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  • Abstract Number: 1910 • 2012 ACR/ARHP Annual Meeting

    Regulation of Microrna 223 Expression in a Gouty Arthritis

    Gianina Statache1, Ashleigh-Ann Rainey1, Seth Masters2, Andra Balanescu3, Iain B. McInnes4 and Mariola Kurowska-Stolarska5, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Immunology Research Centre, Trinity College Dublin, Dublin, United Kingdom, 3Internal Medicine and Rheumatology, University of Medicine and Pharmacy, Bucharest, Romania, 4University of Glasgow, Glasgow, United Kingdom, 5Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Gout is an inflammatory chronic disease caused by deposition of uric acid crystals in the joint and connective tissues causing pain and disability. Current…
  • Abstract Number: 1911 • 2012 ACR/ARHP Annual Meeting

    Efficacy and Safety of Canakinumab Vs Triamcinolone Acetonide in Patients with Gouty Arthritis Unable to Use Nonsteroidal Anti-Inflammatory Drugs and Colchicine, and On Stable Urate Lowering Therapy (ULT) or Unable to Use ULT

    T. Bardin1, A. So2, R. Alten3, M. Bloch4, M. R. John5, G. Krammer5, J. M. Nebesky5, A. Tao6 and N. Schlesinger7, 1Service de Rhumatologie, Hôpital Lariboisière, Paris, France, 2Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, 3Charité Univ Medicine, Berlin, Germany, 4Holdsworth House Medical Practice, Sydney, Australia, 5Novartis Pharma AG, Basel, Switzerland, 6Novartis Pharmaceuticals Corporation, East Hanover, NJ, 7UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Background/Purpose: The primary treatment goals for gouty arthritis (GA) are rapid relief of pain and inflammation during acute attacks, and long-term hyperuricemia management. A post-hoc…
  • Abstract Number: 1912 • 2012 ACR/ARHP Annual Meeting

    Colchicine, As Assessed by Target Joint Pain Scores, Is Effective At 16 Hours in Patients with Acute Gout Flares

    Suman Wason1, Thomas Lauterio1, Steve Crockett1 and Matthew W. Davis2, 1Clinical Development, URL Pharma, Philadelphia, PA, 2Clinical Pharmacology, URL Pharma, Philadelphia, PA

    Background/Purpose: The management of patients with gout remains suboptimal, leading to increasing frequency and severity of recurrent flares that eventually lead to joint destruction and…
  • Abstract Number: 1913 • 2012 ACR/ARHP Annual Meeting

    Complete Tophus Response in Patients with Chronic Gout Initiating Pegloticase Treatment

    Michael A. Becker1, Neil J. Gonter2, Janet E. Pope3, Raymond L. Malamet4 and Herbert S. B. Baraf5, 1Medicine, University of Chicago, Chicago, IL, 2Rheumatology Associates of North Jersey, Teaneck, NJ, 3Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, 4Global Medical Affairs, Savient Pharmaceuticals, Inc., Bridgewater, NJ, 5Arthritis & Rheumatism Associates, Wheaton, MD

    Background/Purpose: Pegloticase, a recombinant modified mammalian uricase that acts via enzymatic degradation of uric acid to allantoin, is approved in the US for the treatment…
  • Abstract Number: 1914 • 2012 ACR/ARHP Annual Meeting

    The Diagnosis and Management of Gout in 2012: Survey of US and Canadian Rheumatologists

    John J. Cush1 and Robert T. Keenan2, 1Baylor Research Institute, Dallas, TX, 2Rheumatology, Duke University, Durham, NC

    Background/Purpose: The introduction of novel treatment modalities for gout has escalated interest and education on this topic.  Although gout is the most common inflammatory arthropathy…
  • Abstract Number: 1915 • 2012 ACR/ARHP Annual Meeting

    Elevated Serum Homocysteine Levels Were Related Not with Serum Uric Acid Levels but with Decreased Renal Function in Chronic Gouty Patients

    Sang Tae Choi1, Jung-Soo Song1, Jin Su Kim2, Eun-Jin Kang3, Kwang-Hoon Lee4 and You-Jung Ha5, 1Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, 2Chung-Ang University College of Medicine, Seoul, South Korea, 3Rheumatology, Busan Medical Center, Busan, South Korea, 4Dongguk University Ilsan Hospital, Goyang, South Korea, 5Kwandong University college of Medicine, Goyang, South Korea

    Background/Purpose: Hyperhomocysteinemia, which is related with cardiovascular diseases and metabolic syndrome, is regarded as one of the important factors in endothelial cell damage processes. It…
  • Abstract Number: 1916 • 2012 ACR/ARHP Annual Meeting

    Serum Uric Acid As a Biomarker for Mitigation of Infusion Reactions in Patients Treated with Pegloticase for Refractory Chronic Gout

    Herbert S. B. Baraf1, Robert A. Yood2, John S. Sundy3, Faith D. Ottery4 and Michael A. Becker5, 1Arthritis & Rheumatism Associates, Wheaton, MD, 2Reliant Medical Group, Worcester, MA, 3Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, 4Medical Affairs, Savient Pharmaceuticals, Inc., East Brunswick, NJ, 5Medicine, University of Chicago, Chicago, IL

    Background/Purpose: Using data pooled from the randomized, placebo-controlled trials (RCTs) of pegloticase, post-hoc analyses of urate-lowering, antibody titers and the patterns of infusion-related reactions (IRs)…
  • Abstract Number: 1812 • 2012 ACR/ARHP Annual Meeting

    A Retrospective Evaluation of the Clinical and Economic Implications of Gout in Nursing Home Residents in Hawaii Treated with Allopurinol

