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Abstract Number: 2442

The Relationship Between Fatigue and Disease Activity as Determined by Different Indices in Patients with Psoriatic Arthritis (PsA)

Mehmet Tuncay Duruoz1, Halise Hande Gezer 2, Kemal Nas 3, Erkan Kilic 4, Betul Sargin 5, Sevtap Acer Kasman 1, Hakan Alkan 6, Nilay Sahin 7, Gizem Cengiz 8, Nihan Cuzdan 9, Ilknur Albayrak Gezer 10, Dilek Keskin 11, Cevriye Mulkoglu 12, Hatice Resorlu 13, Şebnem Ataman 14, Ajda Bal 15, Okan Kucukakkas 16, Ozan Volkan Yurdakul 16, Meltem Alkan Melikoglu 17, Yildiray Aydin 3, Fikriye Figen Ayhan 18, Hatice Bodur 19, Mustafa Calis 8, Erhan Capkin 20, Gul Devrimsel 21, Kevser Gök 22, Sami Hizmetli 23, Ayhan Kamanli 3, Yasar Keskin 16, Hilal Kocabas 24, Oznur Kutluk 25, Nesrin Sen 26, Omer Faruk Sendur 27, Ibrahim Tekeoglu 3, Sena Tolu 28, Murat Toprak 29 and Tiraje Tuncer 25, 1Marmara University School of Medicine, PMR Department, Rheumatology Division, İstanbul, Turkey, 2Marmara University School of Medicine, PMR Department, Rheumatology Division, İstanbul, Istanbul, Turkey, 3Sakarya University School of Medicine, PMR Department, Rheumatology and Immunology Division, Sakarya, Turkey, 4Afyonkarahisar State Hospital, Afyonkarahisar, Turkey, 5Adnan Menderes University School of Medicine, PMR Department, Rheumatology Division, Aydın, Turkey, 6Pamukkale University School of Medicine, PMR Department, Rheumatology Division, Denizli, Turkey, 7Balıkesir University School of Medicine, PMR Department, Balıkesir, Turkey, 8Erciyes University School of Medicine, PMR Department, Rheumatology Division, Kayseri, Turkey, 9Şanlıurfa Training and Research Hospital, Rheumatology Clinic, Şanlıurfa, Turkey, 10Selçuk University School of Medicine, PMR Department, Konya, Turkey, 11Kırıkkale University School of Medicine, PMR Department, Kırıkkale, Turkey, 12Ankara Training and Research Hospital, PMR Clinic, Ankara, Turkey, 13Çanakkale Onsekiz Mart University School of Medicine, PMR Department, Çanakkale, Turkey, 14Ankara University School of Medicine, Physical Medicine and Rehabilitation, Rheumatology Department, Ankara, Ankara, Turkey, 15Dışkapı Yıldırım Beyazıt Training and Research Hospital, PMR Clinic, Ankara, Turkey, 16Bezmialem Vakıf University School of Medicine, PMR Department, İstanbul, Turkey, 17Atatürk University School of Medicine, PMR Department, Rheumatology Division, Erzurum, Turkey, 18Uşak University School of Health Sciences, PMR Department, Uşak, Turkey, 19Yıldırım Beyazıt University School of Medicine, PMR Department, Ankara, Turkey, 20Karadeniz Teknik University School of Medicine, PMR Department, Trabzon, Turkey, 21Recep Tayyip Erdoğan University School of Medicine, PMR Department, Riza, Turkey, 22Numune Training and Research Hospital, Rheumatology Clinic, Ankara, Turkey, 23Cumhuriyet University School of Medicine, PMR Department, Rheumatology Division, Sivas, Turkey, 24Necmettin Erbakan University Meram School of Medicine, PMR Department, Rheumatology Division, Konya, Turkey, 25Akdeniz University School of Medicine, PMR Department, Rheumatology Division, Antalya, Turkey, 26Kartal Dr. Lütfi Kırdar Training and Research Hospital, Rheumatology Clinic, İstanbul, Turkey, 27Adnan Menderes University School of Medicine, PMR Department, Aydın, Turkey, 28Medipol University School of Medicine, PMR Department, İstanbul, Turkey, 29Yüzüncü Yıl University School of Medicine, PMR Department, Van, Turkey

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: Disease Activity and patient outcomes, Fatigue, Psoriatic arthritis

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Session Information

Date: Tuesday, November 12, 2019

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster III: Psoriatic Arthritis, Clinical Features

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Fatigue is a substantial problem in patients with psoriatic arthritis (PsA) that needs to be considered in the core set of domains. This study aimed to evaluate the relationship between fatigue and disease activity levels as determined by various scales in patients with PsA.

