ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2414

The Global Antiphospholipid Syndrome Score in Women with Systemic Lupus Erythematosus and Adverse Pregnancy Outcomes

Karen Schreiber1, Massimo Radin2, Irene Cecchi3, Elena Rubini4, Dario Roccatello5, Søren Jacobsen6, Maria Jose Cuadrado7 and Savino Sciascia8, 1Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6University of Copenhagen, Copenhagen, Denmark, 7Clinica Universidad de Navarra, Madrid, Spain, 8Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: , , ,

Session Information

Date: Tuesday, October 23, 2018

Title: Reproductive Issues in Rheumatic Disorders Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) are associated with pregnancy complications.

Methods: 143 women ever pregnant with SLE who presented in our outpatient clinic were included. The individual GAPSS was calculated for each patient by calculating the sum of each risk factor score, as follows: three for hyperlipidaemia, one for arterial hypertension, five for aCL IgG/IgM, four for anti-b2 glycoprotein I IgG/IgM, 3 for anti-phosphatidylserine/prothrombin antibodies (aPS/PT) IgG/M and four for lupus anticoagulant (LA).

Results:

Significantly higher GAPSS values were seen in patients with the following pregnancy history when compared to those without a history of pregnancy complications: any pregnancy complication (mean GAPSS 8.4, S.D. 4.5) vs. no pregnancy complication (mean GAPSS 3.1, S.D. 2.6, mean difference 5.2, t-test: p=0.000, 95%CI 4.0-6.4); three or more consecutive miscarriages of < 10 weeks gestation (mean GAPSS 9.4, S.D. 4.5) vs. no miscarriages <10 weeks gestation (mean GAPSS 4.8, S.D. 4.1, mean difference 4.6; t-test: p=0.002, 95%CI 1.7-7.4); any miscarriages (mean GAPSS 6.3, S.D. 4.3) vs. no miscarriages (mean GAPSS 4.7, S.D. 4.3, mean difference 1.6, t-test: p=0.045, 95%CI 0.03-3.1); fetal death (mean GAPSS 9.0, S.D. 3.8) vs. no fetal death (mean GAPSS 3.8, S.D. 3.4, mean difference 5.3, t-test: p=0.000, 95%CI 3.7-6.8); miscarriage <10 weeks gestation (mean GAPSS 9.1, S.D. 4.2) vs. no miscarriage < 10 weeks (mean GAPSS 3.8, S.D. 3.4, mean difference 5.3, t-test: p=0.000, 95%CI 3.9-6.7); premature birth (< 34 weeks) (mean GAPSS7.8, S.D. 4.7) vs. no premature birth (mean GAPSS 4.8, S.D. 4.1, mean difference 2.9, t-test: p=0.01, 95%CI 0.7-5.2); pre-eclampsia (PET) (< 34 weeks) (mean GAPSS 7.8, S.D. 5.1) vs. no PET (mean GAPSS 4.7, S.D 4.0, mean difference 3.1, t-test: p=0.002, 95%CI 1.1-5.2); stillbirth (mean GAPSS 9.1, S.D. 5.1) vs. no stillbirth (mean GAPSS 4.8, S.D 4.1, mean difference 4.3, t-test: p=0.002, 95%CI 1.6-6.9); placental infarction (mean GAPSS 10.6, S.D. 4.2) vs. no placental infarction (mean GAPSS 4.9, S.D 4.1, mean difference 5.6, t-test: p=0.004, 95%CI 1.8-9.4).

Conclusion:

Higher GAPSS values are found in women with SLE and aPL with previous pregnancy complications compared to those without pregnancy complications. The clinical utility of the GAPSS score in pregnancy seems promising and should be validated in a prospective cohort.

Disclosure: K. Schreiber, None; M. Radin, None; I. Cecchi, None; E. Rubini, None; D. Roccatello, None; S. Jacobsen, None; M. J. Cuadrado, None; S. Sciascia, None.

To cite this abstract in AMA style:

Schreiber K, Radin M, Cecchi I, Rubini E, Roccatello D, Jacobsen S, Cuadrado MJ, Sciascia S. The Global Antiphospholipid Syndrome Score in Women with Systemic Lupus Erythematosus and Adverse Pregnancy Outcomes [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/the-global-antiphospholipid-syndrome-score-in-women-with-systemic-lupus-erythematosus-and-adverse-pregnancy-outcomes/. Accessed .

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