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Abstract Number: 3128 • 2016 ACR/ARHP Annual Meeting
A Longitudinal Dual Energy Computed Tomography Study on the Effect of Urate Lowering Therapies on the Reduction of Tophus Burden in Patients with Chronic Gout
Hanna Ellmann¹, Sara Bayat¹, Isabelle Oliveira¹, Matthias Englbrecht^2,3, Elizabeth Araujo⁴, Alexander Cavallaro⁵, Silvana Mendonca⁶, Michael Lell⁵, Bernhard Manger², Georg Schett⁷ and Juergen Rech⁷, ¹Medical Department 3, Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Medical Department 3; Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Department of Radiology, University of Erlangen-Nuremberg, Department of Radiology, Erlangen, Germany, ⁶Americas Medical City, Rio de Janeiro, Brazil, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Dual energy computed tomography (DECT) allows reliably detecting and quantifying tophus burden in patients with chronic gout. Longitudinal studies on the effect of uric…
Abstract Number: 3130 • 2016 ACR/ARHP Annual Meeting
Development and Pilot Testing of an Online Educational Tool for Gout Patients — Mygoutcare®
Puja Khanna¹, Aaron Rankin², Veronica Berrocal³, Larry An⁴ and Dinesh Khanna⁵, ¹Rheumatology, University of Michigan, Ann Arbor, MI, ²Medicine Rheumatology, University of Michigan, Ann Arbor, MI, ³Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Medicine, University of Michigan, Ann Arbor, MI, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Recent management guidelines for gout have identified several unmet educational needs in gout patients. Qualitative studies have documented the paucity of patient-focused materials which…
Abstract Number: 3139 • 2016 ACR/ARHP Annual Meeting
Breaking the Cycle: Analyzing Preventable Hospital Admissions Due to Gout
Pieusha Malhotra¹, Nikky Keer² and Robert Yood³, ¹Internal Medicine, Department of Medicine, Division of Rheumatic Diseases and Musculoskeletal Medicine, Saint Vincent Hospital, Worcester, MA, ²Internal medicine, Department of Medicine, Division of Rheumatic Diseases and Musculoskeletal Medicine, Saint Vincent Hospital, Worcester, MA, ³Department of rheumatology and musculoskeletal medicine, Department of Medicine, Division of Rheumatic Diseases and Musculoskeletal Medicine, Saint Vincent Hospital, Worcester, MA
Background/Purpose: Despite available effective treatment options and published guidelines for gout management, many patients suffer from recurrent gout attacks. Increases in gout prevalence and continued…
Abstract Number: 3140 • 2016 ACR/ARHP Annual Meeting
Assessment of American College of Rheumatology Gout Quality Measures at a University Practice Plan
Soo Choi¹, John FitzGerald¹, Robin Clarke² and Andrew Hackbarth³, ¹Rheumatology, UCLA, Los Angeles, CA, ²Faculty Practice Group, UCLA, Los Angeles, CA, ³UCLA, Los Angeles, CA
Background/Purpose: Gout is the most common chronic inflammatory arthritis. Gout prevalence has been rising over the past several decades, and gout is associated with significant…
Abstract Number: 3188 • 2016 ACR/ARHP Annual Meeting
Association of Gout with Risk of Advanced Chronic Kidney Disease
Austin Stack¹, Betina Blak², Michelle Johnson³, Victoria Parsons³, Andrew Maguire⁴, Alyssa B Klein⁵, John Ferguson⁶ and Robert Morlock⁷, ¹Nephrology, University Hospital Limerick & Health Research Institute,University of Limerick, Limerick, Ireland, ²AstraZeneca,, Luton, United Kingdom, ³Oxon Epidemiology Ltd, London, United Kingdom, ⁴Epidemiology, Oxon Epidemiology Ltd, London, United Kingdom, ⁵AstraZeneca, Gaithersburg, MD, ⁶Graduate Entry Medical School, University of Limerick, Limerick, Ireland, ⁷Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: It is speculated that gout is a risk factor for kidney disease progression. The aim of this study was to evaluate the association of…
Abstract Number: 3199 • 2016 ACR/ARHP Annual Meeting
Urate Crystal Deposition and Bone Erosion in Gout: Inside-out or Outside-in? a Dual Energy Computed Tomography Study
Patapong Towiwat¹, Anthony Doyle¹, Gregory Gamble², Paul Tan¹, Opetaia Aati², Anne Horne², Lisa K. Stamp³ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand
Background/Purpose: Imaging and pathology studies have shown that bone erosion is closely associated with monosodium urate (MSU) crystal deposition in tophaceous gout. It is currently…
Abstract Number: 22 • 2015 ACR/ARHP Annual Meeting
Expression of High Mobility Group Box 1 Protein and the Receptor for Advanced Glycation End Products in Primary Gouty Arthritis
Yu-Feng Qing¹, Quan-Bo Zhang², Shu-Yue Pan³ and Jingguo Zhou⁴, ¹Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nanchong, China, ²Department of geriatrics of the Affiliated Hospital of North Sichuan Medical College, Sichuan 637007, China, Nachong, China, ³Department of Rheumatology and Immunology of the Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nachong, China, ⁴Department of Rheumatology and Immunology, Affliated hospital of North Sichuan Medical College, Nanchong, China
Background/Purpose: To investigate the role of high mobility group box 1 protein (HMGB1) and the receptor for advanced glycation end products (RAGE) in the pathogenesis…
