Session » Biology and Pathology of Bone and Joint Poster I: Osteoarthritis Pathogenesis

Date: Monday, November 9, 2015

Time: 9:00AM-11:00AM

Meeting: 2015 ACR/ARHP Annual Meeting

9:00AM-11:00AM: Abstract Number: 1131

A Histone Deacetylase Inhibitor SAHA Induce MCPIP1 Expression and Suppress IL-6 Expression By Upregulating Cebpα Expression and Downregulating the Expression of Mir-9 in Human OA Chondrocytes

9:00AM-11:00AM: Abstract Number: 1132

Altered Histone 3 Dynamics at the Matrix Metalloproteinase 1 (MMP1) Transcription Start Site Contributes to MMP1 Suppression in Betaine Supplemented Synovial Fibroblasts in Rheumatoid Arthritis

9:00AM-11:00AM: Abstract Number: 1152

Comprehensive Novel Proteomic Analysis of RA Synovial Fluid Highlights the Distinct Protein Profiles of Bone and Cartilage Metabolism

9:00AM-11:00AM: Abstract Number: 1146

Deficiency of TLR2 and TLR4 Impairs Autophagic Flux in Chondrocytes

9:00AM-11:00AM: Abstract Number: 1139

Differential Inflammatory Profile in Experimental Models of Arthritis

9:00AM-11:00AM: Abstract Number: 1127

Downregulation of nuclear Factor-Erythroid 2-Related Factor (Nrf2)/Heme Oxygenase-1 Axis in Diabetic Cartilage: Towards a Better Phenotyping of diabetes-Related Osteoarthritis

9:00AM-11:00AM: Abstract Number: 1144

Effect of PEP-1-Glrx-1 on Catabolic Gene Expression in Human Articular Chondrocytes and in Mouse Carrageenan-Induced Paw Edema Model

9:00AM-11:00AM: Abstract Number: 1145

Expression of Xylosyltransferase-1 Is Modulated By Fibronectin Fragment in Human Articular Chondrocytes

9:00AM-11:00AM: Abstract Number: 1130

Global DNA Methylation Analysis of Osteoarthritic Subchondral Bone Reveals Significant Regional Variation and Similarity to Overlying Cartilage

9:00AM-11:00AM: Abstract Number: 1134

Identification of Novel Micro-RNAs in IL-1β-Stimulated OA Chondrocytes By Next-Generation Sequencing

9:00AM-11:00AM: Abstract Number: 1136

IL-1β-Induced Stress Granules Sequester COX-2 mRNA and Regulates Its Expression in Human OA Chondrocytes

9:00AM-11:00AM: Abstract Number: 1128

Insulin-Induced Cartilage Degradation in Osteoarthritis Is Associated to Defective Autophagy

9:00AM-11:00AM: Abstract Number: 1142

Joint Specific Function of Synovial Fibroblasts – Integrating Positional Transcriptomes and Anatomic Patterns of Arthritis

9:00AM-11:00AM: Abstract Number: 1135

Krüppel-like Factors (Klfs), Novel Transcriptional Regulators of Articular Chondrocytes That Are Abnormally Expressed in Osteoarthritic Cartilage

9:00AM-11:00AM: Abstract Number: 1137

Low Molecular Weight Polyphenol Harpagoside Inhibits IL-1β-Induced Expression of IL-6 By Blocking the Expression and Activity of c-Fos in Primary Human Osteoarthritis Chondrocytes

9:00AM-11:00AM: Abstract Number: 1133

Microrna-128 Interference Mitigates the Progression of Keen Osteoarthritis By Regulating Sirtuin-1

9:00AM-11:00AM: Abstract Number: 1150

Novel Chitosan Hydrogels for the Treatment of Osteoarthritis: Mechanical Support, Lubrication and Prevention of Cartilage Degradation in a Rabbit Model of Osteoarthritis

9:00AM-11:00AM: Abstract Number: 1143

Reduced Hydrogen Sulfide Synthesis in the Joint, a New Player in the Pathogenesis of Osteoarthritis

9:00AM-11:00AM: Abstract Number: 1140

Resident Non-Classical Monocytes Are Critically Important for Tissue Destruction in Arthritis

9:00AM-11:00AM: Abstract Number: 1138

Suppressor of Cytokine Signaling 1 Inhibits Interleukin-1β Induced Matrix Metalloproteinases Expression in Human Chondrocytes By Modulating p38-CREB- C/Ebpβ Pathway

9:00AM-11:00AM: Abstract Number: 1141

Synovial Ultrasound Power Doppler Enhancement Reflects Multiple Cytokine Expression in Synovial Tissue, Distinguishing Distinct High Macrophage-Associated and Low Inflammation Profiles

9:00AM-11:00AM: Abstract Number: 1147

TGFß1 Blocks Chondrocyte Hypertrophy and Increases Cell Viability in Cultured Cartilage Explants but Does Not Protect Against Proteoglycan Loss

9:00AM-11:00AM: Abstract Number: 1149

The Active Metabolite of Fostamatinib, R406, Only Decreases the Inflammation-Driven Extracellular Matrix Turnover of the Joint at High Concentrations Ex Vivo

9:00AM-11:00AM: Abstract Number: 1151

The Proteomic Profile of Histological Samples Derived from a Surgical Mouse Model of Osteoarthritis Reveals an Unexpected Mode of Action for the Anti-Aggrecanase-2 Monoclonal Antibody CRB0017

9:00AM-11:00AM: Abstract Number: 1148

The Role of TRPC6 in CXCR2-Mediated Chondrocyte Phenotypic Stability

9:00AM-11:00AM: Abstract Number: 1129

Transthyretin Deposition Accelerates the Development of Experimental Osteoarthritis in Mice

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