ACR Meeting Abstracts

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Abstracts tagged "Adverse events"

  • Abstract Number: 1516 • 2018 ACR/ARHP Annual Meeting

    Infection Events in Japanese Patients with Rheumatoid Arthritis Treated with Tofacitinib: Interim All-Case Post-Marketing Surveillance

    Naoto Tamura1, Masataka Kuwana2, Tatsuya Atsumi3, Syuji Takei4, Masayoshi Harigai5, Takao Fujii6, Hiroaki Matsuno7, Tsuneyo Mimori8, Shigeki Momohara9, Kazuhiko Yamamoto10, Yoshinari Takasaki11, Kazuto Nomura12, Yutaka Endo12, Tomohiro Hirose12, Yosuke Morishima12, Naonobu Sugiyama12, Noritoshi Yoshii12 and Michiaki Takagi13, 1Juntendo University, Tokyo, Japan, 2Nippon Medical School, Tokyo, Japan, 3Hokkaido University, Sapporo, Japan, 4Medical Center for Children, Kagoshima, Japan, 5Tokyo Women’s Medical University, Tokyo, Japan, 6Wakayama Medical University, Wakayama, Japan, 7Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, 8Kyoto University, Kyoto, Japan, 9Hakkeikai Inc Medical Institution, Shizuoka, Japan, 10The University of Tokyo, Tokyo, Japan, 11Juntendo Koshigaya Hospital, Juntendo University Faculty of Medicine, Saitama, Japan, 12Pfizer Japan Inc, Tokyo, Japan, 13Yamagata University Faculty of Medicine, Yamagata, Japan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Previously, the efficacy and safety of tofacitinib were demonstrated in patients (pts)…
  • Abstract Number: 2461 • 2018 ACR/ARHP Annual Meeting

    Analysis of Severe Adverse Drug Reactions to Disease Modifying Drugs in an Inception Rheumatoid Arthritis Cohort

    Zulema Rosales Rosado1,2, Judit Font Urgelles1, Pia Mercedes Lois1, Cristina Vadillo Font1, Dalifer Freites Núñez2, Isabel Hernández-Rodríguez1, Juan A Jover Jover1 and Lydia A Alcazar2, 1Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 2Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain

    Background/Purpose: There is a well-known risk of developing adverse drug reactions (ADR) in rheumatic patients due, mainly, to the Disease Modifying Drugs (DMARD) widely used.…
  • Abstract Number: 1529 • 2018 ACR/ARHP Annual Meeting

    Long-Term, Real-World Safety of Adalimumab in Rheumatoid Arthritis

    Leslie R. Harrold1,2, Jenny Griffith3, Heather J Litman4, Bernice Gershenson1, Syed Islam3, Christine J Barr2, Dianlin Guo3, Patrick Zueger5, Jonathan Fay3 and Jeffrey Greenberg2,6, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC, Waltham, MA, 3AbbVie, Inc., North Chicago, IL, 4Corrona LLC, Waltham, MA, 5AbbVie Inc., North Chicago, IL, 6New York University School of Medicine, New York, NY

    Background/Purpose: The incidence of adverse events (AE) among rheumatology medication users has not been well documented in real-world disease registry datasets in the US.  We…
  • Abstract Number: 2582 • 2018 ACR/ARHP Annual Meeting

    Post-Marketing Safety of Secukinumab in Adult Patients with Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis: Cumulative Analysis across >96,000 Patient-Treatment Years Exposure

    Atul A. Deodhar1, Dafna D Gladman2, Iain B. McInnes3, Filip van Den Bosch4, Abhijit Shete5, Ruquan You6, Samina Hussain7 and Jorge Safi8, 1Oregon Health & Science University, Portland, OR, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 4Rheumatology, Ghent University Hospital and VIB Ghent University, Gent, Belgium, 5Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland, 6Shanghai Novartis Trading Limited, Shanghai, China, 7Novartis Healthcare Private Limited, Hyderabad, India, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ

    Background/Purpose: Secukinumab, a fully human monoclonal IgG1 antibody that selectively neutralizes IL-17A, is currently approved in >75 countries for use in psoriasis /psoriatic arthritis and…
  • Abstract Number: 1537 • 2018 ACR/ARHP Annual Meeting

    Frequency and Duration of Early Non-Serious Adverse Events in Rheumatoid Arthritis Patients Treated with Tofacitinib 5 Mg Twice Daily As Monotherapy and Combination Therapy

