ACR Meeting Abstracts

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Abstracts tagged "Adenosine receptors and scleroderma"

  • Abstract Number: 1852 • 2013 ACR/ARHP Annual Meeting

    Adenosine A2A Receptors (A2AR) Promote Scarring By Repressing Mir-29a

    Ross C. Radusky1, Miguel Perez-Aso2, Andrew G. Franks Jr.3, Bruce N. Cronstein4 and Edwin SL Chan1, 1Medicine, New York University School of Medicine, New York, NY, 2Department of Translational Medicine, New York University School of Medicine, New York, NY, 3Dermatology & Medicine (Rheumatology), New York University, New York, NY, 4Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: We have previously demonstrated that the nucleoside adenosine stimulates collagen production and induces dermal fibrosis in vitro and in vivo. Recent studies have demonstrated…
  • Abstract Number: 788 • 2012 ACR/ARHP Annual Meeting

    Tenofovir, a Potent Anti-Viral Agent, Is an Ecto-5’Nucleotidase (CD73) Inhibitor That Prevents Dermal Fibrosis in a Murine Model of Scleroderma

    Jessica L. Feig1, Doreen Tivon1, Miguel Perez-Aso1, Timothy Cardozo1 and Bruce N. Cronstein2, 1Department of Translational Medicine, New York University School of Medicine, New York, NY, 2Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Acyclic nucleoside phosphonates are a key class of antivirals commonly used in the treatment of both DNA and retroviral infections.  Adefovir and tenofovir are…
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