ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0311

The Link Between Joints and Entheses in Psoriatic Arthritis: An Ultrasound Study Supporting the Synovio-entheseal Complex Theory

Gizem Ayan1, Ilaria Tinazzi2, Sibel Bakirci3, Ummugulsum Gazel4, Dilek Solmaz5, Umut Kalyoncu6 and Sibel Aydin7, 1University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA, Ottawa Hospital Research Institute, OTTAWA, ON, Canada, 2Sacro Cuore Don Calabria Hospital, Unit of Rheumatology, Negrar-Verona, VR, ITALY, Verona, Italy, 3Antalya Research and Training Hospital, Antalya, TURKEY; University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA, Antalya, Turkey, 4University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA; The Ottawa Hospital Research Institute, Ottawa, ON, CANADA, ottawa, Canada, 5Izmir Katip Celebi University, Department of Internal Medicine, Division of Rheumatology, Izmir, TURKEY, Izmir, Turkey, 6Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 7University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA; The Ottawa Hospital Research Institute, Ottawa, ON, CANADA, Ottawa, ON, Canada

Meeting: ACR Convergence 2020

Keywords: ,

Session Information

Date: Friday, November 6, 2020

Title: Spondyloarthritis Including Psoriatic Arthritis – Diagnosis, Manifestations, & Outcomes Poster I: Psoriatic Arthritis

Session Type: Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The aim of this study is to explore the link between the severity of the joint and entheses involvement in psoriatic arthritis (PsA) using musculoskeletal ultrasound (US).

Methods: PsA patients from 2 centers in the Psoriatic Arthritis- International Database (PsArt-ID) (n=126) underwent an ultrasound assessment of 46 joints and 12 large entheses. The correlation between joint and enthesitis scores on the US was analyzed in addition to the clinical indices versus the US.

Results: Fifty-six of the 126 patients (44.4%) were male and the mean (SD) age was 54.8 (14.6) years. The mean PsA duration was 7.6 (8.3) years. Greyscale (GS) synovitis score for the joints was moderately correlated with the total enthesitis score (r=0.410, p< 0.001) (Table). The Global Outcome Measure in Rheumatology in Clinical Trials-European League Against Rheumatism Synovitis Score (GLOESS) score was also found in correlation with the total enthesitis score (r=0.400, p< 0.001) (Table). The link between the US and clinical examination findings only showed a poor correlation between swollen joint counts (SJC) and joint-US scores (r=0.298, p=0.001 for GLOESS). Assessment of the entheses on US showed a poor-moderate correlation between the entheseal damage scores and tender joint counts (TJC) (r=0.217, p= 0.018) and SJC (r=0.326, p= p< 0.001). In terms of the clinical examination and activity parameters, none of the clinical parameters and acute phase reactants were correlated to Leeds Enthesitis Index.

Conclusion: Our study showed a link between the severity of the sonographic findings in the joints and the entheses. The link between these two anatomical structures supports the synovio-entheseal complex theory.

Table. Correlation between joint and entheses ultrasound scores

Disclosure: G. Ayan, None; I. Tinazzi, None; S. Bakirci, None; U. Gazel, None; D. Solmaz, None; U. Kalyoncu, Abbvie, 1, Amgen, 1, Jannsenn, 1, Lilly, 1, Novartis, 1, UCB, 1; S. Aydin, None.

To cite this abstract in AMA style:

Ayan G, Tinazzi I, Bakirci S, Gazel U, Solmaz D, Kalyoncu U, Aydin S. The Link Between Joints and Entheses in Psoriatic Arthritis: An Ultrasound Study Supporting the Synovio-entheseal Complex Theory [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/the-link-between-joints-and-entheses-in-psoriatic-arthritis-an-ultrasound-study-supporting-the-synovio-entheseal-complex-theory/. Accessed .

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