ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1216

The Relationship Between Serum Homocysteine, Uric Acid and Renal Function in Chronic Gouty Patients: 2 Year Follow-up Results

Eun-Hye Park1, Sang Tae Choi2 and Jung-Soo Song1, 1Chung-Ang University College of Medicine, Seoul, South Korea, 2Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Kidney and gout

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Session Title: Metabolic and Crystal Arthropathies: Mechanisms of Disease

Session Type: Abstract Submissions (ACR)

Background/Purpose: Hyperhomocysteinemia is one of the important factors for the endothelial cell damage and also a risk factor for cardiovascular events. Gout is known to be associated with cardiovascular disease (CVD) as well. Although both hyperhomocysteinemia and gout are related to CVD, the only few cases about serum homocysteine (Hcy) in gouty patients have been reported. In this study, we investigated the associations between serum Hcy level and the other parameters including serum uric acid level, renal function, and cholesterol profiles in chronic gouty patients with longitudinal follow-up data.

Methods: Ninety-one male patients with chronic gout and 97 age-matched healthy male controls were included in this study, and the average age of each was 51.19 ± 15.08 and 51.57 ± 17.01 years old, respectively. Among them, 33 patients with gout and 39 healthy controls underwent follow-up tests for Hcy levels with 24.00 ± 9.12 months on average. Serum Hcy levels were measured by a competitive immunoassay using direct chemiluminescent. The estimated glomurular filtration rate (eGFR) was calculated using modification of diet in renal disease equation, and then chronic kidney disease (CKD) was defined as an eGFR below 60 ml/min/1.73m2.

Results: In the serum uric acid level, there was no significant difference between chronic gouty patients and controls (6.15 ± 2.23 mg/dL vs 5.82 ± 1.22 mg/dL, p = 0.214). In contrast, gouty patients showed significantly higher levels in serum Hcy than those in controls (13.96 ± 4.05 μmol/L vs 12.67 ± 3.51 μmol/L, p = 0.022). In patients with chronic gout, serum Hcy level was negatively correlated with eGFR (γ= -0.413, p < 0.001), while it was uncorrelated with serum uric acid levels or cholesterol profiles. Serum Hcy levels were not different between the groups treated with allopurinol and with benzbromarone. When we observed the follow-up results in chronic gouty group, the change of serum Hcy level was positively correlated with the change of serum creatinine level (γ = 0.560, p < 0.001), and negatively correlated with the change of eGFR (γ = -0.556, p < 0.001). However the change of serum Hcy level was uncorrelated with the changes of uric acid level or the lipid profiles. The chronic gouty patients with CKD showed significantly higher serum Hcy level than those without CKD (17.45 ± 4.68 μmol/L vs 13.15 ± 3.46 μmol/L, p < 0.001), and the follow-up result also showed similar tendency (19.12 ± 4.29 μmol/L vs 15.69 ± 5.73 μmol/L, p = 0.059). In multiple linear analyses, serum Hcy level was affected by eGFR (β = -0.385, p< 0.001), however, was not affected by the serum uric acid level.

Conclusion: Serum Hcy level was elevated in chronic gouty patients than in controls. The change of serum Hcy level was negatively correlated with the change of eGFR. Hyperhomocysteinemia in chronic gouty patients was related with decreased renal function, and was not with serum uric acid or lipid profiles.


Disclosure:

E. H. Park,
None;

S. T. Choi,
None;

J. S. Song,
None.

  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-relationship-between-serum-homocysteine-uric-acid-and-renal-function-in-chronic-gouty-patients-2-year-follow-up-results/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.