ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 1538 • 2012 ACR/ARHP Annual Meeting

    ANCA-Associated Vasculitis in Hispanic Americans: An Unrecognized Severity

    Ranadeep Mandhadi1, Fadi Aldaghlawi2, Asad Khan2, Vajiha Irshad3, Joel A. Block2 and Antoine Sreih4, 1Mount Sinai Hospital, Chicago, IL, 2Rush University Medical Center, Chicago, IL, 3Internal Medicine, Stroger Hospital of Cook County, Chicago, IL, 4Medicine/Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: ANCA-associated vasculitis, once a disease thought to predominate in Caucasians, is now increasingly recognized in diverse ethnic populations. However, there has been little systematic…
  • Abstract Number: 1541 • 2012 ACR/ARHP Annual Meeting

    Does Leflunomide Have a Place As Remission Maintenance Therapy in ANCA-Associated Vasculitis? A Bayesian Network Meta-Analysis with Hypothesis Driven Sensitivity Analyses to Adjust for Potential Biases

    Glen S. Hazlewood1, Claudia Metzler2, George A. Tomlinson3, Wolfgang L. Gross4, Brian M. Feldman5, Loic Guillevin6 and Christian Pagnoux7, 1Medicine, University of Toronto, Toronto, ON, Canada, 2University of Lubeck, Bad Branstedy, Germany, 3University of Toronto, Toronto, ON, Canada, 4Dept of Clinical Rheumatology, Medical University at Lubeck, Lubeck, Germany, 5Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 6Internal Medicine, Cochin University Hospital, Paris, France, 7Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada

    Background/Purpose: Primary: To determine the relative treatment effects of maintenance therapy in adult patients with ANCA-associated vasculitis who have achieved remission, using a Bayesian network…
  • Abstract Number: 1542 • 2012 ACR/ARHP Annual Meeting

    The Efficacy of Rituximab Vs Cyclophosphamide for Treatment of Renal Disease in ANCA-Associated Vasculitis: The RAVE Trial Geetha D, Fervenza FC for the RAVE-Itn Research Group

    Duvuru Geetha1 and Fernando Fervenza2, 1Nephrology, Johns Hopkins University, Baltimore, MD, 2Mayo Clinic, Rochester, MN

    Background/Purpose: Rituximab (RTX) is non-inferior to cyclophosphamide (CYC) followed by azathioprine (AZA) for remission-induction in severe ANCA associated vasculitis (AAV) but details of outcomes among…
  • Abstract Number: 1543 • 2012 ACR/ARHP Annual Meeting

    Rituximab for ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Trials

    Carolina Mejia1 and Carlos J. Lozada2, 1Internal Medicine, Mount Sinai Medical Center, Miami, FL, 2Dept of Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL

    Background/Purpose:  Over the past 40 years, cyclophosphamide/glucocorticoids combination therapy has been the standard regimen  for remission induction in ANCA-associated vasculitis.. Although a major advance in…
  • Abstract Number: 1545 • 2012 ACR/ARHP Annual Meeting

    Long-Term Follow-up of 118 Polyarteritis Nodosa and Microscopic Polyangiitis without Poor-Prognosis Factors

    Maxime Samson1, Xavier Puechal2, Hervé Devilliers3, Camillo Ribi4, Pascal Cohen5, Boris Bienvenu6, Christian Pagnoux7, Luc Mouthon8, Loic Guillevin9 and French Vasculitis Study Group FVSG10, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 2Internal Medicine, Hôpital Cochin, Paris, France, 3Internal medicine, Hôpital Général, Dijon, France, 4Internal Medicine, Hôpital Universitaire Cantonal de Genève, Geneve, Switzerland, 5National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 6Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, 7Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, 8Internal Medicine, Hopital Cochim, Paris, France, 9Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, 10Internal Medicine, Service de médecine interne, Centre de Références des Vascularites, Université Paris Descartes, APHP, Hôpital Cochin, 75005 Paris, France., Paris, France

    Background/Purpose: Polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA) are 2 vasculitides characterized by necrotizing inflammation of the vessel wall. They share several clinical features and…
  • Abstract Number: 1524 • 2012 ACR/ARHP Annual Meeting

    The Use of the International Classification of Function, Disability and Health As a Conceptual Framework for Comparison of the Content of Core Outcome Instruments with the Patient Perspective in Vasculitis

