ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1121

Volatility Of The Site and Type Of Lesions In The Spine In Patients With Recent Onset Spondyloarthritis and Possible Spondyloarthritis Over a 3-Month Period

Rosaline van den Berg1, Manouk de Hooge1, Victoria Navarro-Compán1, Monique Reijnierse2, Floris van Gaalen1, Karen Fagerli3, Robert Landewé4,5, Maikel van Oosterhout6, Roberta Ramonda7, Tom Huizinga1 and Désirée van der Heijde1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 5Rheumatology, Atrium Medical Center, Heerlen, Netherlands, 6Rheumatology, GHZ Hospital, Gouda, Netherlands, 7Rheumatology Unit, University of Padova, Padova, Italy

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: MRI and spondylarthritis

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Imaging of Rheumatic Diseases II: Imaging in Spondyloarthritis and Osteoarthritis

Session Type: Abstract Submissions (ACR)

Background/Purpose: Inflammatory lesions on MRI of the sacroiliac joints show volatility over a short period of 3 months in patients with recent onset axial spondyloarthritis (axSpA)1. We investigated whether the site and/or type of lesions in the spine change over a 3-month period in patients with recent onset axSpA and possible axSpA.

Methods: 158 patients with back pain (≥3 months, ≤2 years, onset <45 years) included in the SPondyloArthritis Caught Early (SPACE)-cohort from the 5 participating centers underwent MRI of the spine (MRI-spine) at baseline and after 3 months. MRIs-spine were scored by 2 readers independently, blinded for the time sequence. Presence of corner inflammatory lesions (CIL; type A and B) and fatty lesions (FL) were scored2,3. Scores of both time points were compared on the vertebral unit level (VU; 23 per patient) for inflammatory lesions and on the quadrant level (4 per VU) for all lesions. Quadrants were summed (14536 in total) to study (changes in) the number, site and type of lesions. All possible changes were studied for each reader separately.

Results: On the VU level, reader 1 scored no CIL at both time points in 98/158 patients (62.0%). In 16.5% of the patients the number of inflamed VUs increased over 3 months (mean 1.7 SD 1.3; range 1-4); in 21.5% the number decreased (mean -2.1 SD 1.6; range -7 to -1). The upper 9 VUs were almost never affected. On the quadrant level, no CIL and FL were scored at both time points in 68/158 (43.7%) patients. In 18 patients, lesions (in 9 patients CIL; in 6 patients FL; in 3 patients both CIL and FL) did not change over time (mean 1.9 SD 1.7; range 1-8). In 72/158 patients (45.6%) site and type of lesions changed over time; in 18/72 purely occurrence of lesions (any type) was seen (mean 1.7 SD 0.8; range 1-3) and in 19/72 purely resolving of lesions (any type) was seen (mean -2.2 SD 1.8; range -8 to -1). Within the remaining 35/72 patients, various types of changes were seen (e.g. occurrence of CIL in a quadrant and disappearance of FL in another quadrant etc; mean number of changed quadrants 6.7 SD 5.1; range 1-22) as well as lesions that remained stable. Remarkably, more FL occurred in quadrants without previous CIL (46 FL; in 23 patients) than in quadrants with previous CIL (14 FL; in 7 patients), and 118 FL (whether or not surrounded by CIL) resolved over time (in 48 patients) (table). The results of reader 2 are very similar to reader 1 (table).

Conclusion: Almost half of the patients (45.6%) showed changes in site and/or type of lesions in the spine over a 3-month period only. Noteworthy, FL occurred more frequently de novo than in quadrants with previous CIL. Furthermore, FL can resolve over time, also when surrouneded by inflammation. The value of FLs in the spine need to be re-evaluated.

References: 1de Hooge ARD 2012;71(Suppl3):301 2Lambert J Rheumatol 2009;36 Suppl 84:3-17 3Østergaard J Rheumatol 2009;36 Suppl 84:18-34

 

 

3 months

 

Reader 1 / reader 2

No lesions

CIL type A

CIL type B

FL

CIL type A & FL

CIL type B & FL

Baseline

No lesions

14013 / 14024

57 / 46

4 / 4

46 / 54

1 / 2

0 / 2

CIL type A

4 / 1

48 / 43

3 / 3

12 / 14

2 / 2

5 / 1

CIL type B

12 / 5

4 / 5

3 / 3

2 / 2

0 / 1

1 / 1

FL

53 / 58

5 / 3

2 / 1

157 / 167

4 / 5

0 / 1

CIL type A & FL

64 / 50

2 / 2

1 / 0

7 / 10

2 / 9

0 / 0

CIL type B & FL

1 / 2

1 / 0

2 / 0

8 / 5

3 / 4

7 / 6

FL; fatty lesion. CIL; corner inflammatory lesion


Disclosure:

R. van den Berg,
None;

M. de Hooge,
None;

V. Navarro-Compán,
None;

M. Reijnierse,
None;

F. van Gaalen,
None;

K. Fagerli,
None;

R. Landewé,
None;

M. van Oosterhout,
None;

R. Ramonda,
None;

T. Huizinga,
None;

D. van der Heijde,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/volatility-of-the-site-and-type-of-lesions-in-the-spine-in-patients-with-recent-onset-spondyloarthritis-and-possible-spondyloarthritis-over-a-3-month-period/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology