ACR Meeting Abstracts

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Abstracts tagged "ACPA and osteoclastogenesis"

  • Abstract Number: 1109 • 2016 ACR/ARHP Annual Meeting

    Targeting IL-8 and CXCR1/2 Abrogates RANKL- and ACPA-Mediated Osteoclastogenesis

    Yanying Liu1, Akilan Krishnamurthy1, Aase Hensvold1, Vijay Joshua1, Muhammad Sohel Mia1, Heidi Wähämaa1, Meng Sun1, Marianne Engström1, Guozhong Fei2, Vivianne Malmström3, Bence Rethi1 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University hospital, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Increased circulating levels of Interleukin-8 (IL-8) have been linked to the bone loss associated with breast cancer metastasis. Recently, we have shown that anti-citrullinated…
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