ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 2721 • 2018 ACR/ARHP Annual Meeting

    Venous Thromboembolism in ANCA Associated Vasculitis. a Population-Based Cohort Study from Southern Sweden

    Matina Liapi1, David Jayne2, Mårten Segelmark3 and Aladdin Mohammad4, 1Medicine, Blekinge Hospital, Karlskrona, Sweden, 2Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3Clinical Sciences, Nephrology, Lund University, Lund, Sweden, 4Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden

    Background/Purpose: To estimate the rate and predictors of venous thromboembolic events (VTEs) in a population-based cohort of patients with ANCA- associated vasculitis (AAV). Methods: 322…
  • Abstract Number: 2852 • 2018 ACR/ARHP Annual Meeting

    Excessive Formation of Neutrophil Extracellular Traps: Different Role in the Pathogenesis of ANCA-Associated Vasculitis and Systemic Lupus Erythematosus

    Laura van Dam1, Tineke Kraaij1, Sylvia W.A. Kamerling1, Hans U. Scherer2, Ton Rabelink1, Cees van Kooten1 and Y.K. Onno Teng1, 1Nephrology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: ANCA-associated vasculitis (AAV) and systemic lupus erythematosus (SLE) both cause glomerulonephritis with pauci-immune and full-house immunofluorescence patterns, respectively. Although AAV and SLE are clinically…
  • Abstract Number: 1753 • 2018 ACR/ARHP Annual Meeting

    Interstitial Lung Disease in ANCA-Associated Vasculitis Defines a Unique Subgroup of Patients at High Risk for Respiratory Death: A Cluster Analysis

    Zachary Wallace1, Yuqing Zhang2, John H. Stone3 and Hyon K. Choi4, 1Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 3Home Address, Sudbury, MA, 4Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA

    Background/Purpose: ANCA-associated vasculitis (AAV) has a propensity for heterogeneous organ involvement. ANCA specificity has increasingly been favored over clinical diagnosis (e.g., microscopic polyangiitis) for subgrouping…
  • Abstract Number: 2722 • 2018 ACR/ARHP Annual Meeting

    Incidence and Predictors of Severe Infections in ANCA Associated Vasculitis in a Population-Based Cohort – Preliminary Results

    Jens Rathmann1, David Jayne2, Goran Jönsson3, Mårten Segelmark4, Jan-Åke Nilsson5 and Aladdin Mohammad2, 1Rheumatology, Skanes University Hospital, Lund, Lund, Sweden, 2Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3Clinical Sciences Lund, Department of Infection Medicine, Lund University, Lund, Sweden, 4Clinical Sciences, Nephrology, Lund University, Lund, Sweden, 5Department of Rheumatology, Skåne University Hospital, Malmö, Sweden

    Background/Purpose: To determine the incidence rates, predictors and outcome of severe infections in ANCA associated vasculitis (AAV). Methods: We conducted a population-based cohort study in…
  • Abstract Number: 2971 • 2018 ACR/ARHP Annual Meeting

    Rituximab Associated Hypogammaglobulinemia in Autoimmune Disease: Long Term Outcomes

    Joanna Tieu1,2, Seerapani Gopaluni3,4, Rona Smith1 and David Jayne1, 1Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 2Department of Medicine, University of Adelaide, Adelaide, Australia, 3Medicine, University of Cambridge, Cambridge, United Kingdom, 4Vasculitis and Lupus, Addenbrooke’s Hospital, Cambridge, United Kingdom

    Background/Purpose: Despite a low incidence of hypogammaglobulinemia (HG) in clinical trials using rituximab (RTX), HG occurs in follow-up of patients with autoimmune disease. Immunoglobulin replacement…
  • Abstract Number: 1758 • 2018 ACR/ARHP Annual Meeting

    A 24 Month Analysis of Rituximab Safety and Efficacy in Eosinophilic Granulomatosis with Polyangiitis

    Vítor Teixeira1,2, Aladdin Mohammad1,3 and David Jayne1, 1Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 2Rheumatology Department, CHLN - Santa Maria Hospital, Lisbon Academic Medical Center, Lisbon, Portugal, 3Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) frequently pursues a refractory course leading to high glucocorticoid exposure and toxicity. A previous retrospective study found rituximab (RTX)…
  • Abstract Number: 2725 • 2018 ACR/ARHP Annual Meeting