Abstract Number: 91 • 2015 ACR/ARHP Annual Meeting
Coevolution of a Uric Acid Transporter and Uricase: Implications for Gout
Philip K. Tan¹, Eric A. Gaucher² and Jeffrey N. Miner³, ¹Ardea Biosciences, San Diego, CA, ²Georgia Institute of Technology, Atlanta, GA, ³Discovery Biology, Ardea Biosciences, San Diego, CA
Background/Purpose: Gout is caused by chronic hyperuricemia, leading to uric acid deposition. Humans and apes have relatively high serum uric acid (sUA) levels due to…
Abstract Number: 116 • 2015 ACR/ARHP Annual Meeting
The Effect of the Formal Approval of Colchicine on Utilization of Emergency Department and Rheumatology Outpatient Services By Patients with Gout
Leah Krull^1,2, Erin Patton^3,4 and Harry D. Fischer^5,6, ¹Internal Medicine, Mount Sinai Beth Israel, New York, NY, ²Medicine, Mount Sinai Icahn School of Medicine, New York, NY, ³Rheumatology, Mount Sinai Icahn School of Medicine, New York, NY, ⁴Medicine/Rheumatology, Mount Sinai Beth Israel, New York, NY, ⁵Division of Rheumatology, Mount Sinai Beth Israel, New York, NY, ⁶Medicine/Rheumatology, Mount Sinai Icahn School of Medicine, New York, NY
Background/Purpose: Although colchicine has been used in the management of gout for decades, it had never undergone the formal approval process by the Food and…
Abstract Number: 121 • 2015 ACR/ARHP Annual Meeting
Serum Uric Acid Levels and Gout Flares in a US Managed Care Setting
Aki Shiozawa¹, Erin Buysman², Stephanie Korrer² and Hyon Choi³, ¹Global Outcomes and Epidemiology Research, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ²Health Economics and Outcomes Research, Optum, Eden Prairie, MN, ³Massachussetts General Hospital/Harvard Medical School, Boston, MA
Background/Purpose: Gout is a common chronic inflammatory condition due to hyperuricemia. Gout patients typically have the clinical manifestation of acute painful flare attacks. While the…
Abstract Number: 211 • 2015 ACR/ARHP Annual Meeting
The Epidemiology of Gout: Marked Increase in Incidence and Comorbidities over 20 Years
Mohanad Elfishawi¹, Nour Zleik¹, Zoran Kvrgic¹, Clement J. Michet Jr.², Cynthia S. Crowson³, Eric L. Matteson⁴ and Tim Bongartz¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Several studies have suggested that the prevalence of gout has increased over recent years. The majority of this data has been derived from insurance…
Abstract Number: 212 • 2015 ACR/ARHP Annual Meeting
Rising Incidence and Prevalence of Gout in the Canadian General Population
Sharan K. Rai¹, J Antonio Avina-Zubieta², Natalie McCormick³, Mary De Vera⁴, Kamran Shojania⁵, Eric C. Sayre⁶ and Hyon K. Choi⁷, ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁴Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Gout is increasingly becoming recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian general population-based data on the disease burden…
Abstract Number: 213 • 2015 ACR/ARHP Annual Meeting
A Method for Counting Monosodium Urate Crystals in the Synovial Fluid of Gout Patients
Paola Montagna, Renata Brizzolara, Carmela Ferrone, Stefano Soldano, Maurizio Cutolo and Marco A. Cimmino, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose: Gout is the most common form of arthritis, and its prevalence is increasing. The identification of monosodium urate (MSU) crystals in synovial fluid (SF)…
Abstract Number: 216 • 2015 ACR/ARHP Annual Meeting
Effects of Monosodium Urate Crystals on Mlo-Y4 Cell Viability; Is There a Role for Osteocytes in Erosive Gout?
Ashika Chhana¹, David Musson², Karen E. Callon³, Dorit Naot¹, Gregory Gamble³, Geraldine M. McCarthy^4,5, Jillian Cornish³ and Nicola Dalbeth³, ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand, ⁴University College Dublin, Dublin, Ireland, ⁵Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Imaging and histology studies have identified monosodium urate (MSU) crystals present in subchondral bone in erosive gout, suggesting that these crystals could interact with…
Abstract Number: 217 • 2015 ACR/ARHP Annual Meeting
Circulating Levels of Neo-Epitopes Reflecting Connective Tissue Turnover As Biomarkers of Gout and Frequent Gout Attacks in Men
Ana Valdes¹, Tina Manon-Jensen², Wendy Jenkins³, Anne Sofie Siebuhr⁴, Morten Asser Karsdal⁴, Sally Doherty⁵, Abhishek Abhishek³, Helen Richardson³, Weiya Zhang⁶, Michael Doherty⁷ and Anne C. Bay-Jensen⁸, ¹Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ²Antibody Research Unit, Nordic Bioscience, 2370, Denmark, ³Devision of Rheumatology, University of Nottingham, NG5 1PB, England, ⁴Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁵Division of ROD, University of Nottingham, Nottingham, United Kingdom, ⁶Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ⁷Academic Rheumatology, City Hospital, Nottingham, United Kingdom, ⁸Biomarkers and Research, Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Recurrent flares constitute the main clinical burden of gout. The neo-epitope blood-based biomarkers, C1M and C3M, measuring matrix metalloproteinases (MMP)-mediated connective tissue degradation, have previously…

