Session » (0955–0977) Systemic Sclerosis & Related Disorders – Basic Science Poster I

10:30AM-12:30PM

Abstract Number: 0964

A Single-Cell Atlas Reveals Dermal Endothelial Heterogeneity and Disease-Specific Pathways in Autoimmune Disorders

10:30AM-12:30PM

Abstract Number: 0958

Asynchronous Resolution of Inflammation and Fibrosis in A Prolonged Experimental Model Suggests Distinct Temporal Dynamics And Resolution Mechanisms in Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0973

Effects of a Novel Hybrid Protein Based on S100 on Macrophage Polarization and Its Therapeutic Efficacy in a Bleomycin-Induced Systemic Sclerosis Mouse Model.

10:30AM-12:30PM

Abstract Number: 0969

FOXO1 Mediated Polysialic Acid Dysregulation in Severe Systemic Sclerosis (SSc): A Novel Biomarker and Therapeutic Target?

10:30AM-12:30PM

Abstract Number: 0970

Genomic instability in systemic sclerosis is promoted by metabolic remodelling via a FOXO1-dependent axis

10:30AM-12:30PM

Abstract Number: 0963

Increased expression of M2 pro-fibrotic markers in circulating monocytes and cultured monocyte-derived macrophages from systemic sclerosis patients with progressive interstitial lung disease (ILD)

10:30AM-12:30PM

Abstract Number: 0965

Inhibition of Nicotinamide N-Methyltransferase Reverses Fibroblast Activation via Epigenetic and Metabolic Remodeling in Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0966

Integrated Bulk and Single Cell Analysis Confirms Differential Upregulation of the Proton Sensing Receptor GPR68 in Systemic Sclerosis Across Disease Stage and Subset

10:30AM-12:30PM

Abstract Number: 0975

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

10:30AM-12:30PM

Abstract Number: 0976

LMPTP Drives Fibrosis in Systemic Sclerosis via TGF-beta Signaling Activation

10:30AM-12:30PM

Abstract Number: 0959

Longitudinal Multiomic Study of Skin, Peripheral Blood, and Serum: Serum Proteome Reflects the Disease Process at the End-organ Level and Predicts the Course of Modified Rodnan Skin Score

10:30AM-12:30PM

Abstract Number: 0956

Mapping Metabolic Changes in Skin Fibrosis in Systemic Sclerosis by Spatial Proteomics

10:30AM-12:30PM

Abstract Number: 0968

Mesenchymal Stromal Cells in Systemic Sclerosis are Dysfunctional and Have a Profibrotic and Senescent Phenotype

10:30AM-12:30PM

Abstract Number: 0957

Multi-Omic Profiling Reveals a Monocyte-Vascular Signature Associated with the Regression of Skin Fibrosis in SSc

10:30AM-12:30PM

Abstract Number: 0960

Pharmaceutical Blockade of the Neonatal Fc Gamma Receptor Ameliorates Autoimmunity, Inflammation and Fibrosis in the Topoisomerase I Mouse Model of Systemic Sclerosis

10:30AM-12:30PM

Abstract Number: 0972

Prominent endothelial senescence in systemic sclerosis skin

10:30AM-12:30PM

Abstract Number: 0961

Retinoic acid-related orphan receptor-α: A novel upstream regulator of Hippo signaling and potential therapeutic target in fibrosis

10:30AM-12:30PM

Abstract Number: 0967

Single-Cell RNA Sequencing Reveals a Prominent Pro-Inflammatory Gene Signature of Dermal Fibroblasts in Pre-Stages of SSc

10:30AM-12:30PM

Abstract Number: 0962

Spatial Proteomics Analysis of the organization of tertiary lymphoid structures in Systemic Sclerosis Skin

10:30AM-12:30PM

Abstract Number: 0955

Surveying RNA methylation in scleroderma highlights roles for demethylases ALKBH5 and FTO in fibrosis

10:30AM-12:30PM

Abstract Number: 0977

The nuclear receptor DAX1 regulates WNT/β-catenin signaling to promote fibroblast activation and skin fibrosis in systemic sclerosis

10:30AM-12:30PM

Abstract Number: 0974

Tissue resident macrophages derived from induced pluripotent stem cells induce tissue fibrosis in human skin equivalent models of systemic sclerosis

10:30AM-12:30PM

Abstract Number: 0971

Unraveling the role of the hippo pathway in systemic sclerosis: A focus on TEADs and VGLL3