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Abstract Number: 869 • 2018 ACR/ARHP Annual Meeting
Failure to Reach Serum Urate Target Is Associated with Elevated Mortality in Gout
Fernando Perez-Ruiz^1,2,3, Pascal Richette^4,5, Austin Stack⁶, Ravichandra Karra Gurunath⁷, MARIA JESUS GARCIA DE YEBENES Y PROUS⁸ and Loreto Carmona⁹, ¹Rheumatology Division, Hospital Universitario Cruces, Baracaldo, Spain, ²University of the Basque Country (UPV/EHU), Bilbao, Spain, ³BioCruces Health Research Institute, Barakaldo, Spain, ⁴Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France, ⁵Rheumatology, Université Paris Diderot, Paris, France, ⁶Nephrology, University Hospital Limerick & Health Research Institute,University of Limerick, Limerick, Ireland, ⁷Grünenthal GmbH, Aachen, Germany, ⁸Institute for Musculoskeletal Health, Madrid, Spain, ⁹Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain
Background/Purpose: Gout is associated with an increased risk of cardiovascular events and death. It has been shown that both overall and risk of death are…
Abstract Number: 870 • 2018 ACR/ARHP Annual Meeting
Patient-Reported Burden of Gout in 2017 from the United States
Puja P. Khanna¹, Douglas C.A. Taylor², An-Chen Fu² and Robert Morlock³, ¹University of Michigan, Ann Arbor, MI, ²Ironwood Pharmaceuticals, Inc., Cambridge, MA, ³YourCareChoice, Ann Arbor, MI
Background/Purpose: Gout is reported to impact 3.9% of the US adult population (Zhu. Arthritis Rheum 2011;63:3136-41). Treatment encompasses controlling acute attacks (flares) and, dependent on…
Abstract Number: 872 • 2018 ACR/ARHP Annual Meeting
Is the Serum Uric Acid Therapeutic Target Protective of Chronic Kidney Disease, Cardiovascular Disease, and Mortality for Patients with Gout? a Longitudinal Study
Douglas C.A. Taylor¹, Dena Jaffe², Moshe Hoshen³, Galit Shefer³, Asaf Bachrach³, Becca Feldman³, An-Chen Fu¹ and Hyon K. Choi⁴, ¹Ironwood Pharmaceuticals, Inc., Cambridge, MA, ²Kantar Health, Tel Aviv, Israel, ³Clalit Research Institute, Tel Aviv, Israel, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Many studies have found that serum uric acid (sUA) levels are associated with the incidence of chronic kidney disease (CKD), cardiovascular disease (CVD), and…
Abstract Number: 873 • 2018 ACR/ARHP Annual Meeting
General Safety of Febuxostat and Allopurinol in a Cardiovascular Outcomes Study in Patients with Gout
Kenneth Saag¹, Michael A. Becker², William B. White³, Andrew Whelton⁴, Jeffrey Borer⁵, Philip Gorelick⁶, Barbara Hunt⁷, Majin Castillo⁷ and Lhanoo Gunawardhana⁷, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Chicago Pritzker School of Medicine, Chicago, IL, ³Cardiology, University of Connecticut School of Medicine, Farmington, CT, ⁴Johns Hopkins University School of Medicine, Hunt Valley, MD, ⁵State University of New York Downstate Medical Center, Brooklyn, NY, ⁶Michigan State University College of Human Medicine, Grand Rapids, MI, ⁷Takeda Pharmaceuticals International, Deerfield, IL
Background/Purpose: The cardiovascular (CV) safety study CARES has the longest study duration of any randomized controlled trial in patients (pts) with gout and CV disease.…
Abstract Number: 874 • 2018 ACR/ARHP Annual Meeting
Preventing a Large Majority of Incident Gout Cases By Modifying Key Risk Factors: Findings from a Prospective Cohort of 44,629 Men over 26 Years
Sharan K. Rai^1,2, Na Lu³, Chio Yokose⁴ and Hyon K. Choi^3,4, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, ³Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Many modifiable risk factors have been found to be independently associated with the risk of developing gout, including dietary factors (e.g., intakes of red…
Abstract Number: 944 • 2018 ACR/ARHP Annual Meeting
Gout: A Potential Risk Factor for Uveitis in the Older Adults?
Jasvinder A. Singh and John Cleveland, Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Elevated intraocular levels of these pro-inflammatory cytokines and systemic levels of C-reactive protein are seen in uveitis, which leads to 30,000 new cases of…
Abstract Number: 1006 • 2018 ACR/ARHP Annual Meeting
Physical Activity at Lower Intensities Reduces Localized IL-1b in a Murine Model of Gout By Systemically Down-Regulating TLR2 Expression on Circulating Neutrophils and Suppressing CXCL1 Expression
Kyle Jablonski¹, Nicholas A. Young², Bianca Sandoval³, Ifeoma Okafor⁴, Emily Schwarz³, Caitlin Henry³, Peter Harb³, Anuradha Kalyanasundaram⁵, Wael Jarjour⁶ and Naomi Schlesinger⁷, ¹The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Physiology and Cell Biology, The Ohio State University, Columbus, OH, ⁶Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁷Department of Medicine/Rheumatology Division, Rutgers- Robert Wood Johnson Medical School, New Brunswick, New Brunswick, NY
