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Abstract Number: 218 • 2015 ACR/ARHP Annual Meeting
Diet-Wide Association Study of Serum Urate Levels in 13,782 Individuals of European Ancestry
Tony R. Merriman¹, Nicola Dalbeth², Ruth Topless³ and Tanya Flynn³, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Otago, Dunedin, New Zealand
Background/Purpose: Gout is a consequence of an innate immune reaction to monosodium urate crystals deposited in joints. Acute gout attacks are commonly triggered by dietary…
Abstract Number: 224 • 2015 ACR/ARHP Annual Meeting
Silent Monosodium Urate Crystals Deposits in Asymptomatic Hyperuricemia Lead to a Higher Need for Coronary Revascularization
Mariano Andrés¹, María Amparo Quintanilla², Francisca Sivera³, José Sánchez-Payá⁴, Juan M Ruiz-Nodar⁵, Eliseo Pascual^1,6 and Paloma Vela^1,6, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, ³Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ⁴Servicio de Medicina Preventiva, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain, ⁶Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. In a preliminary, cross-sectional study we found that silent deposits of monosodium urate (MSU)…
Abstract Number: 229 • 2015 ACR/ARHP Annual Meeting
Uric Acid and Incident Dementia over 10 Years
Pascal Richette¹, Aicha Soumare², Stéphanie Debette², Thomas Bardin^3,4 and Christophe Tzourio², ¹Université Paris Diderot, UFR médicale, Paris, France; APHP Hôpital Lariboisière, Fédération de Rhumatologie and Inserm U1132, Hôpital Lariboisière, Paris, France, ²INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France, ³Service de Rhumatologie, Hôpital Lariboisière, Paris, France, ⁴Rhumatology Departement, Hôpital Lariboisière, Paris, France
Background/Purpose: In patients with gout, maintaining the serum uric acid (SUA) levels too low with ULT is a matter of concern because UA is thought…
Abstract Number: 231 • 2015 ACR/ARHP Annual Meeting
Uric Acid Levels Predict Mortality in Women
Jenni E Kauppi¹, Tuomo Nieminen^2,3, Mika Kähönen^4,5, Anne Kerola⁶, Antti Jula⁷, Jaana Leiviskä⁸ and Markku J. Kauppi^9,10, ¹School of medicine, University of Tampere, Tampere, Finland, ²Department of Internal Medicine, South Karelia Central Hospital, Lappeenranta, Finland, ³Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland, ⁴Department of Clinical physiology, School of Medicine, University of Tampere, Tampere, Finland, ⁵Department of Clinical Physiology, Medical Imaging Centre, Pirkanmaa Hospital District, Tampere, Finland, ⁶Faculty of Medicine, University of Helsinki, Helsinki, Finland, ⁷Department of Health, National Institute for Health and Welfare, Turku, Finland, ⁸Department of Health, National Institute for Health and Welfare, Helsinki, Finland, ⁹School of Medicine, University of Tampere, Tampere, Finland, ¹⁰Department of Rheumatology, Päijät-Häme Central Hospital, Lahti, Finland
Background/Purpose: Hyperuricemia induces chronic inflammation and is associated with many diseases such as metabolic syndrome, high blood pressure, chronic kidney disease and cardiovascular diseases. The…
Abstract Number: 232 • 2015 ACR/ARHP Annual Meeting
Hyperuricemia, Urate Lowering Therapy and Kidney Function: A Systemic Review and Meta-Analysis
Gaurav Sharma¹, Abhishek Dubey¹ and Jasvinder A. Singh², ¹Internal Medicine, Seth GS Medical College and KEM Hospital, Mumbai, India, ²University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To determine whether hyperuricemia is associated with deterioration of kidney function and to examine whether urate-lowering therapies (ULTs) can improve or maintain kidney function.…
Abstract Number: 242 • 2015 ACR/ARHP Annual Meeting
Higher Serum Uric Acid Levels Are Associated with an Increased Risk of Flares: A Systematic Review
Aki Shiozawa¹, Shelagh M Szabo², Antoinette Cheung², Anna Bolzani² and Hyon K. Choi³, ¹Global Outcomes and Epidemiology Research, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ²Redwood Outcomes, Vancouver, BC, Canada, ³Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Acutely painful flares represent the typical clinical burden of gout. Effective therapy can reduce serum uric acid (sUA) levels; however, epidemiologic evidence for the…
