Session » Systemic Sclerosis & Related Disorders – Basic Science Poster I

10:30AM-12:30PM

Abstract Number: 0951

A Feedback Loop Involving mtDNA, Platelets and Neutrophil Extracellular Traps Amplifies Inflammation in Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0966

CDDO-Me Attenuates Pro-fibrotic Activation in Macrophages and Fibroblasts in Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0962

Characterizing the Contribution of Myeloid Cells to Limited and Diffuse Cutaneous Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0970

Deubiquitylase (DUB) BRCC36 Isopeptidase Complex (BRISC) Inhibitors Prevent IFNAR1 Deubiquitination to Restore Natural Type I IFN Response in Autoimmunity

10:30AM-12:30PM

Abstract Number: 0972

Downregulated Fli1 in Scleroderma Myeloid Cells Contributes to Cardiac Fibrosis via a Galectin-3/mTOR Dependent Pathway

10:30AM-12:30PM

Abstract Number: 0964

Engaging the PD-1 Pathway Attenuates Inflammation Associated Fibrosis in Systemic Sclerosis Fibroblasts and a Preclinical Mouse Model

10:30AM-12:30PM

Abstract Number: 0953

Establishment of Systemic Sclerosis Associated Pulmonary Arterial Hypertension Specific Endothelial Cells Through iPSCs and Their Functional and Molecular Analyses

10:30AM-12:30PM

Abstract Number: 0957

Increased Collagen Deposition and Altered Immune Cell Profiles Are Present in Early and Late Stage Systemic Sclerosis with Gastrointestinal Involvement

10:30AM-12:30PM

Abstract Number: 0954

Increased Proliferating Natural Killer Cells Exhibit an Aberrant Pro-Inflammatory Gene Signature in Systemic Sclerosis Patients

10:30AM-12:30PM

Abstract Number: 0955

Inhibition of Interleukin-2-Inducible T Cell Kinase with Soquelitinib Demonstrates Efficacy in Preventing Lung Damage in Murine Models of Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0971

Ligand-Receptor Analysis Reveals Myeloid-Mediated Pro-Inflammatory Responses and Loss of Mesenchymal Signaling Driven by TNFR1 in Experimental Pulmonary Hypertension

10:30AM-12:30PM

Abstract Number: 0973

Mechano-transduction via MRTF-A Pathway Is Required for Cytokine Release by Scleroderma Macrophages

10:30AM-12:30PM

Abstract Number: 0961

Multi-omics Study of Systemic Sclerosis Immunoglobulins G Effects on Endothelial Cells: A Distinct Profile in Anti-Topoisomerase I Positive Patients

10:30AM-12:30PM

Abstract Number: 0968

Proteomic, Transcriptomic, and Functional Characterization of Circulating Extracellular Vesicles in Progressive Scleroderma Interstitial Lung Disease

10:30AM-12:30PM

Abstract Number: 0959

Radiomics Non-Invasively Conveys Time-Resolved Molecular Pathway Activity in Experimental Fibrosing Interstitial Lung Disease

10:30AM-12:30PM

Abstract Number: 0969

Role and Mechanism of the Wnt3a-FZD5 Pathway in Regulating the Transformed Intermediate State of Alveolar Epithelial Cells Involved in Pulmonary Fibrosis in Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0965

Scleroderma Associated Interstitial Lung Disease Is Characterized by Aberrant Lung Epithelial Remodeling

10:30AM-12:30PM

Abstract Number: 0956

Secreted Frizzled-Related Protein 2 (sFRP2) Regulates Wnt Signaling to Affect Mesenchymal Transition of Lung Epithelial Cells Participates in Interstitial Lung Disease

10:30AM-12:30PM

Abstract Number: 0952

Single Cell RNA-seq of Scleroderma-associated Interstitial Lung Disease Lung Explants Reveals an Active, Cytotoxic Natural Killer Cell Population

10:30AM-12:30PM

Abstract Number: 0963

Stratification According to Autoantibody Status in Systemic Sclerosis Reveals Distinct Molecular Signatures

10:30AM-12:30PM

Abstract Number: 0958

TCR Motifs Identify Unique Clones in African Americans with Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0960

The Esophageal Epithelium in Systemic Sclerosis: Cellular and Molecular Dysregulation Revealed by Single-Cell RNA Sequencing

10:30AM-12:30PM

Abstract Number: 0967

Transcriptional Heterogeneity of Immune Cells in the Esophagus of Systemic Sclerosis Patients: A Comparison of Upper and Lower Esophageal Regions