Background/Purpose: Exercise was originally believed to exacerbate inflammation in rheumatic disease, however, recent studies have shown that regular physical activity is anti-inflammatory. In gout, there…
Abstract Number: 1030 • 2018 ACR/ARHP Annual Meeting
Parenteral Injection of Human Adipose-Derived Mesenchymal Stem Cells Attenuates Inflammation in an Acute Model of Gouty Arthritis
Juan Pablo Medina¹, Sandra Perez-Baos¹, Esperanza Naredo², Alberto Lopez-Reyes³, Gabriel Herrero-Beaumont⁴ and Raquel Largo⁴, ¹Joint and Bone Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ²Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ³Synovial fluid analysis department, Instituto Nacional de Rehabilitación, Mexico City, Mexico, ⁴Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain
Background/Purpose: The regenerative and immunomodulatory properties of Adipose-Derived Mesenchymal Stem Cells (ASCs) make them a potential therapeutic approach for the treatment of chronic inflammatory diseases,…
Abstract Number: 1031 • 2018 ACR/ARHP Annual Meeting
Orally Administered Cherry Juice Inhibits Localized Nfκb Activity and Histopathological Infiltrates in a Murine Model of Gout
Nicholas A. Young¹, Peter Harb², Ifeoma Okafor³, Caitlin Henry², Emily Schwarz², Kyle Jablonski⁴, Bianca Sandoval², Wael Jarjour⁵ and Naomi Schlesinger⁶, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Rheumatology and Immunology, Columbus, OH, ³Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Gout is caused by the inflammation induced from the precipitation of monosodium urate (MSU) crystals in joints and is the most common inflammatory arthritis…
Abstract Number: 1124 • 2018 ACR/ARHP Annual Meeting
Epidemiological Characteristics of Inpatient Admissions for Acute Inflammatory Gout Arthropathy and Factors Affecting Length of Stay: A National Level Study
Vagishwari Murugesan and Jennifer Tran, Internal Medicine, Medstar Washington Hospital Center, Washington, DC
Background/Purpose:Gout is a common cause of inflammatory arthritis due to accumulation of monosodium urate crystals in joints, bones and soft tissues. The aim of the…
Abstract Number: 1126 • 2018 ACR/ARHP Annual Meeting
Gout and Chronic Pain in Older Adults: A Medicare Claims Study
Jasvinder A. Singh and John Cleveland, Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To assess if gout is associated with a higher risk of incident chronic pain in older adults, 65 years or older. Methods: This study…
Abstract Number: 1127 • 2018 ACR/ARHP Annual Meeting
Risk of Stroke Among Patients with Gout in Taiwan: A Nationwide Population Study
Ping-Han Tsai and Chang-Fu Kuo, Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: To determine whether the Taiwanese patients with gout have a higher risk of stroke.Methods: Using the National Health Insurance database, we identified a cohort…
Abstract Number: 1128 • 2018 ACR/ARHP Annual Meeting
Impact of Urate-Lowering Therapy on the Risk of Cardiovascular Events and All-Cause Mortality Among Individuals with Gout
In Ah Choi¹, Hoyeon Jang² and Gil-Won Kang², ¹Division of Rheumatology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of (South), ²Department of Health Informatics and Management, College of Medicine, Chungbuk National University, Cheongju, Korea, Republic of (South)
Background/Purpose: Gout results from an increased body pool of urate that occurs with hyperuricemia. Although urate-lowering therapy (ULT) is beneficial to prevent gout attack, current…
Abstract Number: 1129 • 2018 ACR/ARHP Annual Meeting
Prevalence, Incidence, Determinants, and Impacts of Depression and Anxiety in Gout: A Systematic Review
Alyssa Howren^1,2,3, Enav Z. Zusman^1,2,3, Sharan K. Rai^2,4,5, Kam Shojania^2,6 and Mary A. De Vera^1,2,3, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Collaboration for Outcomes Research and Evaluation (CORE), Vancouver, BC, Canada, ⁴Program in Population Health Sciences, Graduate School of Arts and Sciences, Harvard University, Boston, MA, ⁵Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: A previously synthesized positive association between gout and depression has combined studies of both prevalent and incident depression. To disentangle these data and provide…
Abstract Number: 1130 • 2018 ACR/ARHP Annual Meeting
Chronic Risk Factors for Recurrent Gout Flares Among Established Gout Patients: A Prospective Cohort Analysis
Yuqing Zhang¹, Jie Wei², Chio Yokose², Sharan K. Rai^3,4 and Hyon K. Choi², ¹Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁴Graduate School of Arts and Sciences, Harvard University, Cambridge, MA
Background/Purpose: Understanding the risk factors for recurrent flares among established gout patients is directly relevant to clinical care; however, relevant data are scarce. A previous…

