Abstracts tagged "analgesics"

Abstract Number: 2049 • 2019 ACR/ARP Annual Meeting
National Estimates of Pain Medication Use in Patients with Osteoarthritis
Mohammed Saeed¹, ¹Capital Health, Trenton, NJ
Background/Purpose: The epidemiology of pain medication use among patients with osteoarthritis is not well explored. Chronic kidney disease (CKD) modifies choice of analgesics. The aim…
Abstract Number: 2195 • 2019 ACR/ARP Annual Meeting
BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel
Joel A. Block¹, Bharat Patel ² and Sandy Yacoub Garas ³, ¹Rush University Medical Center, Chicago, IL, ²GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, ³GlaxoSmithKline Consumer Healthcare, Warren, NJ
Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with…
Abstract Number: 2197 • 2019 ACR/ARP Annual Meeting
Clinically Relevant Improvements in Knee Osteoarthritis Pain with Diclofenac Sodium Gel 1%
Marc C. Hochberg¹, Bharat Patel ², Sandy Yacoub Garas ³ and Roy Altman ⁴, ¹University of Maryland School of Medicine, Baltimore, MD, ²GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, ³GlaxoSmithKline Consumer Healthcare, Warren, NJ, ⁴University of California, Los Angeles
Background/Purpose: Topical agents are recommended for the initial treatment of patients with knee osteoarthritis (OA). Diclofenac sodium gel 1% (DSG 1%), a topical nonsteroidal anti-inflammatory…
Abstract Number: 425 • 2018 ACR/ARHP Annual Meeting
Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients with Moderate-to-Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study
Naoki Ishiguro¹, Shusuke Oyama², Ryunosuke Higashi³ and Kunio Yanagida⁴, ¹Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Data Science, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ³Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ⁴Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd, Osaka, Japan
Background/Purpose: ONO-4474 is an orally available, peripheral-specific, pan-tropomyosin receptor kinase (pan-Trk) inhibitor currently under development for treatment of musculoskeletal pain in OA patients. This study…
Abstract Number: 1374 • 2018 ACR/ARHP Annual Meeting
The Relationship between Loneliness and Osteoarthritis in US Adults from a Nationally Representative Survey
Adeela Cheema¹, Louise Hawkley², Kristen Wroblewski³ and Kichul Ko⁴, ¹Section of Geriatrics and Palliative Medicine, Department of Medicine, University of Chicago, Chicago, IL, ²NORC, University of Chicago, Chicago, IL, ³Department of Public Health Sciences, University of Chicago, Chicago, IL, ⁴Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL
Background/Purpose: Loneliness in adults is a growing phenomenon across the Western world. It is associated with increased mortality, depression, coronary heart disease and stroke. Moreover,…
Abstract Number: 15L • 2017 ACR/ARHP Annual Meeting
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Titration-to-Effect Study of Orally Administered CR845 in Patients with Osteoarthritis of the Hip or Knee
Sukirti Bagal, Catherine Munera, Patricia Brady and Joseph Stauffer, Cara Therapeutics, Stamford, CT

