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Session » B-cell Biology and Targets in Autoimmune Disease

Meeting: 2012 ACR/ARHP Annual Meeting

Abstract Number: 1741
Suppression of Glomerulonephritis in NZB/W F1 Mice by a Selective Inhibitor of Bruton’s Tyrosine Kinase (RN486)
Abstract Number: 1742
A Novel Murine Model of B Cell-Mediated Proteinuria Suggests Cytokines Mediate Podocyte Injury
Abstract Number: 1743
IL-5-Induced FasL+ Regulatory B Cells Are Inhibited by IL-4 and Cyclosporine
Abstract Number: 1744
Regulatory B Cells Supress the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Abstract Number: 1745
Amelioration of Experimental Autoimmune Arthritis by Adoptive Transfer of Foxp3-Expressing Regulatory B Cells Is Associated with the Regulatory T Cell/T helper 17 cell Balance
Abstract Number: 1746
Semaphorin 3A Increases the Regulatory Characteristics of B-Regulatory Cells
Abstract Number: 1747
Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection with Antibodies to Snrnps and Survival of Motor Neuron (SMN) Complex
Abstract Number: 1748
Antibody Secreting Cells Arising After Vaccination of Lupus Patients May Produce High Affinity Autoantibodies
Abstract Number: 1749
Targeting of CD22 by Epratuzumab Potentially Raises the Threshold of B Cell Receptor Activation
Abstract Number: 1750
Phosphoprotein Changes Induced with Epratuzumab, an Antibody Targeting CD22 On B Cells
Abstract Number: 1751
Effect of Repeated Infusions of Rituximab in Patients with Primary Sjögren’s Syndrome
Abstract Number: 1752
Depletion of CD4-Effector Memory T Cells and Clonally Expanded IgG4 Memory B Cells May Explain the Therapeutic Efficacy of Rituximab in IgG4-Related Disease: Studies Using Flow Cytometry and Single-Cell Sequencing
Abstract Number: 1753
A Rheumatoid Factor Paradox: Inhibition of Rituximab-Induced Complement Dependent Cytotoxicity of B Cells
Abstract Number: 1754
Disruption of Dominant B-Cell and Plasma Cell Clones in Rheumatoid Arthritis Synovium by Rituximab Correlates with Treatment Response
Abstract Number: 1755
The Alternative ΔCD20 Transcript Variant Is Not Expressed in B Cells and Synovial Tissue From Patients with Rheumatoid Arthritis
Abstract Number: 1756
Peripheral Blood B Cell Subsets and BAFF/APRIL Receptor Expression, Together with Circulating BAFF and APRIL Levels, Are Disturbed in Rheumatoid Arthritis but Not in Ankylosing Spondylitis
Abstract Number: 1757
B Cell Activating Factor Receptor Expression After Rituximab: Comparison of Patients with Rheumatoid Arthritis and Thrombotic Thrombocytopenic Purpura
Abstract Number: 1758
Serum BAFF Levels and Relationship with BAFF Binding Receptors in Patients with Rheumatoid Arthritis Relapsing After B Cell Depletion Therapy
Abstract Number: 1759
Expression of Surface APRIL and Its Receptor, TACI, Is Upregulated On B Cells From Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients
Abstract Number: 1760
A Gene Expression Signature to Monitor Depletion of Plasma Cells Following MEDI-551 (anti-CD19) Administration
Abstract Number: 1761
Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti-CD19 Monoclonal Antibody That Co-Engages the B Cell Antigen Receptor and the FcγRIIb Inhibitory Receptor
Abstract Number: 1762
IL-6 Receptor Inhibition by Tocilizumab Modulates Double Negative (CD19+IgD-CD27-) B Cells in RA
Abstract Number: 1763
The Role of SYK in Human B CELL Activation and Its Relevance to Autoimmune Diseases
Abstract Number: 1764
B Cells in Early Rheumatoid Arthritis: ZAP-70 More Than SYK Characterize Seropositive Disease
Abstract Number: 1765
Rheumatoid Arthritis Is Associated with Signaling Alterations in Naturally Occurring Autoreactive B-Lymphocytes
Abstract Number: 1766
Synovial Gene Expression and Response to Rituximab: Preliminary Data
Abstract Number: 1767
Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis
Abstract Number: 1768
The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations
Abstract Number: 1769
Affinity Purification and Characterisation of Anti-CCP Antibodies From Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis
Abstract Number: 1770
Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method
Abstract Number: 1771
Anti Carbamylated Protein Antibodies (Anti-CarP) Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis
Abstract Number: 1772
Expansion of Autoreactive Unresponsive CD21-/Low B Cells in Sjögren’s Syndrome Associated Lymphoproliferation
Abstract Number: 1773
Hyperammaglobulinemia in Primary Sjögren’s Syndrome Is Induced by Triggering of TLR7 and 9
Abstract Number: 1774
Identification of Target Antigens of Anti-Endothelial Cell Antibodies in Patients with ANCA-Associated Systemic Vasculitis: A Proteomic Approach
Abstract Number: 2575
Inhibition of Pathogenic Autoantibodies by Accelerating the Exit of Germinal Center B Cells Via Manipulation of Regulator of G-Protein Signaling
Abstract Number: 2576
Production of Citrullinated Filaggrin-Specific IgG in Rheumatoid Arthritis Patients Is Associated with an Expansion of Citrullinated Filaggrin Tetramer-Binding Switched Memory Blood B Cells
Abstract Number: 2577
Characterization of Circulating Human B Cells That Bind Cyclic Citrullinated Peptide Antigens in Clinically Active Rheumatoid Arthritis
Abstract Number: 2578
Monoclonal IgG Antibodies (ACPAs) From Synovial Fluid B Cells of Rheumatoid Arthritis Patients – Antigen-Driven Affinity Maturation and Cross Reactivity
Abstract Number: 2579
Novel Autoantibodies to 14-3-3 Eta Are Highly Specific for Rheumatoid Arthritis
Abstract Number: 2580
Marginal Zone Defects in Wiskott-Aldrich Syndrome Are Dependent On B Cell Intrinsic Toll-Like Receptor Signals

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