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Abstracts tagged "adenosine"

  • Abstract Number: 0019 • ACR Convergence 2021

    Increased Circulating CD39+FoxP3+CD4+ Treg Cells in Early Rheumatoid Arthritis Facilitate the Antiinflammatory Action of Methotrexate

    Laura Nuño1, Alejandro Villalba1, Marta Novella-Navarro2, Irene Monjo1, Diana Peitado1, Sara Garcia-Carazo1, Alejandro Balsa2 and Maria-Eugenia Miranda-Carus1, 1Hospital La Paz - IdiPAZ, Madrid, Spain, 2Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain

    Background/Purpose: Inhibition of AICAR transformylase by MTX results in augmented release of adenine nucleotides to the extracellular space; these are rapidly hydrolysed by ectonucleotidases CD39…
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