Methods: A total of 1134 patients (726 females, 408 males) diagnosed with PsA according to the CASPAR criteria were included (Turkish League Against Rheumatism (TLAR) Network multi-center study). Demographic features and clinical conditions of the patients were recorded. The following parameters were assessed: Maastricht Ankylosing Spondylitis Enthesis Score (MASES), Psoriasis Area and Severity Index (PASI), VAS fatigue (0-10 points: 0 – < 2 absent or mild, 2 – < 5 moderate, and 5 – 10 severe fatigue), Hospital Anxiety and Depression Scale (HAD), Fibromyalgia Rapid Screening Tool (FIRST). Disease activity was evaluated using the scores of DAS28, DAPSA, BASDAI, minimal disease activity (MDA), and very low disease activity (VLDA). The Spearman correlation coefficient was used for correlations. The Mann-Whitney U and chi-squared tests were used for between-group comparisons. A P value of less than 0.05 was considered to be statistically significant.

Results: The mean age of the patients was 46.9 (SD:12.1) years, and the median disease duration was four years (range 0-44 years). The mean fatigue score was 4.9 (SD:2.8), being absent or mild, moderate, and severe fatigue in 14.8%, 24.9%, and 60% of the patients, respectively. The mean of women’s fatigue VAS was 5.4 (SD:2.7) while the men’s fatigue VAS mean was 4.01 (SD:2.7) (p< 0.05).  Fatigue has good correlation with VAS-pain (rho: 0.595), FIRST (rho: 0.513), anxiety (rho: 0.436), depression (rho: 0.388), MASES (rho: 0.297) and it has poor correlation with PASI (rho: 0.073). DAS28 and DAPSA remission, MDA, and VLDA rates were 24.3%, 2.6%, 13.6%, and 2.3%, respectively. The fatigue score was significantly lower in patients with DAS28 remission, DAPSA remission, MDA and VLDA (p< 0.05) and fatigue has a significant correlation with disease activity levels on DAS28 and DAPSA (p< 0.05) (Table 1). The DAS28, DAPSA, and BASDAI scores showed significant between-group differences across the three severity groups of fatigue, being the highest disease activity among patients with severe fatigue (p< 0.05). Significantly higher FIRST, anxiety and depression scores were noted in patients with DAS28 remission and fatigue compared with patients in remission but no fatigue (p< 0.05). 

Conclusion: Fatigue is common and associated with disease activity, depression, anxiety, and fibromyalgia in PsA. Patients with remission, according to DAS28, DAPSA, and patients with MDA and VLDA have already mild to moderate fatigue.


Fatigue Table1


Disclosure: M. Duruoz, İbrahim etem, 8, Abdi İbrahim, 8, Abdi Ibrahim, 8, Abvie, 2, 8, AMGEN, 8, AMGEN, Novartis, ILKO, ONKO, İbrahim Ethem, Abdi İbrahim, 8, Ibrahim Ethem, 8, ILKO, 8, Novartis, 8, ONKO, 8; H. Gezer, None; K. Nas, None; E. Kilic, None; B. Sargin, None; S. Acer Kasman, None; H. Alkan, None; N. Sahin, None; G. Cengiz, None; N. Cuzdan, None; I. Albayrak Gezer, None; D. Keskin, None; C. Mulkoglu, None; H. Resorlu, None; �. Ataman, None; A. Bal, None; O. Kucukakkas, None; O. Yurdakul, None; M. Alkan Melikoglu, None; Y. Aydin, None; F. Ayhan, None; H. Bodur, None; M. Calis, None; E. Capkin, None; G. Devrimsel, None; K. Gök, None; S. Hizmetli, None; A. Kamanli, None; Y. Keskin, None; H. Kocabas, None; O. Kutluk, None; N. Sen, None; O. Sendur, None; I. Tekeoglu, None; S. Tolu, None; M. Toprak, None; T. Tuncer, None.

To cite this abstract in AMA style:

Duruoz M, Gezer H, Nas K, Kilic E, Sargin B, Acer Kasman S, Alkan H, Sahin N, Cengiz G, Cuzdan N, Albayrak Gezer I, Keskin D, Mulkoglu C, Resorlu H, Ataman �, Bal A, Kucukakkas O, Yurdakul O, Alkan Melikoglu M, Aydin Y, Ayhan F, Bodur H, Calis M, Capkin E, Devrimsel G, Gök K, Hizmetli S, Kamanli A, Keskin Y, Kocabas H, Kutluk O, Sen N, Sendur O, Tekeoglu I, Tolu S, Toprak M, Tuncer T. The Relationship Between Fatigue and Disease Activity as Determined by Different Indices in Patients with Psoriatic Arthritis (PsA) [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/the-relationship-between-fatigue-and-disease-activity-as-determined-by-different-indices-in-patients-with-psoriatic-arthritis-psa/. Accessed .
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