Abstracts tagged "ACPA and RANK/RANKL pathway"

Abstract Number: 1327 • 2013 ACR/ARHP Annual Meeting
Autoantibodies To Citrullinated Proteins Associate With Bone Destruction Marker and Are Modulated By First Anti Rheumatic Treatment In Early Rheumatoid Arthritis
Aase Haj Hensvold¹, Vijay Joshua¹, Saedis Saevarsdottir², Michaela Larkin², Lena Israelsson², Ferhan Qureshi³, Per-Johan Jakobsson², Nadine A. Defranoux⁴, Lars Klareskog², Vivianne Malmström⁵ and Anca I Catrina², ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Crescendo Bioscience, Inc., South San Francisco, CA, ⁴Crescendo Bioscience Inc., South San Francisco, CA, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Antibodies against citrullinated proteins (especially anti citrullinated-vimentin antibodies) and high levels of RANKL have been linked to altered bone metabolism in early RA. We…