Abstracts tagged "Adalimumab"

Abstract Number: 1522 • 2017 ACR/ARHP Annual Meeting
Patients with Ankylosing Spondylitis Had Better Adalimumab Survival Than Patients with Non-Radiographic Axial Spondyloarthritis
Alper Sari¹, Berkan Armagan¹, Abdulsamet Erden², Levent Kilic^1,2, Omer Karadag^2,3, Ali Akdogan¹, Umut Kalyoncu² and Ihsan Ertenli², ¹Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ²Department of Internal Medicine, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United Kingdom
Patients with ankylosing spondylitis had better adalimumab survival than patients with non-radiographic axial spondyloarthritis Background/Purpose: Drug survival rate is generally accepted as a reliable indicator of…
Abstract Number: 1906 • 2017 ACR/ARHP Annual Meeting
Tofacitinib with and without Methotrexate Versus Adalimumab with Methotrexate for the Treatment of Rheumatoid Arthritis: Patient-Reported Outcomes from a Phase 3b/4 Randomized Trial
Vibeke Strand¹, Eduardo Mysler², Robert J Moots³, Gene Wallenstein⁴, Ryan DeMasi⁵, Zhen Luo⁶, Koshika Soma⁴, Noriko Iikuni⁷ and Roy Fleischmann⁸, ¹Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ²Organización Médica de Investigación, Buenos Aires, Argentina, ³Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, Collegeville, PA, ⁶Pfizer Inc, Shanghai, China, ⁷Pfizer Inc, New York, NY, ⁸Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We compared patient-reported outcomes (PROs) among patients receiving tofacitinib monotherapy,…
Abstract Number: 515 • 2017 ACR/ARHP Annual Meeting
Leukopenia and Tumor Necrosis Factor Alpha Inhibitor Therapy
Wenlu Xiong¹, Rochella A. Ostrowski², William Adams³ and Rodney Tehrani⁴, ¹Rheumatology, Vanderbilt University Medical Center, Nashville, TN, ²Rheumatology, Loyola University Medical Center, Maywood, IL, ³Clinical Research Office, Loyola University Medical Center, Maywood, IL, ⁴Rheumatology & Immunology, Loyola University Medical Center, Maywood, IL
- Background/Purpose: Tumor necrosis factor (TNF) alpha, a key proinflammatory cytokine in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), has been a major target in…
Abstract Number: 2017 • 2017 ACR/ARHP Annual Meeting
Prospective Study of Bio-Free Remission Maintenance Using Ultrasonography in Rheumatoid Arthritis Patients: 52-Week Result
Koichi Amano¹, Kazutoshi Aoki², Yoshiaki Kuga³, Koji Nishimura⁴, Hayato Nagasawa⁵, Takuma Tsuzuki Wada⁶, Kenji Takagi⁷, Junji Hayashi⁸, Motohide Kaneko⁹, Ryota Sakai¹⁰, Akiko Shibata¹¹, Kentaro Chino¹¹, Shuntaro Saito¹¹, Ayumi Okuyama¹², Tsuneo Kondo¹², Hirofumi Takei¹² and Toshihide Mimura¹³, ¹Department of Rheumatology and Clinical Immunology,, Saitama Medical Center, Saitama Medical University, Saitama, Japan, ²Aoki Clinic, Saitama, Japan, ³Wakaba Hospital, Sakado, Japan, ⁴internal medicine, Saitama Medical Center, Japan Community Health care Organization, Saitama, Japan, ⁵Nagasawa Clinic, Kawagoe, Japan, ⁶Department of Rheumatology and Applied Immunology, Faculty of Medicine,, Saitama Medical University, Saitama, Japan, ⁷Rheumatology and Clinical Immunology, Higashi-Omiya General Hospital, Saitama, Japan, ⁸Orthopedic Surgery, Niizashiki Chuo General Hospital, Niiza, Japan, ⁹Kaneko Clinic, Kawaguchi, Japan, ¹⁰Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan, ¹¹Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan, ¹²Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan, ¹³Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Recently, a significant number of rheumatoid arthritis (RA) patients can reach low disease activity (LDA) by using biologics such as adalimumab. However biologics therapy…
