Abstracts tagged "Age Associated/Autoimmune B cells"

Abstract Number: 1906 • ACR Convergence 2021
IL-13Ra1-Mediated Signaling Regulates Age-Associated/Autoimmune B-Cell Expansion and Lupus Pathogenesis
Danny Flores Castro¹, Zhu Chen², Sanjay Gupta³, Michela Manni³, Juan Rivera Correa³, Max Chao⁴, Yurii Chinenov⁴, Tania Pannellini⁵, Habib Zaghouni⁶, Rolf Jessberger⁷ and Alessandra Pernis⁸, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, Palisades Park, NJ, ²Department of Rheumatology and Immunology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China (People's Republic), ³Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ⁴David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁵Research Division and Precision Medicine Laboratory, Hospital for Special Surgery, New York, NY, ⁶Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO, ⁷Institute of Physiological Chemistry, Technische Universitat, Dresden, Germany, ⁸Department of Medicine, Weill Cornell Medicine, New York, NY
Background/Purpose: Age-associated B cells (ABCs) are an emerging B cell subset that aberrantly expand in SLE. ABC generation and differentiation exhibit marked sexual dimorphism and…