Abstracts tagged "ANCA"

Abstract Number: 2722 • 2018 ACR/ARHP Annual Meeting
Incidence and Predictors of Severe Infections in ANCA Associated Vasculitis in a Population-Based Cohort – Preliminary Results
Jens Rathmann¹, David Jayne², Goran Jönsson³, Mårten Segelmark⁴, Jan-Åke Nilsson⁵ and Aladdin Mohammad², ¹Rheumatology, Skanes University Hospital, Lund, Lund, Sweden, ²Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ³Clinical Sciences Lund, Department of Infection Medicine, Lund University, Lund, Sweden, ⁴Clinical Sciences, Nephrology, Lund University, Lund, Sweden, ⁵Department of Rheumatology, Skåne University Hospital, Malmö, Sweden
Background/Purpose: To determine the incidence rates, predictors and outcome of severe infections in ANCA associated vasculitis (AAV). Methods: We conducted a population-based cohort study in…
Abstract Number: 2971 • 2018 ACR/ARHP Annual Meeting
Rituximab Associated Hypogammaglobulinemia in Autoimmune Disease: Long Term Outcomes
Joanna Tieu^1,2, Seerapani Gopaluni^3,4, Rona Smith¹ and David Jayne¹, ¹Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ²Department of Medicine, University of Adelaide, Adelaide, Australia, ³Medicine, University of Cambridge, Cambridge, United Kingdom, ⁴Vasculitis and Lupus, Addenbrooke’s Hospital, Cambridge, United Kingdom
Background/Purpose: Despite a low incidence of hypogammaglobulinemia (HG) in clinical trials using rituximab (RTX), HG occurs in follow-up of patients with autoimmune disease. Immunoglobulin replacement…
Abstract Number: 1758 • 2018 ACR/ARHP Annual Meeting
A 24 Month Analysis of Rituximab Safety and Efficacy in Eosinophilic Granulomatosis with Polyangiitis
Vítor Teixeira^1,2, Aladdin Mohammad^1,3 and David Jayne¹, ¹Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ²Rheumatology Department, CHLN - Santa Maria Hospital, Lisbon Academic Medical Center, Lisbon, Portugal, ³Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) frequently pursues a refractory course leading to high glucocorticoid exposure and toxicity. A previous retrospective study found rituximab (RTX)…
Abstract Number: 2725 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics and Long-Term Follow-up of 382 Microscopic Polyangiitis Patients
Yann Nguyen¹, Christian Pagnoux², Alexandre Karras³, Thomas Quémeneur⁴, Francois Maurier⁵, Mohamed Hamidou⁶, Alain Le Quellec⁷, Noémie Jourde-Chiche⁸, Pascal Cohen¹, Alexis Régent¹, François Lifermann⁹, Arsène Mékinian¹⁰, Chahéra Khouatra¹¹, Eric Hachulla¹², Jacques Ninet¹³, Jacques Pourrat¹⁴, Marc Ruivard¹⁵, Pascal Godmer¹⁶, Jean-Francois Viallard¹⁷, Benjamin Terrier¹, Luc Mouthon¹, Loïc Guillevin¹ and Xavier Puéchal¹, ¹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ²Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ³Department of Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, Paris, France, ⁴Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, ⁵Médecine interne, Hôpitaux Privés de Metz, Metz, France, ⁶Department of Internal Medicine, CHU de Nantes, France, Nantes, France, ⁷Department of Internal Medicine, Hôpital Saint-Eloi, CHU de Montpellier, France, Montpellier, France, ⁸Nephrology, Department of Nephrology, AP-HM, CHU Conception, Marseille, France, Marseille, France, ⁹Dax, Dax, France, ¹⁰Department of Internal Medicine, Hôpital Saint-Antoine, APHP, Paris, France, Paris, France, ¹¹Department of Respiratory Medicine, National Reference Center for Rare Pulmonary Diseases, Hospices civils de Lyon, Hôpital Louis Pradel, Lyon, France, Lyon, France, ¹²Department of Internal Medicine, National Reference Center for Systemic Sclerosis, Hôpital Claude Huriez, CHRU Lille, France, Lille, France, ¹³Department of Internal Medicine, Hôpital Edouard Herriot HCL, CHU de Lyon, France, Lyon, France, ¹⁴Department of Nephrology, Hôpital de Rangueil, CHU Toulouse, France, Toulouse, France, ¹⁵Department of Internal Medicine, CHU Estang, Clermont-Ferrand, France, Clermont-ferrand, France, ¹⁶Department of Internal Medicine, CH Vannes, France, Vannes, France, ¹⁷Department of Internal Medicine, Hôpital Haut-Lévêque, Bordeaux, France, CHU Bordeaux, France
