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Abstract Number: 2299 • 2016 ACR/ARHP Annual Meeting
Predictors of Mortality in People with Recent Onset of Gout: A Prospective Observational Study
Zoe Vincent¹, Gregory Gamble², Meaghan House², Julie Knight¹, Anne Horne², William J. Taylor³ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Otago, Wellington, New Zealand
Background/Purpose: Many studies have reported that gout is associated with increased risk of cardiovascular events and mortality. However, information regarding gout disease severity is limited…
Abstract Number: 2300 • 2016 ACR/ARHP Annual Meeting
Tophaceous Gout and the Risk of Mortality: A General Population-Based Study
Hyon K. Choi¹, Leo Lu², Sharan K. Rai^3,4 and Yuqing Zhang⁵, ¹Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Arthritis Research Canada, Vancouver, BC, Canada, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA
Tophaceous Gout and the Risk of Mortality: A General Population-Based Study Background/Purpose: A recent study based on data from a gout specialty clinic (N=706) found…
Abstract Number: 2301 • 2016 ACR/ARHP Annual Meeting
Gout and Subsequent Risk of Incident Erectile Dysfunction: A Population-Based Cohort Study from the United Kingdom
Alyshah Abdul Sultan¹, Christian Mallen², Richard Hayward¹, Sara Muller², Rebecca Whittle³, Matthew Hotston⁴ and Edward Roddy², ¹Research Institute of Primary Care & Health Sciences, Keele University, Keele, United Kingdom, ²Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ³Research Institute for Primary Care and Health Sciences, Keele University, Stoke-on-Trent, United Kingdom, ⁴Urology, Royal Cornwall Hospital, Truro, United Kingdom
Background/Purpose: Gout is the most prevalent inflammatory arthritis, affecting 2.4% of adults in the UK. Recently, a link has been suggested between gout and erectile…
Abstract Number: 2303 • 2016 ACR/ARHP Annual Meeting
Trends in Gout and Rheumatoid Arthritis Hospitalizations in Canada from 2000-2011
Sharan K. Rai^1,2, J. Antonio Avina-Zubieta^2,3, Natalie McCormick^2,4, Mary A. De Vera^2,5, Diane Lacaille^2,6, Eric C. Sayre² and Hyon K. Choi^7,8, ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁵Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁶Medicine, University of British Columbia, Vancouver, BC, Canada, ⁷Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁸Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: Gout and rheumatoid arthritis (RA) are the two most common forms of inflammatory arthritis worldwide. As hospitalizations for both conditions lead to substantial health…
Abstract Number: 2304 • 2016 ACR/ARHP Annual Meeting
Decreased Occurrence of Colon Cancer Among Gout Patients: Assessment By Physician Diagnosis and Colonoscopy
Anastasia Slobodnick^1,2, Svetlana Krasnokutsky Samuels³, Aaron Lehmann⁴, Robert Keenan⁵, Fritz Francois⁶ and Michael H. Pillinger^3,7, ¹Medicine/Rheumatology, NYU School of Medicine, New York, NY, ²Medicine/Rheumatology, VA New York Harbor Health Care System, NY Campus, New York, NY, ³VA New York Harbor Health Care System, New York, NY, ⁴Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁵Division of Rheumatology, Duke University, Durham, NC, ⁶Medicine/Gastroenterology, NYU School of Medicine, New York, NY, ⁷NYU School of Medicine, New York, NY
Background/Purpose: The relationship between gout and cancer remains unclear. Whereas some studies have reported possible anti-cancer benefits of uric acid and monosodium urate crystals, others…
Abstract Number: 2305 • 2016 ACR/ARHP Annual Meeting
Mapping the Topography of Gout Flares: Solutions for Flare Reporting in Gout Clinical Trials
Novell Teoh¹, Gregory Gamble², Anne Horne², William J. Taylor³, Kate Palmano⁴ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Otago, Wellington, New Zealand, ⁴Consultant Scientist, Waikato, New Zealand
Background/Purpose : Recurrent flares of inflammatory arthritis are the central clinical feature of gout. However, methods of gout flare reporting in research settings are inconsistent…
Abstract Number: 2306 • 2016 ACR/ARHP Annual Meeting
Improving Predictive Value of Gout Case Definitions in Electric Medical Records Utilizing Natural Language Processing: a Novel Informatics Approach
Sian Yik Lim¹, Sara R. Schoenfeld², Abhishek Chakrabortty³, Tianxi Cai³, Andrew Cagan⁴, Vivian Gainer⁵ and Hyon K. Choi⁶, ¹Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Department of Biostatistics, Harvard Medical School, Boston, MA, ⁴Research Computing, Partners HealthCare, Charlestown, MA, ⁵Partners HealthCare, Boston, MA, ⁶Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: To date, most of the models used to identify gout cases within large administrative databases have relied solely only on administrative billing codes. The…
Abstract Number: 3055 • 2016 ACR/ARHP Annual Meeting
Ultrasound Features of the First Metatarsophalangeal Joint in Gout and Asymptomatic Hyperuricaemia: Comparison with Normouricaemic Individuals
Sarah Stewart¹, Nicola Dalbeth^2,3, Alain Vandal⁴, Bruce Allen⁵, Rhian Miranda⁶ and Keith Rome⁷, ¹School of Podiatry, Auckland University of Technology, Auckland, New Zealand, ²Auckland District Health Board, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand, ⁴Counties Manukau District Health Board, Auckland, New Zealand, ⁵Horizon Radiology, Auckland, New Zealand, ⁶Auckland City Hospital Radiology, Auckland, New Zealand, ⁷School of Clinical Sceince, Health & Rehabilitation Research Institute, AUT University, Auckland, New Zealand