    Clinical Characteristics and Long-Term Follow-up of 382 Microscopic Polyangiitis Patients

    Yann Nguyen1, Christian Pagnoux2, Alexandre Karras3, Thomas Quémeneur4, Francois Maurier5, Mohamed Hamidou6, Alain Le Quellec7, Noémie Jourde-Chiche8, Pascal Cohen1, Alexis Régent1, François Lifermann9, Arsène Mékinian10, Chahéra Khouatra11, Eric Hachulla12, Jacques Ninet13, Jacques Pourrat14, Marc Ruivard15, Pascal Godmer16, Jean-Francois Viallard17, Benjamin Terrier1, Luc Mouthon1, Loïc Guillevin1 and Xavier Puéchal1, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 2Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 3Department of Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, Paris, France, 4Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, 5Médecine interne, Hôpitaux Privés de Metz, Metz, France, 6Department of Internal Medicine, CHU de Nantes, France, Nantes, France, 7Department of Internal Medicine, Hôpital Saint-Eloi, CHU de Montpellier, France, Montpellier, France, 8Nephrology, Department of Nephrology, AP-HM, CHU Conception, Marseille, France, Marseille, France, 9Dax, Dax, France, 10Department of Internal Medicine, Hôpital Saint-Antoine, APHP, Paris, France, Paris, France, 11Department of Respiratory Medicine, National Reference Center for Rare Pulmonary Diseases, Hospices civils de Lyon, Hôpital Louis Pradel, Lyon, France, Lyon, France, 12Department of Internal Medicine, National Reference Center for Systemic Sclerosis, Hôpital Claude Huriez, CHRU Lille, France, Lille, France, 13Department of Internal Medicine, Hôpital Edouard Herriot HCL, CHU de Lyon, France, Lyon, France, 14Department of Nephrology, Hôpital de Rangueil, CHU Toulouse, France, Toulouse, France, 15Department of Internal Medicine, CHU Estang, Clermont-Ferrand, France, Clermont-ferrand, France, 16Department of Internal Medicine, CH Vannes, France, Vannes, France, 17Department of Internal Medicine, Hôpital Haut-Lévêque, Bordeaux, France, CHU Bordeaux, France

    Background/Purpose: Microscopic polyangiitis (MPA) is a systemic ANCA-associated small-vessel necrotizing vasculitis characterized by general symptoms, and visceral manifestations, including rapidly progressive glomerulonephritis and alveolar hemorrhage.…
  • Abstract Number: 1761 • 2018 ACR/ARHP Annual Meeting

    Evaluation of the Functional Activity of Endothelial Progenitor Cells in Patients with ANCA-Associated Vasculitis

    Ana Paula Toledo Del Rio1, Stephanie Ospina Prieto1, Bruno Kosa Lino Duarte1, Manoel Barros Bertolo1,2, Margareth de Castro Ozelo1 and Zoraida Sachetto1, 1Internal Medicine, Faculty of Medical Science - State University of Campinas/Unicamp, Campinas, Brazil, 2INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil

    Background/Purpose: ANCA-associated vasculitis (AAV) are relapsing diseases with high morbidity and mortality. The vascular damage present in these patients requires continuous repair with the participation…
  • Abstract Number: 2726 • 2018 ACR/ARHP Annual Meeting

    Severe Infections in Systemic Necrotizing Vasculitis: Incidence and Risk Factors

    Claudia Elizabeth Pena1, Ana Carolina Costi2, Lucila Garcia3, Mariana Pera4 and Mercedes Garcia1, 1Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 2Rheumatology Section, HIGA General San Martin La Plata, La Plata, Argentina, 3HIGA General San Martin La Plata, La Plata, Argentina, 4HIGA General San Martin La Plata, la plata, Argentina

    Background/Purpose: Infections in patients with systemic necrotizing vasculitis represent one of the main causes of mortality. Risk factors of infection such as corticosteroid use, intensity…
  • Abstract Number: 1762 • 2018 ACR/ARHP Annual Meeting

    Plasma iC3b Level As a Biomarker of Disease Relapse in ANCA-Associated Vasculitis

