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Abstract Number: 163 • 2014 ACR/ARHP Annual Meeting
Is the Rate of Skin Reactions to Febuxostat Increased in Patients with a History of Skin Intolerance to Allopurinol? a Retrospective, Hospital-Based Study Involving 101 Patients Consecutively Treated with Allopurinol and Febuxostat
Thomas Bardin¹, Gérard Chales², Tristan Pascart³, René-Marc Flipo⁴, Jean-Claude Roujeau⁵, Aurélie Delayen⁶ and Pierre Clerson⁷, ¹Clinique de Rhumatologie. Service de Rhumatologie. Centre Viggo Petersen., Hôpital Lariboisière, Paris, France, ²Dept of Rheumatology, CHR - Hopital Sud, Rennes, France, ³Rheumatology, Saint-Philibert Hospital, LOMME, France, ⁴rheumatology, Rene Salengro hospital, Lille, France, ⁵Dermatology, University Paris Est, Créteil, France, ⁶Orgamétrie biostatistiques, Roubaix, France, ⁷Orgametrie, Roubaix, France
Background/Purpose: Allopurinol can lead to skin toxicity. Minor skin reactions are reported in 2-4% of patients and life threatening severe cutaneous reactions (SCARs) in 0.1-0.4%.…
Abstract Number: 158 • 2014 ACR/ARHP Annual Meeting
Performance of Joint Ultrasonography in the Diagnosis of Suspected Acute Crystal Arthritis : Results of a Prospective Study of 112 Patients
Pascal Zufferey¹, Isabelle Fabreguet¹, Roxana Valcov¹, Alexandre Dumusc¹ and Alexander K. So Sr.², ¹DAL, RHU/CHUV, Lausanne, Switzerland, ²Dal/Rhu, CHUV, Lausanne, Switzerland
Background/Purpose The gold standard for diagnosing gout and CCP arthritis is the identification of monosodium urate (MSU) crystals in joint fluid. Ultrasound (US) features of…
Abstract Number: 103 • 2014 ACR/ARHP Annual Meeting
Rheumatology e-Consult Services: a Rheumatology Workforce Management Model
Thomas Schmidt¹, Charles Lappan² and Daniel Battafarano³, ¹Rheumatology, SAUSHEC/ Brooke Army Medical Center, San Antonio, TX, ²United States Army, San Antonio, TX, ³Rheumatology, San Antonio Military Medical Center, JBSA - Ft Sam Houston, TX
Background/Purpose: The regional distribution of adult rheumatologist in the United States (U.S.) was recently analyzed by the American College of Rheumatology (ACR)1. Regional workforce shortages…
Abstract Number: 72 • 2014 ACR/ARHP Annual Meeting
The Association Between Doctor-Diagnosed Arthritis and Falls and Fall Injuries Among Middle-Aged and Older Adults
Kamil E. Barbour¹, Louise Murphy², Kristina A. Theis³, Charles G. Helmick⁴, Jennifer Hootman⁵ and Judy A. Stevens⁶, ¹Arthritis Program, CDC, Atlanta, GA, ²Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA, ³Centers for Disease Control and Prevention, Atlanta, GA, Georgia, ⁴National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, ⁵Population Health, Centers for Disease Control and Prevention, Atlanta, GA, ⁶Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Falls are the leading cause of injury-related morbidity and mortality among older adults (age ≥65 years), with more than one in three falling each…
Abstract Number: 47 • 2014 ACR/ARHP Annual Meeting
The Risk of Aplastic Anemia and Pancytopenia with Colchicine: A Retrospective Study of Integrated Health System Database
Jasvinder A. Singh¹, Shuo Yang² and Jeff Foster³, ¹University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose Colchicine is a commonly used medication, sometime associated with bone marrow toxicity. The objective of this study was to examine the risk of severe…
Abstract Number: L11 • 2014 ACR/ARHP Annual Meeting
Raman Spectroscopy: Point of Service Diagnosis Is Sensitive and Specific-a Tool for Improving Accuracy and Reducing Future Hospital Admission
Nora Singer¹, Bolan Li², Yener Yeni³, Emma Barnboym⁴, Steven Lewis⁵, Daniel Oravec⁶, Donald Haggins⁷ and Ozan Akkus², ¹Rheumatology, MetroHealth Medical Center and CWRU, Cleveland, OH, ²Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, ³Section of Biomechanics, Bone and Joint Cetner, Henry Ford Hospital, Detroit, MI, ⁴Rheumatology, MetroHealth Medical Center, Cleveland, OH, ⁵Medicine, MetroHealth Medical Center, Cleveland, OH, ⁶Bone and Joint Center, Henry Ford Hospital, Detroit, MI, ⁷Rheumatology, Henry Ford Hospital, Detroit, MI
Background/Purpose: The diagnosis of gout or pseudogout hinges upon identification of monosodium urate (MSU) crystals and calcium pyrophosphate (CPPD) crystals in synovial fluid (SF) aspirates…
Abstract Number: L10 • 2014 ACR/ARHP Annual Meeting
Lesinurad, a Novel Selective Uric Acid Reabsorption Inhibitor, in Two Phase III Clinical Trials: Combination Study of Lesinurad in Allopurinol Standard of Care Inadequate Responders (CLEAR 1 and 2)
Kenneth G. Saag¹, Scott Adler², Nihar Bhakta³, Maple Fung³, Jeff Kopicko³, Chris Storgard³ and Thomas Bardin⁴, ¹Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, ²AstraZeneca Pharmaceuticals, Wilmington, DE, ³Ardea Biosciences, Inc., San Diego, CA, ⁴Clinique de Rhumatologie. Service de Rhumatologie. Centre Viggo Petersen., Hôpital Lariboisière, Paris, France
Background/Purpose: Inadequate response to allopurinol monotherapy is common. Lesinurad (RDEA594) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in…
