ACR Meeting Abstracts

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Abstracts tagged "Adenosine receptors"

  • Abstract Number: 890 • 2019 ACR/ARP Annual Meeting

    Adenosine A2A Receptor Signaling Activates FoxO1 and FoxO3 and Promotes Cartilage Autophagy

    Benjamin Friedman1, Carmen Corciulo 2, Cristina Castro-Rivera 2 and Bruce Cronstein 2, 1Department of Medicine, Division of Rheumatology NYUSoM, NYC, 2NYU Langone, New York

    Background/Purpose: Osteoarthritis (OA) is a debilitating and costly condition caused by loss of articular cartilage secondary to chondrocyte dysfunction. Autophagy is a homeostatic pathway that…
  • Abstract Number: 1967 • 2019 ACR/ARP Annual Meeting

    Adenosine A2A Receptor Signals Through AMPK and SIRT1 to Increase Chondrocyte Homeostasis

    Benjamin Friedman1 and Bruce Cronstein 2, 1Department of Medicine, Division of Rheumatology NYUSoM, NYC, 2NYU Langone, New York

    Background/Purpose: OA is characterized by loss of cartilage and chondrocyte dysfunction. Our lab has shown CGS21680 (CGS, 1µM) activation of adenosine A2AR leads to chondrocyte…
  • Abstract Number: 1038 • 2018 ACR/ARHP Annual Meeting

    Tenofovir, a Nucleoside Analog Reverse Transcriptase Inhibitor for Treatment of HIV, Promotes Osteoclast Differentiation and Decreases Osteoblast Formation By a Mechanism Depending on ATP Release and Adenosine

    Francisco Miguel Conesa-Buendia1, Patricia Llamas2, Raquel Largo3, Gabriel Herrero-Beaumont3, Bruce N. Cronstein4 and Aranzazu Mediero5, 1Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, 2Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, 3Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 4Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, 5Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain

    Background/Purpose: Human Immunodeficiency Virus (HIV) infection devastates the immune system but also affects tissues and organs such as kidney, liver, central nervous system, heart and…
  • Abstract Number: 1039 • 2018 ACR/ARHP Annual Meeting

    Tenofovir Induces Osteopenia and Dipyridamole, an Inhibitor of the Ent-1 Nucleoside Transporter, Reverses the Osteopenic Effect of Tenofovir In Vivo

    Francisco Miguel Conesa-Buendia1, Patricia Llamas2, Tuere Wilder3, Raquel Largo4, Gabriel Herrero-Beaumont4, Bruce N. Cronstein5 and Aranzazu Mediero6, 1Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, 2Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, 3Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 4Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 5Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, 6Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain

    Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, one of the most commonly used antivirals in HIV, also leads to increases…
  • Abstract Number: 1996 • 2018 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor (A2AR) Stimulation Enhances Mitochondrial Metabolism and Mitigates Reactive Oxygen Species-Mediated Mitochondrial Injury

    Cristina Castro1, Carmen Corciulo2, Maria de la Encarnacion Solesio Torregrosa3, Evgeny Pavlov4 and Bruce N. Cronstein5, 1Medicine, NYU School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3NYU College of Dentistry, New York City, NY, 4Assistant Professor, Basic Science and Craniofacial Biology, NYU College of Dentistry, New York City, NY, 5Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population. With age and injury, chondrocytes have diminished mitochondrial…
  • Abstract Number: 1997 • 2018 ACR/ARHP Annual Meeting

    Adenosine A2A Receptors Maintain Chondrocyte and Cartilage Homeostasis By Maintaining Expression of Anti-Inflammatory Regulators (Nur-77) and Suppressing Expression of Pro-Inflammatory Mediators

    Carmen Corciulo1, Cristina Castro2, Samson Jacob3, David Fenyo3 and Bruce N. Cronstein4, 1Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Medicine, NYU School of Medicine, New York, NY, 3Institute for Systems Genetics, NYU School of Medicine, New York, NY, 4Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: We have recently reported that adenosine A2A receptor (A2AR) knockout mice develop spontaneous osteoarthritis (OA) and intra-articular injection of adenosine prevents OA progression in…
  • Abstract Number: 2001 • 2018 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor Stimulation Regulates Autophagy in Chondrocytes

    Benjamin Friedman1, Carmen Corciulo2, Cristina Castro3 and Bruce N. Cronstein1, 1Rheumatology, New York University School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis (OA) is a debilitating condition characterized by chondrocyte dysfunction and loss of cartilage. Autophagy, a homeostatic process that occurs in times of cellular…
  • Abstract Number: 2036 • 2018 ACR/ARHP Annual Meeting

    Adenosine Receptors Expression As Predictor of Response to Methotrexate Therapy in Patients with Rheumatoid Arthritis