Abstract Number: 611 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Early Adalimumab Therapy in Psoriatic Arthritis Patients from Reuma.Pt
Helena Santos¹, Mónica Eusébio², Joana Borges³, Diana Gonçalves⁴, Pedro Ávila-Ribeiro⁵, Daniela Santos Faria⁶, Carina Lopes⁷, João Rovisco⁸, Ana Águeda⁹, Patrícia Nero¹⁰, Paula Valente¹¹, Ana Rita Cravo¹² and Maria José Santos¹³, ¹Instituto Português de Reumatologia, Lisbon, Portugal, ²Sociedade Portuguesa de Reumatologia, LIsboa, Portugal, ³Instituto Português de Reumatologia, Lisboa, Portugal, ⁴Centro Hospitalar de São João, Coimbra, Portugal, ⁵Centro Hospitalar Lisboa Norte, Lisbon, Portugal, ⁶ULSAM, Ponte de Lima, Portugal, ⁷Hospital de Egas Moniz-CHLO, Lisbon, Portugal, ⁸Centro Hospitalar e Universitário de Coimbra, Lisbon, Portugal, ⁹Centro Hospitalar do Baixo Vouga, Aveiro, Portugal, ¹⁰Hospital CUF Descobertas, Lisbon, Portugal, ¹¹Centro Hospitalar Entre o Douro e Vouga, Lisbon, Portugal, ¹²Medical, AbbVie, Lisbon, Portugal, ¹³Reuma.pt, Almada, Portugal, Almada, Portugal
Background/Purpose: There is a lack of evidence on the effect of biologics in early treatment of psoriatic arthritis (PsA) patients (Pts). Benefit of concomitant use…
Abstract Number: 2271 • 2017 ACR/ARHP Annual Meeting
Safety of Adalimumab±Methotrexate for the Treatment of Polyarticular Juvenile Idiopathic Arthritis (pJIA)
Hermine I. Brunner¹, Nicola Ruperto², Kabita Nanda³, Mary Toth⁴, Ivan Foeldvari⁵, John F. Bohnsack⁶, Diana Milojevic⁷, C. Egla Rabinovich⁸, Daniel J Kingsbury⁹, Katherine Marzan¹⁰, Pierre Quartier¹¹, Kirsten Minden¹², Elizabeth Chalom¹, Gerd Horneff¹³, Rolf M. Kuester¹⁴, Jason A Dare¹⁵, Mareike Bereswill¹⁶, Jasmina Kalabic¹⁶, Hartmut Kupper¹⁶, Daniel J Lovell¹ and Alberto Martini², ¹PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²PRINTO-IRCCS Gaslini, Genova, Italy, ³University of Washington School of Medicine and Seattle Children's Hospital, Bayside, NY, ⁴Akron Children's Hospital, Akron, OH, ⁵Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ⁶University of Utah, Department of Pediatrics, Salt Lake City, UT, ⁷The Floating Hospital for Children at Tufts Medical Center, Boston, MA, ⁸Duke University Medical Center, Durham, NJ, ⁹Randall Children’s Hospital at Legacy Emanuel, Portland, OR, ¹⁰Children's Hospital Los Angeles, Los Angeles, CA, ¹¹Hopital Necker-Enfants Malades, Paris, France, ¹²Kinderklinik der Charite, Otto-Heubner Centrum, Berlin, Germany, ¹³Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, ¹⁴Orthopädiezentrum Altona, Hamburg, Germany, ¹⁵Arkansas Children’s Hospital, Little Rock, AR, ¹⁶AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose: JIA is the most common chronic inflammatory rheumatic disease of childhood. Due to their known safety and efficacy, TNF inhibitors are used for long-term…
Abstract Number: 619 • 2017 ACR/ARHP Annual Meeting
Integrated Efficacy Analysis of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients with Active Psoriatic Arthritis