    Ara Dikranian1, Jürgen Wollenhaupt2, Valderilio F Azevedo3, Louis Bessette4, David Gold5, Jose L Rivas6, Harry Shi7, Lisy Wang8, John Woolcott7, Andrea Shapiro9 and Peter Nash10, 1Cabrillo Center for Rheumatic Disease, San Diego, CA, 2Schön Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 3Universidade Federal do Paraná, Curitiba, Brazil, 4Laval University, Kirkland, QC, Canada, 5Pfizer Canada, Montreal, QC, Canada, 6Pfizer SLU, Madrid, Spain, 7Pfizer Inc, Collegeville, PA, 8Pfizer Inc, Groton, CT, 9Pfizer Inc, Peapack, NJ, 10University of Queensland, Brisbane, Australia

    Background/Purpose: Tolerability remains ill-defined in clinical trials and most commonly refers to non-serious adverse events (AEs) that may impact patient (pt) satisfaction and adherence to…
  • Abstract Number: 2585 • 2018 ACR/ARHP Annual Meeting

    Secukinumab Immunogenicity in Patients with Psoriatic Arthritis and Ankylosing Spondylitis during a 52-Week Treatment Period

    Atul A. Deodhar1, Dafna D Gladman2, Iain B. McInnes3, Vibeke Strand4, Mengyuan Ren5, Sebastian Spindeldreher6, Luminita Pricop7, Brian Porter7, Jorge Safi7, Abhijit Shete8 and Gerard Bruin6, 1Oregon Health & Science University, Portland, OR, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 4Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 5Novartis Pharmaceuticals, Shanghai, China, 6Novartis Institutes for BioMedical Research, Basel, Switzerland, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ, 8Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland

    Background/Purpose: Secukinumab, a fully human monoclonal IgG1 antibody (mAb) that selectively targets IL-17A, is efficacious for the treatment of psoriasis, psoriatic arthritis (PsA) and ankylosing…
  • Abstract Number: 1539 • 2018 ACR/ARHP Annual Meeting

    Safety of Methotrexate and Leflunomide Combination Therapy in the Treatment of Rheumatoid Arthritis

    María Badilla1, Nicia Moldenhauer2, Diego Neira3, Luis Muñoz4 and Oscar Neira1, 1Rheumatology Section., Hospital del Salvador, Universidad de Chile., Santiago, Chile, 2Rheumatology Section, Hospital del Salvador, Universidad de Chile, Santiago, Chile, 3Internal Medicine Departament, Hospital del Salvador, Universidad de Chile, Santiago, Chile, 4Pharmacy Department, Hospital del Salvador, Santiago, Chile

    Background/Purpose: Best treatment of Rheumatoid Arthritis (RA) requires to begin early, with a tight control, including nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, disease-modifying antirheumatic drugs (DMARDs)…
  • Abstract Number: 2604 • 2018 ACR/ARHP Annual Meeting

    Incidence of Serious Gastrointestinal Events and Inflammatory Bowel Disease Among Tildrakizumab-Treated Patients with Moderate to Severe Plaque Psoriasis: Data from 3 Large Randomized Clinical Trials

    Melinda Gooderham1, Boni E. Elewski2, David M. Pariser3, Howard Sofen4, Alan M Mendelsohn5, Nicole Cichanowitz6 and Qing Li6, 1Probity Medical Research, and Skin Center for Dermatololgy, Waterloo, and Peterborough, ON, Canada, 2University of Alabama at Birmingham, Birmingham, AL, 3Eastern Virginia Medical School and Virginia Clinical Research, Inc., Norfolk, VA, 4Ronald Reagan UCLA Medical Center, Department of Medicine (Dermatology) UCLA, Los Angeles, CA, 5Sun Pharmaceutical Industries, Inc., Princeton, NJ, 6Merck & Co., Inc., Kenilworth, NJ

    Background/Purpose: Tildrakizumab (TIL), a high-affinity, humanized, immunoglobulin G1κ, anti–interleukin-23p19 monoclonal antibody, has demonstrated efficacy in the treatment of chronic plaque psoriasis.1,2 Here, we evaluate the…
  • Abstract Number: 1542 • 2018 ACR/ARHP Annual Meeting

    Real-World Data from a Post-Approval Safety Surveillance Study of Tofacitinib Vs Biologic Dmards and Conventional Synthetic Dmards: Five-Year Results from a US-Based Rheumatoid Arthritis Registry

