Abstracts tagged "Anakinra"

Abstract Number: 169 • 2017 ACR/ARHP Annual Meeting
New Autoinflammatory Phenotype Associated with Homozygous AGBL3 Variant
Ahmet Gül¹, Neslihan Abaci² and Sema Sirma Ekmekci², ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Genetics, Istanbul University Institute for Experimental Medical Research, Istanbul, Turkey
Background/Purpose: To identify new genes/pathways associated with autoinflammatory phenotype. Methods: We screened genomic variations by whole exome sequencing in 3 families presented with autoinflammatory findings…
Abstract Number: 368 • 2017 ACR/ARHP Annual Meeting
Evaluation of Efficacy and Safety of Opocalcium Colchicine, and Anti-IL1 Treatment in Childhood Colchicine-Resistant Familial Mediterranean Fever
Kenan Barut, Amra Adrovic, Sezgin Sahin, Asli Kaplan and Ozgur Kasapcopur, Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: The colchicine-resistant FMF (crFMF) is defined as 6 or more polyserositis attacks in the last year despite the regular usage of colchicine in the…
Abstract Number: 940 • 2017 ACR/ARHP Annual Meeting
IL1RN Variation Is Associated with Systemic Juvenile Idiopathic Arthritis and Predicts Non-Response to Anakinra Treatment
Emily Shuldiner¹, Victoria Arthur¹, Anne Hinks², Patricia Woo³, Wendy Thomson², Elaine F. Remmers⁴ and Michael J. Ombrello¹, ¹Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ³University College London, London, United Kingdom, ⁴Genetics and Genomics Branch, NIH, NIAMS, Bethesda, MD
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a childhood inflammatory disease whose pathophysiology is poorly understood. sJIA is phenotypically heterogeneous with variable manifestations and responses…
Abstract Number: 2090 • 2017 ACR/ARHP Annual Meeting
Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with Veterans Affairs Medical Center
Julianna Desmarais¹ and Cong-Qiu Chu², ¹Department of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ²Rheumatology, Oregon Health & Science University, Portland, OR
Background/Purpose: Anakinra is an IL-1 blocking medication used off label to relieve acute inflammation from gout and pseudogout. The efficacy and safety of this treatment…
Abstract Number: 74 • 2017 Pediatric Rheumatology Symposium
Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis
Esraa M. A. Eloseily^1,2, Peter Weiser¹, Hilary Haines³, Melissa Mannion⁴, Matthew L. Stoll¹, Timothy Beukelman¹, Prescott Atkinson⁵ and Randy Q. Cron¹, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pediatrics, Assiut University, Assiut, Egypt, ³Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, ⁴Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatric Allergy and Immunology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Familial, or primary, hemophagocytic lymphohistiocytosis (pHLH), is a rare but highly fatal condition due to mutations in lymphocyte cytolytic pathway genes. Secondary HLH (sHLH),…
Abstract Number: 214 • 2016 ACR/ARHP Annual Meeting
Anakinra Compared to Prednisone on the Treatment of Acute CPPD Crystal Arthritis, a Randomized, Controlled, Double-Blind Study
Alexandre Dumusc¹, Borbala Pazar Maldonado¹, Charles Benaim², Isabelle Fabreguet¹, Pascal Zufferey¹, Bérengère Aubry-Rozier¹ and Alexander So¹, ¹Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, ²Physical Medicine and Rehabilitation Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland
Background/Purpose: Calcium pyrophosphate crystal-induced arthritis (CPPD) is an acute crystal arthritis, frequently involving the wrist or the knee. Monosodium urate in gout or CPPD…
Abstract Number: 215 • 2016 ACR/ARHP Annual Meeting
Anakinra Is Effective and Well Tolerated in Medically Complex Patients Including Transplant Recipients with Gout