Abstract Number: 163 • 2013 ACR/ARHP Annual Meeting
The Frequency Of Single Nucleotide Polymorphisms In Urate Transporter Genes and Their Association With Uric Acid Concentration Based On Data From Genome-Wide Association Studies In The Korean Population
Chan-Nam Son¹, So-Young Bang², Sang-Cheol Bae³ and Jae-Bum Jun³, ¹Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea, ²Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ³Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Gouty arthritis is characterized by hyperuricemia, which results from overproduction of, or impaired renal excretion of, uric acid. Recently, interest has increased in renal…
Abstract Number: 179 • 2013 ACR/ARHP Annual Meeting
The Association Between Single Nucleotide Polymorphism ABCG2 rs2231142 and Hyperuricemia: A Case-Control Study
Bingqing Zhang¹, Weigang Fang², Yun Zhang^3,4, Shufen Liu³, Yuanjie Li³ and Xuejun Zeng², ¹Peking Union Medical College, Beijing, China, ²Medicine, Peking Union Medical College Hospital, Beijing, China, ³Peking Union Medical College Hospital, Beijing, China, ⁴Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
Background/Purpose: The prevalence of hyperuricemia and gout in China increased markedly in the past decades. Genome-wide association studies in Caucasian population have identified multiple…
Abstract Number: 2290 • 2013 ACR/ARHP Annual Meeting
Global Metabolite Profiling Of Synovial Fluids From Different Forms Of Inflammatory Arthritis For The Identification Of Putative Biomarker In Rheumatoid Arthritis
Jiwon Hwang¹, Joong Kyong Ahn², Jaejoon Lee¹, Inyoung Kim¹, Seulkee Lee¹, Chan Hong Jeon³, Eun-Mi Koh¹ and Hoon-Suk Cha¹, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
Background/Purpose: Metabolomics is the study of unique chemical fingerprints of specific cellular processes. Metabolite profiling is recently applied in identifying biomarkers in medical research including…
Abstract Number: 2046 • 2013 ACR/ARHP Annual Meeting
Lower-Dose Indomethacin Submicron Particle Capsules’ Efficacy In Acute Pain: Results From Two Phase 3 Studies
Roy D. Altman¹, Allan Gibofsky², Mark Jaros³ and Clarence Young⁴, ¹David Geffen School of Medicine, UCLA, Los Angeles, CA, ²Medicine and Public Health, Hospital for Special Surgery, New York, NY, ³Summit Analytical, Denver, CO, ⁴Iroko Pharmaceuticals, Philadelphia, PA
Background/Purpose: Indomethacin is used to treat acute gouty arthritis and other acute pain conditions but, like other NSAIDs, is associated with dose-related gastrointestinal, cardiovascular, and…
Abstract Number: 1970 • 2013 ACR/ARHP Annual Meeting
The Utility Of Fluorescence Optical Imaging For Detecting Clinically Silent Synovitis Of The Hands and Wrists
Yogan Kisten¹, Noémi Györi², Hamed Rezaei³, Anna Karlsson¹, Carolina Romanus², Ronald van Vollenhoven⁴ and Erik af Klint⁵, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ²Unit for Clinical Therapy Research Inflammaroty Diseases (ClinTRID) Department of Medicine, the Karolinska Insitute, Stockholm, Sweden, ³Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ⁴Unit for Clinical Research Therapy. Inflammatory Diseases (ClinTrid), Karolinska Institute, Stockholm, Sweden, ⁵Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The rheumatology clinic of the Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: The detection of subclinical synovial inflammation (“silent synovitis”) would be of critical importance for the detection of rheumatoid arthritis (RA) in its earliest pathophysiological…
Abstract Number: 1983 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Birefringent Crystals In Three Inflammation-Prone Tissues
Jane Park¹, Divya Soman², Martine P. Roudier³ and Peter A. Simkin⁴, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Pathology, University of Washington, Seattle, WA, ⁴Div of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: When serum is hyperuricemic, so too are all interstitial fluids other than CSF and sweat. Anecdotally, urate crystals deposit as grossly visible tophi in…
Abstract Number: 1985 • 2013 ACR/ARHP Annual Meeting
Prescription Patterns Of Colchicine Before and After Food and Drug Administration Approval
Eswar Krishnan¹, Jasvinder A. Singh² and Linjun Chen¹, ¹Medicine, Stanford University, Palo Alto, CA, ²Department of Medicine, University of Alabama, Tuscaloosa, AL
Background/Purpose: Colchicine, a commonly used drug, had never been subjected to rigorous safety and efficacy studies prior to 2009, when under Hatch-Waxman ACT (1984) and…
Abstract Number: 1930 • 2013 ACR/ARHP Annual Meeting
Patients’ Response To a Sleep Question and Disease Activity In Multiple Rheumatic Conditions
Sapna Sangani¹ and Martin J. Bergman², ¹Medicine, Mercy Catholic Medical Center, Lansdowne, PA, ²Medicine, Drexel University College of Medicine, Philadelphia, PA
Patient's Response To A Sleep Question And Disease Activity Levels In Multiple Rheumatic ConditionsBackground/Purpose: Sleep disturbances can have an impact on the quality of life…

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