    Catherine E. Najem1, Martin Schmidt2, Chad Stiening3, David Cuthbertson4, Simon Carette5, Nader A. Khalidi6, Curry L. Koening7, Carol Langford8, Carol A. McAlear9, Paul A. Monach10, Larry W. Moreland11, Christian Pagnoux12, Philip Seo13, Ulrich Specks14, Antoine G. Sreih1, Steven R. Ytterberg15 and Peter A. Merkel16,17, 1Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Kypha, Inc., St. Louis, MO, 3Kypha, Inc., St Louis, MO, 4Biostatistics and Informatics, Department of Pediatrics, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 5Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 6Rheumatology, McMaster University, Hamilton, ON, Canada, 7Rheumatology, Division of Rheumatology, University of Utah, Salt Lake City, UT, 8Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 9Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, 10Section of Rheumatology, Boston University School of Medicine, Boston, MA, 11Division of Rheumatology and Clinical Immunology, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 12Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 13Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 14Mayo Clinic College of Medicine, Rochester, MN, 15Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, 16Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 17Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose:C3, the central protein of the complement cascade, participates in an amplification loop that can lead to complement deposition and host tissue damage. If elevated,…
  • Abstract Number: 2727 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Clinical and Subclinical Ophthalmologic Manifestations in Association with Systemic Symptoms, Disease Activity and Damage in Patients with Granulomatosis with Polyangiitis

    Andrea Hinojosa-Azaola1, Annette García-Castro2 and Alejandra Juárez-Flores3, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Ophthalmologic involvement in Granulomatosis with Polyangiitis (GPA) is present in 50-60% of the patients and can affect any part of the ocular glove and…
  • Abstract Number: 1763 • 2018 ACR/ARHP Annual Meeting

    Characterizing the Gut and Plasma Metabolomes in Patients with ANCA-Associated Vasculitis

    Catherine E. Najem1, Jung-Jin Lee2, Ceylan Tanes2, Cassidy Strange2, Elliot Friedman2, Antoine G. Sreih1, Rennie L. Rhee1, Abdallah Geara3, Hongzhe Li4, Kyle Bittinger2, James D. Lewis5, Gary Wu5 and Peter A. Merkel4, 1Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, 4Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, 5Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose:To explore the mechanisms by which an altered gut microbiota might predispose to ANCA-associated vasculitis (AAV), a comprehensive metabolic profiling of fecal and plasma bile…
  • Abstract Number: 2729 • 2018 ACR/ARHP Annual Meeting

    Increased Risk of Cerebrovascular Accident Among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-Analysis of Cohort Studies

    Patompong Ungprasert1, Karn Wijarnpreecha2 and Wisit Cheungpasitporn3, 1Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2Internal medicine, Bassett medical center, cooperstown, NY, 3Medicine, University of Mississippi Medical center, Jackson, MS

    Increased Risk of Cerebrovascular Accident among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-analysis of Cohort StudiesAbstractBackground/Purpose: An increased risk of cardiovascular…
  • Abstract Number: 13 • 2018 ACR/ARHP Annual Meeting

    Shared Genetic Origins Among Anti-Proteinase 3 and Anti-Glomerular Basement Membrane Double-Positive Human Autoantibodies

    Jeffrey R. Ord1, Amy G. Clark1 and Mary H. Foster2, 1Duke University Medical Center, Durham, NC, 2Medicine, Duke University Medical Center, Durham, NC

    Background/Purpose: Patients with ANCA vasculitis and anti-glomerular basement membrane (GBM) nephritis (Goodpasture’s Disease) develop pathogenic autoantibodies (autoAb) that destroy the microvasculature in lungs and kidneys.…
  • Abstract Number: 1764 • 2018 ACR/ARHP Annual Meeting

    The Utility of Serum Angiopoietin-1 and Angiopoietin-2 in Patients with Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis

    Yoko Wada1, Takeshi Kuroda2, Masaaki Nakano3 and Ichiei Narita1, 1Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Health Administration Center, Niigata University, Niigata, Japan, 3Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan

    Background/Purpose: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are antagonistic ligands which bind with similar affinity to the extracellular domain of the tyrosine kinase with Ig-like and…
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