Total Body Water Correlates with Ocular Sicca Symptoms in Primary SjöGren’s Syndrome

Gabriela Hernandez-Molina¹, Paloma Almeda-Valdés², Guadalupe López-Carrasco², Miguel Astudillo-Angel¹, Victor Zamora-Legoff³, Carlos Aguilar-Salinas⁴ and Ivette Cruz-Bautista⁵, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ²Endocrinology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ³Rheumatology and Immunology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico D.F., Mexico, ⁴Endocrinology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico D.F., Mexico, ⁵Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Sjogren's syndrome

Session Information

Date: Monday, November 6, 2017

Title: Sjögren's Syndrome Poster II: Clinical Research

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Patients with primary Sjögrens’ syndrome (PSS) suffer from severe alterations in both the quality and quantity of saliva and tears. Body water represents around 50-55% of the body weight. Tears contain 98% of water and saliva 99.5%. We evaluated the percentage of total body water (TBW) among patients with PSS assessed its correlation with the severity of sicca symptoms.

Methods: We included 85 patients with PSS and 85 non-diabetic controls matched by gender, age (±3 years) and body mass index (±1kg/m²) (BMI). We assessed the Schirmer-I test, non-stimulated whole salivary flow (NSWSF) and ocular staining. We evaluated ocular as well as oral symptoms during the past 15 days, using for each symptom, a VAS scale (0-10, a higher score implies worst symptoms). We obtained the TBW percentage with a bioelectric impedance analysis (BIA-SECA-514, Hamburgo).

Results: 80% were women, mean age 54.8±13.7 years and mean disease duration 11.5±7.52 years. The percentage of TBW was similar among patients and controls (PSS 46.85±4.6 vs. 46.9±4.5, p=0.88). However among the patients, the TBW negatively correlated with age (ρ=-0.25, p=0.02), disease duration (ρ=-0.30, p=0.005), BMI (ρ=-0.78, p=0.001) and the ocular VAS scale (ρ=-0.28, p=0.01), but not with the NSWSF or the oral VAS scale. When we compared the patients in the 25% percentile (group with the lowest % of water) vs. the remaining patients, the former group was older (56.6±8.1 vs. 54±14.2, p=0.02), with longer disease duration (12.4±5.9 vs. 10.8±7.12, p=0.03), lower scores at the Schirmer test (1 (range 0-8) vs. 2 (range 0-9), p=0.01), higher BMI (31.1±5.1 vs. 23.7±2.9, p=0.001) as well as with higher ocular VAS scores (8.3±1.4 vs. 6.7±2.5, p=0.007). At the linear regression analysis, the variables that remained associated with the TBW were disease duration (b -0.22, p=0.001), BMI (b -0.76, p<0.001) and the ocular VAS scale (b-0.15, p<0.001).

Conclusion: Patients with PSS had similar TBW percentages than controls. However among PSS patients, the TBW had a negative correlation with the intensity of ocular symptoms independently of disease duration, age and BMI.

Disclosure: G. Hernandez-Molina, None; P. Almeda-Valdés, None; G. López-Carrasco, None; M. Astudillo-Angel, None; V. Zamora-Legoff, None; C. Aguilar-Salinas, None; I. Cruz-Bautista, None.

To cite this abstract in AMA style:

Hernandez-Molina G, Almeda-Valdés P, López-Carrasco G, Astudillo-Angel M, Zamora-Legoff V, Aguilar-Salinas C, Cruz-Bautista I. Total Body Water Correlates with Ocular Sicca Symptoms in Primary SjöGren’s Syndrome [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/total-body-water-correlates-with-ocular-sicca-symptoms-in-primary-sjogrens-syndrome/. Accessed .

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