Abstracts tagged "Aging and animal models"

Abstract Number: 888 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models
Morena Scotece¹, Ignacio Rego-Pérez ², Ana Victoria Lechuga-Vieco ³, María Concepción Jiménez Gómez ³, Purificación Filgueira-Fernández ⁴, José Antonio Enriquez ³ and Francisco J. Blanco ², ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Madrid, Spain, ⁴Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Galicia, Spain
Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…

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