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Abstract Number: 1549 • 2012 ACR/ARHP Annual Meeting
Sibling Relative Risk and Heritability of Kawasaki Disease: A Nationwide Population Study in Taiwan
I-Jun Chou¹, Chang-Fu Kuo², Jing-Long Huang³, Chang-Teng Wu¹, Shao-Hsuan Hsia¹ and Hsiao-Chun Chang⁴, ¹Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ³Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁴Division of Rheumatology, Immunology and Allergy, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: Kawasaki disease (KD) is an autoimmune disease involving primarily medium-sized vessels and is the leading cause of acquired cardiac disease in children. The pathogenesis…
Abstract Number: 1189 • 2012 ACR/ARHP Annual Meeting
Stromal Cell Markers in the Synovial Tissue of Patients with Early Arthritis and Preclinical Rheumatoid Arthritis
Yuen Kei Choi¹, Olga N. Karpus², Paul Peter Tak³, Jörg Hamann⁴, Christopher D. Buckley⁵, Andrew Filer⁶ and Danielle M. Gerlag⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²1Departments of Experimental Immunology and Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, ³Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁶Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Stromal cells in synovial tissue (ST) of patients with arthritis may have an important role in the initiation and persistence of the inflammatory infiltrate.…
Abstract Number: 1112 • 2012 ACR/ARHP Annual Meeting
Patients with Erosive Osteoarthritis Have Less Extensive Synovitis Than Patients with Rheumatoid Arthritis On Histopathology
Allen P. Anandarajah¹, Stephen Kates², Kate Burns³ and Ellen Giampoli⁴, ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²Orthopedic Surgery, University of Rochester Medical Center, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Pathology, University of Rochester Medical Ctr, Rochester, NY
Background/Purpose: Patients with erosive osteoarthritis (EOA) often develop disfiguring deformities and associated decline in hand function. We have previously demonstrated that synovitis was a common…
Abstract Number: 1036 • 2012 ACR/ARHP Annual Meeting
The Prevalence of Chondrocalcinosis of the Acromioclavicular Joint On Chest Radiographs and correlation with Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Konstantinos M. Parperis¹, Guillermo F. Carrera², Keith E. Baynes², Alan P. Mautz², Melissa S. DuBois², Ross M. Cerniglia² and Lawrence M. Ryan³, ¹Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ²Radiology, Medical College of Wisconsin, Milwaukee, WI, ³Department of Rheumatology, Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Digital imaging combined with picture archiving and communication system (PACS) access allows detailed image retrieval and magnification. Calcium pyrophosphate dihydrate (CPPD) crystals preferentially deposit…
Abstract Number: 815 • 2012 ACR/ARHP Annual Meeting
Exploratory Analysis of Radiographic Change in Patients Treated with Intensive Urate-Lowering Therapy
Nicola Dalbeth¹, Anthony Doyle², Fiona M. McQueen³, John S. Sundy⁴ and Herbert S. B. Baraf⁵, ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand, ⁴Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, ⁵Arthritis & Rheumatism Associates, Wheaton, MD
Background/Purpose: In patients with gout, tophi are strongly associated with radiographic damage. Effective urate-lowering therapy (ULT) reduces tophus size. However, no studies to date have…
Abstract Number: 821 • 2012 ACR/ARHP Annual Meeting
Association of Serum Uric Acid and Incident Fractures in Elderly Men
Nancy E. Lane¹, Neeta Parimi², Barton Wise³, Peggy Cawthon⁴, Eric Orwoll⁵ and MrOS Investigators Group⁶, ¹Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ²Clinical Research, CPMC Research Institute, SF, CA, ³Int Medicine, UC Davis, School of Medicine, Sacramento, CA, ⁴Clinical Research, CPMC Research Institute, San Francisco, CA, ⁵Int Medicine, Portland, OR, ⁶Sacramento, CA
Background/Purpose: Normal mineral metabolism is critical for skeletal integrity. Uric acid (UA) is produced from purines by the enzyme xanthine oxidase, and elevated levels may…
Abstract Number: 768 • 2012 ACR/ARHP Annual Meeting
An Easy to Use Referral Model for Arthritis From the Rotterdam Early Arthitis Cohort
C. Alves¹, Jolanda J. Luime¹, Darian P. Shackleton², P.J. Barendregt³, A.H. Gerards⁴ and Johanna M.W. Hazes¹, ¹Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ²Medisch Centrum Parklaan, Netherlands, ³Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ⁴Department of Rheumatology, Vlietland Hospital, Schiedam, Netherlands
Background/Purpose: The first hurdle general practitioners (GPs) face to identify Rheumatoid Arthritis(RA) is to recognize presence of arthritis. Due to the low incidence of arthritis…
Abstract Number: 742 • 2012 ACR/ARHP Annual Meeting
Utility of HLA-B5801 Genotyping and Renal Dosing of the Starting Dose of Allopurinol in Preventing Allopurinol Hypersensitivity Syndrome: A Cost-Effectiveness Analysis