Background/Purpose: Microscopic polyangiitis (MPA) is a systemic ANCA-associated small-vessel necrotizing vasculitis characterized by general symptoms, and visceral manifestations, including rapidly progressive glomerulonephritis and alveolar hemorrhage.…
Abstract Number: 1761 • 2018 ACR/ARHP Annual Meeting
Evaluation of the Functional Activity of Endothelial Progenitor Cells in Patients with ANCA-Associated Vasculitis
Ana Paula Toledo Del Rio¹, Stephanie Ospina Prieto¹, Bruno Kosa Lino Duarte¹, Manoel Barros Bertolo^1,2, Margareth de Castro Ozelo¹ and Zoraida Sachetto¹, ¹Internal Medicine, Faculty of Medical Science - State University of Campinas/Unicamp, Campinas, Brazil, ²INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil
Background/Purpose: ANCA-associated vasculitis (AAV) are relapsing diseases with high morbidity and mortality. The vascular damage present in these patients requires continuous repair with the participation…
Abstract Number: 2726 • 2018 ACR/ARHP Annual Meeting
Severe Infections in Systemic Necrotizing Vasculitis: Incidence and Risk Factors
Claudia Elizabeth Pena¹, Ana Carolina Costi², Lucila Garcia³, Mariana Pera⁴ and Mercedes Garcia¹, ¹Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ²Rheumatology Section, HIGA General San Martin La Plata, La Plata, Argentina, ³HIGA General San Martin La Plata, La Plata, Argentina, ⁴HIGA General San Martin La Plata, la plata, Argentina
Background/Purpose: Infections in patients with systemic necrotizing vasculitis represent one of the main causes of mortality. Risk factors of infection such as corticosteroid use, intensity…
Abstract Number: 1762 • 2018 ACR/ARHP Annual Meeting
Plasma iC3b Level As a Biomarker of Disease Relapse in ANCA-Associated Vasculitis
Catherine E. Najem¹, Martin Schmidt², Chad Stiening³, David Cuthbertson⁴, Simon Carette⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol Langford⁸, Carol A. McAlear⁹, Paul A. Monach¹⁰, Larry W. Moreland¹¹, Christian Pagnoux¹², Philip Seo¹³, Ulrich Specks¹⁴, Antoine G. Sreih¹, Steven R. Ytterberg¹⁵ and Peter A. Merkel^16,17, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Kypha, Inc., St. Louis, MO, ³Kypha, Inc., St Louis, MO, ⁴Biostatistics and Informatics, Department of Pediatrics, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁶Rheumatology, McMaster University, Hamilton, ON, Canada, ⁷Rheumatology, Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁸Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁹Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ¹⁰Section of Rheumatology, Boston University School of Medicine, Boston, MA, ¹¹Division of Rheumatology and Clinical Immunology, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹²Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ¹³Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹⁴Mayo Clinic College of Medicine, Rochester, MN, ¹⁵Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, ¹⁶Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁷Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose:C3, the central protein of the complement cascade, participates in an amplification loop that can lead to complement deposition and host tissue damage. If elevated,…
Abstract Number: 2727 • 2018 ACR/ARHP Annual Meeting
Prevalence of Clinical and Subclinical Ophthalmologic Manifestations in Association with Systemic Symptoms, Disease Activity and Damage in Patients with Granulomatosis with Polyangiitis
Andrea Hinojosa-Azaola¹, Annette García-Castro² and Alejandra Juárez-Flores³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Ophthalmologic involvement in Granulomatosis with Polyangiitis (GPA) is present in 50-60% of the patients and can affect any part of the ocular glove and…
Abstract Number: 1763 • 2018 ACR/ARHP Annual Meeting
Characterizing the Gut and Plasma Metabolomes in Patients with ANCA-Associated Vasculitis
