Session » (0066–0095) T Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster

Date: Sunday, November 12, 2023

Time: 9:00AM-11:00AM

Meeting: ACR Convergence 2023

9:00AM-11:00AM: Abstract Number: 0082

A VAV1-Directed Molecular Glue Degrader, MRT-6160, Reduces Joint Inflammation in a Collagen-Induced Arthritis Autoimmune Disease Model

9:00AM-11:00AM: Abstract Number: 0070

Activation of Joint CD8+ TRM Localize Autoantibody Mediated Arthritis

9:00AM-11:00AM: Abstract Number: 0069

All-trans Retinoic Acid (atRA) Enhances FoxP3 Protein Stability Under Inflammatory Conditions Through Altering the FoxP3 Protein-interactome

9:00AM-11:00AM: Abstract Number: 0068

Anti-TNFR2 VHH Agonistic Antibodies Promote and Stabilize Treg Immunosuppressive Activity

9:00AM-11:00AM: Abstract Number: 0079

CD4 T Cell Repertoire Features in RA Patients with High-risk HLA-DRB1 Alleles

9:00AM-11:00AM: Abstract Number: 0076

Characterizing GMCSF Producing T-cells in Rheumatoid Arthritis and Effect of Methotrexate on Them

9:00AM-11:00AM: Abstract Number: 0077

Circulating CD4+CXCR5-PD-1hiICOS+ Cells Are Elevated in Patients with Newly Diagnosed Giant Cell Arteritis and Associate with the Clinical Outcome

9:00AM-11:00AM: Abstract Number: 0078

Circulating CD4+CXCR5+PD-1hi Follicular Helper T Cells Are Elevated in Patients with Rheumatoid Arthritis and Predict Treatment Response to Abatacept or TNF Blockers

9:00AM-11:00AM: Abstract Number: 0072

Circulating T-cell Immunosenescence Is High in Patients with Immune-Mediated Inflammatory Diseases (IMIDs) and Is Associated with Interferons

9:00AM-11:00AM: Abstract Number: 0067

Dimethyl Fumarate Modulates T Cell Metabolism and Function in Systemic Lupus Erythematosus Patient Samples

9:00AM-11:00AM: Abstract Number: 0074

Distinct PD-1 Receptor Engagement Leads to Different Pharmacodynamic Effects

9:00AM-11:00AM: Abstract Number: 0084

Excess IL-18 Protects from Experimental Autoimmune Encephalomyelitis Mainly via Preferential Augmentation of Suppressor/Regulatory over Autoreactive T-cell Function

9:00AM-11:00AM: Abstract Number: 0083

Expression of mRNA Vaccine Antigen in Hematopoietic Cells Is Necessary for Induction of Optimal Vaccine-Specific CD4+ T Cell Responses

9:00AM-11:00AM: Abstract Number: 0085

Fibroblasts Promote Upregulation of Cannabinoid Type 2 Receptor on Inflammatory Cells in Dermatomyositis

9:00AM-11:00AM: Abstract Number: 0094

Granzyme K Elicits a New Pathway for Complement Activation in RA Synovium

9:00AM-11:00AM: Abstract Number: 0087

Immune Checkpoint Inhibitor Therapy Expands an Activated, anti-PD-1 Drug-bound CD8 T Cell Population That Is Clonally Linked in Blood and Synovial Fluid of ICI-arthritis Patients

9:00AM-11:00AM: Abstract Number: 0091

Impaired X-Chromosome Inactivation Maintenance in T Cells Is Associated with Features of Reduced Disease Severity in a Toll-Like Receptor 7-Driven Model of Systemic Autoimmunity

9:00AM-11:00AM: Abstract Number: 0095

Kynurenine Is a Proinflammatory Metabolite That Activates a Positive Feedback Loop of Rab4A-dependent CD98 Expression and mTORC1 and mTORC2 Activation in SLE

9:00AM-11:00AM: Abstract Number: 0066

Mitochondrial Dysfunction and Fatigue in Sjögren’s Disease

9:00AM-11:00AM: Abstract Number: 0092

Multi-omics Immune Profiling of Cytotoxic T Cells from Ankylosing Spondylitis Patients Identified a Subset of Clonally Exapnded CTLs That Evade Immune Exhaustion

9:00AM-11:00AM: Abstract Number: 0086

Optimizing PD-1 Agonist Signaling with Membrane Proximal Binding of Rosnilimab, a Clinical Stage PD-1 Agonist IgG1 Antibody

9:00AM-11:00AM: Abstract Number: 0073

PD-1hi Cells Are Highly Present in the Rheumatoid Joint, and Express Regulatory Capacities

9:00AM-11:00AM: Abstract Number: 0080

Pharmacological Inhibition of PRMT5 Demonstrates Broad Efficacy in Multiple Preclinical Models of Autoimmunity and Inflammation by Suppressing Th1, Th17 and TNF-Mediated Inflammatory Responses

9:00AM-11:00AM: Abstract Number: 0089

Pre-Clinical Characterization of MTX-101, a Novel Bispecific CD8 Treg Modulator with the Potential to Restore CD8 Treg Functions in Patients with Rheumatological Autoimmune Diseases

9:00AM-11:00AM: Abstract Number: 0075

Proteomic, Transcriptomic, and T-Cell Receptor (TCR) Profiling of Synovial Integrin-Expressing (InEx) T Cells in Axial Spondyloarthritis (axSpA)

9:00AM-11:00AM: Abstract Number: 0081

RA Disease Activity Influence the Frequency and Phenotype of Citrulline Reactive CD4 T Cells in DRB1*04:04 ACPA+ RA Patients

9:00AM-11:00AM: Abstract Number: 0090

Reduced Frequency of RORγt+ Regulatory T Cells Is Associated with Secukinumab Response in Axial Spondyloarthritis

9:00AM-11:00AM: Abstract Number: 0071

Sex Based Differences in Morphological and Functional Niches of the Human Thymus, Identified by Non-supervised Spatial Transcriptomic Profiling, May Underlie Sex Bias in Autoimmune Disease

9:00AM-11:00AM: Abstract Number: 0093

Single Cell RNA-seq and Mass Cytometry Reveal a Cytotoxic CD8 Effector T Cell Population Associated with Interstitial Lung Disease in Systemic Sclerosis Patients

9:00AM-11:00AM: Abstract Number: 0088

SLAMF4 Orchestrates the Pathological Cytotoxic Response of CD4+ T Cells in Rheumatoid Arthritis

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