ACR Meeting Abstracts

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Abstracts tagged "Adverse events"

  • Abstract Number: 2194 • 2018 ACR/ARHP Annual Meeting

    Develop a New Platform for Post-Marketing Vigilance Though Smart System of Disease Management (SSDM) Mobiles Tools: A Real World Cohort Study of RA Patients from China

    Yongfu Wang1, Hua Wei2, Jing Yang3, Chun Li4, Rong Mu5, Bin Wu6, Hongzhi Wang7, Yong Wang8, Xiaohan Wang9, Huifang Guo10, Jing Xue11, Jinli Ru12, Xiafei Xin13, Fengxiao Zhang14, Lirong Kang1, Hong Liu3, Xiaoling Liu15, Tong Xie16, Lingxun Shen17, Huiqin Yang18, Shouxin Li19, Fen Li20, Fen Wang21, Rui Wu22, Yuan Liu23, Hui Xiao23, Yuhua Jia23, Fei Xiao23 and Jianlin Huang24, 1The First Affiliated Hospital of BaoTou Medical College, Baotou, China, 2Northern Jiangsu People's Hospital, Yangzhou, China, 3Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, 4Peking University People's Hospital, Beijing, China, 5Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 6Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China, 7The First Hospital of Jiaxing, Jiaxing, China, 8The first Hospital Affiliated to AMU (Southernwest Hospital), Chongqing, China, 9Department of Rheumatology and Immunology, Anyang district hospital, Anyang, China, 10The Second Hospital of Hebei Medical University, Shijiazhuang, China, 1188 Jiefang Road, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 12The Second hospital of Shanxi Medical University, Taiyuan, China, 13Department of Rheumatology and Immunology, NingBo First Hospital, Zhejiang, Ningbo, China, 14Department of Rheumatology and Immunology, Hebei General Hospital, Shijiazhuang, China, 15The 1st Affiliated Hospital of Guangzhou University of TCM, Guangzhou, China, 16Affiliated hospital of Guangdong medical University, Zhanjiang, China, 17Union Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China, 18Wuhan No 1 Hospital, wuhan, China, 19Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology, wuhan, China, 20The Second Xiangya Hospital of Central South University, Changsha, China, 21Department of Rheumatology, First Affiliated Hospital of Medical University Of Anhui, Hefei, China, 22The First Affiliated Hospital of Nanchang University, Nanchang, China, 23Shanghai Gothic Internet Technology Co., Ltd., Shanghai, China, 24Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China

    Background/Purpose: Adverse events (AE) during treatment in RA patients are unavoidable. Monitoring AEs in real time during long-term treatment is critical for AE detection and…
  • Abstract Number: 2976 • 2018 ACR/ARHP Annual Meeting

    Immune Checkpoint Inhibitor-Associated Myositis: A Characteristic Phenotype with a Poor Outcome Related to Concomitant Myocarditis

    Celine Anquetil1,2, Joe-Elie Salem3,4, Benedicte Lebrun-Vignes5, Douglas B Johnson6, Andrew Mammen7,8, Werner Stenzel9, Sarah Leonard-louis10, Olivier Benveniste11,12, Javid J Moslehi3 and Yves Allenbach2,13, 1Internal Medicine and Clinical Immunlogy, Assistance Public - Hopitaux de Paris, Pitié-Salpêtrière University Hospital, PARIS, France, 2CDR en myologie UMR974,, Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, PARIS, France, 3Division of Cardiovascular Medicine and Cardio-Oncology Program, Department of Medicine, Vanderbilt University Medical Center, Nasheville, TN, 4Department of Pharmacology, Regional Center of Pharmacovigilance, INSERM, CIC-1421, Paris, France, 5Department of Pharmacology, Regional Center of Pharmacovigilance, INSERM, CIC-1421, PARIS, France, 6Division of Oncology, Department of Medicine, Vanderbilt University Medical Center, Nasheville, TN, 7National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 8Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 9Charité - Universitätsmedizin, Department of Neuropathology, Berlin, Germany, Berlin, Germany, 10Département de Neuropathologie, Centre de Référence des Maladies Neuro-Musculaires Paris Est, Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Universitaire Pitié-Salpêtrière, Paris, France, 11Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, 12Centre de Recherche en Myologie, UMRS974, Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, Paris, France, 13Internal Medicine and Clinical Immunology, Sorbonne University - Assistance Public - Hopitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: Immune checkpoint inhibitors (ICI) are a major breakthrough in cancer treatment providing frequent durable responses and improving overall survival. Blocking immune checkpoints (Programmed cell…
  • Abstract Number: 1233 • 2018 ACR/ARHP Annual Meeting

