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Abstract Number: 1496

The Performance of Different Classification Criteria in Patients with Primary Sjogren’s Syndrome and Analysis of Their Contribution for Definitive Diagnosis, When Either Criteria Used Alone or in Combination

Zehra Kosuva Ozturk1, Gokce Kenar2, Handan Yarkan3, Berrin Zengin2, Gercek Can2, Fatos Onen2 and Merih Birlik4, 1internal medicine, dokuz eylul universty, izmir, Turkey, 2Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, 3Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 4Rheumatology, Dokuz Eylul University Faculty of Medicine, izmir, Turkey

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: classification criteria and diagnostic criteria, Sjogren's syndrome

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Session Information

Date: Monday, November 6, 2017

Title: Sjögren's Syndrome Poster II: Clinical Research

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Many classification criteria sets have for primary Sjšgren’s Syndrome (pSS).We aimed to compare the performance of 3 classification criteria sets for pSS, to determine the agreement between each other and expert opinion and to investigate diagnostic contribution with any combined use of these criteria. For those assessments, American-European Consensus Criteria (AECG), American Collage of Rheumatology (ACR) / Sjšgren International Clinical Alliance (SICCA) criteria and L.S. Martin et.al. criteria named Mathematical model (M.model) had chosen.

Methods: 86 patients(F:96%,mean age:51.7±11.8) with the diagnosis of pSS were enrolled to the study.Expert opinion had been taken as gold standard for pSS diagnosis.Patients were questioned for eye/mouth dryness.Antinuclear antibody ,complement,anti-Ro-La,serum protein electrophoresis,rheumatoid factor,break-up time (BUT) and Schirmer,minor salivary gland biopsy results were analysed cautiously.The aforementioned criteria sets, were implemented to assess the classification.The percentage of exact agreement and Kappa test was calculated.

Results: Number of patients classified as pSS according to ACR/SICCA, AECG and M.model criteria were 75 (87%), 63 (73%) and 58(67%) respectively. 9 patients (10%) did not fulfill any of these 3 criteria but they were diagnosed as pSS according to expert opinion (Figure1)The Kappa test was moderate between the ACR/SICCA and AECG criteria and slightly low between the M.model with the AECG and ACR/SICCA criteria (Table 1). According to our proposed combination model, number of patients classified as pSS, either AECG or M.model was 74; either AECG or ACR/SICCA model was 76; either ACR/SICCA or M.model was 77(Table 2). In the triple combination of our model, if all 3 criteria used concomitantly, only 46 of patients fulfill the criteria simultaneously; however if any of 3 criteria sets used 77patients fulfill as pSS.

Conclusion: In this study, ACR/SICCA classification criteria for pSS was found the most compatible criteria set with expert opinion.

Table 1.The agreement between three pSS classification criteria sets.(%, Kappa test)

AECG

ACR/SICCA

M.MODEL

AECG

%83 K:0.50

%68 K:0.25

ACR/SICCA

%83 K:0.50

%75 K:0.34

M.MODEL

%68 K:0.25

%75 K:0.34

Table 2. Number of patients fulfilling classification criteria

Classsification criteria (n) (%)

According to 1 criteria

ACR/SICCA

AECG

M.model

75 63 58

87,2 73,2 67,4

According to either of 2 criteria

ACR/SICCA or M.model

AECG or ACR/SICCA

AECG or M. model

77 76 74

89,5 88,3 86

According to either of 3 criteria

AECG or ACR/SICCA or M.model

77

89,5


Disclosure: Z. Kosuva Ozturk, None; G. Kenar, None; H. Yarkan, None; B. Zengin, None; G. Can, None; F. Onen, None; M. Birlik, None.

To cite this abstract in AMA style:

Kosuva Ozturk Z, Kenar G, Yarkan H, Zengin B, Can G, Onen F, Birlik M. The Performance of Different Classification Criteria in Patients with Primary Sjogren’s Syndrome and Analysis of Their Contribution for Definitive Diagnosis, When Either Criteria Used Alone or in Combination [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/the-performance-of-different-classification-criteria-in-patients-with-primary-sjogrens-syndrome-and-analysis-of-their-contribution-for-definitive-diagnosis-when-either-criteria-used-alone-or-in-com/. Accessed .
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