Christopher Palma¹, Taylor Topping² and Darren Tabechian¹, ¹Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Pharmacy, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Anakinra is a biologic response modifier that competitively antagonizes the biologic effects of interleukin-1β. Conventional treatments for the inflammatory response to acute gout are…
Abstract Number: 247 • 2016 ACR/ARHP Annual Meeting
ANTI-Interleukin 1 Therapy in FMF Amyloidosis: A Single Center Experience
Serdal Ugurlu, Bilgesu Ergezen and Huri Ozdogan, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: Recently there is increasing number of reports pointing out the efficacy of anti-interleukin 1(anti-IL1)therapy to control AA amyloidosis secondary to autoinflammatory diseases. Here we…
Abstract Number: 942 • 2016 ACR/ARHP Annual Meeting
A Nationwide Experience with the Off Label Use of Interleukin 1 Targeting Treatment in Familial Mediterranean Fever Patients
Servet Akar¹, Pınar Cetin², Umut Kalyoncu³, Omer Karadag⁴, Ismail Sari⁵, Muhammed Cinar⁶, Sedat Yılmaz⁷, Ahmet Mesut Onat⁸, Bunyamin Kisacik⁹, Abdulsamet Erden³, Ayşe Balkarli¹⁰, Orhan Kucuksahin¹¹, Sibel Yilmaz Oner¹², Soner Senel¹³, Abdurrahman Tufan¹³, Haner Direskeneli¹², Mustafa Ferhat Oksuz¹⁴, Yavuz Pehlivan¹⁴, Ozun Bayndır¹⁵, Gokhan Keser¹⁶, Kenan Aksu¹⁷, Ahmet Omma¹⁸, Timucin Kasifoglu¹⁹, Ali Ugur Unal²⁰, Fatih Yildiz²¹, Mehmet Ali Balci²², Sule Yavuz¹³, Sukran Erten²³, Metin Ozgen²⁴, Mehmet Sayarlioglu²⁵, Atalay Dogru²⁶, Gozde Yildirim Cetin²⁷, Fatma Alibaz-Oner²⁰, Mehmet Engin Tezcan²⁸, Omer Nuri Pamuk²⁹ and Fatos Onen³⁰, ¹Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ²Dokuz Eylul University, izmir, Turkey, ³Hacettepe University, Ankara, Turkey, ⁴Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ⁶GATA, Ankara, Turkey, ⁷Division of Rheumatology, Gülhane Military Medical Academy, School of Medicine, Ankara, Turkey, ⁸Gaziantep University School of Medicine, Ankara, Turkey, ⁹Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ¹⁰Antalya EAH, Antalya, Turkey, ¹¹Internal Medicine-Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey, ¹²Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ¹³PsART study group, Ankara, Turkey, ¹⁴Rheumatology, Uludag University Medcal Faculty, Bursa, Turkey, ¹⁵İnternal Medicine Division of Rheumatology, Ege University Medical Faculty, Izmir, Turkey, ¹⁶Rheumatology, Ege University Medical Faculty, Izmir, Turkey, ¹⁷Ege University, İzmir, Turkey, ¹⁸Department of Internal Medicine, Rheumatology Division, Ankara Numune Hospital, Ankara, Turkey, ¹⁹İnternal Medicine Division of Rheumatology, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, ²⁰Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ²¹Rheumatology, Van EAH, Adana, Turkey, ²²Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²³Rheumatology, Yildirim Beyazit University Faculty Of Medicine, Ankara, Turkey, ²⁴Department of Internal Medicine Division of Rheumatology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey, ²⁵Rheumatology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey, ²⁶Suleyman Demirel University, Isparta, Turkey, ²⁷Deparment of Rheumatology, Sutcu Imam University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey, ²⁸Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, ²⁹Rheumatology, Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, Edirne, Turkey, ³⁰Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
Background/Purpose: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease and colchicine is the mainstay of treatment. Around 30-45% of FMF patients were reported…
Abstract Number: 259 • 2015 ACR/ARHP Annual Meeting
How Safe IT Is to TREAT Pregnant FMF Patients with Anakinra ?