Yanyan Zhu¹, Ada Man², Tuhina Neogi³ and Hyon K. Choi⁴, ¹Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Allopurinol is the leading choice of urate-lowering therapy (~ 95%) for gout which affects 8.3 million US adults. However, allopurinol is associated with a…
Abstract Number: 560 • 2012 ACR/ARHP Annual Meeting
Proteomic Profiling of Synovial Fluid Reveals Candidate Psoriatic Arthritis Biomarkers
Daniela Cretu¹, Ihor Batruch², Punit Saraon³, Dafna D. Gladman⁴, Fawnda Pellett⁵, Eleftherios Diamandis⁶ and Vinod Chandran⁷, ¹Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada, ²Department of Pathology and Lab Medicine,, Mount Sinai Hospital, Toronto, ON, Canada, ³Department of Pathology and Lab Medicine, Mount Sinai Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁵Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁷Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a unique form of arthritis occurring in 30% of psoriasis patients. There is a high prevalence of undiagnosed PsA in…
Abstract Number: 268 • 2012 ACR/ARHP Annual Meeting
Knee Osteoarthritis and Serum Uric Acid Concentration: The Third National Health and Examination Survey
Tony Ning¹, Carl Pieper², Virginia B. Kraus³, William E. Kraus⁴ and Kim M. Huffman⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, ³Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ⁴Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Osteoarthritis (OA) is a disease that is thought to be the result of many factors, which includes inflammatory causes. A recent study examined the…
Abstract Number: 153 • 2012 ACR/ARHP Annual Meeting
Prevention of Recurrent Calcium Stones in Subjects with Hyperuricosuria: A Randomized Controlled Trial of Febuxostat Vs Allopurinol
David S. Goldfarb¹, Patricia A. MacDonald², Lhanoo Gunawardhana³, Solomon Chefo³ and Lachy McLean⁴, ¹New York Universtiy Langone Medical Center, New York, NY, ²Takeda Pharmaceuticals USA, Inc., Deerfield, IL, ³Takeda Global Research & Development Center, Inc., Deerfield, IL, ⁴Takeda Global Research & Development Center, Inc, Deerfield, IL
Background/Purpose: About one-third of patients with recurrent calcium oxalate (CaOx) stones have hyperuricosuria as a urinary risk factor. Febuxostat (FEB), a newer xanthine oxidase inhibitor…
Abstract Number: 155 • 2012 ACR/ARHP Annual Meeting
Accuracy of International Classification of Disease Codes for Calcium Pyrophosphate Disease in the Veterans Adminstration Healthcare System
Karri A. Huber¹, Lawrence M. Ryan² and Ann K. Rosenthal³, ¹Rheumatology, MCW Froedtert Hospital, Milwaukee, WI, ²Department of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ³Div of Rheumatology, Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Calcium pyrophosphate disease (CPPD) commonly affects elderly patients, but few advances in our management of this disease have occurred in the 50 years since…
Abstract Number: 160 • 2012 ACR/ARHP Annual Meeting
Pegloticase Long-Term Safety: Data From the Open-Label Extension Trial
Michael A. Becker¹, Herbert S. B. Baraf², Robert A. Yood³, Aileen M. Dillon⁴, Janitzia Vazquez-Mellado⁵, Faith D. Ottery⁶, Dinesh Khanna⁷ and John S. Sundy⁸, ¹Medicine, University of Chicago, Chicago, IL, ²Arthritis & Rheumatism Associates, Wheaton, MD, ³Reliant Medical Group, Worcester, MA, ⁴Rheumatology Section, Kaiser Foundation Hospital, San Francisco, CA, ⁵Rheumatology, Hospital General de Mexico, Mexico city, Mexico, ⁶Medical Affairs, Savient Pharmaceuticals, Inc., East Brunswick, NJ, ⁷Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁸Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
Background/Purpose: Pegloticase is a recombinant modified mammalian uricase conjugated to mPEG and approved for treatment of refractory chronic gout. Pegloticase safety was evaluated during 2…
Abstract Number: 161 • 2012 ACR/ARHP Annual Meeting
Increased Serum Uric Acid: Consequence or Cause of Increased Cardiovascular Risk
Inger L. Meek¹, Harald E. Vonkeman² and Mart A.F.J. van de Laar³, ¹Rheumatology & Clinical Immunology, Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ²Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ³Rheumatology, Medisch Spectrum Twente & University of Twente, Enschede, Netherlands
Background/Purpose: Reports on cardiovascular (CV) disease in hyperuricemia and gout show conflicting results. Some studies show hyperuricemia to be an independent risk factor for CV…
Abstract Number: 135 • 2012 ACR/ARHP Annual Meeting
A Pilot Study of the Efficacy of IL1 Blockade by Anakinra in Acute Calcific Periarthritis of the Rotator Cuff
Pascal Zufferey¹, Melanie Faucherre², Pierre A. Varisco¹, Berengere Aubry Sr.¹, Isabelle Fabreguet³ and Alexander K. So Sr.¹, ¹Dal/Rhu, CHUV, Lausanne, Switzerland, ²Dal /Rhu, CHUV, Lausanne, Switzerland, ³CHUV, Lausanne, Switzerland
Background/Purpose: Calcific periarthritis of rotator cuff can induce acute and severe shoulder pain and is accompnied by signs of acute inflammation. The calcific deposits are…

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