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Abstract Number: 2255 • 2018 ACR/ARHP Annual Meeting
Increased Cost Burden in an Early Diagnosed Cohort of Uncontrolled Versus Controlled Gout: Analysis of a Large US Payer Database
Brian LaMoreaux¹, Megan Francis-Sedlak² and Robert J Holt², ¹Horizon Pharma USA, Inc, Lake Forest, IL, ²Horizon Pharma USA, Inc., Lake Forest, IL
Background/Purpose: Gout is a progressive systemic inflammatory disease that is widely prevalent, estimated to effect 3.9% or 8.3 million people of the United State (US)…
Abstract Number: 2352 • 2018 ACR/ARHP Annual Meeting
Predictors of Patient and Physician Perceptions of Gout Disease Activity
Nicola Dalbeth¹, Christopher Frampton², Scott Baumgartner³, Maple Fung³ and Hyon K. Choi⁴, ¹University of Auckland, Auckland, New Zealand, ²University of Otago, Christchurch, New Zealand, ³Formerly Ardea Biosciences, San Diego, CA, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: It is unknown what factors contribute to patient and physician perceptions of gout disease activity, and how these perceptions align. The aim of this…
Abstract Number: 2362 • 2018 ACR/ARHP Annual Meeting
Understanding Patients’ Perceptions of Gout
Kelly Gavigan¹, Kayla Jordan², Alexa Meara³ and W. Benjamin Nowell¹, ¹Global Healthy Living Foundation, Upper Nyack, NY, ²University of Texas at Austin, Austin, TX, ³Internal Medicine/Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Past research has shown that patients’ (pts’) knowledge of their disease influences health-related behavior. The objective of this study is to explore gout pts’…
Abstract Number: 2962 • 2018 ACR/ARHP Annual Meeting
Diagnostic Accuracy of Gout in Electronic Health Records and the Role of Rheumatology Electronic Consults
Juliana Chang¹ and Maida Wong², ¹Internal Medicine, University of California, Irvine, School of Medicine, Orange, CA, ²Rheumatology, Tibor Rubin VA Medical Center, Orange, CA
Background/Purpose: Gout is the most prevalent inflammatory arthritis globally. Despite treatment advances, it still has a significant effect on quality of life and healthcare costs.…
Abstract Number: 2964 • 2018 ACR/ARHP Annual Meeting
Detection of Uric Acid Crystals in the Vasculature of Patients with Gout Using Dual-Energy Computed Tomography
Sharon Barazani¹, WeiWei Chi², Renata Pyzik³, Adam Jacobi⁴, Tom O'Donnell⁵, Zahi Fayad³, Venkatesh Mani³ and Yousaf Ali², ¹Medical School, Icahn School of Medicine at Mount Sinai, New York, NY, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Translational and Molecular Imaging Institute (TMII), Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Siemens Healthcare, New York, NY
Background/Purpose: Many recent studies have shown an association between gout and increased cardiovascular risk, however the mechanism by which this occurs is unclear. Dual-Energy Computed…
Abstract Number: 2965 • 2018 ACR/ARHP Annual Meeting
Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation
Anyan Cheng¹, Roxana Coras^1,2, Robert Terkeltaub^3,4, Ru Liu-Bryan^1,3 and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³VA San Diego Healthcare System, San Diego, CA, ⁴Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA
Background/Purpose: Emerging evidence indicates that macrophage activation is critically supported by glucose metabolic shifts. Although macrophages are key contributors to inflammation, little is known about…
Abstract Number: 2966 • 2018 ACR/ARHP Annual Meeting
Ultrasound Shows Rapid Reduction of Uric Load during Treat-to-Target Approach in Gout Patients: Results from a Longitudinal Study
Hilde B Hammer¹, Lars Fritjof Karoliussen², Lene Terslev³, Espen A. Haavardsholm¹, Tore Kvien⁴ and Till Uhlig⁵, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Rigshospitalet Glostrup, Copenhagen, Denmark, ⁴RAID working group for EULAR, Zurich, Switzerland, ⁵Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Uric monosodium urate (MSU) depositions are detected by ultrasound (US), and US is included in the ACR/EULAR classification criteria for gout. OMERACT definitions for…
Abstract Number: 2968 • 2018 ACR/ARHP Annual Meeting
Role of Choline in Gouty Inflammation
Elsa Sanchez-Lopez¹, Zhenyu Zhong¹, Alex Stubelius², Shannon R Sweeney³, Ru Liu-Bryan^4,5, Juan Carlos Lacal⁶, Stefano Tiziani^3,7,8, Robert Terkeltaub^4,9, Monica Guma⁹ and Michael Karin¹, ¹Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA, ³Department of Nutritional Sciences. The University of Texas at Austin., Austin, TX, ⁴VA San Diego Healthcare System, San Diego, CA, ⁵Medicine-Rheumatology, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA, ⁶Translational Oncology. Department of Oncology, Hospital Universitario Fuenlabrada, Madrid, Spain, ⁷Department of Molecular Biosciences, College of Natural Sciences. The University of Texas at Austin., Austin, TX, ⁸Department of Pediatrics, Dell Medical School. The University of Texas at Austin., Austin, TX, ⁹Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA
Background/Purpose: Gout is characterized by deposition of monosodium urate (MSU) crystals in articular joints, where they activate macrophages inducing NLRP3 inflammasome activation and bioactive IL-1β…
Abstract Number: 2969 • 2018 ACR/ARHP Annual Meeting
Allopurinol Dose Escalation Slows Progression of CT Bone Erosion in People with Gout: Imaging Sub-Study of a Randomized Control Trial
