Abstracts tagged "abatacept and histopathologic"

Abstract Number: 2551 • 2014 ACR/ARHP Annual Meeting
Presence of Germinal Centers at Baseline Is Associated with Clinical Response of Glandular Essdai Domain after Abatacept Treatment in Primary Sjogren’s Syndrome
Erlin A. Haacke¹, Frans G.M. Kroese², Petra M. Meiners³, Bert van der Vegt¹, Arjan Vissink⁴, Fred K.L. Spijkervet³ and Hendrika Bootsma², ¹Pathology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: Abatacept inhibits the costimulatory interaction of T-lymphocytes and antigen-presenting cells. Treatment of early and active primary Sjögren's Syndrome (pSS) with abatacept decreases disease activity.…