    Rituximab Safety in Patients with Rheumatoid Arthritis. an Eleven-Year Follow-up Observational Study

    Raul Castellanos-Moreira Sr.1, Sebastian C Rodriguez-Garcia1, M. Victoria Hernández2, Virginia Ruiz-Esquide3, Oscar Camacho Sr.1, Andrea Cuervo1, Julio Ramírez3, Juan Cañete1, Jose Gomez Puerta1 and Raimon Sanmarti1, 1Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, 2Rheumatology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 3Rheumatology, Hospital Clínic de Barcelona, Barcelona, Spain

    Background/Purpose:  Rituximab (RTX) is a chimeric monoclonal antibody approved for the treatment rheumatoid arthritis (RA) patients who failed to respond to tumor necrosis factor inhibitors.…
  • Abstract Number: 2253 • 2018 ACR/ARHP Annual Meeting

    Cardiovascular Disease, Other Purported Risk Factors, and Allopurinol-Associated Severe Cutaneous Adverse Reactions: A General Population-Based Cohort Study

    Na Lu1, Chio Yokose2, Hui Xie1,3, Gloria Li1, Sharan K. Rai4,5, Seoyoung C. Kim6 and Hyon K. Choi2, 1Arthritis Research Canada, Richmond, BC, Canada, 2Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, 3Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, 4Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 5Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, 6Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: A recent US Medicaid study found that in addition to certain races (Asians and Blacks), older age, female sex, chronic kidney disease (CKD), and…
  • Abstract Number: 2995 • 2018 ACR/ARHP Annual Meeting

    Healthcare Cost of Potential Glucocorticoid-Associated Adverse Events in Patients with Giant Cell Arteritis

    Jennie H. Best1, Amanda Kong2, David Smith2, Ibrahim Abbass1 and Margaret Michalska1, 1Genentech, Inc., South San Francisco, CA, 2IBM Watson Health, Bethesda, MD

    Background/Purpose: To quantify the healthcare expenditures associated with oral glucocorticoids-related-adverse events (OGCs-AEs), among patients in the US with giant cell arteritis (GCA) using claims data…
  • Abstract Number: 1263 • 2018 ACR/ARHP Annual Meeting

    Develop a Master Algorithm for Drug Withdraw Strategy in Reduction of Adverse Events – a Machine Learning Model from the Smart System of Disease Management (SSDM)

