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Abstract Number: 1873 • 2013 ACR/ARHP Annual Meeting
Use Of Mendelian Randomization Associates Increased Serum Urate Caused By Genetic Variation In Uric Acid Transporters With Improved Renal Function
Tony R. Merriman¹, Tanya Flynn², Janak de Zoysa³, Nicola Dalbeth⁴ and Kim Hughes², ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Waitemata District Health Board, Auckland, New Zealand, ⁴Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Hyperuricemia is the central risk factor for gout. In observational studies hyperuricemia also predicts the development and progression of chronic kidney disease independent of…
Abstract Number: 1786 • 2013 ACR/ARHP Annual Meeting
91% Of Early RA Patients Are Positive For Serum 14-3-3η Or Its Auto-Antibodies
Walter P. Maksymowych¹, Dirkjan van Schaardenburg², Désirée van der Heijde³, Robert Landewé⁴, Gilles Boire⁵, Maarten Boers⁶, Vivian P. Bykerk⁷, Edward C. Keystone⁸, Katherine A. Siminovitch⁹, Mairead Murphy¹⁰ and Anthony Marotta¹¹, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Jan van Breemen Research Institute | Reade, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Int Med/Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁵Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁷Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁸Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁹Mount Sinai Hospital, Toronto, ON, Canada, ¹⁰Augurex Life Sciences Corp., North Vancouver, BC, Canada, ¹¹Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: Current serological markers such as RF and ACPA are useful for early diagnosis and perhaps for screening people at risk, but there remains a…
Abstract Number: 1627 • 2013 ACR/ARHP Annual Meeting
Typing TREX1 Gene In Patients With Systemic Lupus Erythematosus
Micaela Fredi¹, Marika Bianchi², Laura Andreoli³, Gaetano Grieco², Ivana Olivieri⁴, Simona Orcesi⁴, Elisa Fazzi⁵, Cristina Cereda² and Angela Tincani³, ¹Rheumatology Chair, Rheumatology Chair, University of Brescia and Pavia, Brescia, Italy, ²Laboratory of Experimental Neurobiology, C. Mondino National Institute of Neurology Foundation, Pavia, Italy, ³Rheumatology Unit, University of Brescia, Brescia, Italy, ⁴Child Neurology and Psychiatry Unit C. Mondino National Institute of Neurology Foundation, Pavia, Italy, ⁵Child Neurology and Psychiatry Unit, Mother-Child Department, Civil Hospital, University of Brescia, Brescia, Italy
Background/Purpose: An increased expression of type I interferon regulated genes (IFN signature) has been reported in patients (pts) with Systemic Lupus Erythematosus (SLE) and it…
Abstract Number: 1293 • 2013 ACR/ARHP Annual Meeting
Serum Matrix Metalloproteinase 13 As a Translational Marker For Efficacy Of Anti-Arthritic Treatments In Rat Collagen Induced Arthritis and Mouse Model Of Lipopolysaccharide-Induced Bone Resorption
Ines Glojnaric, Snjezana Cuzic, Boska Hrvacic, Vanesa Ivetic Tkalcevic, Miroslava Dominis Kramaric and Vesna Erakovic Haber, Fidelta Ltd., Zagreb, Croatia
Background/Purpose: Matrix metalloproteinase 13 (MMP-13) is expressed by chondrocytes and synovial cells in human osteoarthritis and rheumatoid arthritis (RA) (Takaishi et al., 2008). Serum MMP-13…
Abstract Number: 1174 • 2013 ACR/ARHP Annual Meeting
Impact Of Bariatric Surgery On Serum Urate Targets in People With Morbid Obesity and Diabetes: A Prospective Longitudinal Study
Nicola Dalbeth¹, Peggy Chen², Marie White³, Gregory Gamble⁴, Caran Barratt-Boyes², Peter J. Gow⁵ and Brandon Orr-Walker², ¹Medicine, University of Auckland, Auckland, New Zealand, ²Counties Manukau District Health Board, Auckland, New Zealand, ³CCRep, Auckland, New Zealand, ⁴Department of Medicine, University of Auckland, Auckland, New Zealand, ⁵Rheumatology Dept, Middlemore Hospital, Auckland, New Zealand
Background/Purpose: Weight loss leads to reduced serum urate (SU) in people with obesity. However, the clinical relevance of such reductions in SU are unknown. This…
Abstract Number: 1176 • 2013 ACR/ARHP Annual Meeting
Pharmacokinetics and Pharmacodynamics Of Pegloticase In Patients With End-Stage Renal Failure Receiving Hemodialysis
Anthony J. Bleyer¹, David E. Wright² and Alan Glicklich³, ¹Wake Forest University School of Medicine, Winston-Salem, NC, ²Savient Pharmaceuticals, Inc., San Diego, CA, ³Savient Pharmaceuticals, Inc., Bridgewater, NJ
Background/Purpose: Among the estimated 8.3 million adults in the US with gout, approximately 40% have coexistent chronic kidney disease (CKD).1,2 Further, the presence of gout…
Abstract Number: 1185 • 2013 ACR/ARHP Annual Meeting
More Than One-Third Of Patients Reach Serum Urate Target and Continue To Report Multiple Flares
Dinesh Khanna¹, Puja Khanna², Chris Storgard³, Scott Baumgartner⁴ and Robert Morlock⁵, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³4939 Directors Place, Ardea Bioscience, San Diego, CA, ⁴Ardea Biosciences, San Diego, CA, ⁵Ardea Bioscience, San Diego, CA
Background/Purpose: Gout is a common inflammatory arthritis, and its worldwide prevalence is increasing. EULAR and ACR guidelines recommend a target serum urate (sUA) ≤6 mg/dL.…
