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Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting
Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation
Man Wai Tang¹, Samuel Garcia², Danielle M. Gerlag^3,4, Kris A. Reedquist⁵ and Paul P. Tak^6,7, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴GlaxoSmithKline, Cambridge, United Kingdom, ⁵Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁷University of Cambridge, Cambridge & GlaxoSmithKline, UK, Stevenage, United Kingdom
Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…
Abstract Number: 1118 • 2014 ACR/ARHP Annual Meeting
Olecranon Bursitis Is Often Hemorrhagic and Responds to Steroid Injections
Kyriakos A. Kirou¹ and Naveed Chaudhry², ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose . Olecranon bursitis is a common presentation to an outpatient rheumatology practice. The differential diagnosis includes crystalline bursitis (gout and pseudogout), inflammatory bursitis due…
Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Melissa Ramirez¹, Josh Potvin¹, Diana Ramirez² and Anthony M. Reginato³, ¹Division of Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…
Abstract Number: 830 • 2014 ACR/ARHP Annual Meeting
Profound Hypouricemia Induced in Human Subjects By Novel Bifunctional Inhibitors of Xanthine Oxidase and URAT1
Raymond P. Warrell Jr.¹, Anna Klukovits², Keith Barnes³, Chitkala Satyanarayana⁴, Chris Cheeseman⁵ and John Piwinski¹, ¹Relburn-Metabolomics, Inc., Westfield, NJ, ²SOLVO Biotechnology, Budapest, Hungary, ³AMRI, Albany, NY, ⁴AMRI, Singapore, Singapore, ⁵University of Alberta, Alberta, AB, Canada
Background/Purpose: A prototype anticancer drug (RLBN1001) induced marked hypouricemia in studies of > 350 human subjects. Preliminary exploration suggested dual effects on uric acid (UA)…
Abstract Number: 829 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Deposit of Monosodium Urate Crystals Associates to a More Severe Coronary Calcification in Hyperuricemic Patients with Acute Coronary Syndrome
Mariano Andrés¹, María Amparo Quintanilla², Francisca Sivera¹, Paloma Vela^3,4 and Juan Miguel Ruiz-Nodar⁵, ¹Sección de Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ²Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, ³Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ⁴Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain
Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. Monosodium urate (MSU) crystals are found in ~25% of patients with asymptomatic hyperuricemia (AH)…
Abstract Number: 820 • 2014 ACR/ARHP Annual Meeting
Herpes Zoster Infection Risk in Auto-Immune and Inflammatory Diseases: Implications for Vaccination
Huifeng Yun¹, Shuo Yang², Lang Chen³, Fenglong Xie⁴, Kevin L. Winthrop⁵, John Baddley³, Kenneth G. Saag⁶, Jasvinder A. Singh⁷ and Jeffrey R. Curtis⁸, ¹Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁵Division of Infectious Diseases, Oregon Health and Science University, Portland, OR, ⁶Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Herpes zoster (HZ) vaccine is recommended for healthy people age >= 60 years in US. It is unclear whether the absolute risk for younger…
Abstract Number: 615 • 2014 ACR/ARHP Annual Meeting
Analysis of the Gut Transcriptome in HLA-B27 Transgenic Rats By RNA-Seq Reveals Prominent Interferon and IL-23/IL-17 Axis Signatures
Tejpal Gill¹, Mark Asquith², Steve Brooks¹, James T. Rosenbaum² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²OHSU, Portland, OR
Background/Purpose: Expression of HLA-B27 and human beta 2-microglobulin (hb2m) in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). SpA overlaps with IBD in…
Abstract Number: 431 • 2014 ACR/ARHP Annual Meeting
Joint Dermal Temperature Specifically Identifies the Individual RA Patient Most Likely to Develop Radiographic Change on Sharp Score; An Exam in Less Than a Minute Can Predict Who Specifically Needs Biologic Therapy
Maria Greenwald¹, Joann Ball² and Harold Paulus³, ¹Desert Medical Advances, PALM DESERT, CA, ²rheumatology, Desert Medical Advaces, Palm Desert, CA, ³Rheumatology, UCLA, Los Angeles, CA
Background/Purpose: Joint dermal temperature (temp) measured in less than a minute can identify specifically the individual RA patient most likely to develop radiographic change on…