Peter Nash¹, Laura C Coates², Roy Fleischmann³, Kim Papp⁴, Juan J. Gomez-Reino⁵, Keith S Kanik⁶, Cunshan Wang⁶, Joseph Wu⁶, Thijs Hendrikx⁷ and William C Ports⁶, ¹Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, ⁴Probity Medical Research and K. Papp Clinical Research Inc, Waterloo, ON, Canada, ⁵Fundacion Ramon Dominguez, Hospital Clinico Universitario, Santiago de Compostela, Spain, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for treatment of psoriatic arthritis (PsA). We examined tofacitinib efficacy in patients (pts) with active…
Abstract Number: 2280 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Switching to Adalimumab As the Second- and Third-Line Biological Drug in Patients with Juvenile Idiopathic Arthritis
Ekaterina Alexeeva¹, Tatiana Dvoryakovskaya², Victor Gladkikh^3,4, Andrei Moskalev^4,5, Rina Denisova¹, Ksenia Isaeva¹, Olga Lomakina¹, Margarita Soloshenko¹ and Anna Karaseva¹, ¹Reumatology department, Federal State Autonomous Institution"National Scientific and Practical Center of Children's Health"Of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, ²Pediatrics, The Federal State Autonomous Educational Institution of Higher Education The First Moscow State Medical University named after I.M. Sechenov Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation, ³Department of Biostatistics, EOL Labs ltd, Novosibirsk, Rwanda, ⁴Laboratory of Computational Physics, Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russian Federation, ⁵Department of Biostatistics, EOL Labs ltd, Novosibirsk, Russian Federation
Background/Purpose: The range of biological drugs currently used in JIA therapy includes not only anti-TNF but also other varieties. However, despite the high effectiveness and…
Abstract Number: 961 • 2017 ACR/ARHP Annual Meeting
Adalimumab Reduces CXCR4 Expression during Inflammatory Arthritis and in Fibroblast-like Synoviocytes and Osteoclasts Under Chronic TNF Exposure
Bohdan P. Harvey¹, Li Li¹, Mark Konrad¹, Heather Knight¹, Susan Westmoreland², Melanie Ruzek¹ and Zehra Kaymakcalan¹, ¹AbbVie Bioresearch Center, Worcester, MA, ²AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: The CXCL12/CXCR4 chemokine axis has been implicated in the pathogenesis of RA. The expression of this chemokine and receptor has been shown to be…
Abstract Number: 2283 • 2017 ACR/ARHP Annual Meeting
Adalimumab Therapy in Juvenile Idiopathic Arthritis: Addition of Lidocaine for Prevention of Injection Site Pain or Not? That Is the Question. a Comparison Study
Barbara Ostrov¹, Brandt Groh², Lisabeth V. Scalzi³, C. April Bingham², Natalya Gaffney², Meredith Buckley², Lisa Robbins² and Rosanne Ayala⁴, ¹Pediatrics, Penn State Hershey Medical Center, Hershey, PA, ²Pediatrics, Penn State College of Medicine, Hershey, PA, ³Penn State Hershey Medical Center, Hershey, PA, ⁴Penn State College of Medicine, Hershey, PA
Background/Purpose: Up to 37% of patients prescribed adalimumab (AD) report significant injection-site pain (Registered Prescribing Information, 2016). For AD to be a stable pre-filled product,…
Abstract Number: 1038 • 2017 ACR/ARHP Annual Meeting
Impact of Patient Support Program Utilization on Patient Activation Measure Scores Among Patients with Rheumatoid Arthritis