Background/Purpose: CR845 is a selective kappa opioid receptor agonist with a peripheral mechanism of action. Here we report preliminary results from a Phase 2b study…
Abstract Number: 389 • 2017 ACR/ARHP Annual Meeting
S-110483 a New Potent EP4 Receptor Antagonist with Immunomodulatory and Analgesic Activities
Takashi Maeda¹, Toshitaka Ochiai², Toshie Nagayasu-Tanaka¹, Yuta Morisaki¹, Haruka Takizawa¹, Seiji Ishihara¹, Shigeo Kurokawa¹, Kiyoharu Ukai¹ and Masahiro Suda¹, ¹Pharmacology Department, Kaken Pharmaceutical Co., LTD, Kyoto, Japan, ²Kaken Pharmaceutical Co., LTD, Kyoto, Japan
Background/Purpose: Prostaglandin (PG) E2 is known to enhance the expansion of T helper 17 (Th17) cell population via EP4 receptor (EP4) in the early phase…
Abstract Number: 374 • 2016 ACR/ARHP Annual Meeting
Anxiolytic Effects of the Novel α2δ Ligand Mirogabalin (DS-5565) in Sluka Model, an Experimental Animal Model of Fibromyalgia
Yuki Domon¹, Naohisa Arakawa¹, Hiroyasu Murasawa², Hiroyuki Kobayashi², Kensuke Saeki² and Yutaka Kitano¹, ¹Pain & Neuroscience Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan, ²Nihon Bioresearch Inc., Hashima, Japan
Anxiolytic Effects of the Novel Alpha-2-Delta Ligand Mirogabalin (DS-5565) in Sluka Model, an Experimental Animal Model of Fibromyalgia Yuki Domona, Naohisa Arakawaa, Hiroyasu Murasawab, Hiroyuki…
Abstract Number: 2186 • 2016 ACR/ARHP Annual Meeting
Analgesic Use and Subsequent Risk of Falls in Participants with or at Risk of Knee Osteoarthritis
Wei-Hsuan Lo-Ciganic¹, Lysbeth Floden², Erin L. Ashbeck³, Lili Zhou¹ and C. Kent Kwoh^3,4, ¹Department of Pharmacy, Practice and Science, University of Arizona, College of Pharmacy, Tucson, AZ, ²Department Pharmacy, Practice and Science, University of Arizona, College of Pharmacy, Tucson, AZ, ³The University of Arizona Arthritis Center, Tucson, AZ, ⁴Rheumatology, University of Arizona, College of Medicine, Tucson, AZ
Background/Purpose: Analgesics including opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, and nutraceuticals are commonly used for pain relief in osteoarthritis (OA). Although it has been reported…
Abstract Number: 2224 • 2016 ACR/ARHP Annual Meeting
Influence of Caffeine on Opioid Analgesics in Fibromyalgia
J. Ryan Scott¹, Daniel J. Clauw², Chad M. Brummett¹, Richard E. Harris¹, Afton L. Hassett¹ and Steven E. Harte³, ¹Anesthesiology, University of Michigan, Ann Arbor, MI, ²Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, ³Department of Anesthesiology, University of Michigan, Ann Arbor, MI
Background/Purpose: Caffeine’s action as an NSAID adjuvant are well understood, yet little clinical research has explored its effects on opioid analgesia. We present data from…
Abstract Number: 1437 • 2015 ACR/ARHP Annual Meeting
Prevalence of Pain, Its Impact and Management in a Population-Based Cohort of Patients with Rheumatoid Arthritis: Data from the Australian Rheumatology Association Database
Bethan Richards^1,2, Rachelle Buchbinder³, Marissa N. Lassere⁴ and Lyn March⁵, ¹Sydney Medical School, University of Sydney, Sydney, Australia, ²Royal Prince Alfred Hospital, Mulgrave, Vic, Australia, ³Monash Department of Clinical Epidemiology, Cabrini Institute and Monash University, Melbourne, Australia, ⁴Dept of Rheumatology, St George Hospital, Kogarah, Australia, ⁵Department of Rheumatology, Northern Clinical School, Institute of Bone and Joint Research, Kolling Institute, University of Sydney & Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, Australia
Background/Purpose: Despite advances in the treatments available for rheumatoid arthritis (RA), many patients continue to experience musculoskeletal pain. Untreated and under-treated pain are well known to increase…
Abstract Number: 2232 • 2015 ACR/ARHP Annual Meeting
Risk of Osteoporotic Fractures with Use of Cyclooxygenase-2 Inhibitors
Deepan Dalal¹, Devyani Misra², Christine Peloquin³, Tuhina Neogi⁴, Yuqing Zhang⁵, David T. Felson⁶ and Maureen Dubreuil⁷, ¹Rheumatology, Boston Medical Center, Boston, MA, ²Medicine, Section of, BUSM, Boston, MA, ³Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁴Clinical Epidemiology, BUSM, Boston, MA, ⁵BUSM, Boston, MA, ⁶Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁷Rheumatology, Boston VA HealthCare System, Boston, MA
Background/Purpose: In animal models, cyclo-oxygenase (COX)-2 stimulates osteoclasts through prostaglandin E2 (PGE2). Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) preferentially inhibiting COX-2 (ie-coxibs) should prevent bone…
Abstract Number: 1427 • 2015 ACR/ARHP Annual Meeting
Analgesic Effects of the Novel Alpha-2-Delta Ligand Mirogabalin (DS-5565) in Experimental Animal Models of Fibromyalgia
Yuki Domon¹, Naohisa Arakawa¹, Shun-ichi Yasuda², Kensuke Saeki², Mayumi Kano², Masami Kato² and Yutaka Kitano¹, ¹Biological Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan, ²Hashima Laboratory, Nihon Bioresearch Inc., Gifu, Japan
Background/Purpose: Mirogabalin (DS-5565) is a novel ligand of the α2δ subunit of voltage-gated calcium channels. Mirogabalin possesses unique binding characteristics to α2δ subunits, and potent…
Abstract Number: 2241 • 2014 ACR/ARHP Annual Meeting
Intermittent Analgesic Use and Risk of Pain Exacerbation in Knee Osteoarthritis: A Web Based Case-Crossover Study
Tahereh Erfani¹, Yuqing Zhang², Joanna Makovey¹, Ben Metcalf³, Lyn March¹, Kim Bennell³ and David J. Hunter¹, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Boston University School of Medicine, Boston, MA, ³University of Melbourne, Melbourne, Australia
Background/Purpose: The pain experienced by osteoarthritis (OA) patients is neither constant nor stable and most patients experience episodes of pain exacerbations or flares. A number…
Abstract Number: 1451 • 2014 ACR/ARHP Annual Meeting
Use of Analgesics in Patients with Knee and/or Hip Osteoarthritis: Results from the Amsterdam Osteoarthritis Cohort
Joyce van Tunen¹, Marike van der Leeden^1,2, Martin van der Esch¹, Leo D. Roorda¹, Willem F. Lems^3,4 and Joost Dekker⁵, ¹Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, ²Rehabilitation Medicine/EMGO, VU University Medical Center, Amsterdam, Netherlands, ³Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁴Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁵Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose Use of analgesics is recommended by international guidelines to reduce pain complaints related to knee and/or hip osteoarthritis. Underuse of analgesics might be substantial…

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