Abstracts tagged "Abatacept and macrophages"

Abstract Number: 2164 • 2012 ACR/ARHP Annual Meeting
Evidence for NF-Kb Intracellular Signaling Involvement Following CTLA4-Ig (Abatacept) Treatment of Human Macrophages
Renata Brizzolara¹, Paola Montagna¹, Stefano Soldano², Alberto Sulli³, Bruno Seriolo⁴, Barbara Villaggio⁵, Pierfranco Triolo⁶, Lamberto Felli⁷ and Maurizio Cutolo⁸, ¹Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁵Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁶Rheumatoid Arthritis Unit, Orthopedic Surgery Department, CTO Hospital, Turin, taly, Turin, Italy, ⁷Orthopedic Department, University of Genova, Genova, Italy, ⁸Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose: The transcription factor NF-kB is an intracellular signaling essential for the expression of a variety of immune-response genes, including those related to pro-inflammatory cytokines…