Abstracts tagged "Adenosine receptors and scleroderma"

Abstract Number: 1852 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptors (A2AR) Promote Scarring By Repressing Mir-29a
Ross C. Radusky¹, Miguel Perez-Aso², Andrew G. Franks Jr.³, Bruce N. Cronstein⁴ and Edwin SL Chan¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Department of Translational Medicine, New York University School of Medicine, New York, NY, ³Dermatology & Medicine (Rheumatology), New York University, New York, NY, ⁴Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We have previously demonstrated that the nucleoside adenosine stimulates collagen production and induces dermal fibrosis in vitro and in vivo. Recent studies have demonstrated…
Abstract Number: 788 • 2012 ACR/ARHP Annual Meeting
Tenofovir, a Potent Anti-Viral Agent, Is an Ecto-5’Nucleotidase (CD73) Inhibitor That Prevents Dermal Fibrosis in a Murine Model of Scleroderma
Jessica L. Feig¹, Doreen Tivon¹, Miguel Perez-Aso¹, Timothy Cardozo¹ and Bruce N. Cronstein², ¹Department of Translational Medicine, New York University School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Acyclic nucleoside phosphonates are a key class of antivirals commonly used in the treatment of both DNA and retroviral infections. Adefovir and tenofovir are…