵Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, ¹⁶Pneumology, CHU de Grenoble, Grenoble, France, ¹⁷Internal Medicine, Lille CEDEX, France, ¹⁸Internal Medicine, HEGP, Paris, France, ¹⁹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²⁰Department of Internal Medicine, Hospital Saint-Louis, Paris, France, ²¹Radiology, Hôpital Pitié-Salpêtrière, Paris, France, ²²Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France, ²³Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France
Background/Purpose: The association of pulmonary fibrosis (PF) with anti neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), especially microscopic polyangiitis (MPA), is rare but related to poor…
Abstract Number: 741 • 2013 ACR/ARHP Annual Meeting
Granulomatosis With Polyangiitis Central Nervous System Involvement: Presentation and Management
Gonzalo De Luna^1,2, Benjamin Terrier³, Pierre Kaminsky⁴, Francois Maurier⁵, Roser Solans⁶, Raphaèle Seror⁷, Xavier Puéchal⁸, Luc Mouthon⁹ and Loic Guillevin¹⁰, ¹Medecine Interne, Cochin University Hospital, Paris, France, ²Internal Medicine, Hospital Ramon y Cajal, Madrid, Spain, ³Internal Medicine, Cochin University Hospital, Paris, France, ⁴Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Orphan disease unit, Nancy, F-54000, France;, Nancy, France, ⁵HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁶Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain, ⁷Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, ⁸National Referral Center for Rare Systemic Auto-immune Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ⁹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ¹⁰Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Granulomatosis with polyangiitis (GPA), a small-sized–vessel vasculitis, commonly involves ear, nose & throat (ENT), lungs and kidneys, and, more rarely, the central nervous system…
Abstract Number: 2782 • 2013 ACR/ARHP Annual Meeting
Retreatment With Rituximab In The Rituximab In ANCA-Associated Vasculitis (RAVE) Trial
Eli Miloslavsky¹, Ulrich Specks², Peter A Merkel³, Philip Seo⁴, Robert F. Spiera⁵, Carol A. Langford⁶, Gary S. Hoffman⁷, Cees G.M. Kallenberg⁸, E. William St Clair⁹, Nadia Tchao¹⁰, Linna Ding¹¹, David Ikle¹², Brett Jepson¹², Paul Brunetta¹³ and John H. Stone¹⁴, ¹Division of Rheumatology, Massachusetts General Hopsital, Boston, MA, ²Mayo Clinic, Rochester, MN, ³Division of Rheumatology, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁴Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ⁵Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁷Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁸Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁹Medicine, Duke Unversity Medical Center, Durham, NC, ¹⁰Immune Tolerance Network, Bethesda, MD, ¹¹NIAID, Bethesda, MD, ¹²Rho, Chapel Hill, NC, ¹³Biotherapeutics, Genentech, So San Francisco, CA, ¹⁴Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Retrospective studies have demonstrated that repeat rituximab treatment may be effective in re-inducing remission in relapsing ANCA-associated vasculitis. We analyzed data from the Rituximab…
Abstract Number: 743 • 2013 ACR/ARHP Annual Meeting
Efficacy Of Rituximab For Otolaryngologic (ENT) Manifestations Of Granulomatosis With Polyangiitis (GPA, Wegener’s granulomatosis)
Lindsay Lally¹, Robert Lebovics², Wei-Ti Huang³ and Robert F. Spiera¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Otolaryngology, St. Luke's-Roosevelt Hospital Center, New York, NY, ³Biostatistics, Hospital for Special Surgery, New York, NY
Background/Purpose: ENT involvement is the most prevalent manifestation of GPA. Rituximab (RTX) is a proven effective remission induction therapy for severe GPA with vasculitic manifestations. …
Abstract Number: 2784 • 2013 ACR/ARHP Annual Meeting
Mononeuritis Multiplex Predicts The Need For Immunosuppressive Or Immunomodulatory Drugs For Eosinophilic Granulomatosis With Polyangiitis, Polyarteritis Nodosa and Microscopic Polyangiitis Patients Without Poor-Prognosis Factors
