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Abstract Number: 2350 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Febuxostat in 55 Gouty Patients with Stage 4/5 Chronic Kidney Disease: Results from a Retrospective Multicenter Study
Pierre-Antoine Juge¹, Marie-Elise Truchetet², Sébastien Ottaviani³, Cécile Vigneau⁴, Clotilde Loustau⁵, Divi Cornec⁶, Tristan Pascart⁷, Emilie Cornec-Legall⁸, Marine Florien⁹, Florian Bailly¹⁰, Thierry Schaeverbeke⁵, Alain Saraux¹¹, Philippe Dieude¹², Rene-Marc Flipo¹³, Georges Jean-Baptiste¹⁴, Pascal Richette¹⁵, Frederic Lioté¹⁶, Thomas Bardin^17,18, Gerard H. Chales¹⁹ and Hang-Korng Ea²⁰, ¹Rheumatology Department, Centre de Viggo Petersen, Lariboisère Hospital, Paris, France, ²Rheumatology, Pellegrin Hospital, Bordeaux, France, ³Hopital Lariboisière, Paris, France, ⁴Nephrology, Rennes University Hospital, Rennes, France, ⁵Rheumatology Department, Bordeaux Hospital, Bordeaux, France, ⁶Department of rheumatology, Brest Occidentale University, Brest, France, ⁷Rheumatology, Saint-Philibert Hospital, Lille, France, ⁸Nephrology Departement, Brest Hospital, Brest, France, ⁹Rheumatology Department, Pierre-Zobda-Quitman La Meynard, Fort-de-France, France, ¹⁰Rheumatology Department, La Pitié-Salpétrière Hospital, Paris, France, ¹¹Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹²Rheumatology, Bichat Claude-bernard, Universitary Hospital, APHP, Paris, France, ¹³Rheumatology, University Hospital, Lille, France, ¹⁴Rheumatology and Internal Medicine, Zobda Quitman Hospital, Fort-de-France, Martinique, ¹⁵Université Paris Diderot, UFR médicale, Paris, France; APHP Hôpital Lariboisière, Fédération de Rhumatologie and Inserm U1132, Hôpital Lariboisière, Paris, France, ¹⁶Rheumatology Department; Inserm UMR-S606; Paris-Diderot University, hôpital Lariboisiere, Paris, France, ¹⁷Service de Rhumatologie, Hôpital Lariboisière, Paris, France, ¹⁸Rhumatology Departement, Hôpital Lariboisière, Paris, France, ¹⁹CHU RENNES, Rennes, France, ²⁰INSERM UMR1132, Paris Diderot University, Paris, France
Background/Purpose: Although allopurinol is the first urate lowering therapy (ULT), its limited dosage in gouty patients with stage 4 or 5 chronic kidney disease (CKD…
Abstract Number: 2351 • 2015 ACR/ARHP Annual Meeting
A Study to Evaluate the Pharmacodynamics, Pharmacokinetics and Safety of Arhalofenate in Combination with Febuxostat When Treating Hyperuricemia Associated with Gout
Alexandra Steinberg, Yun-Jung Choi, Robert Martin, Charles McWherter and Pol Boudes, Cymabay Therapeutics, Newark, CA
Background/Purpose: Arhalofenate is a novel Urate-Lowering Anti-Flare Therapy (ULAFT) for the treatment of gout. It lowers serum uric acid (sUA) by blocking URAT1, a tubular…
Abstract Number: 2352 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety in Patients with Tophaceous Gout Receiving Lesinurad and Febuxostat Combination Therapy: Interim Analysis of an Extension Study
Nicola Dalbeth¹, Graeme Jones², Robert Terkeltaub³, Dinesh Khanna⁴, Jeff Kopicko⁵, Scott Adler⁶, Nihar Bhakta⁵, Maple Fung⁵, Chris Storgard⁵, Scott Baumgartner⁵ and Fernando Perez-Ruiz⁷, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Medicine-Rheumatology, University of California, San Diego, La Jolla, CA, ⁴Div of Rheumatology, University of Michigan, Ann Arbor, MI, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶AstraZeneca Pharmaceuticals, Wilmington, DE, ⁷Servicio de Reumatologia, Hospital Universitario Cruces, Baracaldo, Spain
Background/Purpose: In the randomized, double-blind, placebo-controlled, Phase III CRYSTAL trial, more patients taking lesinurad 200 mg (LESU200) or 400 mg (LESU400), in combination with febuxostat…
Abstract Number: 2354 • 2015 ACR/ARHP Annual Meeting
The Safety and Efficacy of Lower Serum Urate Levels: A Pooled Analysis of Gout Subjects Receiving Lesinurad and Xanthine Oxidase Inhibitors
Robert Terkeltaub¹, Fernando Perez-Ruiz^2,3,4, Jeff Kopicko⁵, Maple Fung⁵, Scott Adler⁶, Chris Storgard⁷, Scott Baumgartner⁵ and Nicola Dalbeth⁸, ¹Medicine-Rheumatology, University of California, San Diego, La Jolla, CA, ²Rheumatology Division, Hospital Universitario Cruces, Barakaldo, Spain, ³BioCruces Health Research Institute, Baracaldo, Spain, ⁴Servicio de Reumatologia, Hospital De Cruces, Baracaldo, Spain, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶AstraZeneca Pharmaceuticals, Wilmington, DE, ⁷4939 Directors Place, Ardea Biosciences, Inc., San Diego, CA, ⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Previous studies have shown that long-term urate-lowering therapy (ULT) is required for improvements in gout flare frequency and tophi reduction, and that lower serum…
Abstract Number: 2356 • 2015 ACR/ARHP Annual Meeting