Filip van Den Bosch^1,2, Siegfried Wassenberg³, Andrew Östör⁴, Chen Wang⁵, Vishvas Garg⁵ and Jasmina Kalabic⁶, ¹Ghent University Hospital, Ghent, Belgium, ²Rheumatology, Ghent University Hospital, Gent, Belgium, ³Rheumazentrum Ratingen, Ratingen, Germany, ⁴Addenbrooke's Hospital, Cambridge, United Kingdom, ⁵AbbVie Inc., North Chicago, IL, ⁶AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose : AbbVie’s Patient (pt) Support Program (PSP) is offered to pts who are prescribed adalimumab (ADA) for their Rheumatoid arthritis (RA). The purpose of…
Abstract Number: 2298 • 2017 ACR/ARHP Annual Meeting
Etanercept, Adalimumab and Methotexate Utilization By Juvenile Idopathic Arthritis Patients and the Occurrence of Uveitis
Katherine Roshak¹, Joan M Sopczynski², Ricardo Suehiro² and Lisa Marshall¹, ¹Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ²Pfizer, Collegeville, PA
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic arthritis with onset before 16 years of age, that persists for at least 6 weeks, and has…
Abstract Number: 1155 • 2017 ACR/ARHP Annual Meeting
Impact of Adalimumab on Immunosuppressant Use in Patients with Active and Inactive Non-Infectious Intermediate, Posterior, or Pan-Uveitis in the Ongoing Open Label Study: Visual-III
Sergio Schwartzman¹, Irene Van der Horst-Bruinsma², Alfredo Adan³, Hiroshi Goto⁴, Koju Kamoi⁵, Martina Kron⁶, Alexandra P. Song⁷, Kevin Douglas⁷, Sophia Pathai⁸ and C. Stephen Foster⁹, ¹Hospital for Special Surgery, New York, NY, ²Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁴Tokyo Medical University, Tokyo, Japan, ⁵Tokyo Medical and Dental University, Tokyo, Japan, ⁶AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁷AbbVie Inc., North Chicago, IL, ⁸AbbVie Ltd, Maidenhead, United Kingdom, ⁹Massachusetts Eye Research and Surgery foundation and Harvard Medical School, Boston, MA
Background/Purpose: The morbidity associated with the use of immunosuppressants is well described in patients (pts) with autoimmune ophthalmic disease and presents a challenge to treating…
Abstract Number: 2393 • 2017 ACR/ARHP Annual Meeting
Evaluation of Live Zoster Vaccine in a Subset of Patients with Rheumatoid Arthritis Treated with Tofacitinib with or without Methotrexate, and Adalimumab with Methotrexate: Results from a Phase 3b/4 Randomized Trial
Leonard H. Calabrese¹, Carlos Abud-Mendoza², Stephen Lindsey³, Sang Heon Lee⁴, Liza Takiya⁵, Noriko Iikuni⁶, Koshika Soma⁷, Zhen Luo⁸ and Roy Fleischmann⁹, ¹Cleveland Clinic Foundation, Cleveland, OH, ²Hospital Central, San Luis Potosí, Mexico, ³Ochsner Medical Center, Baton Rouge, LA, ⁴Konkuk University School of Medicine, Seoul, Korea, Republic of (South), ⁵Pfizer Inc, Collegeville, PA, ⁶Pfizer Inc, New York, NY, ⁷Pfizer Inc, Groton, CT, ⁸Pfizer Inc, Shanghai, China, ⁹Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Patients (pts) with RA are at increased risk for herpes…
Abstract Number: 1352 • 2017 ACR/ARHP Annual Meeting
The Relevance of Elevated CRP As an Inclusion Criterion in Clinical Trials in Patients with Rheumatoid Arthritis
Craig Scoville¹, Jessica L. Suboticki², Sheng Zhong³ and Edward C. Keystone⁴, ¹Idaho Falls Arthritis Clinic, Idaho Falls, ID, ²AbbVie Inc., Mettawa, IL, ³AbbVie Inc., North Chicago, IL, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Elevated C-reactive protein (CRP) is often used as an entry criterion in clinical trials (CT) with rheumatoid arthritis (RA) patients (pts), resulting in the…

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