Abstracts tagged "Adult-onset Still’s disease"

Abstract Number: 32 • 2019 ACR/ARP Annual Meeting
Aberration of Histone Lysine Methylation in Adult-Onset Still’s Disease Are Novel Biomarker Candidates Associated with the Disease Activity
Yoshimi Aizaki¹, Yasuto Araki ¹, Kojiro Sato ² and Toshihide Mimura ¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan
Background/Purpose: Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder characterized by spiking fever, transient rash, arthritis and leukocytosis. Macrophage and neutrophil activation is a…
Abstract Number: 784 • 2019 ACR/ARP Annual Meeting
Application of Systems Biology-Based In Silico Tools for Optimal Treatment Strategy Identification in Still’s Disease
Cristina Segu-Verges¹, Mireia Coma ¹, Christoph Kessel ², Serge Smeets ³, Dirk Foell ² and Anna Aldea ⁴, ¹Anaxomics, Barcelona, Catalonia, Spain, ²University Hospital Muenster, Muenster, Germany, ³Novartis, Amsterdam, Netherlands, ⁴Novartis, Barcelona, Catalonia, Spain
Background/Purpose: Systemic JIA (sJIA) and Adult Onset Still’s Disease may represent a disease continuum1 of the same autoinflammatory disorder, Still’s Disease. Current challenges in its…
Abstract Number: 1245 • 2019 ACR/ARP Annual Meeting
Efficacy of Canakinumab Treatment in Adult-onset Still’s Disease
Corrado Campochiaro¹, Alessandro Tomelleri ², De Luca Giacomo ³, Nicola Farina ², Elena Baldissera ², Giulio Cavalli ² and Lorenzo Dagna ², ¹Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy, ²Unit of Immunology, Rheumatology, Allergy and Rare Diseases. IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University., Milan, Italy, ³Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Milan, Italy
Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare auto-inflammatory condition characterized by fever, arthritis, skin rash, and multi-organ inflammation. The pathogenesis of AOSD is centrally…
Abstract Number: 1250 • 2019 ACR/ARP Annual Meeting
Can Patient-Reported Outcomes and Disease Activity Scores Predict Patient Acceptable Symptom State in Adult-Onset Still’s Disease?
Emre Bilgin ¹, Timuçin Kaşifoğlu ², Ahmet Omma ³, Cemal Bes ⁴, Muhammet Çınar ⁵, Hakan Emmungil ⁶, Orhan Küçükşahin ⁷, Servet Akar ⁸, Kenan Aksu ⁹, Fatih Yıldız ¹⁰, Nilüfer Kanıtez ¹¹, Abdulsamet Erden ¹², Sezin Turan ¹³, Ediz Dalkılıç ¹⁴, Selime Ermurat ¹⁵, Mutlu Hayran ¹⁶ and Umut Kalyoncu¹⁷, ¹Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, ²Eskişehir Osmangazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Eskişehir, Turkey, ³Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ⁴University of Medical Sciences, İstanbul, Turkey, ⁵University of Medical Sciences, Ankara, Turkey, ⁶Trakya University, Edirne, Turkey, ⁷Liv Hospital, Ankara, Turkey, ⁸Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey, ⁹Ege University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ¹⁰Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaraş, Turkey, ¹¹Koç University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, ¹²Ministry of Health Ankara City Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ¹³Trakya University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Edirne, Turkey, ¹⁴Uludağ University, Bursa, Turkey, ¹⁵Uludağ University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Bursa, Turkey, ¹⁶Hacettepe University, Faculty of Medicine, Department of Preventive Oncology, Ankara, Turkey, ¹⁷Hacettepe University Department of Rheumatology, Ankara, Turkey
Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare, chronic and auto-inflammatory disorder with multisystemic involvement. Patient Acceptable Symptom State (PASS) is the highest level of…
Abstract Number: 1262 • 2019 ACR/ARP Annual Meeting
Clinical Features of Elderly-onset Adult Still’s Disease
Sayaka Takenaka¹, Takehisa Ogura ¹, Yuto Takakura ¹, Takaharu Katagiri ¹, Yuki Inoue ¹, Ayako Hirata ¹ and Hideto Kameda ², ¹Division of Rheumatology, Department of Internal medicine Toho University Ohashi Medical Center, Tokyo, Japan, ²Toho University, Tokyo, Japan, Tokyo, Japan
Background/Purpose: The peak age at the onset of adult Still's disease (ASD) has been between 20 and 35 years old. However, the proportion of elderly-onset…
Abstract Number: 1270 • 2019 ACR/ARP Annual Meeting
Effectiveness and Safety of Off-label Use of Tocilizumab in Refractory Autoimmune Diseases: A Multicenter Study
