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Abstract Number: 2320

Ultrasonographic Monitoring Of Response To Infliximab In Patients With Rheumatoid Arthritis

Xiaomei Leng1, Weiguo Xiao2, Xiaochun Zhu3, Zhonghui Xu1, Wei Yu1, Jing Lu2, Jiakai Wang2, Xiaoru Xia3, Yongji Li3, Yi Liu4, Yi Zhao4, Honghao Tang5, Dongbao Zhao6, Yeqing Shi6, Huji Xu7, Jun Bao7, Lin Chen7, Ling Lin7, Ling Zhou7, Guoqiang Chen8, Weihong Zhang8 and Yan Zhao1, 1Peking Union Medical College Hospital, Beijing, China, 2The First Hospital of China Medical University, Shenyang, China, 3The First Hospital of Wenzhou Medical College, Wenzhou, China, 4Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, 5West China Hospital of Sichuan University, Chengdu, China, 6Changhai Hospital of Shanghai, Shanghai, China, 7Shanghai Changzheng Hospital, Shanghai, China, 8The First People’s Hospital of Foshan, Foshan, China

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: infliximab, rheumatoid arthritis (RA) and ultrasonography

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Session Information

Title: Rheumatoid Arthritis Treatment - Small Molecules, Biologics and Gene Therapy III

Session Type: Abstract Submissions (ACR)

 

Background/Purpose: To evaluate the efficacy of treatment with infliximab on joint inflammation and bone erosion in rheumatoid arthritis (RA) patients using ultrasonography.

Methods: 80 eligible subjects were enrolled from 7 sites. Subjects received infliximab 3 mg/kg IV infusion at 0, 2, 6 weeks, repeated every 8 weeks until 22 weeks. Endpoints included 7-joint and 12-joint ultrasound (US) synovitis scores at 22 weeks, and correlations between US scores and DAS28 (using CRP) / radiography (modified Sharp score (MSS)/van der Heijde scoring) / HAQ outcome. The 7 joints included those of the clinically dominant hand and foot: wrist, second and third metacarpophalangeal and proximal interphalangeal, and second and fifth metatarsophalangeal joints.

Results: The patients (81.25% women) had a mean age of 47.22±14.27 years (mean±SD). Baseline 7-joint and 12-joint synovitis scores were 22.35±11.67 and 42.09±29.64 in grayscale and power Doppler (GS+PD) US, 15.45±5.54 and 29.41±16.12 in GS US, and 6.90±7.26 and 12.68±15.65 in PD US. At baseline, DAS28 was 5.73±1.05, MSS was 17.75±25.27, SDAI was 187.29±55.68, CDAI was 152.16±45.82, and HAQ score was 1.36±0.79. 64 patients (80.00%) completed all visits and 66 patients (82.50%) completed treatment for 22 weeks. After 22 weeks of therapy, 7-joint GS+PD US scores significantly decreased to 18.97±10.81 and the GS US and PD US scores significantly decreased to 11.98±6.42 (P<0.01) and 3.34±4.59 (P<0.01), respectively (Figure). There were significant decreases in scores for 12-joint GS+PD US (28.47±20.93), GS US (22.65±15.19, P<0.01), PD US (5.82±8.17, P<0.01), DAS28 (3.20±1.31, P<0.01), SDAI (77.73±54.27), and CDAI (62.13±41.95). MSS increased (18.04±23.91, P>0.05) and HAQ score significantly decreased (0.56±0.61, P<0.01). There was a positive correlation between US scores and RA activity evaluation indexes, including DAS28, SDAI and CDAI (correlation coefficients 0.5535, 0.6364 and 0.5532) (Table). 14 patients experienced an adverse event and 2 patients experienced a serious adverse event.

Conclusion: In this study, treatment with TNF inhibitors relieved synovitis in patients with moderate to severe RA. US is a viable tool for examining patients with RA in daily practice because it significantly reflects therapeutic response. The 7-joint US synovitis score can be used for the evaluation of clinical efficacy in the clinic, instead of the 12-joint method. This trial showed that there is a positive correlation between US scores and DAS28. Large multicenter, prospective, randomized controlled studies are needed to confirm this preliminary observation.


Disclosure:

X. Leng,
None;

W. Xiao,
None;

X. Zhu,
None;

Z. Xu,
None;

W. Yu,
None;

J. Lu,
None;

J. Wang,
None;

X. Xia,
None;

Y. Li,
None;

Y. Liu,
None;

Y. Zhao,
None;

H. Tang,
None;

D. Zhao,
None;

Y. Shi,
None;

H. Xu,
None;

J. Bao,
None;

L. Chen,
None;

L. Lin,
None;

L. Zhou,
None;

G. Chen,
None;

W. Zhang,
None;

Y. Zhao,
None.

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