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Abstracts tagged "Anakinra"

  • Abstract Number: 2090 • 2017 ACR/ARHP Annual Meeting

    Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with Veterans Affairs Medical Center

    Julianna Desmarais1 and Cong-Qiu Chu2, 1Department of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 2Rheumatology, Oregon Health & Science University, Portland, OR

    Background/Purpose: Anakinra is an IL-1 blocking medication used off label to relieve acute inflammation from gout and pseudogout. The efficacy and safety of this treatment…
  • Abstract Number: 169 • 2017 ACR/ARHP Annual Meeting

    New Autoinflammatory Phenotype Associated with Homozygous AGBL3 Variant

    Ahmet Gül1, Neslihan Abaci2 and Sema Sirma Ekmekci2, 1Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Department of Genetics, Istanbul University Institute for Experimental Medical Research, Istanbul, Turkey

    Background/Purpose: To identify new genes/pathways associated with autoinflammatory phenotype. Methods: We screened genomic variations by whole exome sequencing in 3 families presented with autoinflammatory findings…
  • Abstract Number: 368 • 2017 ACR/ARHP Annual Meeting

    Evaluation of Efficacy and Safety of Opocalcium Colchicine, and Anti-IL1 Treatment in Childhood Colchicine-Resistant Familial Mediterranean Fever

    Kenan Barut, Amra Adrovic, Sezgin Sahin, Asli Kaplan and Ozgur Kasapcopur, Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey

    Background/Purpose: The colchicine-resistant FMF (crFMF) is defined as 6 or more polyserositis attacks in the last year despite the regular usage of colchicine in the…
  • Abstract Number: 940 • 2017 ACR/ARHP Annual Meeting

    IL1RN Variation Is Associated with Systemic Juvenile Idiopathic Arthritis and Predicts Non-Response to Anakinra Treatment

    Emily Shuldiner1, Victoria Arthur1, Anne Hinks2, Patricia Woo3, Wendy Thomson2, Elaine F. Remmers4 and Michael J. Ombrello1, 1Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, 2Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, 3University College London, London, United Kingdom, 4Genetics and Genomics Branch, NIH, NIAMS, Bethesda, MD

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a childhood inflammatory disease whose pathophysiology is poorly understood. sJIA is phenotypically heterogeneous with variable manifestations and responses…
  • Abstract Number: 74 • 2017 Pediatric Rheumatology Symposium

    Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis

    Esraa M. A. Eloseily1,2, Peter Weiser1, Hilary Haines3, Melissa Mannion4, Matthew L. Stoll1, Timothy Beukelman1, Prescott Atkinson5 and Randy Q. Cron1, 1Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Pediatrics, Assiut University, Assiut, Egypt, 3Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, 4Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 5Pediatric Allergy and Immunology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Familial, or primary, hemophagocytic lymphohistiocytosis (pHLH), is a rare but highly fatal condition due to mutations in lymphocyte cytolytic pathway genes. Secondary HLH (sHLH),…
  • Abstract Number: 214 • 2016 ACR/ARHP Annual Meeting

    Anakinra Compared to Prednisone on the Treatment of Acute CPPD Crystal Arthritis, a Randomized, Controlled, Double-Blind Study

    Alexandre Dumusc1, Borbala Pazar Maldonado1, Charles Benaim2, Isabelle Fabreguet1, Pascal Zufferey1, Bérengère Aubry-Rozier1 and Alexander So1, 1Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, 2Physical Medicine and Rehabilitation Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland

    Background/Purpose:   Calcium pyrophosphate crystal-induced arthritis (CPPD) is an acute crystal arthritis, frequently involving the wrist or the knee. Monosodium urate in gout or CPPD…
  • Abstract Number: 215 • 2016 ACR/ARHP Annual Meeting

    Anakinra Is Effective and Well Tolerated in Medically Complex Patients Including Transplant Recipients with Gout

    Christopher Palma1, Taylor Topping2 and Darren Tabechian1, 1Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Pharmacy, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Anakinra is a biologic response modifier that competitively antagonizes the biologic effects of interleukin-1β. Conventional treatments for the inflammatory response to acute gout are…
  • Abstract Number: 247 • 2016 ACR/ARHP Annual Meeting

    ANTI-Interleukin 1 Therapy in FMF Amyloidosis: A Single Center Experience

    Serdal Ugurlu, Bilgesu Ergezen and Huri Ozdogan, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: Recently there is increasing number of reports pointing out the efficacy of anti-interleukin 1(anti-IL1)therapy to control AA amyloidosis secondary to autoinflammatory diseases. Here we…
  • Abstract Number: 942 • 2016 ACR/ARHP Annual Meeting

    A Nationwide Experience with the Off Label Use of Interleukin 1 Targeting Treatment in Familial Mediterranean Fever Patients