Background/Purpose: The first metatarsophalangeal joint (1MTPJ) is frequently affected in gout. This study aimed to identity ultrasound features of the 1MTPJ in people with gout…
Abstract Number: 3062 • 2016 ACR/ARHP Annual Meeting
Use of Script Concordance Testing to Evaluate the Efficacy of a Web-Based Module on Gout: Three Years of Experience
Bernadette C. Siaton¹, Elizabeth Clayton², Alexandra M. Kueider³ and Matthew Rietschel⁴, ¹Rheumatology, University of Maryland School of Medicine, Baltimore, MD, ²Edmund J. MacLaughlin, M.D., L.L.C., Easton, MD, ³Laboratory of Behavioral Neuroscience -Unit of Clinical and Translational Neuroscience, National Institute on Aging, Baltimore, MD, ⁴University of Maryland School of Nursing, Baltimore, MD
Background/Purpose: Despite the prevalence of musculoskeletal conditions, the majority of internal medicine trainees at the University of Maryland complete residency with little exposure to rheumatology…
Abstract Number: 3072 • 2016 ACR/ARHP Annual Meeting
Increased Platelet Reactivity in Gout: Relationship to Tophus Burden and Colchicine Use
Richard Conway¹, Claire-Louise Murphy², Anne Madigan³, Patricia Kavanagh⁴, Liz Geraghty³, Niamh Redmond⁵, Laura Helbert⁶, John J. Carey⁷, Eimear Dunne⁸, Dermot Kenny⁸ and Geraldine M. McCarthy⁹, ¹CARD Newman Research Fellow, University College Dublin, Dublin, Ireland, ²Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ³Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ⁴Rheumatology Department, Mater Public Hospital, Dublin 7, Ireland, ⁵UCD Clinical Research Centre, Dublin, Ireland, ⁶Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ⁷Rheumatology, Galway University Hospitals, Galway, Ireland, ⁸Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland, ⁹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland
Background/Purpose: Patients with gout have an increased risk of cardiovascular events. The presence of tophi is associated with enhanced cardiovascular risk. Increased platelet reactivity is…
Abstract Number: 3073 • 2016 ACR/ARHP Annual Meeting
Non-Additive Interaction of the Glucokinase Regulatory Protein and APOBEC1 Complementation Factor Loci with Alcohol Consumption to Influence the Risk of Gout
Humaira Rasheed¹, Lisa K. Stamp², Nicola Dalbeth³ and Tony R. Merriman⁴, ¹University of Engineering and Technology, Lahore, Pakistan, ²University of Otago, Christchurch, New Zealand, ³University of Auckland, Auckland, New Zealand, ⁴Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Genome-wide association studies (GWAS) have identified loci associated with serum urate levels and the risk of gout. Some of these loci interact in a…
Abstract Number: 3074 • 2016 ACR/ARHP Annual Meeting
Population-Specific Association Between ABCG2 Variants and Tophaceous Disease in People with Gout
Wendy He¹, Amanda Phipps-Green², Lisa K. Stamp³, Tony R. Merriman⁴ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Tophi contribute to musculoskeletal disability, joint damage and poor health-related quality of life in people with gout. The aim of this study was to…
Abstract Number: 3075 • 2016 ACR/ARHP Annual Meeting
Mitochondrial Genetic Variation, Copy Number and Susceptibility to Gout in the New Zealand Polynesian Population
Tony R. Merriman¹, James Boocock², Nicola Dalbeth³, Lisa K. Stamp⁴, Eli A. Stahl⁵, Hyon K. Choi⁶, Elizabeth Matisoo-Smith⁷ and Anna Gosling⁸, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Auckland, Auckland, New Zealand, ⁴University of Otago, Christchurch, New Zealand, ⁵Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Boston, MA, ⁶Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁷Anatomy, University of Otago, Dunedin, New Zealand, ⁸Biochemistry, University of Otago, Dunedin, New Zealand
Background/Purpose: Mitochondria play a central role in induction of an NLRP3 inflammatory response essential for gouty pathology. Mitochondria are in part self-encoding, possessing a 16.5…
Abstract Number: 3125 • 2016 ACR/ARHP Annual Meeting
Secular Trend of Premature Mortality in Gout: A Contrast from Rheumatoid Arthritis
Sharan K. Rai^1,2, Leo Lu³, Yuqing Zhang⁴ and Hyon K. Choi⁵, ¹Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Arthritis Research Canada, Vancouver, BC, Canada, ³Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Gout and rheumatoid arthritis (RA), the two most common inflammatory arthritides, are both associated with premature mortality. General population-based studies have found substantially reduced…
Abstract Number: 3127 • 2016 ACR/ARHP Annual Meeting
Ultrasound Evaluation of the Achilles Tendon in Tophaceous Gout: A Case-Control Study
Matthew Carroll¹, Nicola Dalbeth², Mark Boocock¹ and Keith Rome¹, ¹School of Clinical Sceince, Health & Rehabilitation Research Institute, AUT University, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand
Ultrasound Evaluation of the Achilles Tendon in Tophaceous Gout: A Case-Control Study Background/Purpose: Tendon involvement in the lower limbs in gout is frequent. Tophus deposition…

