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Abstracts tagged "Adult-onset Still’s disease"

  • Abstract Number: 784 • 2019 ACR/ARP Annual Meeting

    Application of Systems Biology-Based In Silico Tools for Optimal Treatment Strategy Identification in Still’s Disease

    Cristina Segu-Verges1, Mireia Coma 1, Christoph Kessel 2, Serge Smeets 3, Dirk Foell 2 and Anna Aldea 4, 1Anaxomics, Barcelona, Catalonia, Spain, 2University Hospital Muenster, Muenster, Germany, 3Novartis, Amsterdam, Netherlands, 4Novartis, Barcelona, Catalonia, Spain

    Background/Purpose: Systemic JIA (sJIA) and Adult Onset Still’s Disease may represent a disease continuum1 of the same autoinflammatory disorder, Still’s Disease. Current challenges in its…
  • Abstract Number: 1245 • 2019 ACR/ARP Annual Meeting

    Efficacy of Canakinumab Treatment in Adult-onset Still’s Disease

    Corrado Campochiaro1, Alessandro Tomelleri 2, De Luca Giacomo 3, Nicola Farina 2, Elena Baldissera 2, Giulio Cavalli 2 and Lorenzo Dagna 2, 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy, 2Unit of Immunology, Rheumatology, Allergy and Rare Diseases. IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University., Milan, Italy, 3Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Milan, Italy

    Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare auto-inflammatory condition characterized by fever, arthritis, skin rash, and multi-organ inflammation. The pathogenesis of AOSD is centrally…
  • Abstract Number: 1250 • 2019 ACR/ARP Annual Meeting

    Can Patient-Reported Outcomes and Disease Activity Scores Predict Patient Acceptable Symptom State in Adult-Onset Still’s Disease?

    Emre Bilgin 1, Timuçin Kaşifoğlu 2, Ahmet Omma 3, Cemal Bes 4, Muhammet Çınar 5, Hakan Emmungil 6, Orhan Küçükşahin 7, Servet Akar 8, Kenan Aksu 9, Fatih Yıldız 10, Nilüfer Kanıtez 11, Abdulsamet Erden 12, Sezin Turan 13, Ediz Dalkılıç 14, Selime Ermurat 15, Mutlu Hayran 16 and Umut Kalyoncu17, 1Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, 2Eskişehir Osmangazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Eskişehir, Turkey, 3Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 4University of Medical Sciences, İstanbul, Turkey, 5University of Medical Sciences, Ankara, Turkey, 6Trakya University, Edirne, Turkey, 7Liv Hospital, Ankara, Turkey, 8Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey, 9Ege University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, 10Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaraş, Turkey, 11Koç University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, 12Ministry of Health Ankara City Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 13Trakya University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Edirne, Turkey, 14Uludağ University, Bursa, Turkey, 15Uludağ University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Bursa, Turkey, 16Hacettepe University, Faculty of Medicine, Department of Preventive Oncology, Ankara, Turkey, 17Hacettepe University Department of Rheumatology, Ankara, Turkey

    Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare, chronic and auto-inflammatory disorder with multisystemic involvement. Patient Acceptable Symptom State (PASS) is the highest level of…
  • Abstract Number: 1262 • 2019 ACR/ARP Annual Meeting

    Clinical Features of Elderly-onset Adult Still’s Disease

    Sayaka Takenaka1, Takehisa Ogura 1, Yuto Takakura 1, Takaharu Katagiri 1, Yuki Inoue 1, Ayako Hirata 1 and Hideto Kameda 2, 1Division of Rheumatology, Department of Internal medicine Toho University Ohashi Medical Center, Tokyo, Japan, 2Toho University, Tokyo, Japan, Tokyo, Japan

    Background/Purpose: The peak age at the onset of adult Still's disease (ASD) has been between 20 and 35 years old. However, the proportion of elderly-onset…
  • Abstract Number: 1270 • 2019 ACR/ARP Annual Meeting

    Effectiveness and Safety of Off-label Use of Tocilizumab in Refractory Autoimmune Diseases: A Multicenter Study

    Martin Michaud1, Thomas Sene 2, Pascal Chazerain 2, Geoffrey Urbanski 3, Frederique Retornaz 4, Boris Bienvenu 5, Laurent Chiche 4, Florian Catros 6, Laurent Sailler 7, Laurent Alric 8, Jean Thomas Giraud 9, Léo Caudrelier 10, Slim Lassoued 10, Sophie Ancellin 6, Olivier Lidove 2 and Francis Gaches 6, 1Joseph Ducuing Hospital, Toulouse, France, 2Hôpital Croix Saint Simon, Paris, France, 3CHU Angers, Angers, France, 4Hôpital Européen, Marseille, France, 5Hôpital Saint Joseph, Marseille, France, 6Hôpital Joseph Ducuing, Toulouse, France, 7University Hospital of Toulouse, Toulouse, France, 8CHU Toulouse, Toulouse, France, 9Hôpital de Tarbes, Tarbes, France, 10Hôpital de Cahors, Cahors, France