Huri Ozdogan¹, Serdal Ugurlu² and Bilgesu Ergezen¹, ¹Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: To assess the safety and efficacy of anakinra in pregnant FMF patients. Methods: Six FMF patients, treated with anakinra during pregnancy were monitored for…
Abstract Number: 261 • 2015 ACR/ARHP Annual Meeting
Anakinra Treatment in Patients with Familial Mediterranean Fever: A Single-Center Experience
Serdal Ugurlu¹, Bilgesu Ergezen² and Huri Ozdogan², ¹Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: To review the patients followed in our center with FMF who received anakinra, an anti IL-1 receptor antagonist, because of insufficient colchicine response. Methods: FMF…
Abstract Number: 265 • 2015 ACR/ARHP Annual Meeting
Tocilizumab Compared with Anakinra in Refractory Adult-Onset Still’s Disease. Multicenter Study of 75 Patients
Leyre Riancho-Zarrabeitia¹, Vanesa Calvo-Río¹, Ricardo Blanco¹, Jose L. Hernández², Francisco Ortiz-Sanjuán¹, Alejandro Olivé³, Anne Riveros Frutos⁴, Santos Castañeda⁵, Javier Narváez⁶, Maria Luisa Velloso Feijoo⁷, M. Victoria Hernández⁸, Alberto Sifuentes Giraldo⁹, Olga Maiz-Alonso¹⁰, Esteban Rubio Romero¹¹, Cristina Mata-Arnaiz¹², Adela Gallego Flores¹³, Jordi del Blanco¹⁴, Catalina Gómez-Arango¹⁵, Sara Manrique-Arija¹⁶, Maria Carmen Ordoñez¹⁷, Inmaculada Ros Vilamajo¹⁸, Miguel Angel Caracuel-Ruiz¹⁹, Mercedes Freire²⁰, Jose Llobet²¹, Carlos Marras²², Concepción Moll Tuduri²³, Chamaida Plasencia²⁴, Rosa Roselló²⁵, Ana Urruticoechea²⁶, Inmaculada Jiménez-Moleón²⁷, José Antonio Bernal²⁸, Vera Ortiz-Santamaría²⁹, Juan Ramón De Dios³⁰, Mireia Moreno³¹, Jordi Fiter³², Marina de los Riscos³³, Patricia E. Carreira³³, María José Rodríguez Valls Sr.³⁴, Carmen Gonzalez-Vela³⁵, Javier Loricera¹, Natalia Palmou¹ and Miguel Angel Gonzalez-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Rheumatology, Hospital U German Trias i Pujol, Badalona, Spain, ⁴Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ⁵Rheumatology, H.U. La Princesa, Madrid, Spain, ⁶Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁷H Valme, Sevilla, Spain, ⁸Arthritis Unit, Rheumatology, Hospital Clinic, Barcelona, Spain, ⁹Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁰Rheumatology, HU Donostia, San Sebastián, Spain, ¹¹Rheumatology Department,, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹²Rheumatology, Hospital Laredo, Santander, Spain, ¹³Rheumatology, Hospital de Mérida, Mérida, Spain, ¹⁴Rheumatology, H Sant Jaume, Calella, Spain, ¹⁵Rheumatology, Hospital Basurto,, Santander, Spain, ¹⁶Rheumatology, Hospital Universitario Carlos Haya, Malaga, Spain, ¹⁷HRU Carlos Haya, Malaga, Spain, ¹⁸Hospital Son Llàtzer, Palma de Mallorca, Spain, ¹⁹Plaza Cruz Roja, 1, Hospital Reina Sofia, Córdoba, Spain, ²⁰Hospital Universitario Juan Canalejo, La Coruña, Spain, ²¹Hospital San Pau, Barcelona, Spain, ²²Hospital Universitario Virgen de la Arrixaca, Murcia, Spain, ²³H Mateu Orfila, Mahón, Spain, ²⁴Rheumatology Unit, La Paz University Hospital-Rheumatology, Madrid, Spain, ²⁵H San Jorge, Huesca, Spain, ²⁶Hospital Can Misses, Ibiza, Spain, ²⁷Rheumatology, Hospital San