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Abstracts tagged "abatacept and histopathologic"

  • Abstract Number: 2551 • 2014 ACR/ARHP Annual Meeting

    Presence of Germinal Centers at Baseline Is Associated with Clinical Response of Glandular Essdai Domain after Abatacept Treatment in Primary Sjogren’s Syndrome

    Erlin A. Haacke1, Frans G.M. Kroese2, Petra M. Meiners3, Bert van der Vegt1, Arjan Vissink4, Fred K.L. Spijkervet3 and Hendrika Bootsma2, 1Pathology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 3Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 4Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

    Background/Purpose: Abatacept inhibits the costimulatory interaction of T-lymphocytes and antigen-presenting cells. Treatment of early and active primary Sjögren's Syndrome (pSS) with abatacept decreases disease activity.…
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