Maxime Samson¹, Xavier Puéchal², Hervé Devilliers³, Camillo Ribi⁴, Pascal Cohen⁵, Boris Bienvenu⁶, Christian Pagnoux⁷, Luc Mouthon², Loic Guillevin⁸ and French Vasculitis Study Group (FVSG)², ¹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ²Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ³Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, ⁴Immunology and Allergology, Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland, Geneva, Switzerland, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁶Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, ⁷Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, ⁸Department of Internal Medicine,, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Patients with eosinophilic granulomatosis with polyangiitis (EGPA), polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA) without poor-prognosis factors, as defined by their 1996 Five-Factor Scores…
Abstract Number: 747 • 2013 ACR/ARHP Annual Meeting
Efficacy Of Glucocorticoids To Treat Limited Flares In ANCA-Associated Vasculitis
Eli Miloslavsky¹, Ulrich Specks², Peter A. Merkel³, Philip Seo⁴, Robert F. Spiera⁵, Carol A. Langford⁶, Gary S. Hoffman⁷, Cees G.M. Kallenberg⁸, E. William St. Clair⁹, Nadia Tchao¹⁰, Linna Ding¹¹, David Ikle¹², Brett Jepson¹², Paul Brunetta¹³ and John H. Stone¹⁴, ¹Division of Rheumatology, Massachusetts General Hopsital, Boston, MA, ²Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ⁵Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁷Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁸Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁹Medicine, Duke University Medical Center, Durham, NC, ¹⁰Immune Tolerance Network, Bethesda, MD, ¹¹NIAID, Bethesda, MD, ¹²Rho, Chapel Hill, NC, ¹³Biotherapeutics, Genentech, So San Francisco, CA, ¹⁴Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose: The great majority of patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) achieve disease remission initially, but relapses occur in up to…
Abstract Number: 2785 • 2013 ACR/ARHP Annual Meeting
Urinary Inflammatory Cells Strongly Reflect the Disease Activity and Renal Function in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Yoko Wada¹, Minoru Sakatsume², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ³School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: The antineutrophil cytoplasmic autoantibody (ANCA)- associated vasculitides (AAVs) include microscopic polyangiitis (MPA), granulomatosis with polyangitis (GPA; formerly Wegener’s), and eosinophilic granulomatosis with polyangitis (EGPA).…
Abstract Number: 1538 • 2012 ACR/ARHP Annual Meeting
ANCA-Associated Vasculitis in Hispanic Americans: An Unrecognized Severity
Ranadeep Mandhadi¹, Fadi Aldaghlawi², Asad Khan², Vajiha Irshad³, Joel A. Block² and Antoine Sreih⁴, ¹Mount Sinai Hospital, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Internal Medicine, Stroger Hospital of Cook County, Chicago, IL, ⁴Medicine/Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: ANCA-associated vasculitis, once a disease thought to predominate in Caucasians, is now increasingly recognized in diverse ethnic populations. However, there has been little systematic…
Abstract Number: 1541 • 2012 ACR/ARHP Annual Meeting
Does Leflunomide Have a Place As Remission Maintenance Therapy in ANCA-Associated Vasculitis? A Bayesian Network Meta-Analysis with Hypothesis Driven Sensitivity Analyses to Adjust for Potential Biases
Glen S. Hazlewood¹, Claudia Metzler², George A. Tomlinson³, Wolfgang L. Gross⁴, Brian M. Feldman⁵, Loic Guillevin⁶ and Christian Pagnoux⁷, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²University of Lubeck, Bad Branstedy, Germany, ³University of Toronto, Toronto, ON, Canada, ⁴Dept of Clinical Rheumatology, Medical University at Lubeck, Lubeck, Germany, ⁵Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Internal Medicine, Cochin University Hospital, Paris, France, ⁷Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada
Background/Purpose: Primary: To determine the relative treatment effects of maintenance therapy in adult patients with ANCA-associated vasculitis who have achieved remission, using a Bayesian network…
Abstract Number: 1542 • 2012 ACR/ARHP Annual Meeting
The Efficacy of Rituximab Vs Cyclophosphamide for Treatment of Renal Disease in ANCA-Associated Vasculitis: The RAVE Trial Geetha D, Fervenza FC for the RAVE-Itn Research Group
Duvuru Geetha¹ and Fernando Fervenza², ¹Nephrology, Johns Hopkins University, Baltimore, MD, ²Mayo Clinic, Rochester, MN