    Background/Purpose: There is increasing evidence of Tocilizumab (TCZ) efficacy in refractory auto-immune diseases. The present study aimed at evaluating the real-world experience of using TCZ…
  • Abstract Number: 1271 • 2019 ACR/ARP Annual Meeting

    Adult-Onset Still’s Disease Prognosis Score: Clinical Patterns, Complications and Biologic Treatment

    Ivette Casafont-Solé1, Susana Holgado 1, Javier Narváez 2, Maribel Mora 3, Josep Roca 4, Anahy Brandy-Garcia 1, Lourdes Mateo 1, Melania Martínez-Morillo 1, Laia Gifre 1, Maria Aparicio-Espinar 1, Águeda Prior-Español 1, Anne Riveros-Frutos 1, Clara Sangüesa 1, Jordi Camins-Fàbregas 1, Annika Nack 1, Joan Miquel Nolla 3 and Alejandro Olivé-Marqués 4, 1Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 2Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, 3Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain, 4Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain

    Background/Purpose: Adult-onset Still’s disease (AOSD) is a low prevalent disease with an unpredictable clinical course and variable prognosis. Sometimes, it requires biologic treatment in early…
  • Abstract Number: 32 • 2019 ACR/ARP Annual Meeting

    Aberration of Histone Lysine Methylation in Adult-Onset Still’s Disease Are Novel Biomarker Candidates Associated with the Disease Activity

    Yoshimi Aizaki1, Yasuto Araki 1, Kojiro Sato 2 and Toshihide Mimura 1, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan

    Background/Purpose: Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder characterized by spiking fever, transient rash, arthritis and leukocytosis. Macrophage and neutrophil activation is a…
  • Abstract Number: 1327 • 2018 ACR/ARHP Annual Meeting

    The Effect of Etoposide on Inducing Remission in Refractory Adult-Onset Still’s Disease: A Retrospective, Single-Center Study

    Haiting Wang1, Xiaodong Wang1, Ting Li1 and Shuang Ye2, 1Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Rheumatology, Ren Ji Hospital, South Campus, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Background/Purpose: Adult onset Still¡¯s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Macrophage activation syndrome (MAS) is a life-threatening complication and has been…
  • Abstract Number: 1154 • 2017 ACR/ARHP Annual Meeting

    Use of Including Serum Ferritin and Heme Oxygenase 1 in the Yamaguchi’s Classification for Adult-Onset Still’s Disease: A Multicenter Retrospective Study

    Yohei Kirino1, Yasushi Kawaguchi2, Yoshifumi Tada3, Hiroshi Tsukamoto4, Toshiyuki Ota5, Masahiro Iwamoto6, Hiroki Takahashi7, Kohei Nagasawa8, Syuji Takei9, Takahiko Horiuchi10, Hisae Ichida2, Seiji Minota11, Atsuhisa Ueda1, Akihide Ohta12 and Yoshiaki Ishigatsubo13, 1Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 3Department of Internal Medicine, Division of Rheumatology, Saga University, Saga, Japan, 4Department of medicine and biosystemic science, Kyushu University Hospital, Fukuoka, Japan, 5Department of Rheumatology, Iizuka Hospital, Iizuka, Japan, 6Deivision of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 7Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan, 8Rheumatic Disease Center, Sawara Hospital, Sawara, Japan, 9Pediatrics of Developmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan, 10Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 11Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 12Saga University School of Medicine, Saga, Japan, 13Yokohama City University, Yokohama, Japan

    Background/Purpose: Yamaguchi’s criteria for classification of adult-onset Still’s disease (AOSD) has been widely applied in clinic despite it was established decades ago. However, hyperferritinemia, which…
  • Abstract Number: 1164 • 2017 ACR/ARHP Annual Meeting

    Spectrum of Skin Eruption and Histological Findings in Adult-Onset Still’s Disease and Significance of Atypical Persistent Skin Eruptions