    Yan Zhao1, Jing Yang2, Jianlin Huang3, Hua Wei4, Yongfu Wang5, Rong Mu6, Xiaoxia Zuo7, Hongzhi Wang8, Xinwang Duan9, Jing Xue10, Hongsheng Sun11, Bin Wu12, Lirong Kang5, Feng Wei13, Cundong Mi14, Yanping Zhao15, Yang Li16, Haiying Chen17, Zhenbin Li18, Qingliang Meng19, Yuhua Jia20, Hui Xiao20 and Fei Xiao20, 1Rheumatology, Peking Union Medical College Hospital, Beijing, China, 2Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, 3Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, 4Northern Jiangsu People's Hospital, Yangzhou, China, 5The First Affiliated Hospital of BaoTou Medical College, Baotou, China, 6Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 7Xiangya Hospital Central South University, Changsha, China, 8The First Hospital of Jiaxing, Jiaxing, China, 9Department of rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, 1088 Jiefang Road, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 11Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, 12Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China, 13JIANGMEN CENTRAL HOSPITAL, AFFILIATED JIANGMEN HOSPITAL OF SUN YAT-SEN UNIVERSITY, Jiangmen, China, 14The Second Affiliated Hospital of Guangxi Medical University, Nanning, China, 15The First Affiliated Hospital of Harbin Medical University, Harbin, China, 16The Second Affiliated Hospital of Harbin Medical University, Harbin, China, 17The third hospital of hebei medical university, Shijiazhuang, China, 18Peace Hospital, Shijiazhuang, China, 19Henan Province Hospital of TCM, Zhengzhou, China, 20Shanghai Gothic Internet Technology Co., Ltd., Shanghai, China

    Background/Purpose: Combination therapy with DMARDs for treating RA is considered as standard of care. However, certain rates of adverse events (AEs) are unavoidable. The stigma…
  • Abstract Number: 2339 • 2018 ACR/ARHP Annual Meeting

    The Patient’s Perspective of Glucocorticoid Use: A Systematic Literature Review of Quantitative and Qualitative Studies

    Jonathan Cheah1,2, Joanna Robson3,4, Rachel Black5,6, Susan M. Goodman7,8, Susan Lester9,10, Sarah Mackie11 and Catherine Hill6,12, 1Medicine, Hospital for Special Surgery, New York, NY, 2Medicine, Weill Cornell Medicine, New York, NY, 3Faculty of Health and Applied Science, University of the West of England, Bristol, United Kingdom, 4School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 5Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, 6Medicine, The University of Adelaide, Adelaide, Australia, 7Rheumatology, Weill Cornell Medicine, New York, NY, 8Hospital for Special Surgery, New York, NY, 9Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia, 10Discipline of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia, 11NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 12The Queen Elizabeth Hospital, Adelaide, Australia

    Background/Purpose: Glucocorticoids (GCs) remain widely used and have well documented adverse effects. However, the impact of these adverse effects from the perspective of the patient,…
  • Abstract Number: 1398 • 2018 ACR/ARHP Annual Meeting

    Inflammatory Arthritis DMARD Adverse Effects Are Pervasive and Can Greatly Impact Quality of Life and Work and Social Roles: Initial Results from the Omeract Safety Working Group

    Kathleen M. Andersen1, Ayano Kelly2, Anne Lyddiatt3, Clifton O. Bingham III4, Vivian P. Bykerk5, Marita Cross6, Adena Batterman7, Joan Westreich8, Lyn March9, Michelle Jones10, Beverly Shea11, Peter Tugwell12, Peter Brooks13, Lee S. Simon14, Robin Christensen15 and Susan J. Bartlett16, 1Department of Family Medicine, McGill University, Montreal, QC, Canada, 2Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia, 3Musculoskeletal Group, Cochrane Collaboration, Hamilton, ON, Canada, 4Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, 6Institute of Bone and Joint Research–Kolling Institute, University of Sydney, Sydney, Australia, 7Social Work Programs, Hospital for Special Surgery, New York, NY, 8Department of Social Work Programs, Hospital for Special Surgery, New York, NY, 9Department of Rheumatology, Northern Clinical School, Institute of Bone and Joint Research, Kolling Institute, University of Sydney & Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, Australia, 10Johns Hopkins University School of Medicine, Baltimore, MD, 11University of Ottawa, Ottawa, ON, Canada, 12Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, 13The University of Melbourne, Victoria, Australia, 14SDG LLC Consulting, West Newton, MA, 15Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, 16Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada

    Background/Purpose: There is suboptimal reporting of adverse events (AE) in trials. The OMERACT Safety Working Group is developing a patient-centered AE collection and reporting approach…
  • Abstract Number: 2340 • 2018 ACR/ARHP Annual Meeting