Cecilio, Granada, Spain, ²⁸Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²⁹Rheumatology, Hospital General. Granollers., Granollers, Spain, ³⁰Rheumatology, HU Álava, Vitoria, Spain, ³¹Hospital de Sabadell - Institut Universitari Parc Taulí, Sabadell, Spain, ³²Rheumatology, HU Son Espases. Palma de Mallorca., Palma de Mallorca, Spain, ³³Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ³⁴Rheumatology, Rheumatolgy Unit. Hospital Jerez, Jerez, Spain, ³⁵Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain
Background/Purpose: Interleukin (IL)-1 and IL-6 are pivotal cytokines in the pathogenesis of adult-onset Still’s disease (AOSD). Our aim was to compare the efficacy and safety of…
Abstract Number: 1449 • 2015 ACR/ARHP Annual Meeting
The Effect of IL-1 Receptor Antagonist Anakinra (Kineret®) on Measures of Central Nervous System Inflammation and Headaches in Pediatric Patients with Severe Cryopyrin-Associated Periodic Syndromes
Hans Olivecrona¹, Raphaela Goldbach-Mansky², Torbjörn Kullenberg¹ and Mika Leinonen³, ¹Swedish Orphan Biovitrum, Stockholm, Sweden, ²Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ³4Pharma AB, Stockholm, Sweden
Background/Purpose: Cryopyrin-Associated Periodic Syndromes (CAPS) include a group of rare inherited autoinflammatory diseases consisting of Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome and the most…
Abstract Number: 3077 • 2015 ACR/ARHP Annual Meeting
Anakinra in Patients with Cortico-Dependent Idiopathic Recurrent Pericarditis: A Randomised Double-Blind Placebo-Controlled Withdrawal Trial
Antonio Brucato¹, Massimo Imazio², Silvia Maestroni¹, Davide Faustino Cumetti³, Anna Valenti¹, Renzo Marcolongo⁴, George Lazaros⁵, Mara Carraro², Fiorenzo Gaita², Gian Luca Erre⁶, Martina Finetti⁷, Marco Gattorno⁷ and Alberto Martini⁸, ¹Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ²Cardiology, Maria Vittoria Hospital, Torino, Italy, ³Internal Medicine, Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁴Clinical Immunology, Hospital of Padova, Padova, Italy, ⁵Department of Cardiology, Hippokration General Hospital, Athens, Greece, ⁶Rheumatology, Hospital of Sassari, Sassari, Italy, ⁷Pediatry, G. Gaslini Institute, Genova, Italy, ⁸Istituto G. Gaslini, Pediatria II, PRINTO, and University of Genoa, Genoa, Italy
Background/Purpose: Patients with recurrent pericarditis either do not respond or are intolerant to treatment with NSAIDs drugs, corticosteroids and colchicine. We aimed to assess the…
Abstract Number: 3094 • 2015 ACR/ARHP Annual Meeting
Dose Adjustment of Anakinra (Kineret®) Based on Clinical Response in Patients with Severe Cryopyrin-Associated Periodic Syndromes
Bengt Hallen¹, Torbjörn Kullenberg¹, Mika Leinonen², Margareta Wiken¹, Raphaela Goldbach-Mansky³ and Hans Olivecrona¹, ¹Swedish Orphan Biovitrum, Stockholm, Sweden, ²4Pharma AB, Stockholm, Sweden, ³Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD
Background/Purpose: Cryopyrin-Associated Periodic Syndromes (CAPS) include a group of rare inherited autoinflammatory diseases consisting of Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome and the most…

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