    Servet Akar1, Pınar Cetin2, Umut Kalyoncu3, Omer Karadag4, Ismail Sari5, Muhammed Cinar6, Sedat Yılmaz7, Ahmet Mesut Onat8, Bunyamin Kisacik9, Abdulsamet Erden3, Ayşe Balkarli10, Orhan Kucuksahin11, Sibel Yilmaz Oner12, Soner Senel13, Abdurrahman Tufan13, Haner Direskeneli12, Mustafa Ferhat Oksuz14, Yavuz Pehlivan14, Ozun Bayndır15, Gokhan Keser16, Kenan Aksu17, Ahmet Omma18, Timucin Kasifoglu19, Ali Ugur Unal20, Fatih Yildiz21, Mehmet Ali Balci22, Sule Yavuz13, Sukran Erten23, Metin Ozgen24, Mehmet Sayarlioglu25, Atalay Dogru26, Gozde Yildirim Cetin27, Fatma Alibaz-Oner20, Mehmet Engin Tezcan28, Omer Nuri Pamuk29 and Fatos Onen30, 1Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 2Dokuz Eylul University, izmir, Turkey, 3Hacettepe University, Ankara, Turkey, 4Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 5Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, 6GATA, Ankara, Turkey, 7Division of Rheumatology, Gülhane Military Medical Academy, School of Medicine, Ankara, Turkey, 8Gaziantep University School of Medicine, Ankara, Turkey, 9Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 10Antalya EAH, Antalya, Turkey, 11Internal Medicine-Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey, 12Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 13PsART study group, Ankara, Turkey, 14Rheumatology, Uludag University Medcal Faculty, Bursa, Turkey, 15İnternal Medicine Division of Rheumatology, Ege University Medical Faculty, Izmir, Turkey, 16Rheumatology, Ege University Medical Faculty, Izmir, Turkey, 17Ege University, İzmir, Turkey, 18Department of Internal Medicine, Rheumatology Division, Ankara Numune Hospital, Ankara, Turkey, 19İnternal Medicine Division of Rheumatology, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey, 20Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, 21Rheumatology, Van EAH, Adana, Turkey, 22Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, 23Rheumatology, Yildirim Beyazit University Faculty Of Medicine, Ankara, Turkey, 24Department of Internal Medicine Division of Rheumatology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey, 25Rheumatology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey, 26Suleyman Demirel University, Isparta, Turkey, 27Deparment of Rheumatology, Sutcu Imam University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey, 28Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, 29Rheumatology, Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, Edirne, Turkey, 30Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey

    Background/Purpose: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease and colchicine is the mainstay of treatment. Around 30-45% of FMF patients were reported…
  • Abstract Number: 259 • 2015 ACR/ARHP Annual Meeting

    How  Safe IT Is to TREAT Pregnant FMF Patients with Anakinra ?

    Huri Ozdogan1, Serdal Ugurlu2 and Bilgesu Ergezen1, 1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey

    Background/Purpose: To assess the safety and efficacy of anakinra in pregnant FMF patients. Methods: Six FMF patients, treated with anakinra during pregnancy were monitored for…
  • Abstract Number: 261 • 2015 ACR/ARHP Annual Meeting

    Anakinra Treatment in Patients with Familial Mediterranean Fever: A Single-Center Experience

    Serdal Ugurlu1, Bilgesu Ergezen2 and Huri Ozdogan2, 1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, 2Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: To review the patients followed in our center with FMF who received anakinra, an anti IL-1 receptor antagonist, because of insufficient colchicine response.  Methods: FMF…
  • Abstract Number: 265 • 2015 ACR/ARHP Annual Meeting

    Tocilizumab Compared with Anakinra in Refractory Adult-Onset Still’s Disease. Multicenter Study of 75 Patients

