Abstracts tagged "amino acid and plasmablast differentiation"

Abstract Number: 2814 • 2019 ACR/ARP Annual Meeting
Methionine Commits Immunometabolism and Epigenetic Regulation of BACH2 Loci in B Cells, Resulting in Biases Toward Plasmablast Differentiation in the Pathogenesis of SLE
Mingzeng Zhang¹, Shigeru Iwata ¹, Maiko Hajime ¹, Naoaki Ohkubo ¹, Yasuyuki Todoroki ², Hiroko Miyata ², Jie Fan ², Shingo Nakayamada ¹, Kaoru Yamagata ¹ and Yoshiya Tanaka ³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational & Environmental Health Kitakyushu, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health Japan, Kitakyushu, Japan
Background/Purpose: Amino acids play an important role in various metabolic processes. However, the role of amino acid metabolism in the regulation of human B cell…