    Joel Kremer1, Laura C. Cappelli2, Carol J. Etzel3, Jeffrey Greenberg3, Jamie Geier4, Ann Madsen4, Connie Chen4, Alina Onofrei3, Christine J Barr3, Dimitrios A. Pappas3, Kimberly J Dandreo3, Andrea Shapiro5, Carol A Connell6 and Arthur Kavanaugh7, 1Albany Medical College and the Center for Rheumatology, Albany, NY, 2Johns Hopkins University, Baltimore, MD, 3Corrona LLC, Waltham, MA, 4Pfizer Inc, New York, NY, 5Pfizer Inc, Peapack, NJ, 6Pfizer Inc, Groton, CT, 7University of California, San Diego School of Medicine, La Jolla, San Diego, CA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. A prospective observational 5-year study, embedded within the US Corrona RA registry,…
  • Abstract Number: 2723 • 2018 ACR/ARHP Annual Meeting

    Patient Experience in ANCA-Associated Vasculitis Evolves over Time from Diagnosis and Both Benefits and Adverse Impacts Are Felt with Current Therapy

    Peter Rutherford1, Dieter Goette1, James O`Donoghue2 and Xierong Liu2, 1Medical Affairs, Vifor Pharma, Zurich, Switzerland, 2Elma Research, London, United Kingdom

    Background/Purpose: ANCA-associated vasculitis (AAV) leads to both acute illness and a long-term condition in which the disease remits and relapses. Therapy is often complex and…
  • Abstract Number: 346 • 2018 ACR/ARHP Annual Meeting

    Immune-Related Adverse Events: Development of a Pilot Immune-Related Adverse Events Clinic for Expedited and Effective Patient Care

    Pankti Reid1 and Reem Jan2, 1Internal Medicine, rheumatology, University of Chicago, Chicago, IL, 2Medicine, Rheumatology, University of Chicago, Chicago, IL

    Background/Purpose: The growing use of cancer immunotherapy and checkpoint inhibitors has led to a steep rise in immune-related adverse events (irAEs). Despite expanding research efforts,…
  • Abstract Number: 1612 • 2018 ACR/ARHP Annual Meeting

    Myocardial Infarctions Among Ankylosing Spondylitis Patients in a Large US Insurance Database

    Maureen Dubreuil1, Christine Peloquin2, David T. Felson3 and Tuhina Neogi3, 1Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston, MA, 2Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 3Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Risk of myocardial infarction (MI) is estimated to be increased up to 60% in ankylosing spondylitis (AS).  Studies in patients with rheumatoid arthritis, psoriatic…
  • Abstract Number: 2724 • 2018 ACR/ARHP Annual Meeting

    Variable Response to Induction Therapy and Significant Burden of Treatment Adverse Events over the First 12 Months in Incident ANCA-Associated Vasculitis (AAV) Patients – a Study of Routine Clinical Practice in the EU

    Peter Rutherford1, Dieter Goette1, Melinda Stamm2 and Xierong Liu2, 1Medical Affairs, Vifor Pharma, Zurich, Switzerland, 2Elma Research, London, United Kingdom

    Background/Purpose: Aims of therapy in incident AAV patients include ensuring rapid diagnosis, assessment of comorbidity, disease activity, and vasculitis damage before commencing treatment with a…
  • Abstract Number: 350 • 2018 ACR/ARHP Annual Meeting

    Clinical Correlates of Immune-Related Adverse Events for Patients with Melanoma Treated with Checkpoint Inhibitors and a Noted Significant Difference in Peripheral Lymphocyte Counts

    Pankti Reid1, Tara Chongsuwat2, Anisha Dua3 and Jason Luke4, 1Internal Medicine, rheumatology, University of Chicago, Chicago, IL, 2Oncology Research Coordinator, University of Chicago, Chicago, IL, 3Medicine, University of Chicago, Chicago, IL, 4Hematology Oncology, University of Chicago, Chicago, IL

    Background/Purpose: Checkpoint immunotherapy has become the standard of care in treating advanced melanoma. These medications have been associated with immune-related adverse events (irAEs). Accurate methods…
  • Abstract Number: 1768 • 2018 ACR/ARHP Annual Meeting

    Kidney Involvement, Poor Performance Status, and Higher Cumulative Dose of Glucocorticoid Are the Risk Factors of the Discontinuation of Immunosuppressant in Patients with Antineutrophil Cytoplasmic Antibody Associated Vasculitis

    Takamasa Murosaki, Takeo Sato, Katsuya Nagatani and Seiji Minota, Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan

    Background/Purpose: The use of immunosuppressant (IS) with glucocorticoid is recommended as remission induction treatment for severe cases with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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