Abstracts tagged "ACPA and osteoclastogenesis"

Abstract Number: 1109 • 2016 ACR/ARHP Annual Meeting
Targeting IL-8 and CXCR1/2 Abrogates RANKL- and ACPA-Mediated Osteoclastogenesis
Yanying Liu¹, Akilan Krishnamurthy¹, Aase Hensvold¹, Vijay Joshua¹, Muhammad Sohel Mia¹, Heidi Wähämaa¹, Meng Sun¹, Marianne Engström¹, Guozhong Fei², Vivianne Malmström³, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University hospital, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Increased circulating levels of Interleukin-8 (IL-8) have been linked to the bone loss associated with breast cancer metastasis. Recently, we have shown that anti-citrullinated…