    The Impact of Chronic Glucocorticoid Use Amongst Patients with Rheumatoid Arthritis: A Qualitative Study

    Jonathan Cheah1,2, Sarah Young3, Susan M. Goodman4,5, Catherine Hill6,7, Susan Beard8, Pamela Richards9, Sarah Mackie10, Joanna Robson11,12 and Iris Navarro-Millán5,13, 1Medicine, Hospital for Special Surgery, New York, NY, 2Medicine, Weill Cornell Medicine, New York, NY, 3Binghamton University, Binghamton, NY, 4Rheumatology, Weill Cornell Medicine, New York, NY, 5Hospital for Special Surgery, New York, NY, 6The Queen Elizabeth Hospital, Adelaide, Australia, 7Medicine, The University of Adelaide, Adelaide, Australia, 8Patient Research Partner, Adelaide, Australia, 9Patient Research Partner, Bristol, United Kingdom, 10NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 11Faculty of Health and Applied Science, University of the West of England, Bristol, United Kingdom, 12School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 13Weill Cornell Medicine, New York, NY

    Background/Purpose: Glucocorticoids (GCs) have well documented adverse effects. However, the absolute risk and importance of these effects have not been well documented from the perspective…
  • Abstract Number: 1515 • 2018 ACR/ARHP Annual Meeting

    Malignancy in Japanese Patients with Rheumatoid Arthritis Treated with Tofacitinib: Interim Analysis of All-Case Post-Marketing Surveillance

    Naoto Tamura1, Masataka Kuwana2, Tatsuya Atsumi3, Syuji Takei4, Masayoshi Harigai5, Takao Fujii6, Hiroaki Matsuno7, Tsuneyo Mimori8, Shigeki Momohara9, Kazuhiko Yamamoto10, Yoshinari Takasaki11, Kazuto Nomura12, Yutaka Endo12, Tomohiro Hirose12, Yosuke Morishima12, Naonobu Sugiyama12, Noritoshi Yoshii12 and Michiaki Takagi13, 1Juntendo University, Tokyo, Japan, 2Nippon Medical School, Tokyo, Japan, 3Hokkaido University, Sapporo, Japan, 4Medical Center for Children, Kagoshima, Japan, 5Tokyo Women’s Medical University, Tokyo, Japan, 6Wakayama Medical University, Wakayama, Japan, 7Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, 8Kyoto University, Kyoto, Japan, 9Hakkeikai Inc Medical Institution, Shizuoka, Japan, 10The University of Tokyo, Tokyo, Japan, 11Juntendo Koshigaya Hospital, Juntendo University Faculty of Medicine, Saitama, Japan, 12Pfizer Japan Inc, Tokyo, Japan, 13Yamagata University Faculty of Medicine, Yamagata, Japan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. The efficacy and safety of tofacitinib have been demonstrated in patients (pts)…
  • Abstract Number: 2390 • 2018 ACR/ARHP Annual Meeting

    Incidence of and Risk Factors for Adrenal Suppression Following Ultrasound-Guided Intra-Articular Corticosteroid Injection with Triamcinolone Acetonide in Juvenile Idiopathic Arthritis

    Katherine K Ngo1, Angelina Bernier1, Melissa E Elder2, Renee F Modica2 and Akaluck Thatayatikom1, 1Pediatrics, University of Florida, Gainesville, FL, 2Department of Pediatrics, University of Florida, Gainesville, FL

    Background/Purpose: Intra-articular corticosteroid injection (IACI) is routinely used in juvenile idiopathic arthritis (JIA) with oligoarticular disease and as adjunct therapy for other types of JIA.…
  • Abstract Number: 1516 • 2018 ACR/ARHP Annual Meeting

    Infection Events in Japanese Patients with Rheumatoid Arthritis Treated with Tofacitinib: Interim All-Case Post-Marketing Surveillance

