Abstract Number: 1355 • 2018 ACR/ARHP Annual Meeting
Asymptomatic Hyperuricemia Is Associated with Increased Prevalence of Symptomatic Knee Osteoarthritis: Data from Third National Health and Nutrition Examination Survey
Background/Purpose: Inflammation plays a pathogenetic role in OA, and catabolic cytokines including IL-1β potentiate joint space narrowing. Elevated serum urate (sUA) levels promote crystal-induced stimulation…Abstract Number: 1744 • 2018 ACR/ARHP Annual Meeting
Prognostic Value of Right Heart Involvement in Systemic Sclerosis:Not Only Pulmonary Arterial Hypertension
Background/Purpose: In SSc, cardiac dysfunction is associated with poor prognosis. Right ventricular involvement is frequently secondary to PAH. Echocardiography is the routine imaging tool to…Abstract Number: 1908 • 2018 ACR/ARHP Annual Meeting
Bariatric Surgery Does Not Affect the Incidence of Rheumatoid Arthritis in Obese Subjects
Background/Purpose: Obesity is among the risk factors for rheumatoid arthritis (RA). Bariatric surgery is an effective treatment to achieve weight loss and to prevent obesity-related…Abstract Number: 1950 • 2018 ACR/ARHP Annual Meeting
Self-Reported Depression and Anxiety Among US Adults Aged 18-44 Years with Arthritis, National Health Interview Survey 2014-2016
Background/Purpose: Depression and anxiety are frequent comorbid conditions among adults with arthritis, and are associated with poorer quality of life, reduced adherence and efficacy of…Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…Abstract Number: 2131 • 2018 ACR/ARHP Annual Meeting
Prevalence of Systemic Lupus Erythematosus (SLE) and Associated Comorbidities in the 2011-2015 Medicare Population
Background/Purpose: Prevalence of systemic lupus erythematosus (SLE) has been estimated in different US regions. An estimate based on the 2005 US population showed SLE affecting…Abstract Number: 2204 • 2018 ACR/ARHP Annual Meeting
Clinical Utility of a Multi-Energy Spectral CT in Crystal Arthritis
Background/Purpose: The gold standard for the diagnosis of crystal-related arthritis requires aspiration and visualization of crystals from synovial fluid or tophus material. However, crystal identification…Abstract Number: 2218 • 2018 ACR/ARHP Annual Meeting
Use of Anakinra in Hospitalized Patients with Acute Crystalline Arthritis
Background/Purpose: Medically complex individuals may have contraindications to standard therapies for acute arthritis secondary to gout or calcium pyrophosphate disease (CPPD). Observational studies have demonstrated…Abstract Number: 2219 • 2018 ACR/ARHP Annual Meeting
Safety, Pharmacokinetics and Pharmacodynamics of NC-2500, a Novel Xanthine Oxidoreductase Inhibitor, in Healthy Volunteers
Background/Purpose: Gout flare due to rapid urate reduction after initiating urate-lowering therapy (ULT) is one of the major issues in the therapy. International guidelines recommend…Abstract Number: 2223 • 2018 ACR/ARHP Annual Meeting
Proton Pump Inhibitors and Risk of Calcium Pyrophosphate Deposition (CPPD) in a Population-Based Study
Background/Purpose: There are no therapies available that specifically target CPPD, with treatment limited to symptomatic management. Hypomagnesemia is a recognized risk factor for CPPD, and…Abstract Number: 2229 • 2018 ACR/ARHP Annual Meeting
Can We Predict Inadequate Response to Allopurinol Dose Escalation? Analysis of a Randomized Controlled Trial
Background/Purpose: The two most common causes of inadequate serum urate (SU) lowering with allopurinol are low adherence and under-dosing. Those who are adherent, but do…Abstract Number: 2238 • 2018 ACR/ARHP Annual Meeting
Non-Coding Urate-Associated Variants Function in a Conserved Lincrna Regulatory Domain That Alters MAF transcription
Background/Purpose: Genome-wide association studies (GWAS) have revealed that the large majority of disease-associated single nucleotide polymorphisms (SNPs) are located in the non-coding regions of the…Abstract Number: 2245 • 2018 ACR/ARHP Annual Meeting
Lubricin/Proteoglycan 4 (PRG4) Inhibits NLRP3 Inflammasome Assembly in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including…Abstract Number: 2250 • 2018 ACR/ARHP Annual Meeting
Mitigation of Inflammation Induced By Monosodium Urate Crystals in Mice By Treatment with Svp-Rapamycin
Background/Purpose: Initiation of urate-lowering therapies is typically associated with an increase in gout flares due to mobilization of pro-inflammatory urate crystals. SEL-212 is a novel…Abstract Number: 2252 • 2018 ACR/ARHP Annual Meeting
Serum Urate Ant Its Clearance in Patients with Chronic Kidney Disease Under Peritoneal Dialysis
Background/Purpose: Hyperuricemia and gout are common in patients with chronic kidney disease (CKD), some ultimately requiring replacement therapy. Serum urate (SU) levels appear to achieve…
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