ACR Meeting Abstracts
Abstract Number: 1975 • ACR/ARP Annual Meeting 2019
Uxia Nogueira-Recalde1, Irene Lorenzo-Gomez 2, Francisco J. Blanco 3, María I. Loza 4, Diego Grassi 5, Valery Shirinsky 6, Ivan Shirinsky 6, martin lotz 7, Paul D. Robbins 8, Eduardo Domínguez 4 and Beatriz Carames 2, 1Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, 2Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, 3Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 4Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain, 5Institute for Interdisciplinary Neuroscience (IINS), Bordeaux, Nouvelle-Aquitaine, France, Bordeaux, France, 6Scientific Research Institute of Clinical immunology, Novosibirsk, Rusia, Novosibirsk, Russia, 7Department of Molecular Medicine. Scripps Research, La Jolla, CA, USA, La Jolla, CA, 8Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN
Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset.…