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Abstract Number: 3071 • 2016 ACR/ARHP Annual Meeting
Recombinant Human Proteoglycan-4 (rhPRG4) Inhibits Monosodium Urate (MSU) Crystal Phagocytosis By Human Macrophages and Resultant Inflammatory Response
Marwa Qadri¹, Tannin Schmidt², Khaled Elsaid³ and Gregory Jay⁴, ¹Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, ²Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ³Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, ⁴Emergency Medicine, Brown University, Providence, RI
Background/Purpose: Gout is an inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in synovial joints. MSU crystals interact with resident macrophages that…
Abstract Number: 3076 • 2016 ACR/ARHP Annual Meeting
Development of a Matrix-Binding Interlukin-1 Receptor Antagonist Fusion Protein for Extended Retention in the Joint Tissues
James Pancoast¹, Richard Lee^2,3 and Parth Patwari¹, ¹ProteoThera, Inc., Newton, MA, ²Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, ³Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: A primary challenge for intra-articular delivery of protein and peptide therapies has been their short residence time in the joint tissues. The IL-1 receptor…
Abstract Number: 3080 • 2016 ACR/ARHP Annual Meeting
Rheumatologic Consequences of Immunotherapy to Treat Malignancies: The Tip of an Iceberg
Laura Cappelli¹, Anna Kristina Gutierrez², Alan N. Baer², Jemima Albayda³, Rebecca L. Manno², Uzma Haque³, Ami A. Shah³, Evan Lipson⁴, Karen Bleich⁵, Julie Brahmer⁴, Patrick Forde⁴, Dung Le⁶, Jarushka Naidoo⁴ and Clifton Bingham III⁷, ¹Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Johns Hopkins University, Baltimore, MD
Rheumatologic Consequences of Immunotherapy to Treat Malignancies: The Tip of an Iceberg Background/Purpose: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed…
Abstract Number: 3126 • 2016 ACR/ARHP Annual Meeting
Computational Polarizing Microscopy: A Novel Method to Detect Birefringent Crystals Using Lens-Free on-Chip Microscopy
Seung Yoon Lee¹, Yibo Zhang², Daniel E. Furst¹, Ann Rosenthal³, Ralph Schumacher⁴, John FitzGerald¹ and Aydogan Ozcan², ¹Division of Rheumatology, Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Electrical Engineering Department, University of California Los Angeles, School of Engineering, Los Angeles, CA, ³Division of Rheumatology, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, ⁴Division of Rheumatology, Department of Internal Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
Background/Purpose: A compensated polarizing microscopy has been used for detecting monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals to confirm the diagnosis of gout…
Abstract Number: 3129 • 2016 ACR/ARHP Annual Meeting
The Pharmacokinetics of Oxypurinol in Patients Treated with Hemodialysis and Allopurinol
Matthew Doogue¹, Dan Wright², Nick Cross³, John Irvine³, Peter T. Chapman⁴, Murray Barclay⁵ and Lisa K. Stamp¹, ¹University of Otago, Christchurch, New Zealand, ²School of Pharmacy, University of Otago, Dunedin, New Zealand, ³Nephrology, Christchurch Hospital, Christchurch, New Zealand, ⁴Christchurch Hospital, Christchurch, New Zealand, ⁵Medicine, University of Otago, Christchurch, New Zealand
Background/Purpose: Allopurinol is recommended as a first-line pharmacologic urate-lowering therapy in gout. Oxypurinol, the active metabolite of allopurinol, is entirely cleared by the kidneys. Oxypurinol…
Abstract Number: 3164 • 2016 ACR/ARHP Annual Meeting
Spondyloarthritis Pathogenesis Involves Interplay Between Gut Microbiota and Genetic Background
Tejpal Gill¹, Mark Asquith², Stephen Brooks³, James T. Rosenbaum² and Robert A. Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Oregon Health & Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD
Background/Purpose: HLA-B27 and human b2m expression in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). While aspects of rat SpA have been studied…
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Abstract Number: 51 • 2015 ACR/ARHP Annual Meeting
Oral Glucocorticoid Use Is Associated with Osteonecrosis in Adults with Chronic Inflammatory Diseases but Not in Children: A Population-Based Cohort Study
