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Abstracts tagged "Activation triggers"

  • Abstract Number: 2902 • ACR/ARHP Annual Meeting 2018

    Antibodies to PAD4 Drive Monocyte Activation and Differentiation into Osteoclast-like Cells

    Pooja Naik1, Jing Shi2, Felipe Andrade3 and Erika Darrah4, 1Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Department of Medicine/Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Agonistic antibodies to Peptidylarginine Deiminase 4 (PAD4) are hallmarks of a severe form of rheumatoid arthritis (RA) characterized by the most erosive joint damage…

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