Martin Michaud¹, Thomas Sene ², Pascal Chazerain ², Geoffrey Urbanski ³, Frederique Retornaz ⁴, Boris Bienvenu ⁵, Laurent Chiche ⁴, Florian Catros ⁶, Laurent Sailler ⁷, Laurent Alric ⁸, Jean Thomas Giraud ⁹, Léo Caudrelier ¹⁰, Slim Lassoued ¹⁰, Sophie Ancellin ⁶, Olivier Lidove ² and Francis Gaches ⁶, ¹Joseph Ducuing Hospital, Toulouse, France, ²Hôpital Croix Saint Simon, Paris, France, ³CHU Angers, Angers, France, ⁴Hôpital Européen, Marseille, France, ⁵Hôpital Saint Joseph, Marseille, France, ⁶Hôpital Joseph Ducuing, Toulouse, France, ⁷University Hospital of Toulouse, Toulouse, France, ⁸CHU Toulouse, Toulouse, France, ⁹Hôpital de Tarbes, Tarbes, France, ¹⁰Hôpital de Cahors, Cahors, France
Background/Purpose: There is increasing evidence of Tocilizumab (TCZ) efficacy in refractory auto-immune diseases. The present study aimed at evaluating the real-world experience of using TCZ…
Abstract Number: 1271 • 2019 ACR/ARP Annual Meeting
Adult-Onset Still’s Disease Prognosis Score: Clinical Patterns, Complications and Biologic Treatment
Ivette Casafont-Solé¹, Susana Holgado ¹, Javier Narváez ², Maribel Mora ³, Josep Roca ⁴, Anahy Brandy-Garcia ¹, Lourdes Mateo ¹, Melania Martínez-Morillo ¹, Laia Gifre ¹, Maria Aparicio-Espinar ¹, Águeda Prior-Español ¹, Anne Riveros-Frutos ¹, Clara Sangüesa ¹, Jordi Camins-Fàbregas ¹, Annika Nack ¹, Joan Miquel Nolla ³ and Alejandro Olivé-Marqués ⁴, ¹Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ²Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, ³Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain, ⁴Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain
Background/Purpose: Adult-onset Still’s disease (AOSD) is a low prevalent disease with an unpredictable clinical course and variable prognosis. Sometimes, it requires biologic treatment in early…
Abstract Number: 1327 • 2018 ACR/ARHP Annual Meeting
The Effect of Etoposide on Inducing Remission in Refractory Adult-Onset Still’s Disease: A Retrospective, Single-Center Study
Haiting Wang¹, Xiaodong Wang¹, Ting Li¹ and Shuang Ye², ¹Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Rheumatology, Ren Ji Hospital, South Campus, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Background/Purpose: Adult onset Still¡¯s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Macrophage activation syndrome (MAS) is a life-threatening complication and has been…
Abstract Number: 1154 • 2017 ACR/ARHP Annual Meeting
Use of Including Serum Ferritin and Heme Oxygenase 1 in the Yamaguchi’s Classification for Adult-Onset Still’s Disease: A Multicenter Retrospective Study
Yohei Kirino¹, Yasushi Kawaguchi², Yoshifumi Tada³, Hiroshi Tsukamoto⁴, Toshiyuki Ota⁵, Masahiro Iwamoto⁶, Hiroki Takahashi⁷, Kohei Nagasawa⁸, Syuji Takei⁹, Takahiko Horiuchi¹⁰, Hisae Ichida², Seiji Minota¹¹, Atsuhisa Ueda¹, Akihide Ohta¹² and Yoshiaki Ishigatsubo¹³, ¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Department of Internal Medicine, Division of Rheumatology, Saga University, Saga, Japan, ⁴Department of medicine and biosystemic science, Kyushu University Hospital, Fukuoka, Japan, ⁵Department of Rheumatology, Iizuka Hospital, Iizuka, Japan, ⁶Deivision of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ⁷Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan, ⁸Rheumatic Disease Center, Sawara Hospital, Sawara, Japan, ⁹Pediatrics of Developmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan, ¹⁰Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ¹¹Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ¹²Saga University School of Medicine, Saga, Japan, ¹³Yokohama City University, Yokohama, Japan
Background/Purpose: Yamaguchi’s criteria for classification of adult-onset Still’s disease (AOSD) has been widely applied in clinic despite it was established decades ago. However, hyperferritinemia, which…
Abstract Number: 1164 • 2017 ACR/ARHP Annual Meeting
Spectrum of Skin Eruption and Histological Findings in Adult-Onset Still’s Disease and Significance of Atypical Persistent Skin Eruptions
Elina Zuelgaray¹, Maxime Battistella², Camille Sallé de Chou¹, Patrice Cacoub³, François Chasset⁴, Christopher Rein⁵, Nathan Peiffer-Smadja³, Fanny Domont³, Marie Chapalain⁶, Claude Bachmeyer⁴, Laurence Fardet⁶, Bruno Fautrel⁷, Martine Bagot¹ and Jean-David Bouaziz¹, ¹Dermatology Department, Saint-Louis Hospital, Paris, France, ²Pathology Department, Saint-Louis Hospital, Paris, France, ³Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ⁴Dermatology Department, Tenon Hospital, Paris, France, ⁵Rheumatology Department, Hautepierre Hospital, Paris, France, ⁶Dermatology Department, Mondor Hospital, Paris, France, ⁷UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France