Failure to Reach Serum Urate Target Is Associated with Elevated Mortality in Gout

Patient-Reported Burden of Gout in 2017 from the United States

Is the Serum Uric Acid Therapeutic Target Protective of Chronic Kidney Disease, Cardiovascular Disease, and Mortality for Patients with Gout? a Longitudinal Study

General Safety of Febuxostat and Allopurinol in a Cardiovascular Outcomes Study in Patients with Gout

Preventing a Large Majority of Incident Gout Cases By Modifying Key Risk Factors: Findings from a Prospective Cohort of 44,629 Men over 26 Years

Gout: A Potential Risk Factor for Uveitis in the Older Adults?

Physical Activity at Lower Intensities Reduces Localized IL-1b in a Murine Model of Gout By Systemically Down-Regulating TLR2 Expression on Circulating Neutrophils and Suppressing CXCL1 Expression

Parenteral Injection of Human Adipose-Derived Mesenchymal Stem Cells Attenuates Inflammation in an Acute Model of Gouty Arthritis

Orally Administered Cherry Juice Inhibits Localized Nfκb Activity and Histopathological Infiltrates in a Murine Model of Gout

Epidemiological Characteristics of Inpatient Admissions for Acute Inflammatory Gout Arthropathy and Factors Affecting Length of Stay: A National Level Study

Gout and Chronic Pain in Older Adults: A Medicare Claims Study

Risk of Stroke Among Patients with Gout in Taiwan: A Nationwide Population Study

Impact of Urate-Lowering Therapy on the Risk of Cardiovascular Events and All-Cause Mortality Among Individuals with Gout

Prevalence, Incidence, Determinants, and Impacts of Depression and Anxiety in Gout: A Systematic Review

Chronic Risk Factors for Recurrent Gout Flares Among Established Gout Patients: A Prospective Cohort Analysis

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