    Nataliya Milman1, Peter A. Merkel2, Annelies Boonen3, Lee Strunin4, Ryan Borg4 and Peter Tugwell5, 1Rheumatology, Ottawa Hospital, Riverside Campus, Ottawa, ON, Canada, 2University of Pennsylvania, Philadelphia, PA, 3Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 4Community Health Sciences, Boston University School of Public Health, Boston, MA, 5Institute of Population Health, Center For Global Health, University of Ottawa, Ottawa General Hospital, Ottawa, ON, Canada

    Background/Purpose: The International Classification of Functioning, Disability and Health (ICF) is a general health model endorsed by the World Health Organization. It describes health along…
  • Abstract Number: 1531 • 2012 ACR/ARHP Annual Meeting

    Comparative Proteomic Analysis of Neutrophils Between Microscopic Polyangiitis and Granulomatosis with Polyangiitis

    Teisuke Uchida1, Kouhei Nagai2, Toshiyuki Sato2, Mitsumi Arito2, Nobuko Iizuka2, Manae Kurokawa2, Naoya Suematsu2, Kazuki Okamoto2, Shoichi Ozaki3 and Tomohiro Kato4, 1Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine,, Kawasaki, Japan, 2Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, 3Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 4Clinical Proteomics and Molecular Medicine, St. Mariannna University Graduate School of Medicine., Kawasaki, Japan

    Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which dysfunction of polymorphonuclear cells (PMN) is thought to…
  • Abstract Number: 1532 • 2012 ACR/ARHP Annual Meeting

    Serum Angiopoietin-2 Level Reflects the Disease Activity and Renal Function in Antineutrophilic Cytoplasmic Antibody-Associated Vasculitis

    Yoko Wada1, Hiroe Sato1, Takeshi Nakatsue1, Shuichi Murakami1, Takeshi Kuroda2, Masaaki Nakano3 and Ichiei Narita1, 1Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Health Administration Center, Niigata University, Niigata, Japan, 3School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan

    Background/Purpose: Angiopoietin-2 (Ang-2) has emerged as a key mediator of endothelial cell activation. Ang-1 and Ang-2 are antagonistic ligands which bind with similar affinity to…
  • Abstract Number: 2564 • 2012 ACR/ARHP Annual Meeting

    A Risk Score for Predicting Short-Term Incidence of Death or Relapse in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

    Carla Maldini1, Matthieu Resche-Rigon2, David Jayne3, Kerstin Westman4 and Alfred Mahr1, 1Internal Medicine, Hospital Saint-Louis, Paris, France, 2Biostatistics, Hopital Saint-Louis, Paris, France, 3Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom, 4Nephrology and Transplantation, Skåne University Hospital Malmö, Lund University, Malmö, Sweden

    Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), combining granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), is associated with a substantial risk of relapse or…
  • Abstract Number: 1535 • 2012 ACR/ARHP Annual Meeting

    Genetic Background of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Japanese Population: Association of STAT4 with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Vasculitis

    Aya Kawasaki1, Naoya Inoue1, Chihiro Ajimi1, Ikue Ito1, Ken-ei Sada2, Shigeto Kobayashi3, Hidehiro Yamada4, Hiroshi Furukawa5, Makoto Tomita6, Takayuki Sumida7, Shigeto Tohma8, Nobuyuki Miyasaka9, Shoichi Ozaki4, Hiroshi Hashimoto10, Hiroshi Makino2, Masayoshi Harigai11 and Naoyuki Tsuchiya1, 1Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Department of Medicine and Clinical Science, Okayama University, Okayama, Japan, 3Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, 4Internal Medicine, St. Marianna University, Kawasaki, Japan, 5Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 6Clinical Research Center, Tokyo Medical and Dental University, Tokyo, Japan, 7Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 8Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan, 9Department of Medicine and Rheumatology and Global Center of Excellence Program, Tokyo Medical and Dental University, Tokyo, Japan, 10Juntendo University School of Medicine, Tokyo, Japan, 11Dept of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan

    Background/Purpose: In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), geographic difference in the type of vasculitis is well known. While granulomatosis with polyangiitis (GPA) is the…
  • Abstract Number: 2565 • 2012 ACR/ARHP Annual Meeting

    Prevalence of Anti-Neutrophil Cytoplasmic Antibodies in Infective Endocarditis: An Analysis of 109 Cases