Background/Purpose: Rituximab (RTX) is non-inferior to cyclophosphamide (CYC) followed by azathioprine (AZA) for remission-induction in severe ANCA associated vasculitis (AAV) but details of outcomes among…
Abstract Number: 1543 • 2012 ACR/ARHP Annual Meeting
Rituximab for ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Trials
Carolina Mejia¹ and Carlos J. Lozada², ¹Internal Medicine, Mount Sinai Medical Center, Miami, FL, ²Dept of Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Background/Purpose: Over the past 40 years, cyclophosphamide/glucocorticoids combination therapy has been the standard regimen for remission induction in ANCA-associated vasculitis.. Although a major advance in…
Abstract Number: 1545 • 2012 ACR/ARHP Annual Meeting
Long-Term Follow-up of 118 Polyarteritis Nodosa and Microscopic Polyangiitis without Poor-Prognosis Factors
Maxime Samson¹, Xavier Puechal², Hervé Devilliers³, Camillo Ribi⁴, Pascal Cohen⁵, Boris Bienvenu⁶, Christian Pagnoux⁷, Luc Mouthon⁸, Loic Guillevin⁹ and French Vasculitis Study Group FVSG¹⁰, ¹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ²Internal Medicine, Hôpital Cochin, Paris, France, ³Internal medicine, Hôpital Général, Dijon, France, ⁴Internal Medicine, Hôpital Universitaire Cantonal de Genève, Geneve, Switzerland, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁶Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, ⁷Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, ⁸Internal Medicine, Hopital Cochim, Paris, France, ⁹Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ¹⁰Internal Medicine, Service de médecine interne, Centre de Références des Vascularites, Université Paris Descartes, APHP, Hôpital Cochin, 75005 Paris, France., Paris, France
Background/Purpose: Polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA) are 2 vasculitides characterized by necrotizing inflammation of the vessel wall. They share several clinical features and…
Abstract Number: 1524 • 2012 ACR/ARHP Annual Meeting
The Use of the International Classification of Function, Disability and Health As a Conceptual Framework for Comparison of the Content of Core Outcome Instruments with the Patient Perspective in Vasculitis
Nataliya Milman¹, Peter A. Merkel², Annelies Boonen³, Lee Strunin⁴, Ryan Borg⁴ and Peter Tugwell⁵, ¹Rheumatology, Ottawa Hospital, Riverside Campus, Ottawa, ON, Canada, ²University of Pennsylvania, Philadelphia, PA, ³Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Community Health Sciences, Boston University School of Public Health, Boston, MA, ⁵Institute of Population Health, Center For Global Health, University of Ottawa, Ottawa General Hospital, Ottawa, ON, Canada
Background/Purpose: The International Classification of Functioning, Disability and Health (ICF) is a general health model endorsed by the World Health Organization. It describes health along…
Abstract Number: 1531 • 2012 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis of Neutrophils Between Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Teisuke Uchida¹, Kouhei Nagai², Toshiyuki Sato², Mitsumi Arito², Nobuko Iizuka², Manae Kurokawa², Naoya Suematsu², Kazuki Okamoto², Shoichi Ozaki³ and Tomohiro Kato⁴, ¹Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine,, Kawasaki, Japan, ²Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ³Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁴Clinical Proteomics and Molecular Medicine, St. Mariannna University Graduate School of Medicine., Kawasaki, Japan
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which dysfunction of polymorphonuclear cells (PMN) is thought to…
Abstract Number: 1532 • 2012 ACR/ARHP Annual Meeting
Serum Angiopoietin-2 Level Reflects the Disease Activity and Renal Function in Antineutrophilic Cytoplasmic Antibody-Associated Vasculitis
Yoko Wada¹, Hiroe Sato¹, Takeshi Nakatsue¹, Shuichi Murakami¹, Takeshi Kuroda², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Health Administration Center, Niigata University, Niigata, Japan, ³School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Angiopoietin-2 (Ang-2) has emerged as a key mediator of endothelial cell activation. Ang-1 and Ang-2 are antagonistic ligands which bind with similar affinity to…

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