Abstract Number: 2792 • 2014 ACR/ARHP Annual Meeting
Methotrexate Prevents Inflammatory Osteolysis By Activation of the Adenosine a2A Receptor (A2AR)
Background/Purpose Prior studies demonstrate that adenosine, acting at A2AR, mediates the anti-inflammatory effects of methotrexate (MTX) in models of both acute and chronic inflammation. We…Abstract Number: 1729 • 2014 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Promotes Collagen Type 3 Expression Via β-Catenin Activation
Background/Purpose A2AR stimulation promotes collagen 1 and 3 (Col1 and Col3) synthesis, principal mediators of fibrosis and scarring. We have recently demonstrated that the A2AR…Abstract Number: 2570 • 2013 ACR/ARHP Annual Meeting
Tenofovir But Not Adefovir Prevents Liver and Skin Fibrosis In Two Models Of Adenosine-Mediated Injury
Background/Purpose: Acyclic nucleoside phosphonates are a key class of antivirals commonly used in the treatment of both DNA and retroviral infections. Adefovir and tenofovir are…Abstract Number: 2222 • 2013 ACR/ARHP Annual Meeting
Positive Allosteric Modulation Of The Adenosine A2a Receptor Alters Inflammatory Cytokine Production and Alleviates Chronic Arthritis In Rats
Background/Purpose: Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation and joint destruction; a consequence of which is the high local concentration of…Abstract Number: 1851 • 2013 ACR/ARHP Annual Meeting
Adenosine 2A Receptor Promotes Collagen Production By Human Fibroblasts Via Smad2/3-Independent Pathways Involving Cyclic AMP and AKT
Background/Purpose: Activation of Adenosine 2A Receptors (A2AR) promotes fibrosis and collagen synthesis. However, the underlying mechanism by which A2AR stimulate collagen synthesis is still unclear. …Abstract Number: 1830 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Diminishes Wear Particle (UHMWPE)-Mediated Osteolysis, Increases Bone Formation and Regulates Expression Of Axonal Guidance Proteins (AGP) By Macrophages, Osteoclasts (OC) and Osteoblasts (OB)
Background/Purpose: Communication between OC and OB is critical for maintenance of bone homeostasis; both OC and OB release regulatory messengers. Among these signaling molecules are…Abstract Number: 1838 • 2013 ACR/ARHP Annual Meeting
The Use Of Three-Dimensionally Printed β-Tricalcium Phosphate/Hydroxyapatite To Understand The Regulation Of Adenosine Receptors In Osteoclast Formation and Promotion In Bone Regeneration
Background/Purpose: Bone defects resulting from trauma or infection need timely and effective treatments to replace damaged bone. Using specialized three-dimensional (3-D) printing technology, combined with…Abstract Number: 935 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Activates The Pro-Fibrotic Wnt / β-Catenin Signaling In Human Dermal Fibroblasts
Background/Purpose: Upon adenosine formation in stress conditions, the adenosine A2A Receptor (A2AR) activation promotes wound healing, but it is also detrimental in fibrotic conditions such…Abstract Number: 53 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptor As a Potential New Therapeutic Target For The Prevention/Treatment Of Osteoarthritis
Background/Purpose: Osteoarthritis, the most common type of arthritis in the United States, results from trauma and other mechanical factors as well as metabolic changes in…Abstract Number: 2516 • 2012 ACR/ARHP Annual Meeting
Adenosine Receptors Stimulate Bone Regeneration by Targeting Osteoclasts
Background/Purpose: Various types of orthopedic procedures, including spinal fusion and repair of bone defects due to trauma, infection or metastatic disease, require formation of new…Abstract Number: 1965 • 2012 ACR/ARHP Annual Meeting
Adenosine Regulates Bone Metabolism Via A1, A2A and A2B Receptors in Bone Marrow Cells From Normal and Patients with Multiple Myeloma
Background/Purpose: Multiple myeloma is a haematologic malignancy that is characterized by osteolytic bone lesions, wherein coupled bone remodeling is disrupted with increased osteoclast activation and…Abstract Number: 1805 • 2012 ACR/ARHP Annual Meeting
The Pro-Fibrotic Cytokines IL-33 and IL-13 Modulates Dermal Fibrosis Via the A2A Adenosine Receptor
Background/Purpose: We have previously demonstrated that the nucleoside adenosine mediates collagen production and induce dermal fibrosis in in vitro and in vivo models. IL–13 expression…Abstract Number: 1778 • 2012 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Activation Stimulates Increased Expression of Collagen-1 and Collagen-3 by Different Signaling Pathways in Normal Human Dermal Fibroblasts
Background/Purpose: Pathological fibrosis in the skin and other organs is the hallmark of scleroderma and other fibrosing diseases. Adenosine, acting at A2AR, plays a critical…Abstract Number: 15 • 2012 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Stimulation Inhibits OC Formation by Suppressing NFkB Translocation to the Nucleus by A PKA-ERK1/2 Mediated Mechanism
Background/Purpose: Adenosine, a nucleoside released at sites of injury and hypoxia, mediates its effects via activation of G-protein-coupled receptors (A1, A2A, A2B, A3). Previously we…Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…
ACR Meeting Abstracts