Abstract Number: 1189 • 2013 ACR/ARHP Annual Meeting
Allopurinol Dose Titration and Efficacy: A Large-Scale, 6-Month, Multicenter, Prospective Study
Scott Baumgartner¹, Hyon Choi^2,3, Nicola Dalbeth⁴, David Fitz-Patrick⁵, Matt Cravets⁶ and Chris Storgard⁷, ¹Ardea Biosciences, San Diego, CA, ²Section of Rheumatology and the Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Auckland District Health Board, Auckland, New Zealand, ⁵East-West Medical Research Institute, Honolulu, HI, ⁶Ardea Biosciences, Inc., San Diego, CA, ⁷4939 Directors Place, Ardea Bioscience, San Diego, CA
Background/Purpose: Allopurinol is the first-line urate-lowering therapy (ULT) for most people with gout, but target serum uric acid (sUA) levels of 200-300 >300-400 >400-500 >500-600…
Abstract Number: 1190 • 2013 ACR/ARHP Annual Meeting
The Synergistic Effects Of Metabolic Syndrome Indicators and Hyperuricemia In Contributing To Cardiac Event Risk: A Cross-Sectional Examination Of The Nhanes III Data
Daniel A. Albert^1,2 and Sayyad Kyazimzade³, ¹Medicine/Rheumatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, ²Rheumatology, The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH, ³The Dartmouth Institute for Health Policy & Clinical Practice, Lebanon, NH, Lebanon, NH
Background/Purpose: The focus of this project is to assess the contribution of hyperuricemia and gout to the risk for cardiovascular events. In a preliminary analysis…
Abstract Number: 1173 • 2013 ACR/ARHP Annual Meeting
A Clinically Significant Interaction Between Furosemide and Allopurinol: Potential Implications for Clinical Practice
Lisa K. Stamp¹, Claudia Knake² and Andrew Bahn², ¹Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²Physiology, University of Otago, Dunedin, New Zealand
Background/Purpose: The xanthine oxidase (XO) inhibitor allopurinol is the most commonly used urate lowering therapy in gout. Allopurinol is metabolized to oxypurinol, which is responsible…
Abstract Number: 976 • 2013 ACR/ARHP Annual Meeting
Experiential Learning In Musculoskeletal Ultrasound
Hitasha Singh¹ and Karina D. Torralba², ¹Rheumatology, University of Southern California, Los Angeles, CA, ²Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: The Los Angeles County Medical Center-University of Southern California Rheumatology fellowship program has incorporated MSUS in its curriculum since 2009. Apart from didactics with…
Abstract Number: 974 • 2013 ACR/ARHP Annual Meeting
Medical Student Perceptions Of Point-Of-Care Ultrasound In Musculoskeletal Education
Minna J. Kohler¹, Joshua Rempell² and Margaret Seton³, ¹Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, ²Emergency Medicine, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Point-of-care ultrasound (POC US) is increasingly being incorporated into clinical care among rheumatologists and other specialties to expedite diagnosis and assist in needle and…
Abstract Number: 983 • 2013 ACR/ARHP Annual Meeting
Teaching Musculoskeletal Care Through An Inter-Disciplinary and Inter-Professional Clinical Training Program Successfully Provides Trainees With Knowledge and Skills Required To Deliver Excellent Musculoskeletal Care
Grant W. Cannon¹, Andrea Barker², J Peter Beck³, Jeffery Berdan³, Marissa Grotzke⁴, Timothy A. Huhtala⁵, Patrice Kennedy⁶, Phillip Lawrence³, JoAnn Rolando³ and Michael J. Battistone¹, ¹Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ²General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ³Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁴Division of Endocrinology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁵Division of General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁶500 Foothill Boulevard, Salt Lake City VA, Salt Lake City, UT
Background/Purpose: While musculoskeletal (MSK) complaints are some of the most common reasons for primary care and specialty visits, little time is dedicated to this…
Abstract Number: 964 • 2013 ACR/ARHP Annual Meeting
Redesign Of a Rheumatology Curriculum For Internal Medicine Residents: Results Of Needs Assessment Survey
Susan F. Kroop¹, Cecilia P. Chung² and Charlene M. Dewey³, ¹Medicine/Rheumatology, Vanderbilt University Medical School, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN
Background/Purpose: We plan to improve internal medicine (IM) resident competence in caring for patients with rheumatologic disease and increase resident interest in rheumatology as a…
Abstract Number: 898 • 2013 ACR/ARHP Annual Meeting
Sex-Specific Employment Participation Restriction Across Occupational Groups Among Working-Age (18-64 years) U.S. Adults With and Without Arthritis
Kristina A. Theis¹ and Louise Murphy², ¹Athritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Division of Population Health, CDC, Atlanta, GA
Background/Purpose: Previous research has shown arthritis-attributable work limitation to be high (~30%) among U.S. adults with arthritis and for employment to be ~20% lower among…

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