    Naoto Tamura1, Masataka Kuwana2, Tatsuya Atsumi3, Syuji Takei4, Masayoshi Harigai5, Takao Fujii6, Hiroaki Matsuno7, Tsuneyo Mimori8, Shigeki Momohara9, Kazuhiko Yamamoto10, Yoshinari Takasaki11, Kazuto Nomura12, Yutaka Endo12, Tomohiro Hirose12, Yosuke Morishima12, Naonobu Sugiyama12, Noritoshi Yoshii12 and Michiaki Takagi13, 1Juntendo University, Tokyo, Japan, 2Nippon Medical School, Tokyo, Japan, 3Hokkaido University, Sapporo, Japan, 4Medical Center for Children, Kagoshima, Japan, 5Tokyo Women’s Medical University, Tokyo, Japan, 6Wakayama Medical University, Wakayama, Japan, 7Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, 8Kyoto University, Kyoto, Japan, 9Hakkeikai Inc Medical Institution, Shizuoka, Japan, 10The University of Tokyo, Tokyo, Japan, 11Juntendo Koshigaya Hospital, Juntendo University Faculty of Medicine, Saitama, Japan, 12Pfizer Japan Inc, Tokyo, Japan, 13Yamagata University Faculty of Medicine, Yamagata, Japan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Previously, the efficacy and safety of tofacitinib were demonstrated in patients (pts)…
  • Abstract Number: 2461 • 2018 ACR/ARHP Annual Meeting

    Analysis of Severe Adverse Drug Reactions to Disease Modifying Drugs in an Inception Rheumatoid Arthritis Cohort

    Zulema Rosales Rosado1,2, Judit Font Urgelles1, Pia Mercedes Lois1, Cristina Vadillo Font1, Dalifer Freites Núñez2, Isabel Hernández-Rodríguez1, Juan A Jover Jover1 and Lydia A Alcazar2, 1Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 2Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain

    Background/Purpose: There is a well-known risk of developing adverse drug reactions (ADR) in rheumatic patients due, mainly, to the Disease Modifying Drugs (DMARD) widely used.…
  • Abstract Number: 1529 • 2018 ACR/ARHP Annual Meeting

    Long-Term, Real-World Safety of Adalimumab in Rheumatoid Arthritis

    Leslie R. Harrold1,2, Jenny Griffith3, Heather J Litman4, Bernice Gershenson1, Syed Islam3, Christine J Barr2, Dianlin Guo3, Patrick Zueger5, Jonathan Fay3 and Jeffrey Greenberg2,6, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC, Waltham, MA, 3AbbVie, Inc., North Chicago, IL, 4Corrona LLC, Waltham, MA, 5AbbVie Inc., North Chicago, IL, 6New York University School of Medicine, New York, NY

    Background/Purpose: The incidence of adverse events (AE) among rheumatology medication users has not been well documented in real-world disease registry datasets in the US.  We…
  • Abstract Number: 2582 • 2018 ACR/ARHP Annual Meeting

    Post-Marketing Safety of Secukinumab in Adult Patients with Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis: Cumulative Analysis across >96,000 Patient-Treatment Years Exposure

    Atul A. Deodhar1, Dafna D Gladman2, Iain B. McInnes3, Filip van Den Bosch4, Abhijit Shete5, Ruquan You6, Samina Hussain7 and Jorge Safi8, 1Oregon Health & Science University, Portland, OR, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 4Rheumatology, Ghent University Hospital and VIB Ghent University, Gent, Belgium, 5Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland, 6Shanghai Novartis Trading Limited, Shanghai, China, 7Novartis Healthcare Private Limited, Hyderabad, India, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ

    Background/Purpose: Secukinumab, a fully human monoclonal IgG1 antibody that selectively neutralizes IL-17A, is currently approved in >75 countries for use in psoriasis /psoriatic arthritis and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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