Whole Frequency Audiometrical Correlation with Disease Activity in Primary SjöGren's Syndrome in Hispanic Population

Janett Riega-Torres¹, Yolisa Hinojosa-Rios², Jose Luis Treviño-González², Lorena Pérez-Barbosa³, Mario Alberto Garza-Elizondo⁴, David Vega-Morales⁵, Amaury Valdés-Mancha⁶, Jorge Esquivel-Valerio⁴, Mario Jesus Villegas-Gonzalez², Cassandra Skinner-Taylor³ and Diana Flores-Alvarado⁷, ¹Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Servicio de Otorrinolaringología y Cirugía de Cabeza y Cuello. Hospital Universitario “Dr. José Eleuterio González”. Universidad Autónoma de Nuevo León, Monterrey, Mexico, ³Hospital Universitario, Monterrey, Mexico, ⁴Rheumatology, Hospital Universitario, UANL., Monterrey, Mexico, ⁵Universidad Autónoma de Nuevo Léon, Monterrey, Mexico, ⁶Servicio de Reumatología, Departamento de Medicina Interna. Hospital Universitario “Dr. José Eleuterio González”. Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁷Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”. Universidad Autónoma de Nuevo León, Monterrey, Mexico

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Disease Activity and Sjogren's syndrome

Session Information

Date: Tuesday, November 15, 2016

Title: Sjögren's Syndrome - Poster II: Clinical Science

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Sjögren’s syndrome is an autoimmune disorder that can develop hearing loss, It can be diagnosed with high frequency audiometry. Our study aims to correlate the hearing according to the level of disease activity, using the EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) as an evaluation tool and performing high frequency audiometry and tympanogram in a population with primary Sjögren’s syndrome.

Methods:

The audiological evaluation were performed by the same experienced audiologist in an Acoustic Systems soundproof chamber with calibration, model RE-142 manufactured in U.S.A, and Interacustic AC40 audiometer (125-16,000Hz frequencies with bone conduction thresholds at 500-4000Hz frequencies). Pure-tone speech audiometries were conducted measuring speech discrimination thresholds and word recognition. Tympanometry (Audiotest 425 h Interacustic) with acoustic reflex and static acoustic compliance for both ears were tested. Tympanometry was considered normal with middle ear pressures of ± 75 da Pa (deca Pascal: unit of pressure) with compliance of 0.28-1.5ml, and the presence of acoustic reflex when it occurred with stimulation at 70-95 dB in 500; 1000; 2000; and 4000Hz. The tympanograms were classified according to Jerger as types A, As, Ad, B, and C. Hearing loss was accepted if the hearing threshold was 20 dB or higher than 20dB.

Results: A total of 76 patients, 3(3.9%) male and 73(96.1%) women were recruited. The median age was 52.5 years. The disease activity was reported as mild in 23(30.3%) patients, moderate in 28(36.8%) and severe in 25(32.9%). The Pure Tone Average (PTA) in the right ear was 18.72dB (SD11.6) and left ear 20.72dB (SD12.19) in the frequency range 500 to 3000Hz. The comparison between the degree of illness and right and left PTA was P=0.399 and P=0.359 respectively. The PTA in the frequency range 4000 to 8000Hz in the right ear was 29.34dB (SD5.18) and the left ear was 31.40dB (SD17.68), P=0.198 and P=0.115 respectively. The PTA in the frequency range 10000-16000Hz was in the right ear 55.82dB (SD18.10) and the left ear was 55.17dB (SD19.58), P=0.134 and P=0.180, respectively. The prevalence of hearing loss in patients with primary Sjögren’s syndrome in high frequencies (10,000-16,000) in the right ear was 62(94.7%) and the left ear 69(90.8%). No significant differences between the degree of disease activity and the level of hearing in patients with primary Sjögren’s syndrome were found.

Conclusion:

Despite the high prevalence of hearing loss of high frequencies in this cohort of Sjögren’s Syndrome Patients, we observed no correlation with disease activity

Table 1. Pure Tone Average and standard deviation

Test frequency (Hz)	Right ear	Left ear
500-3,000	18.72 ±11.6	20.72 ±12.19
4,000-8,000	29.34 ±5.18	31.40 ±17.68
10,000-16,000	55.82 ±18.10	55.17 ±19.58

Table 2. Mean PTA comparison with ESSPRI using Kruskal-Wallis test
Frequency range	Mean PTA (SD)	P
Right Ear
500-3,000 Mild Moderate Severe	21.19 (20.08) 16.98 (8.32) 18.90 (7.05)	0.399
4,000-8,000 Mild Moderate Severe	29.83 (23.95) 26.01 (15.61) 33.07 (16.94)	0.198
10,000-16,000 Mild Moderate Severe	56.37 (19.53) 51.57 (19.93) 60.65 (13.30	0.134
Left Ear
500-3,000 Mild Moderate Severe	19.88 (11.22) 21.05 (14.31) 21.00 (8.02)	0.359
4,000-8,000 Mild Moderate Severe	27.92 (16.69) 30.11 (19.65) 35.80 (15.55)	0.115
10,000-16,000 Mild Moderate Severe	52.87 (18.05) 51.69 (22.71) 61.32 (15.38)	0.180

Table 3. Prevalence of Hearing loss in primary Sjögren´s syndrome in Hispanic population
Test frequency (Hz)	Number of patients N=76 (%)
Right ear 500-3,000	8 (10.5)
4,000-8,000	32 (42.1)
10,000-16,000 Left ear 500-3,000	62 (94.7) 18 (23.7)
4,000-8,000	41 (53.9)
10,000-16,000	69 (90.8)

Disclosure: J. Riega-Torres, None; Y. Hinojosa-Rios, None; J. L. Treviño-González, None; L. Pérez-Barbosa, None; M. A. Garza-Elizondo, None; D. Vega-Morales, None; A. Valdés-Mancha, None; J. Esquivel-Valerio, None; M. J. Villegas-Gonzalez, None; C. Skinner-Taylor, None; D. Flores-Alvarado, None.

To cite this abstract in AMA style:

Riega-Torres J, Hinojosa-Rios Y, Treviño-González JL, Pérez-Barbosa L, Garza-Elizondo MA, Vega-Morales D, Valdés-Mancha A, Esquivel-Valerio J, Villegas-Gonzalez MJ, Skinner-Taylor C, Flores-Alvarado D. Whole Frequency Audiometrical Correlation with Disease Activity in Primary SjöGren’s Syndrome in Hispanic Population [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/whole-frequency-audiometrical-correlation-with-disease-activity-in-primary-sjogrens-syndrome-in-hispanic-population/. Accessed .

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