    Leyre Riancho-Zarrabeitia1, Vanesa Calvo-Río1, Ricardo Blanco1, Jose L. Hernández2, Francisco Ortiz-Sanjuán1, Alejandro Olivé3, Anne Riveros Frutos4, Santos Castañeda5, Javier Narváez6, Maria Luisa Velloso Feijoo7, M. Victoria Hernández8, Alberto Sifuentes Giraldo9, Olga Maiz-Alonso10, Esteban Rubio Romero11, Cristina Mata-Arnaiz12, Adela Gallego Flores13, Jordi del Blanco14, Catalina Gómez-Arango15, Sara Manrique-Arija16, Maria Carmen Ordoñez17, Inmaculada Ros Vilamajo18, Miguel Angel Caracuel-Ruiz19, Mercedes Freire20, Jose Llobet21, Carlos Marras22, Concepción Moll Tuduri23, Chamaida Plasencia24, Rosa Roselló25, Ana Urruticoechea26, Inmaculada Jiménez-Moleón27, José Antonio Bernal28, Vera Ortiz-Santamaría29, Juan Ramón De Dios30, Mireia Moreno31, Jordi Fiter32, Marina de los Riscos33, Patricia E. Carreira33, María José Rodríguez Valls Sr.34, Carmen Gonzalez-Vela35, Javier Loricera1, Natalia Palmou1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 3Rheumatology, Hospital U German Trias i Pujol, Badalona, Spain, 4Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 5Rheumatology, H.U. La Princesa, Madrid, Spain, 6Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 7H Valme, Sevilla, Spain, 8Arthritis Unit, Rheumatology, Hospital Clinic, Barcelona, Spain, 9Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, 10Rheumatology, HU Donostia, San Sebastián, Spain, 11Rheumatology Department,, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 12Rheumatology, Hospital Laredo, Santander, Spain, 13Rheumatology, Hospital de Mérida, Mérida, Spain, 14Rheumatology, H Sant Jaume, Calella, Spain, 15Rheumatology, Hospital Basurto,, Santander, Spain, 16Rheumatology, Hospital Universitario Carlos Haya, Malaga, Spain, 17HRU Carlos Haya, Malaga, Spain, 18Hospital Son Llàtzer, Palma de Mallorca, Spain, 19Plaza Cruz Roja, 1, Hospital Reina Sofia, Córdoba, Spain, 20Hospital Universitario Juan Canalejo, La Coruña, Spain, 21Hospital San Pau, Barcelona, Spain, 22Hospital Universitario Virgen de la Arrixaca, Murcia, Spain, 23H Mateu Orfila, Mahón, Spain, 24Rheumatology Unit, La Paz University Hospital-Rheumatology, Madrid, Spain, 25H San Jorge, Huesca, Spain, 26Hospital Can Misses, Ibiza, Spain, 27Rheumatology, Hospital San Cecilio, Granada, Spain, 28Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, 29Rheumatology, Hospital General. Granollers., Granollers, Spain, 30Rheumatology, HU Álava, Vitoria, Spain, 31Hospital de Sabadell - Institut Universitari Parc Taulí, Sabadell, Spain, 32Rheumatology, HU Son Espases. Palma de Mallorca., Palma de Mallorca, Spain, 33Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 34Rheumatology, Rheumatolgy Unit. Hospital Jerez, Jerez, Spain, 35Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose: Interleukin (IL)-1 and IL-6 are pivotal cytokines in the pathogenesis of adult-onset Still’s disease (AOSD). Our aim was to compare the efficacy and safety of…
  • Abstract Number: 1449 • 2015 ACR/ARHP Annual Meeting

    The Effect of IL-1 Receptor Antagonist Anakinra (Kineret®) on Measures of Central Nervous System Inflammation and Headaches in Pediatric Patients with Severe Cryopyrin-Associated Periodic Syndromes

    Hans Olivecrona1, Raphaela Goldbach-Mansky2, Torbjörn Kullenberg1 and Mika Leinonen3, 1Swedish Orphan Biovitrum, Stockholm, Sweden, 2Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 34Pharma AB, Stockholm, Sweden

    Background/Purpose: Cryopyrin-Associated Periodic Syndromes (CAPS) include a group of rare inherited autoinflammatory diseases consisting of Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome and the most…
  • Abstract Number: 3077 • 2015 ACR/ARHP Annual Meeting

    Anakinra in Patients with Cortico-Dependent Idiopathic Recurrent Pericarditis: A Randomised Double-Blind Placebo-Controlled Withdrawal Trial

    Antonio Brucato1, Massimo Imazio2, Silvia Maestroni1, Davide Faustino Cumetti3, Anna Valenti1, Renzo Marcolongo4, George Lazaros5, Mara Carraro2, Fiorenzo Gaita2, Gian Luca Erre6, Martina Finetti7, Marco Gattorno7 and Alberto Martini8, 1Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, 2Cardiology, Maria Vittoria Hospital, Torino, Italy, 3Internal Medicine, Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, 4Clinical Immunology, Hospital of Padova, Padova, Italy, 5Department of Cardiology, Hippokration General Hospital, Athens, Greece, 6Rheumatology, Hospital of Sassari, Sassari, Italy, 7Pediatry, G. Gaslini Institute, Genova, Italy, 8Istituto G. Gaslini, Pediatria II, PRINTO, and University of Genoa, Genoa, Italy

    Background/Purpose: Patients with recurrent pericarditis either do not respond or are intolerant to treatment with NSAIDs drugs, corticosteroids and colchicine. We aimed to assess the…
  • Abstract Number: 3094 • 2015 ACR/ARHP Annual Meeting

    Dose Adjustment of Anakinra (Kineret®) Based on Clinical Response in Patients with Severe Cryopyrin-Associated Periodic Syndromes

    Bengt Hallen1, Torbjörn Kullenberg1, Mika Leinonen2, Margareta Wiken1, Raphaela Goldbach-Mansky3 and Hans Olivecrona1, 1Swedish Orphan Biovitrum, Stockholm, Sweden, 24Pharma AB, Stockholm, Sweden, 3Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD

    Background/Purpose: Cryopyrin-Associated Periodic Syndromes (CAPS) include a group of rare inherited autoinflammatory diseases consisting of Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome and the most…
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