    Joy Higa1, Gregory Reardon2 and Gregory Tong3, 1Long Term Care Research Center, Kaneohe, HI, 2Informagenics, LLC, Worthington, OH, 3Takeda Pharmaceuticals America, Inc., Deerfield, IL

    Background/Purpose: We describe patient characteristics, serum uric acid (sUA) levels while on allopurinol, and activities of daily living (ADL) in nursing home residents with gout.…
  • Abstract Number: 1813 • 2012 ACR/ARHP Annual Meeting

    Accuracy of Veterans Affairs Database for Gout-Related Health Care Utilization

    Jasvinder A. Singh, Department of Medicine, University of Alabama, Tuscaloosa, AL

    Background/Purpose: Gout outcome studies have used administrative and claims databases. It is unknown whether administrative-derived data are accurate for gout-related utilization.  The goal of the…
  • Abstract Number: 1814 • 2012 ACR/ARHP Annual Meeting

    Comparing Clinical Characteristics and Comorbidities of Gout Patients Treated with Allopurinol or Febuxostat

    Michael A. Becker1, Xiangyang Ye2, Kasem S. Akhras3, Rima H. Tawk4, Sudhir Unni2, Jason Young2 and Carl V. Asche5, 1Medicine, University of Chicago, Chicago, IL, 2University of Utah College of Pharmacy, Salt Lake City, UT, 3Global Outcomes Research, Takeda Pharmaceuticals International, Inc., Deerfield, IL, 4Center for pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL, 5Center for Outcomes Research, University of Illinois College of Medicine at Peoria, Peoria, IL

    Background/Purpose: Gout is a common acute and potentially progressive disease affecting approximately 8 million Americans. Hyperuricemia (serum urate levels [sUA] >6.8mg/dL) is a major pathogenic…
  • Abstract Number: 1815 • 2012 ACR/ARHP Annual Meeting

    Factors Associated with a Prolonged Hospital Length of Stay for Patients with Acute Gout

    Rebecca Sharim1, Meghan Musselman2 and Marissa Blum3, 1Department of Medicine, Temple University Hospital, Philadelphia, PA, 2Temple University School of Medicine, Philadelphia, PA, 3Medicine/Rheumatology, Temple University School of Medicine, Philadelphia, PA

    Background/Purpose: Management of gout in the hospital setting has been poor.  This study aimed to describe patient characteristics and the treatment patterns of acute gout…
  • Abstract Number: 1816 • 2012 ACR/ARHP Annual Meeting

    Relationship Between Race, Uric Acid Levels, Urate-Lowering Therapy and Resource Use in Patients with Gout

    Kim Coley1, Melissa Saul2 and Karen Pater1, 1Pharmacy & Therapeutics, University of Pittsburgh, Pittsburgh, PA, 2Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Gout is a chronic inflammatory disease caused by the deposition of monosodium urate crystals in joints and soft tissues. The overall prevalence is increasing…
  • Abstract Number: 1661 • 2012 ACR/ARHP Annual Meeting

    CCR1 Potentiates Gouty Inflammation Following Initial CXCR2-Dependent Neutrophil Recruitment to Sites of Monosodium Urate Crystal Deposition in Mice

    Robert P. Friday1, Terry K. Means2, Melissa Tai2, Christian D. Sadik2 and Andrew D. Luster3, 1Rheumatology, Massachusetts General Hospital, Boston, MA, 2Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, 3Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: During attacks of acute gouty arthritis, monosodium urate (MSU) crystals elicit a potent neutrophilic inflammatory response in the affected joint, causing exquisite pain and…
  • Abstract Number: 1628 • 2012 ACR/ARHP Annual Meeting

    Epistatic Interaction Between Solute Carrier 2A9 Genotype and Sugar-Sweetened Beverage Consumption in the Determination of Gout Risk

    Tony R. Merriman1, Nicola Dalbeth2, Peter J. Gow3, Andrew Harrison4, John Highton5, Peter B. B. Jones6, Lisa K. Stamp7, Murray Cadzow8, Marilyn E. Merriman1, Ruth Topless1, Michael A. Black8, Amanda Phipps-Green1 and Caitlin M. Batt8, 1Department of Biochemistry, University of Otago, Dunedin, New Zealand, 2Medicine, University of Auckland, Auckland, New Zealand, 3Rheumatology Dept, Middlemore Hospital, Auckland, New Zealand, 4Rheumatology Unit, Hutt Hospital, Lower Hutt, New Zealand, 5Dept of Medicine, Univ of Otago Med Sch, Dunedin, New Zealand, 6Medicine, Waikato Clinical School, Waikato Hospital, Hamilton, New Zealand, 7Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 8University of Otago, Dunedin, New Zealand

    Background/Purpose: Consumption of drinks sweetened with sugar or high fructose corn syrup increases both serum urate levels and the risk for gout. SLC2A9 encodes a…
  • Abstract Number: 1629 • 2012 ACR/ARHP Annual Meeting

    Microarray Analysis of Acute and Intercritical Gout

    Alicia Rodriguez-Pla1, Lynda Bennett1, Kathryn H. Dao2, Edwardo Delgado3, Typhanie Maurouard1, M. Virginia Pascual4 and John J. Cush5, 1Baylor Healthcare System, Baylor Institute for Immunology Research, Dallas, TX, 2Rheumatology, Baylor Research Institute, Dallas, TX, 3Arthritis Care and Research Center, Dallas, TX, 4Baylor Institute for Immunology Research, Dallas, TX, 5Baylor Research Institute, Dallas, TX

    Background/Purpose: We aimed to identify the immune mechanism underlying gouty inflammation using microarrays analysis and modular gene expression signatures.  Methods: Whole blood along with clinical…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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