Abstract Number: 1242 • 2016 ACR/ARHP Annual Meeting
Rate of Hospitalization for Heart Failure Is Lower in Patients with Controlled Gout Versus Uncontrolled Gout
Background/Purpose: Hyperuricemia is associated with worsened outcomes in heart failure (HF) patients. However, little is known regarding the association between gout and HF itself. This…Abstract Number: 2022 • 2016 ACR/ARHP Annual Meeting
Developing a Gout Needs Assessment Incorporating Patient Perspective on Self-Management, Self-Efficacy and Disease Specific Knowledge, to Inform a Patient Education Initiative
Background/Purpose: Gout is the most common inflammatory arthritis in adults, with great impact on quality of life. Despite excellent therapeutic options, outcomes remain suboptimal. Research supports…Abstract Number: 2160 • 2016 ACR/ARHP Annual Meeting
Allopurinol Use and the Risk of Acute Cardiovascular Events in Patients with Gout and Diabetes
Background/Purpose: To examine the effect of allopurinol on the risk of incident myocardial infarction (MI) or stroke in patients with gout and diabetes Methods: We…Abstract Number: 2241 • 2016 ACR/ARHP Annual Meeting
Health Economics of Uncontrolled Gout in the United States: A Systematic Literature Review
Background/Purpose: Gout is a crystal deposition disease and the most prevalent inflammatory arthritis in the United States (US). Maintaining gout control has been associated with…Abstract Number: 2266 • 2016 ACR/ARHP Annual Meeting
A Melanocortin Fusion Peptide (AQB-565) Optimized for Melanocortin Receptor Engagement Significantly Reduces Inflammation in an In Vivo model of Acute Gout
Background/Purpose: The melanocortins (MCs) are endogenous peptides (including ACTH, α-MSH and γ-MSH), which bind 5 G protein-coupled receptors (MCRs 1 through 5) with varying affinity.…Abstract Number: 2275 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Gout in New Zealand Polynesian People
Background/Purpose: The prevalence of gout in New Zealand Polynesian (Māori and Pacific) populations is approximately twice that of the New Zealand European population, with a…Abstract Number: 2276 • 2016 ACR/ARHP Annual Meeting
Pleiotropic Effect of ABCG2 in Gout
Background/Purpose: The ABCG2 Q141K (rs2231142) variant is an established cause of hyperuricaemia in Europeans. Although the effect size of ABCG2 rs2231142 on serum urate levels…Abstract Number: 2278 • 2016 ACR/ARHP Annual Meeting
Precision of Gout Definitions for Population-Based Genetic Studies: Analysis of the UK Biobank
Background/Purpose : Accurate case-definition is important for epidemiological studies of gout. However, in multipurpose cohort studies frequently used for genome wide association studies, limited information…Abstract Number: 2280 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Crystal-Induced Inflammation Promotes Osteocyte Expression of Pro-Resorptive and Inflammatory Mediators: Implications for Erosive Gout
Background/Purpose: Bone erosion in gout is strongly associated with tophi; lesions comprising of inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are…Abstract Number: 2282 • 2016 ACR/ARHP Annual Meeting
Ferritin Levels Are Associated with Urate and Gout – a Role for Iron Metabolism in Gout ?
Background/Purpose: Transferrin and its cell-surface receptor regulate iron uptake and ferritin sequesters free iron and acts as a store for excess iron. Ferritin has been…Abstract Number: 2286 • 2016 ACR/ARHP Annual Meeting
Bioresponsive Glucocorticoid-Loaded Microparticles to Prevent Acute Gout Flares
Background/Purpose: Gout is a common and very painful form of arthritis triggered by deposits of monosodium urate (MSU) crystals in the joints. Lifestyle factors such…Abstract Number: 2289 • 2016 ACR/ARHP Annual Meeting
Obesity and Echocardiographic Changes in the Different Stages of Gout
Background/Purpose: Studies on gout and its stages as a cardiovascular (CV) risk factor are few and with contradictory results. We compared echocardiographic parameters, known as…Abstract Number: 2290 • 2016 ACR/ARHP Annual Meeting
Crystal-Proven Gout and Disease Severity Factors Influencing the Prevalence of Cardiovascular Diseases
Background/Purpose: Gout is a health disorder affecting many patients worldwide. Clinical gout studies showed a high prevalence of cardiovascular diseases (CVD), raising the question whether…Abstract Number: 2292 • 2016 ACR/ARHP Annual Meeting
Decreased Endothelial and Smooth Muscle Responsiveness in the Vasculature of Gout Patients Compared with Healthy Controls: Relationship Between Flow- and Nitrate-Mediated Dilation, Serum Urate and CRP
Background/Purpose: Gout is an independent risk factor for cardiovascular disease (CVD). Investigators studying the relationship between gout and CVD have focused on acute coronary outcomes,…Abstract Number: 2298 • 2016 ACR/ARHP Annual Meeting
Incident Risk of Acute Gout Among Active Smokers: Data from Nationwide Inpatient Sample
Background/Purpose: Smoking has been found to be negatively correlated with serum uric acid levels by virtue of reduced production and increased consumption of endogenous anti-oxidant…
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