Abstract Number: 380 • 2014 ACR/ARHP Annual Meeting
In Palindromic Rheumatism, Older Age, Shorter Interval Between Attacks and Positive Anti-CCP Antibodies May Predict Progression to RA
Masatoshi Hayashi^1,2, Jackie L. Nam³, Laura Hunt³, Elizabeth Hensor³, Toshihisa Kanamono⁴, Toshihisa Kojima⁵, Naoki Ishiguro⁵ and Paul Emery⁶, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom, ²5-22-1 Wakasato, Nagano Red Cross Hospital, Nagano, Japan, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Departments of Orthopedic surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, ⁵Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁶NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., United Kingdom, Leeds, United Kingdom
Background/Purpose Palindromic rheumatism (PR) is a clinical syndrome characterised by episodes of joint swelling that settle spontaneously. A proportion of patients with PR progress and…
Abstract Number: 263 • 2014 ACR/ARHP Annual Meeting
Nutraceutical Products and Pain or Non-Pain Medications Use in Patients with Knee Osteoarthritis
Mei Chung¹, John B. Wong², Shaoyu Chang³ and Chenchen Wang⁴, ¹Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, ²Medicine/Clinical Decision Making, Tufts Medical Center, Boston, MA, ³Tufts Medical Center, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Knee osteoarthritis (OA) causes substantial health burden and economic costs including medications and neutraceuticals for pain. The aim of this analysis was to describe…
Abstract Number: 183 • 2014 ACR/ARHP Annual Meeting
Musculoskeletal Ultrasound Reveals Calcific Deposition Arthropathy in Seronegative Inflammatory Arthritis Patients
Sheila L. Arvikar¹, Janice Lin² and Minna J. Kohler³, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Dermatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Background/Purpose Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) have vastly improved the diagnosis of rheumatoid arthritis (RA), but the diagnosis and management of seronegative…
Abstract Number: 178 • 2014 ACR/ARHP Annual Meeting
The Effect of Initiating Pharmacologic Insulin on Serum Uric Acid Levels in Patients with Diabetes
Lindsey MacFarlane¹, Chih-Chin Liu² and Daniel H. Solomon³, ¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose Substantial evidence links gout and hyperuricemia to diabetes. Previous studies report an association between increasing uric acid (UA) levels, insulin resistance, and type 2…
Abstract Number: 180 • 2014 ACR/ARHP Annual Meeting
Analytical Comparison Between Point of Care Uric Acid Testing Meters
Jonathan Paraskos¹, Zsofia Berke², Jason Cook¹, Jeffrey N. Miner³, Martin Braddock¹, Adam Platt¹ and Glen Hughes¹, ¹AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, ²R&D, AstraZeneca, Mölndal, Sweden, ³Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: Gout is a chronic, painful, debilitating form of arthritis resulting from elevated levels of serum uric acid (SUA), termed hyperuricemia. Hyperuricemia is caused by…
Abstract Number: 171 • 2014 ACR/ARHP Annual Meeting
High-Protein Diet (Atkins Diet) and Uric Acid Response
Na Lu¹, Iris Shai², Yuqing Zhang¹, Gary Curhan³ and Hyon K. Choi⁴, ¹Boston University School of Medicine, Boston, MA, ²Harvard School of Public Health, Boston, MA, ³German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose The conventional low-purine dietary approach to gout offers limited efficacy, palatability, and sustainability, and promotes increased consumption of refined carbohydrates and saturated fat that…
Abstract Number: 167 • 2014 ACR/ARHP Annual Meeting
Target Serum Urate: Do Patients Know Their Goal?
Brian W. Coburn¹, Kayli A. Bendlin², Harlan Sayles¹, Kathryn S. Hentzen³, Michaela M. Hrdy³ and Ted R. Mikuls¹, ¹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²Pharmacy, Omaha VA Medical Center, Omaha, NE, ³Omaha VA Medical Center, Omaha, NE
Background/Purpose: Treat-to-target approaches are used to achieve therapeutic goals in conditions such as diabetes and rheumatoid arthritis. This strategy has also been widely endorsed in…

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