Background/Purpose: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder characterized by spiking fevers, polyarthritis and an evanescent salmon-pink maculopapular eruption. Several cases of…
Abstract Number: 252 • 2016 ACR/ARHP Annual Meeting
Cytokine Profiles of Korean Patients with Adult Onset Still’s Disease Treated with Biologic Agents
Seung Taek Song¹, SuMan Kang², Sung Won Lee³, Seoung Wan Nam², Hyukhee Kwon² and Dae-Hyun Yoo⁴, ¹Division of Rheumatology, Department of Internal Medicine, Cheongju St. Mary's Hospital, Cheongju, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, ³Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Adult onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Several studies have reported that pro-inflammatory cytokines including interleukin (IL)-1, IL-6,…
Abstract Number: 263 • 2015 ACR/ARHP Annual Meeting
Use of Serum Ferritin and Heme Oxygenase 1 for the Diagnosis of Adult-Onset Still’s Disease: A Preliminary Report of Multicenter Study
Yohei Kirino¹, Yasushi Kawaguchi², Yoshifumi Tada³, Seiji Minota⁴, Toshiyuki Ota⁵, Kohei Nagasawa⁶, Hiroshi Tsukamoto⁷, Syuji Takei^8,9, Takahiko Horiuchi¹⁰, Hiroki Takahashi¹¹, Hisae Ichida², Masahiro Iwamoto⁴, Atsuhisa Ueda¹, Akihide Ohta¹², Yoshiaki Ishigatsubo^1,13 and Hypercytokinemia Study Group, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Department of Internal Medicine, Division of Rheumatology, Saga University, Saga, Japan, ⁴Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ⁵Department of Rheumatology, Iizuka Hospital, Iizuka, Japan, ⁶Rheumatic Disease Center, Sawara Hospital, Fukuoka, Japan, ⁷First Dept of Internal Med, Kyushu University, Fukuoka, Japan, ⁸School of Health Sciences, Faculty of Medicine,, Kagoshima University, Kagoshima City, Japan, ⁹School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ¹⁰Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ¹¹epartment of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan, ¹²Department of Adult and Gerontological Nursing, Saga University School of Medicine, Saga, Japan, ¹³Yokosuka Rheumatic Diseases Center, Yokosuka City Hospital, Yokosuka, Japan
Background/Purpose: Yamaguchi's criteria for classification of adult-onset Still's disease (AOSD) has been widely applied in clinic despite it was established decades ago. However, hyperferritinemia, which…
Abstract Number: 268 • 2015 ACR/ARHP Annual Meeting
TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still’s Disease and Their Association with Disease Activity and Clinical Manifestations
Hyoun-Ah Kim¹, In Je Kim², Jae Ho Han³, Juyang Jung⁴, Chang-Hee Suh⁴ and You-Sun Kim⁵, ¹Department of Rheumatology, Ajou University School of Medicine, Suwan, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea, ³Department of Pathology, Ajou University School of Medicine, Suwon, South Korea, ⁴Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ⁵Department of Biochemistry and Molecular biology, Ajou University School of Medicine, Suwon, South Korea
Background/Purpose: S100A8 and S100A9 are two calcium-binding proteins that belong to the S100 family, and those are expressed by infiltrating monocytes and neutrophils under inflammatory…
Abstract Number: 1400 • 2015 ACR/ARHP Annual Meeting
Hyperferritinemia and Fever in Adults
Kensuke Nakanishi and Mitsuyo Kinjo, Rheumatology, Okinawa Chubu Hospital, Uruma, Japan
Background/Purpose: Clinical associations of hyperferritinemia include: hepatocellular injury, hemophagocytic lymphohistiocytosis (HLH), hematologic malignancy, adult-onset Still’s disease (AOSD), and iron overload. Fever of undetermined origin (FUO)…
Abstract Number: 1243 • 2014 ACR/ARHP Annual Meeting
Macrophage Activation Syndrome Complicating Adult Onset Still’s Disease – Single Center Experience and Literature Review
Aleksander Lenert¹ and Qingping Yao², ¹Orthopaedic and Rheumatologic Institute, Dept. of Rheumatic & Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ²Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening complication typically associated with hematologic malignancies and infections. HLH, also referred to as macrophage activation syndrome (MAS),…

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