    Alfred Mahr1, Frédéric Batteux2, Sarah Tubiana3, Michel Wolff4, Claire Goulvestre2, Thomas Papo5, François Vrtovsnik6, Isabelle Klein7, Bernard Iung8 and Xavier Duval9, 1Internal Medicine, Hospital Saint-Louis, Paris, France, 2Laboratoire d'Immunologie, Hospital Cochin, Paris, France, 3Clinical Investigation, Hospital Bichat, Paris, France, 4Intensive Care Unit, Hospital Bichat, Paris, France, 5Internal Medicine, University Paris-7, INSERM U699, APHP, Bichat Hospital, Paris, France, 6Nephrology, Hospital Bichat, Paris, France, 7Radiology, University Paris-7, APHP, Bichat Hospital, Paris, France, 8Cardiology, Hospital Bichat, Paris, France, 9Infectious Diseases, Hospital Bichat, Paris, France

    Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCAs), particularly those directed against proteinase 3 (anti-PR3) or myeloperoxydase (anti-MPO), are considered a highly specific hallmark of ANCA-associated vasculitis. Thus,…
  • Abstract Number: 1536 • 2012 ACR/ARHP Annual Meeting

    Clinical Features of Patients with Anti-Neutrophil Cytoplasmic Autoantibodies Targeting Native Myeloperoxidase Antigen

    Yuji Yamanishi1, Toshiko Ito-Ihara2, Shigeto Kobayashi3, Peter Y. Shane4, Gary S. Firestein5, Hiroshi Hashimoto6 and Kazuo Suzuki7, 1Division of Rheumatology, Hiroshima Rheumatology Clinic, Hiroshima, Japan, 2Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, Kyoto, Japan, 3Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, 4Tokyo Medical and Dental University, Tokyo, Japan, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, 6Juntendo Tokyo Koto Geriatric Center, Tokyo, Japan, 7National Institute of Infectious Diseases, Tokyo, Japan

    Background/Purpose: ANCA is a useful diagnostic marker in systemic vasculitic disorders with small-vessel involvement, but depending on the particular test used the myeloperoxidase (MPO)-ANCA results…
  • Abstract Number: 2393 • 2012 ACR/ARHP Annual Meeting

    High Mobility Group Box 1 Levels Are Not Associated with Subclinical Carotid Atherosclerosis in Patients with Granulomatosis with Polyangiitis but Are Reduced by Glucocorticoids and Statins

    Alexandre Wagner S. de Souza1, Karina de Leeuw2, Johanna Westra2, Andries J. Smit3, Anne Marijn van der Graaf2, Hans L. A. Nienhuis1, Johan Bijzet2, Pieter C. Limburg4, Coen A. Stegeman5, Marc Bijl6 and Cees G.M. Kallenberg2, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 3Vascular Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 4Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, 5Nephrology, University Medical Center Groningen, Groningen, Netherlands, 6Rheumatology and Clinical Immunology, Martini Hospital, Groningen, Netherlands

    Background/Purpose: High mobility group box 1 (HMGB1) is a non-histone DNA binding protein that is passively released by dying cells or actively secreted by immunocompetent…
  • Abstract Number: 860 • 2012 ACR/ARHP Annual Meeting

    Interleukin-21, B Cell Activating Factor and Unmethylated CpG Oligodeoxynucleotides Synergize in Promoting Anti-Proteinase 3 Autoantibody Production in Vitro

    Nikola Lepse1, Judith Land2, Abraham Rutgers2, Cees G.M. Kallenberg2, Coen A. Stegeman3, Peter Heeringa1 and Wayel H. Abdulahad2, 1Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 3Nephrology, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are characterized by the presence of circulating autoantibodies that are often directed against proteinase 3 (PR3). Although the…
  • Abstract Number: 2379 • 2012 ACR/ARHP Annual Meeting

    Successful Treatment of Churg-Strauss Syndrome with Rituximab

    Christin Dubrau1, Fabian Arndt2, Wolfgang L. Gross and Frank Moosig4, 1Departement of Rheumatology and Clinical Immunology, University Hospital Schleswig-Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany, 2Departement of rheumatology and clinical immunology, University Hospital Schleswig Holstein and Klinikum Bad Bramstedt, Bad Bramstedt, Germany, 3Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany

    Background/Purpose: Rituximab has recently been shown to be equipotent to cyclophosphamide for induction of remission in generalized ANCA-associated vasculitis. A substantial number of observational pro-…
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