Session Information
Date: Monday, October 22, 2018
Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster II: Clinical/Epidemiology Studies
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Spondyloarthritides (SpA) are heterogeneous group of inflammatory diseases, affecting both, axial and peripheral skeleton. Incidence studies in SpA are sparse. There is no data for peripheral SpA as an entity. In axial SpA, recent incidence study reported a decrease of the incidence over decades (1). As data for our country are lacking, we aimed to determine the incidence of SpA in a well defined country region.
Methods:
The study was conducted at rheumatology department of an integrated secondary/tertiary teaching hospital, which provides services to region of around 704,000 adult residents. A retrospective chart review of adult patients diagnosed with SpA for the first time between January 2014 and December 2016 was performed. Potential cases were ascertained by searching the electronic medical records for ICD-10 codes M02*, M07*, M13*, M45*, K50*, K51*and L40*. SpA cases were further stratified into axial and peripheral subgroup. The annual incidence rate of SpA was calculated.
Results: During the three year period we identified 294 new SpA cases (55.1% males, median (IQR) age 46.7 (35.0-57.7) years). We diagnosed ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis and undifferentiated SpA in 22.4%, 39.8%, 7.1%, 3.7%, and 26.9% cases, respectively. We classified 98 patients (33.3%) with axial SpA and the rests with peripheral SpA. Characteristics of SpA cohort and both subgroups are presented in Table 1. The estimated annual incidence rate of SpA in our region was 13.9 cases per 100,000 adults per year (95% CI 12.4-15.6), in axial SpA 4.6 per 100,000 adults (95% CI 3.8-5.6), and in peripheral SpA 9.3 per 100,000 adults (95% CI 8.0-10.6). Gender specific incidence rates are presented in Table 1.
Table 1: Characteristics of Spodyloarthritides
|
Characteristics |
All SpA |
Peripheral SpA |
Axial SpA |
|
No. (%) of cases |
294 (100%) |
196 (66.7%) |
98 (33.3%) |
|
Male gender (%) |
162 (55.1%) |
95 (48.5%) |
67 (67.4%) |
|
Age (years)# |
46.7 (35.0-57.7) |
49.9 (36.4-58.6) |
39.9 (33.7-55.8) |
|
Symptom duration (months)# |
7.1 (1.9-24.7) |
3.5 (1.0-12.1) |
31.7 (10.8-73.2) |
|
HLA B27 positivity (%) |
158/261 (60.5%) |
81/166 (48.8%) |
77/95 (81.1%) |
|
Incidence rate& |
13.9 (12.4-15.6) |
9.3 (8.0-10.6) |
4.6 (3.8-5.6) |
|
Incidence in females& |
12.2 (10.2-14.4) |
9.3 (7.6-11.3) |
2.9 (2.0-4.0) |
|
Incidence in males& |
15.8 (13.5-18.3) |
9.2 (7.5-11.3) |
6.5 (5.1-8.2) |
Legend: SpA spondyloarthritis; # median (IQR); & incidence per 100,000 adults per year and 95% confidence interval.
Conclusion: The incidence rate of SpA is similar to the incidence of rheumatoid arthritis in our country (2). Peripheral SpA is two times more frequent than axial SpA.
References:
1) Wright KA, Crowson CS, Michet CJ, Matteson EL: Time trends in incidence, clinical features and cardiovascular disease in ankylosing spondylitis over three decades: a population-based study. Arthritis Care Res (Hoboken) 2015; 67:836-841.
2) Ješe R, Perdan Pirkmajer K, Hočevar A, Rotar Ž, Markez S, Pavić Nikolić M, et al. The Incidence Rate of Rheumatoid Arthritis in Slovenia. (2018 ACR submitted abstract)
To cite this abstract in AMA style:
Potocnik Pucelj N, Hočevar A, Jese R, Rotar Z, Tomšič M. The Incidence Rate of Spondyloarthritis in Slovenia [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/the-incidence-rate-of-spondyloarthritis-in-slovenia/. Accessed .« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-incidence-rate-of-spondyloarthritis-in-slovenia/