Catherine E. Najem¹, Jung-Jin Lee², Ceylan Tanes², Cassidy Strange², Elliot Friedman², Antoine G. Sreih¹, Rennie L. Rhee¹, Abdallah Geara³, Hongzhe Li⁴, Kyle Bittinger², James D. Lewis⁵, Gary Wu⁵ and Peter A. Merkel⁴, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, ⁴Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, ⁵Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA
Background/Purpose:To explore the mechanisms by which an altered gut microbiota might predispose to ANCA-associated vasculitis (AAV), a comprehensive metabolic profiling of fecal and plasma bile…
Abstract Number: 2729 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Cerebrovascular Accident Among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-Analysis of Cohort Studies
Patompong Ungprasert¹, Karn Wijarnpreecha² and Wisit Cheungpasitporn³, ¹Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ²Internal medicine, Bassett medical center, cooperstown, NY, ³Medicine, University of Mississippi Medical center, Jackson, MS
Increased Risk of Cerebrovascular Accident among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-analysis of Cohort StudiesAbstractBackground/Purpose: An increased risk of cardiovascular…
Abstract Number: 13 • 2018 ACR/ARHP Annual Meeting
Shared Genetic Origins Among Anti-Proteinase 3 and Anti-Glomerular Basement Membrane Double-Positive Human Autoantibodies
Jeffrey R. Ord¹, Amy G. Clark¹ and Mary H. Foster², ¹Duke University Medical Center, Durham, NC, ²Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Patients with ANCA vasculitis and anti-glomerular basement membrane (GBM) nephritis (Goodpasture’s Disease) develop pathogenic autoantibodies (autoAb) that destroy the microvasculature in lungs and kidneys.…
Abstract Number: 1764 • 2018 ACR/ARHP Annual Meeting
The Utility of Serum Angiopoietin-1 and Angiopoietin-2 in Patients with Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Yoko Wada¹, Takeshi Kuroda², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Health Administration Center, Niigata University, Niigata, Japan, ³Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are antagonistic ligands which bind with similar affinity to the extracellular domain of the tyrosine kinase with Ig-like and…
Abstract Number: 2731 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics and Outcomes of ANCA-Vasculitides Associated Renal Disease in a Multi-Ethnic Population from a County Hospital
Shilpa Arora¹, Ambrish Athavale² and Peter Hart², ¹Medicine, John H Jr Stroger Hospital of Cook County, Chicago, IL, ²John H Jr Stroger Hospital of Cook County, Chicago, IL
Background/Purpose: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and renal-limited vasculitis (RLV). We aimed to study the clinical features…
Abstract Number: 904 • 2018 ACR/ARHP Annual Meeting
Long-Term Safety of Rituximab in Granulomatosis with Polyangiitis or Microscopic Polyangiitis: Results of the Four-Year Study of Rituximab in ANCA-Associated Vasculitis Registry
John L. Niles¹, Peter A. Merkel², Lester Mertz³, Patricia B. Lehane⁴, Pooneh Pordeli⁵ and Félix Erblang⁶, ¹Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA, ²Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁵Hoffmann-La Roche Ltd., Mississauga, ON, Canada, ⁶Hoffmann-La Roche Ltd., Basel, Switzerland
Background/Purpose: Potential therapy-related toxicities are important causes of morbidity in patients with the ANCA-associated vasculitides granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Long-term safety…
Abstract Number: 1765 • 2018 ACR/ARHP Annual Meeting
Cerebrospinal Fluid Biomarker of Disease Activity: Significance in ANCA-Related Hypertrophic Pachymeningitis
Yasuhiro Shimojima¹, Dai Kishida² and Yoshiki Sekijima², ¹Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan, ²Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan
Background/Purpose: Hypertrophic pachymeningitis (HP), which becomes the cause of chronic headache, seizure, and cranial neuropathy, is an inflammatory disorder demonstrating focal and diffuse thickening of…

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