Predictors of Mortality in People with Recent Onset of Gout: A Prospective Observational Study

Tophaceous Gout and the Risk of Mortality: A General Population-Based Study

Gout and Subsequent Risk of Incident Erectile Dysfunction: A Population-Based Cohort Study from the United Kingdom

Trends in Gout and Rheumatoid Arthritis Hospitalizations in Canada from 2000-2011

Decreased Occurrence of Colon Cancer Among Gout Patients: Assessment By Physician Diagnosis and Colonoscopy

Mapping the Topography of Gout Flares: Solutions for Flare Reporting in Gout Clinical Trials

Improving Predictive Value of Gout Case Definitions in Electric Medical Records Utilizing Natural Language Processing: a Novel Informatics Approach

Ultrasound Features of the First Metatarsophalangeal Joint in Gout and Asymptomatic Hyperuricaemia: Comparison with Normouricaemic Individuals

Use of Script Concordance Testing to Evaluate the Efficacy of a Web-Based Module on Gout: Three Years of Experience

Increased Platelet Reactivity in Gout: Relationship to Tophus Burden and Colchicine Use

Non-Additive Interaction of the Glucokinase Regulatory Protein and APOBEC1 Complementation Factor Loci with Alcohol Consumption to Influence the Risk of Gout

Population-Specific Association Between ABCG2 Variants and Tophaceous Disease in People with Gout

Mitochondrial Genetic Variation, Copy Number and Susceptibility to Gout in the New Zealand Polynesian Population

Secular Trend of Premature Mortality in Gout: A Contrast from Rheumatoid Arthritis

Ultrasound Evaluation of the Achilles Tendon in Tophaceous Gout: A Case-Control Study

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