Nicola Dalbeth¹, Karen Billington², Anthony Doyle¹, Christopher Frampton³, Paul Tan¹, Jordyn Allan¹, Jill Drake⁴, Anne Horne⁵ and Lisa K. Stamp³, ¹University of Auckland, Auckland, New Zealand, ²Auckland District Health Board, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴University of Otago, Christchurch, Christchurch, New Zealand, ⁵Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Bone erosion is a frequent complication of severe gout. Computed tomography (CT) is considered the gold standard for measurement of bone erosion. CT studies…
Abstract Number: 60 • 2017 ACR/ARHP Annual Meeting
Low and Moderate Intensity Exercise Suppresses Inflammatory Responses in an Acute Mouse Model of Gout and Suggests Therapeutic Efficacy
Nicholas A. Young¹, Kyle Jablonski², Juhi Sharma¹, Evelyn Thomas¹, Brian Snoad¹, Jeffrey Hampton³, Wael Jarjour¹ and Naomi Schlesinger⁴, ¹Department of Internal Medicine, Division of Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Little is known regarding the potential benefits of exercise on managing acute gout. Consequently, recent clinical practice guidelines released by the American College of…
Abstract Number: 99 • 2017 ACR/ARHP Annual Meeting
A Pilot Study of the Use of a Validated Gout Script Concordance Test Assessment in an Interdisciplinary Musculoskeletal Education Program
Bernadette C. Siaton¹, Andrea Barker² and Michael J. Battistone², ¹Rheumatology, University of Maryland School of Medicine, Baltimore, MD, ²Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT
Background/Purpose: A validated script concordance assessment (SCT) for gout was created for use in the internal medicine residency program at the University of Maryland Medical…
Abstract Number: 117 • 2017 ACR/ARHP Annual Meeting
Using Goutpro to Make Medical Trainees Gout Pros- a Single Blinded Randomized Control Study
Linh Ngo¹, Eric Miller², Peter A. Valen³ and Alisa Duran⁴, ¹Division of Rheumatology, University of Minnesota, Minneapolis, MN, ²Medicine, Hennepin County Medical Center, Minneapolis, MN, ³Rheumatology/ Dept of Medicine, University of Minnesota/Minneapolis VAMC, Minneapolis, MN, ⁴Department of Medicine, University of Minnesota, Minneapolis, MN
Background/Purpose: Gout is the most common type of inflammatory arthritis in the U.S., affecting 4% of the population. Despite modern advancements and the availability of…
Abstract Number: 170 • 2017 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Clinically-Ascertained Gout and Subtypes Identifies Multiple Susceptibility Loci Including Transporter Genes
Hirotaka Matsuo¹, Akiyoshi Nakayama², Hirofumi Nakaoka³, Ken Yamamoto⁴, Masayuki Sakiyama⁵, Amara Shaukat⁶, Yu Toyoda⁷, Yukinori Okada⁸, Yoichiro Kamatani⁹, Masahiro Nakatochi¹⁰, Takahiro Nakamura⁵, Tappei Takada⁷, Hiroshi Nakashima⁵, Seiko Shimizu⁵, Makoto Kawaguchi⁵, Asahi Hishida¹¹, Kenji Wakai¹¹, Blanka Stiburkova¹², Karel Pavelka¹³, Lisa K. Stamp¹⁴, Nicola Dalbeth¹⁵, Tatsuo Hosoya¹⁶, Michiaki Kubo⁹, Hiroshi Ooyama¹⁷, Toru Shimizu¹⁸, Kimiyoshi Ichida¹⁹, Tony R. Merriman²⁰ and Nariyoshi Shinomiya²¹, ¹Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, ²Dept Integrative Physiol, National Defense Med College, Tokorozawa, Japan, ³National Inst Genet, Mishima, Japan, ⁴Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Japan, ⁵National Defense Med College, Tokorozawa, Japan, ⁶Univ Otago, Dunedin, New Zealand, ⁷Univ Tokyo Hosp, Tokyo, Japan, ⁸Osaka University, Osaka, Japan, ⁹Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ¹⁰Nagoya Univ Hosp, Nagoya, Japan, ¹¹Nagoya Univ Grad Sch Med, Nagoya, Japan, ¹²Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic, ¹³Institute of Rheumatology, Prague, Czech Republic, ¹⁴University of Otago, Christchurch, New Zealand, ¹⁵University of Auckland, Auckland, New Zealand, ¹⁶Jikei Univ Sch Med, Tokyo, Japan, ¹⁷Ryougoku East Gate Clin, Tokyo, Japan, ¹⁸Kyoto Industr Health Assoc, Kyoto, Japan, ¹⁹Tokyo Univ Pharmacy Life Sci, Tokyo, Japan, ²⁰Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²¹National Defense Med College, Saitama, Japan
Background/Purpose: We performed a genome-wide association study (GWAS) of gout and its subtypes to identify novel gout loci including those that are subtype-specific. Methods: Putative…
Abstract Number: 187 • 2017 ACR/ARHP Annual Meeting
Improved Identification of Pseudogout in Electronic Medical Records By Adding Text String Searching to a Billing Code Algorithm
Sara K. Tedeschi, Kazuki Yoshida and Daniel H. Solomon, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) has a spectrum of manifestations, of which pseudogout is the most acute inflammatory phenotype. To facilitate clinical research on…
Abstract Number: 200 • 2017 ACR/ARHP Annual Meeting
Implementation and Evaluation of a Novel Nurse-Led Telemedicine Intervention for Dose Escalation of Urate-Lowering Therapy in Gout: A Clinical Practice Improvement Project
Sen Hee Tay^1,2, Bernadette Poh Lee Low³, Pamela Shi Hui Tan², Zhi Wei Khong², Siew Hwa Chong⁴, Amelia Santosa^1,2, Anita Yee Nah Lim^1,2 and Gim Gee Teng^2,5, ¹Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore, Singapore, ²Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Singapore, ³Division of Primary Care, Department of Care Integration and Alliance, National University Hospital, National University Health System, Singapore, Singapore, Singapore, ⁴Clinical Nursing Unit, National University Hospital, National University Health System, Singapore, Singapore, Singapore, ⁵Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore, Singapore
Background/Purpose: Urate-lowering therapy (ULT) is the mainstay of gout treatment. In our clinics, time to achieve target serum urate (SU) level during ULT titration was…