Abstract Number: 252 • 2015 ACR/ARHP Annual Meeting
Pyrin (MEFV) Mutations in New York: Revisiting the Mount Sinai Experience with Periodic Fever and Serositis
Daniel Bunker and Mark Matza, Medicine, Mount Sinai Medical Center, New York, NY
Background/Purpose: In 1945, Dr. Sheppard Siegel, a Mount Sinai allergist, described 5 patients with “Benign Paroxysmal Peritonitis,” a disorder now recognized as Familial Mediterranean Fever…
Abstract Number: 291 • 2015 ACR/ARHP Annual Meeting
Correlations Between Muscle-MRI, Muscle Strength and Creatine Kinase Levels in the Anti-Synthetase Syndrome; A Comparative, Cross-Sectional Study
Helena Andersson¹, Eva Kirkhus², Else Merckoll², Ragnhild Walle-Hansen³ and Øyvind Molberg¹, ¹Department of Rheumatology, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway, ²Department of Radiology, Oslo University Hospital, Oslo, Norway, ³Department of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway
Background/Purpose: Muscle MRI is used to describe the myositis component of the anti-synthetase syndrome (ASS), but the value of the examination is limited by lack…
Abstract Number: 358 • 2015 ACR/ARHP Annual Meeting
Bone Microstructure Assessed By Hrpqct in Subjects with Hyperuricemia without Arthritis
Roland Kocijan¹, Arastoo Nia¹, Christian Muschitz², David Simon³, Corinna Geiger¹, Judith Haschka⁴, Arnd Kleyer³, Sara Bayat⁵, Juergen Rech⁵, Annemarie Kocijan⁶, Larissa Dzirlo⁷, Monika Graninger⁷ and Heinrich Resch¹, ¹Medical Department II, Karl Landsteiner Society for Gastroenterology and Rheumatology, St. Vincent Hospital, Vienna, Austria, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Optimal Essen e.U., Vienna, Austria, ⁷Medical Department III, St. Vincent Hospital, Vienna, Austria
Background/Purpose: Gouty arthritis is a common inflammatory joint disorder and hyperuricemia (HU) is known to be the main risk factor. Beside clinical signs of inflammation…
Abstract Number: 609 • 2015 ACR/ARHP Annual Meeting
A Reduction in Serum Uric Acid Levels May be Related to Methotrexate Efficacy in Early Rheumatoid Arthritis: Data from a Canadian Arthritis Cohort
Jason Lee¹, VP Bykerk², George Dresser³, Gilles Boire⁴, Boulos Haraoui⁵, Carol Hitchon⁶, J Carter Thorne², Diane Tin⁷, Shahin Jamal⁸, Edward C. Keystone⁹, Janet E. Pope¹⁰ and CATCH Investigators, ¹Rheumatology, Western University, St. Joseph's Hospital, London, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Clinical Pharmacology and Toxicology, Western University, London, ON, Canada, ⁴Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Institut de Rhumatologie, Montreal, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸Vancouver Coastal Health, Vancouver, BC, Canada, ⁹Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ¹⁰Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada
Background/Purpose: The mechanism of methotrexate in rheumatoid arthritis (RA) is complex. It may increase adenosine levels by blocking conversion to of xanthine to uric acid…
Abstract Number: 685 • 2015 ACR/ARHP Annual Meeting
Sacroiliitis Misdiagnosed As Spondyloarthritis: Clinical Analysis of 581 Cases
Feng Huang, Yanyan Wang, Zheng Zhao and Jianglin Zhang, Rheumatology, Chinese PLA General Hospital, Beijing, China
Background/Purpose: To study other disease conditions which can present with bone marrow edema of the sacroiliac joints mimicking spondyloarthritis(SpA). Methods: In a retrospective study of…
Abstract Number: 1031 • 2015 ACR/ARHP Annual Meeting
Quantifying the Delays to Rheumatologist Consultation and Treatment Among Patients with Systemic Inflammatory Rheumatic Diseases
