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Abstracts tagged "allopurinol and genetics"

  • Abstract Number: 2835 • 2019 ACR/ARP Annual Meeting

    A Burden of Missense Genetic Variants in Urate Secretory Genes Is Associated with Inadequate Response to Allopurinol in People with Gout

    Niamh Fanning1, Ruth Topless 2, Christopher Frampton 1, Murray Cadzow 2, Mary Wallace 3, Nicola Dalbeth 4, Tony Merriman 5 and Lisa Stamp 6, 1University of Otago, Christchurch, Christchurch, New Zealand, 2University of Otago, Otago, New Zealand, 3University of Otago, Dunedin, New Zealand, 4University of Auckland, Auckland, New Zealand, 5University of Otago, Birmingham, AL, 6University of Otago, Christchurch, Christchurch, Canterbury, New Zealand

    Background/Purpose: Current understanding of why the urate lowering effect of allopurinol varies among individuals with gout is limited. The rs2231142 (Q141K) variant of ABCG2 is…
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