Major Cardiovascular Events in Gout Patients with Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating on Allopurinol or Febuxostat (Uloric)
JoAnne Foody¹, Robin Turpin², Beni Tidwell³ and Kathy Schulman⁴, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Medical Affairs, Takeda Pharmaceuticals International, Deerfield, IL, ³ORS, Shrewsbury, MA, ⁴Outcomes Research Solutions, Inc., Waltham, MA
Background/Purpose: Xanthine oxidase inhibitors (XOI) reduce both urate levels and oxidative stress in the vasculature, both of which are cardiovascular disease (CVD) risk factors. However,…
Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting
Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE
Hanna Kim¹, Yin Liu², Adriana Almeida de Jesus¹, Robert Wesley³, Yan Huang¹, Gina A. Montealegre Sanchez¹, Dawn C. Chapelle¹, Wanxia L. Tsai⁴, Massimo G. Gadina⁴, Frederick W. Miller⁵, Sarfaraz Hasni⁶, Adeline Vanderver⁷, Lisa G Rider⁵ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ²Scientific Review Branch, NIAMS, NIH, Bethesda, MD, ³Clinical Center, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁵Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁷Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis…
Abstract Number: 3078 • 2015 ACR/ARHP Annual Meeting
ABCG2 rs2231142 predicts Poor Response to Allopurinol in Patients with Gout
Lisa K. Stamp¹, Mary Wallace², Tony R. Merriman³, Amanda Phipps-Green⁴, Ruth Topless^4,5, Jill Drake⁶, Paul Tan⁷, Nicola Dalbeth⁸ and Rebecca Roberts⁴, ¹Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²Surgical Sciences, University of Otago, Dunedin, New Zealand, ³Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ⁴University of Otago, Dunedin, New Zealand, ⁵Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁶Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand, ⁷University of Auckland, Auckland, New Zealand, ⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Many patients fail to reach target serum urate (SU) on allopurinol. Although the most common causes of inadequate response are non-adherence and low dosing…
Abstract Number: 3165 • 2015 ACR/ARHP Annual Meeting
Do Omega-3 Fatty Acids Reduce Risk of Recurrent Gout Attacks?
MaryAnn Zhang¹, Yuqing Zhang², Robert Terkeltaub³, Clara Chen⁴ and Tuhina Neogi², ¹Internal Medicine, Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ⁴Boston University School of Public Health, Boston, MA
Background/Purpose: Current guidelines for gout management, based in part on epidemiologic data for development of incident gout, recommend limiting intake of high-purine fish. However,…
Abstract Number: 3166 • 2015 ACR/ARHP Annual Meeting
Epistatic Interaction of Functional Inflammasome Genetic Variants in Determining the Risk of Gout
Tony R. Merriman¹, Lisa K. Stamp², Nicola Dalbeth³, Ruth Topless⁴, Richard Day⁵, Diluk Kannangara⁵, Kenneth Williams⁵, Matthijs Janssen⁶, Tim Jansen⁷, Leo A. Joosten⁸, Timothy Radstake⁹, Philip L. Riches¹⁰, Anne-Kathrin Tausche¹¹, Frederic Lioté¹², Alex So^13,14 and Cushla McKinney⁴, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand, ⁴University of Otago, Dunedin, New Zealand, ⁵University of New South Wales, Sydney, Australia, ⁶Rheumatology Dept, Ziekenhuis Rijnstate, Arnhem, Netherlands, ⁷P O Box 581, Haarlem, Netherlands, ⁸Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁹Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁰Centre for Genomic and Experimental Medicine, Western General Hospital, Edinburgh, United Kingdom, ¹¹Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ¹²Rheumatology Department; Inserm UMR-S606; Paris-Diderot University, hôpital Lariboisiere, Paris, France, ¹³Service De Rhumatologie, CHUV, Lausanne, Switzerland, ¹⁴Department of Rheumatology, CHUV, Lausanne, Switzerland
Background/Purpose: The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic individuals. Activation…
Abstract Number: 3167 • 2015 ACR/ARHP Annual Meeting
Association of the Apolipoprotein A1-C3-A4 Gene Cluster with the Risk of Gout: Evidence for a Causal Role in Gout