    Ankita Singh1, Ramnath Misra2 and Amita Aggarwal2, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Methotrexate (MTX) is first line of therapy to treat Rheumatoid Arthritis (RA) patients and one third of patients do not respond to this drug.…
  • Abstract Number: 2800 • 2018 ACR/ARHP Annual Meeting

    Adenosine 2a Receptor Signals Act to Limit Autoimmune Arthritis By Inhibiting Pathogenic Germinal Center T Follicular Helper (GC-Tfh) Cells

    Shirdi Schmiel and Daniel L. Mueller, Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN

    Background/Purpose: CD4 germinal center (GC)-T follicular helper (Tfh) cells are important in the pathogenesis of autoimmune arthritis. Previous studies have shown that adenosine 2a receptor…
  • Abstract Number: 616 • 2018 ACR/ARHP Annual Meeting

    Supplementation of Methotrexate (MTX) with Ticagrelor Therapy Suppresses Disease Activity in Patients with Moderate to Very Active Ra; Further Evidence That Adenosine and Its Receptors Mediate the Anti-Inflammatory Activity of MTX

    Pamela B. Rosenthal1, Jeffrey S. Berger2 and Bruce N. Cronstein1, 1Rheumatology, New York University School of Medicine, New York, NY, 2Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Low dose weekly MTX remains the anchor drug for treatment of Rheumatoid Arthritis. The principal mechanism by which MTX suppresses inflammation in Rheumatoid Arthritis…
  • Abstract Number: 848 • 2018 ACR/ARHP Annual Meeting

    A2A Adenosine Receptor Stimulation Switches TGF-β Signaling to Promote Chondrocyte Proliferation and Cartilage Regeneration

    Carmen Corciulo1, Cristina Castro2, Samson Jacob3, David Fenyo3, Oran Kennedy4 and Bruce N. Cronstein5, 1Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Medicine, NYU School of Medicine, New York, NY, 3Institute for Systems Genetics, NYU School of Medicine, New York, NY, 4Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, 5Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: We previously found that intra-articular injections of liposomal preparations of adenosine completely prevent progression and reverse cartilage loss in post-traumatic OA. TGF-β signaling plays…
  • Abstract Number: 948 • 2018 ACR/ARHP Annual Meeting

    Effects of Antiretroviral Therapy with Tenofovir and Other Antiretroviral Drugs on the Inflammatory State and Bone Remodeling on Newly Diagnosed HIV-Patients at Basal and 3 Months after Starting Treatment

    Aranzazu Mediero1, Francisco Miguel Conesa-Buendia2, Patricia Llamas3, Patricia Atencio4, Ramon Perez-Tanoira4, Alfonso Cabello5, Laura Prieto-Perez4, Beatriz Alvarez4, Manuel Fernandez-Guerrero4, Raquel Largo6, Gabriel Herrero-Beaumont6 and Miguel Gorgolas7, 1Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, 2Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz- UAM, Madrid, Spain, 3Bone and Joint Research Unit, IIS-Fundacion Jimenez Díaz-UAM, Madrid, Spain, 4Internal Medicine Department, IIS-Fundacion Jimenez Diaz, MADRID, Spain, 5Internal MEdicine Department, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain, 6Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 7Internal Medicine Department, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain

    Background/Purpose: Bone alterations have been observed in the course of HIV infection, with a notable decreases in bone mineral density (BMD) and fractures due to…
  • Abstract Number: 64 • 2017 ACR/ARHP Annual Meeting

    The Effect of Adenosine A2A Receptor Stimulation on Mitochondrial Metabolism in the Pathogenesis and Treatment of Osteoarthritis

    Cristina Castro1, Carmen Corciulo2 and Bruce Cronstein3, 1Medicine, NYU School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population. There is no therapy to prevent the progression…
  • Abstract Number: 905 • 2017 ACR/ARHP Annual Meeting

    Regenerating Cartilage and Reversing Osteoarthritis (OA) Stimulation of Adenosine A2A Receptors (A2AR) Increases Cartilage Volume and Matrix in Vitro and In Vivo

    Carmen Corciulo1, Cristina Castro2, Thomas Coughlin3, Tuere Wilder1, Oran Kennedy4 and Bruce Cronstein5, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2Medicine, NYU School of Medicine, New York, NY, 3Orthopaedic Surgery, NYU School of Medicine, New York, NY, 4Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, 5Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: We have recently reported that endogenously produced adenosine, interacting with A2AR, is a critical autocrine factor for maintenance of chondrocyte and cartilage homeostasis and…
  • Abstract Number: 1932 • 2017 ACR/ARHP Annual Meeting

    A2A Adenosine Receptor (A2AR) Stimulation Modulates NR4A2 Orphan Receptor Expression during Osteoclast Differentiation

    Carmen Corciulo1, Tuere Wilder1 and Bruce Cronstein2, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Orphan receptors comprise a large number of evolutionarily conserved molecules that have unknown ligands but may have potent biologic effects. Among these receptors are…
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