    Elina Zuelgaray1, Maxime Battistella2, Camille Sallé de Chou1, Patrice Cacoub3, François Chasset4, Christopher Rein5, Nathan Peiffer-Smadja3, Fanny Domont3, Marie Chapalain6, Claude Bachmeyer4, Laurence Fardet6, Bruno Fautrel7, Martine Bagot1 and Jean-David Bouaziz1, 1Dermatology Department, Saint-Louis Hospital, Paris, France, 2Pathology Department, Saint-Louis Hospital, Paris, France, 3Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, 4Dermatology Department, Tenon Hospital, Paris, France, 5Rheumatology Department, Hautepierre Hospital, Paris, France, 6Dermatology Department, Mondor Hospital, Paris, France, 7UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France

    Background/Purpose: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder characterized by spiking fevers, polyarthritis and an evanescent salmon-pink maculopapular eruption. Several cases of…
  • Abstract Number: 252 • 2016 ACR/ARHP Annual Meeting

    Cytokine Profiles of Korean Patients with Adult Onset Still’s Disease Treated with Biologic Agents

    Seung Taek Song1, SuMan Kang2, Sung Won Lee3, Seoung Wan Nam2, Hyukhee Kwon2 and Dae-Hyun Yoo4, 1Division of Rheumatology, Department of Internal Medicine, Cheongju St. Mary's Hospital, Cheongju, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, 3Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

    Background/Purpose:  Adult onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Several studies have reported that pro-inflammatory cytokines including interleukin (IL)-1, IL-6,…
  • Abstract Number: 263 • 2015 ACR/ARHP Annual Meeting

    Use of Serum Ferritin and Heme Oxygenase 1 for the Diagnosis of Adult-Onset Still’s Disease: A Preliminary Report of Multicenter Study

    Yohei Kirino1, Yasushi Kawaguchi2, Yoshifumi Tada3, Seiji Minota4, Toshiyuki Ota5, Kohei Nagasawa6, Hiroshi Tsukamoto7, Syuji Takei8,9, Takahiko Horiuchi10, Hiroki Takahashi11, Hisae Ichida2, Masahiro Iwamoto4, Atsuhisa Ueda1, Akihide Ohta12, Yoshiaki Ishigatsubo1,13 and Hypercytokinemia Study Group, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 3Department of Internal Medicine, Division of Rheumatology, Saga University, Saga, Japan, 4Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 5Department of Rheumatology, Iizuka Hospital, Iizuka, Japan, 6Rheumatic Disease Center, Sawara Hospital, Fukuoka, Japan, 7First Dept of Internal Med, Kyushu University, Fukuoka, Japan, 8School of Health Sciences, Faculty of Medicine,, Kagoshima University, Kagoshima City, Japan, 9School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, 10Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 11epartment of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan, 12Department of Adult and Gerontological Nursing, Saga University School of Medicine, Saga, Japan, 13Yokosuka Rheumatic Diseases Center, Yokosuka City Hospital, Yokosuka, Japan

    Background/Purpose: Yamaguchi's criteria for classification of adult-onset Still's disease (AOSD) has been widely applied in clinic despite it was established decades ago.  However, hyperferritinemia, which…
  • Abstract Number: 268 • 2015 ACR/ARHP Annual Meeting

    TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still’s Disease and Their Association with Disease Activity and Clinical Manifestations

    Hyoun-Ah Kim1, In Je Kim2, Jae Ho Han3, Juyang Jung4, Chang-Hee Suh4 and You-Sun Kim5, 1Department of Rheumatology, Ajou University School of Medicine, Suwan, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea, 3Department of Pathology, Ajou University School of Medicine, Suwon, South Korea, 4Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 5Department of Biochemistry and Molecular biology, Ajou University School of Medicine, Suwon, South Korea

    Background/Purpose: S100A8 and S100A9 are two calcium-binding proteins that belong to the S100 family, and those are expressed by infiltrating monocytes and neutrophils under inflammatory…
  • Abstract Number: 1400 • 2015 ACR/ARHP Annual Meeting

    Hyperferritinemia and Fever in Adults

    Kensuke Nakanishi and Mitsuyo Kinjo, Rheumatology, Okinawa Chubu Hospital, Uruma, Japan

    Background/Purpose: Clinical associations of hyperferritinemia include: hepatocellular injury, hemophagocytic lymphohistiocytosis (HLH), hematologic malignancy, adult-onset Still’s disease (AOSD), and iron overload. Fever of undetermined origin (FUO)…
  • Abstract Number: 1243 • 2014 ACR/ARHP Annual Meeting

    Macrophage Activation Syndrome Complicating Adult Onset Still’s Disease – Single Center Experience and Literature Review

    Aleksander Lenert1 and Qingping Yao2, 1Orthopaedic and Rheumatologic Institute, Dept. of Rheumatic & Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 2Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening complication typically associated with hematologic malignancies and infections. HLH, also referred to as macrophage activation syndrome (MAS),…
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