Increased Cost Burden in an Early Diagnosed Cohort of Uncontrolled Versus Controlled Gout: Analysis of a Large US Payer Database

Predictors of Patient and Physician Perceptions of Gout Disease Activity

Understanding Patients’ Perceptions of Gout

Diagnostic Accuracy of Gout in Electronic Health Records and the Role of Rheumatology Electronic Consults

Detection of Uric Acid Crystals in the Vasculature of Patients with Gout Using Dual-Energy Computed Tomography

Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation

Ultrasound Shows Rapid Reduction of Uric Load during Treat-to-Target Approach in Gout Patients: Results from a Longitudinal Study

Role of Choline in Gouty Inflammation

Allopurinol Dose Escalation Slows Progression of CT Bone Erosion in People with Gout: Imaging Sub-Study of a Randomized Control Trial

Low and Moderate Intensity Exercise Suppresses Inflammatory Responses in an Acute Mouse Model of Gout and Suggests Therapeutic Efficacy

A Pilot Study of the Use of a Validated Gout Script Concordance Test Assessment in an Interdisciplinary Musculoskeletal Education Program

Using Goutpro to Make Medical Trainees Gout Pros- a Single Blinded Randomized Control Study

Genome-Wide Association Study of Clinically-Ascertained Gout and Subtypes Identifies Multiple Susceptibility Loci Including Transporter Genes

Improved Identification of Pseudogout in Electronic Medical Records By Adding Text String Searching to a Billing Code Algorithm

Implementation and Evaluation of a Novel Nurse-Led Telemedicine Intervention for Dose Escalation of Urate-Lowering Therapy in Gout: A Clinical Practice Improvement Project

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