Abstracts tagged "age-associated B cells and Cholesterol Homeostasis"

Abstract Number: 957 • 2019 ACR/ARP Annual Meeting
Alterations in Cholesterol Homeostasis Regulate Autoimmunity/Age-associated B Cells
Zhu Chen¹, Michela Manni ¹, Danny Flores-Castro ¹, Tania Pannellini ¹ and Alessandra Pernis ², ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, ²1.Autoimmunity and Inflammation Program, Hospital for Special Surgery. 2.David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery. 3.Department of Medicine, Weill Cornell Medical College, Cornell University, New York
Background/Purpose: Age-associated B cells (ABCs) are a novel B cell subset, which expands with age in non-autoimmune mice but accumulates prematurely in autoimmune-prone strains. ABCs…