Tony R. Merriman¹, Amanda Phipps-Green², Ruth Topless², Malcolm D. Smith³, Catherine Hill⁴, Susan Lester⁴, Maureen Rischmueller⁵, Matthijs Janssen⁶, Tim Jansen⁷, Leo A. Joosten⁸, Timothy Radstake⁹, Philip L. Riches¹⁰, Anne-Kathrin Tausche¹¹, Frederic Lioté¹², Alex So^13,14, Andre M. van Rij², Gregory T. Jones¹⁵, Sally McCormick¹⁶, Andrew Harrison², Lisa K. Stamp¹⁷, Nicola Dalbeth¹⁸ and Humaira Rasheed¹⁶, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Rheumatology, Repatriation General Hospital, Adelaide, Australia, ⁴Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia, ⁵Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ⁶Rheumatology Dept, Ziekenhuis Rijnstate, Arnhem, Netherlands, ⁷P O Box 581, Haarlem, Netherlands, ⁸Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁹Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁰Centre for Genomic and Experimental Medicine, Western General Hospital, Edinburgh, United Kingdom, ¹¹Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ¹²Rheumatology Department; Inserm UMR-S606; Paris-Diderot University, hôpital Lariboisiere, Paris, France, ¹³Service De Rhumatologie, CHUV, Lausanne, Switzerland, ¹⁴Department of Rheumatology, CHUV, Lausanne, Switzerland, ¹⁵Surgery, University of Otago, Dunedin, New Zealand, ¹⁶Department of Biochemistry, University of Otago, Dunedin, New Zealand, ¹⁷Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ¹⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Gout is caused by an inflammatory response to monosodium urate (MSU) crystals and is associated with elevated triglyceride and very low density lipoprotein levels.…
Abstract Number: 3168 • 2015 ACR/ARHP Annual Meeting
How Strong Cardiovascular Risk Factor Are Gouty Tophi?
Rada Gancheva¹, Atanas Kundurdjiev², Mariana Ivanova¹, Todor Kundurzhiev³ and Zlatimir Kolarov⁴, ¹University Hospital "St. Iv. Rilski", Clinic of Rheumatology, Sofia, Bulgaria, ²University Hospital "Alexandrovska", Clinic of Nephrology, Sofia, Bulgaria, ³Medical University, Faculty of Public Health, Sofia, Bulgaria, ⁴Clinic of Rheumatology, University Hospital "St. Iv. Rilski", Clinic of Rheumatology, Sofia, Bulgaria
Background/Purpose: We have not found a study determining cardiovascular (CV) risk in the different stages of gout. This led us to use a complex multimodal…
Abstract Number: 3169 • 2015 ACR/ARHP Annual Meeting
Diagnostic Value of Ultrasound for the Diagnosis of Gout in a Prospective Cross-Sectional Study
Alexis Ogdie-Beatty¹, William J. Taylor², Tuhina Neogi³, Jaap Fransen⁴, Tim Jansen⁵, H. Ralph Schumacher Jr.⁶ and Nicola Dalbeth⁷, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Department of Medicine, University of Otago Wellington, Wellington, New Zealand, ³Clinical Epidemiology, BUSM, Boston, MA, ⁴Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, ⁵P O Box 581, Haarlem, Netherlands, ⁶Medicine, Rheumatology, U Penn & VA Med Ctr, Philadelphia, PA, ⁷Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Musculoskeletal ultrasound (US) is a non-invasive option for diagnosing gout. However, little is known about the test characteristics of US for the diagnosis of…
Abstract Number: 2958 • 2014 ACR/ARHP Annual Meeting
Polygenic Analysis of Transport, Metabolism and Immune Related Genomic Compartments in Serum Urate and Gout
Eli A. Stahl¹, Tony R. Merriman², Amanda Dobbyn³, David B. Mount⁴, Peter Kraft⁵ and Hyon K. Choi⁶, ¹Mt Sinai School of Medicine, New York City, NY, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Renal Division, Brigham and Women's Hospital, Boston, MA, ⁵Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁶Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genome wide association studies (GWAS) have identified loci associated with complex traits, and the current challenge is to glean biological insights from these findings.…
Abstract Number: 2959 • 2014 ACR/ARHP Annual Meeting
Twenty-Eight Loci That Influence Serum Urate Levels: Analysis of Association with Gout
Tony R. Merriman¹, Marilyn E. Merriman¹, Ruth Topless¹, Sara Altaf², Grant Montgomery³, Christopher Franklin⁴, Gregory T. Jones⁵, Andre M. van Rij², Douglas HN White⁶, Lisa K. Stamp⁷, Nicola Dalbeth⁸ and Amanda Phipps-Green¹, ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Queensland Institute of Medical Research, Brisbane, Australia, ⁴University of Auckland, Auckland, New Zealand, ⁵Surgery, University of Otago, Dunedin, New Zealand, ⁶Waikato Clinical School, Waikato Hospital, Hamilton, New Zealand, ⁷University of Otago, Christchurch, New Zealand, ⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Twenty-eight genetic loci are associated with serum urate levels in Europeans. Ten are established, with a further 18 of weaker effect more recently detected.…
Abstract Number: 2960 • 2014 ACR/ARHP Annual Meeting
Urate Genetic Loci and the Risk of Incident Cases of Confirmed Gout in Two Prospective Cohort Studies
Hyon K. Choi¹, Gary Curhan², Ying Bao³, Eli A. Stahl⁴, Peter Kraft⁵, Robert M. Plenge⁶, Yuqing Zhang¹ and Tony R. Merriman⁷, ¹Boston University School of Medicine, Boston, MA, ²German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ³Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Department of Biochemistry, University of Otago, Dunedin, New Zealand
Background: Gout is the most common inflammatory arthritis and is caused by hyperuricemia. The Global Urate Genetics Consortium (GUGC) has recently validated 28 SNP associations…