Daniel B. Horton^1,2,3, Kevin Haynes^1,4, Michelle R. Denburg^1,5, Mihir Thacker⁶, Carlos D. Rose², Mary E. Putt¹, Mary B. Leonard⁷ and Brian L. Strom^1,3, ¹Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Pediatrics, Nemours A.I. duPont Hospital for Children, Division of Pediatric Rheumatology, Thomas Jefferson University, Wilmington, DE, ³Rutgers Biomedical and Health Sciences, New Brunswick, NJ, ⁴Clinical Epidemiology, HealthCore, Wilmington, DE, ⁵Pediatrics, Children’s Hospital of Philadelphia, Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁶Orthopedics, Nemours A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, ⁷Pediatrics, Division of Nephrology, Stanford School of Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Glucocorticoids have long been linked to the development of osteonecrosis, mostly in heavily exposed patients from specialty clinics. We tested the hypothesis that oral…
Abstract Number: 94 • 2015 ACR/ARHP Annual Meeting
NGS Panel for the Detection of Monogenic SLE in Children: Initial Results
Alexandre Belot¹, Gillian Rice², Anne-Laure Mathieu¹, Brigitte Bader-Meunier³, Thierry Walzer¹, Tracy A. Briggs², James O'Sullivan⁴, Simon Wiliams⁵, Michael W. Beresford⁶, Yanick Crow^2,7 and GENIAL Investigators, UK JSLE Study Group, ¹INSERM U1111, Lyon, France, ²Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ³Pediatric Rheumatology & Immunology, Necker hospital, Imagine Institution, Paris, France, ⁴University of Manchester, Manchester, United Kingdom, ⁵University of Manchester, Manchester, France, ⁶Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ⁷Neuroinflammation, Institut Imagine, Paris, France
Background/Purpose: Next generation sequencing (NGS) represents a revolution in the field of molecular medicine, and offers a new approach to deciphering the pathogenesis of complex…
Abstract Number: 96 • 2015 ACR/ARHP Annual Meeting
The ABCG2 polymorphism Is Associated with Hyperuricemia in a Community-Based Korean Cohort
Jae-Bum Jun¹, Hye-Jin Jeong², Chang-Nam Son³, Ji-Min Kim³, Sang-Hyon Kim³, So-Young Bang⁴ and Sang-Cheol Bae¹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, ⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea
Background/Purpose: Hyperuricemia is known as a risk factor of diverse diseases such as gout, hypertension, metabolic syndrome, diabetes mellitus, and cardiovascular diseases. Recent genome-wide association…
Abstract Number: 97 • 2015 ACR/ARHP Annual Meeting
Genomic Sequencing of Uric Acid Metabolizing and Clearing Genes in Relationship to Xanthine Oxidase Inhibitor Dose
Matthew Carroll¹, Kristen Cook² and Thomas Shaak³, ¹Rheumatology, Keesler Medical Center, Keesler AFB, MS, ²Internal Medicine, Keesler Medical Center, Keesler AFB, MS, ³Clinical Research Laboratory, Keesler Medical Center, USAF, Keesler AFB, MS
Background/Purpose: Effective long term uric acid lowering therapy with the xanthine oxidase inhibitors (XOI) allopurinol and febuxostat exists. When compliant with therapy, it is unclear…
Abstract Number: 180 • 2015 ACR/ARHP Annual Meeting
Ultrasound Quantification of Fluid Shifts in the Knees of Arthritis Patients before and after Inflation of a Pneumatic Compressive Device
Richard Meehan¹, christopher wilson², eric Hoffman³, Elizabeth Regan⁴ and Lynne Altimier⁵, ¹Medicine, National Jewish Health, Denver, CO, ²biomedical enginering, Unviersity of Colorado- Denver, Denver, CO, ³medicine, national Jewsih Health, westminster, CO, ⁴medicine, national Jewish Health.org, denver, CO, ⁵radiology, National Jewish Health, denver, CO
Background/Purpose: Published studies indicate clinicians may miss the intrasynovial knee space during therapeutic injections in excess of 30% of attempts using landmark guided techniques due…
Abstract Number: 185 • 2015 ACR/ARHP Annual Meeting
Success Rate and Utility of Ultrasound Guided Synovial Biopsies in Clinical Practice
Aurélie Najm, Benoît Le Goff and Yves Maugars, Rheumatology, Rheumatology, Nantes, France
Background/Purpose: Histological and bacteriological analysis of synovial tissue (ST) can be useful in the diagnosis of arthritis of undetermined origin. Ultrasound can assist this biopsy…

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