Jessica Widdifield¹, Sasha Bernatsky², J Carter Thorne³, Claire Bombardier⁴, R. Liisa Jaakkimainen⁵, Vandana Ahluwalia⁶, J. Michael Paterson⁷, Noah Ivers⁴, Debra Butt⁸ and Karen Tu⁸, ¹McGill University, Montreal, QC, Canada, ²Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, ³Southlake Regional Health Centre, Newmarket, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Preventive Med and Biostatisti, University of Toronto, Toronto, ON, Canada, ⁶Past President, Ontario Rheumatology Association, Brampton, ON, Canada, ⁷ICES, Toronto, ON, Canada, ⁸Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Background/Purpose: Optimal care for systemic inflammatory rheumatic diseases often hinges upon early referral from primary care physicians (PCP) to rheumatologists. Our aim was to quantify…
Abstract Number: 1182 • 2015 ACR/ARHP Annual Meeting
Rheumatology Training Experience – European Survey Among Rheumatology Trainees & Newly Qualified Specialists
Francisca Sivera¹, Sofia Ramiro², Nada Cikes³, Maxime Dougados⁴, Laure Gossec⁵, Tore K. Kvien⁶, Ingrid E. Lundberg⁷, Peter Mandl⁸, Arumugam Moorthy⁹, Sonia Panchal⁹, J.A.P. da Silva¹⁰, Johannes W J Bijlsma¹¹ and Working Group on Training in Rheumatology across Europe , ¹Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³University Hospital Centre Zagreb, Zagreb, Croatia, ⁴Hôpital Cochin; PRES Sorbonne Paris-Cité, Université Paris Descartes, INSERM (U1153): Epidemiologie Clinique et Biostatistiques, Paris, France, ⁵AP-HP, Hôpital Pitié Salpêtrière, Rheumatology Department; Sorbonne Universités, UPMC Univ Paris 06, Paris, France, ⁶Diakonhjemmet Hospital, Oslo, Norway, ⁷Karolinska University Hospital, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁸Dpt Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Rheumatology, University Hospitals of Leicester, Leicester, United Kingdom, ¹⁰Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal, ¹¹Rheumatology and Clinical Immunology, ARC Amsterdam; UMC Utrecht, Utrecht, Netherlands
Background/Purpose: To describe the confidence and training experience acquired during rheumatology training in 21 core competences across the different European countries. Methods: As part of…
Abstract Number: 1183 • 2015 ACR/ARHP Annual Meeting
The Country Where You Perform Your Rheumatology Training Is Associated with the Acquired Confidence, the Education Received and the Assessment in Core Competences
Francisca Sivera¹, Sofia Ramiro², Nada Cikes³, Maxime Dougados⁴, Laure Gossec⁵, Tore K. Kvien⁶, Ingrid E. Lundberg⁷, Peter Mandl⁸, Arumugam Moorthy⁹, Sonia Panchal⁹, J.A.P. da Silva¹⁰, Johannes W J Bijlsma¹¹ and Working Group on Training in Rheumatology across Europe, ¹Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³University Hospital Centre Zagreb, Zagreb, Croatia, ⁴Hopital Cochin, Paris Descartes University, Paris, France, ⁵AP-HP, Hôpital Pitié Salpêtrière, Rheumatology Department; Sorbonne Universités, UPMC Univ Paris 06, Paris, France, ⁶Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁷Karolinska University Hospital, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁸Dpt Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Rheumatology, University Hospitals of Leicester, Leicester, United Kingdom, ¹⁰Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal, ¹¹Rheumatology and Clinical Immunology, ARC Amsterdam; UMC Utrecht, Utrecht, Netherlands
Background/Purpose: To assess the association between the country where rheumatology training takes place and the acquired confidence, exposure to education, practical experience and competence assessments…
Abstract Number: 1267 • 2015 ACR/ARHP Annual Meeting
Drug Survival of Second Biologic DMARD Therapy in Patients with Rheumatoid Arthritis: Comparison of a Second Anti-TNF with a Second Non-Anti-TNF after Discontinuation of a First Anti-TNF
T Wilke¹, S Mueller¹, I Majer², M Heisen², A Fuchs³ and U Maywald³, ¹Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM), Hochschule Wismar, Germany, ²Pharmerit International, Rotterdam, Netherlands, ³AOK PLUS, Dresden, Germany
Background/Purpose: There is limited information on drug survival (i.e., continuation versus discontinuation of drug treatment) of RA patients who received a 2nd bDMARD therapy after…

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