Efficacy and Safety of Febuxostat in 55 Gouty Patients with Stage 4/5 Chronic Kidney Disease: Results from a Retrospective Multicenter Study

A Study to Evaluate the Pharmacodynamics, Pharmacokinetics and Safety of Arhalofenate in Combination with Febuxostat When Treating Hyperuricemia Associated with Gout

Efficacy and Safety in Patients with Tophaceous Gout Receiving Lesinurad and Febuxostat Combination Therapy: Interim Analysis of an Extension Study

The Safety and Efficacy of Lower Serum Urate Levels: A Pooled Analysis of Gout Subjects Receiving Lesinurad and Xanthine Oxidase Inhibitors

Major Cardiovascular Events in Gout Patients with Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating on Allopurinol or Febuxostat (Uloric)

Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE

ABCG2 rs2231142 predicts Poor Response to Allopurinol in Patients with Gout

Do Omega-3 Fatty Acids Reduce Risk of Recurrent Gout Attacks?

Epistatic Interaction of Functional Inflammasome Genetic Variants in Determining the Risk of Gout

Association of the Apolipoprotein A1-C3-A4 Gene Cluster with the Risk of Gout: Evidence for a Causal Role in Gout

How Strong Cardiovascular Risk Factor Are Gouty Tophi?

Diagnostic Value of Ultrasound for the Diagnosis of Gout in a Prospective Cross-Sectional Study

Polygenic Analysis of Transport, Metabolism and Immune Related Genomic Compartments in Serum Urate and Gout

Twenty-Eight Loci That Influence Serum Urate Levels: Analysis of Association with Gout

Urate Genetic Loci and the Risk of Incident Cases of Confirmed Gout in Two Prospective Cohort Studies

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