Abstracts tagged "allopurinol and genetics"

Abstract Number: 2835 • 2019 ACR/ARP Annual Meeting
A Burden of Missense Genetic Variants in Urate Secretory Genes Is Associated with Inadequate Response to Allopurinol in People with Gout
Niamh Fanning¹, Ruth Topless ², Christopher Frampton ¹, Murray Cadzow ², Mary Wallace ³, Nicola Dalbeth ⁴, Tony Merriman ⁵ and Lisa Stamp ⁶, ¹University of Otago, Christchurch, Christchurch, New Zealand, ²University of Otago, Otago, New Zealand, ³University of Otago, Dunedin, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵University of Otago, Birmingham, AL, ⁶University of Otago, Christchurch, Christchurch, Canterbury, New Zealand
Background/Purpose: Current understanding of why the urate lowering effect of allopurinol varies among individuals with gout is limited. The rs2231142 (Q141K) variant of ABCG2 is…