A Longitudinal Dual Energy Computed Tomography Study on the Effect of Urate Lowering Therapies on the Reduction of Tophus Burden in Patients with Chronic Gout

Development and Pilot Testing of an Online Educational Tool for Gout Patients — Mygoutcare®

Breaking the Cycle: Analyzing Preventable Hospital Admissions Due to Gout

Assessment of American College of Rheumatology Gout Quality Measures at a University Practice Plan

Association of Gout with Risk of Advanced Chronic Kidney Disease

Urate Crystal Deposition and Bone Erosion in Gout: Inside-out or Outside-in? a Dual Energy Computed Tomography Study

Expression of High Mobility Group Box 1 Protein and the Receptor for Advanced Glycation End Products in Primary Gouty Arthritis

Coevolution of a Uric Acid Transporter and Uricase: Implications for Gout

The Effect of the Formal Approval of Colchicine on Utilization of Emergency Department and Rheumatology Outpatient Services By Patients with Gout

Serum Uric Acid Levels and Gout Flares in a US Managed Care Setting

The Epidemiology of Gout: Marked Increase in Incidence and Comorbidities over 20 Years

Rising Incidence and Prevalence of Gout in the Canadian General Population

A Method for Counting Monosodium Urate Crystals in the Synovial Fluid of Gout Patients

Effects of Monosodium Urate Crystals on Mlo-Y4 Cell Viability; Is There a Role for Osteocytes in Erosive Gout?

Circulating Levels of Neo-Epitopes Reflecting Connective Tissue Turnover As Biomarkers of Gout and Frequent Gout Attacks in Men

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