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Abstracts tagged "Abatacept and macrophages"

  • Abstract Number: 2164 • 2012 ACR/ARHP Annual Meeting

    Evidence for NF-Kb Intracellular Signaling Involvement Following CTLA4-Ig (Abatacept) Treatment of Human Macrophages

    Renata Brizzolara1, Paola Montagna1, Stefano Soldano2, Alberto Sulli3, Bruno Seriolo4, Barbara Villaggio5, Pierfranco Triolo6, Lamberto Felli7 and Maurizio Cutolo8, 1Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, 3Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 4Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 5Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy, 6Rheumatoid Arthritis Unit, Orthopedic Surgery Department, CTO Hospital, Turin, taly, Turin, Italy, 7Orthopedic Department, University of Genova, Genova, Italy, 8Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy

    Background/Purpose: The transcription factor NF-kB is an intracellular signaling essential for the expression of a variety of immune-response genes, including those related to pro-inflammatory cytokines…
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